• The Korean Journal of Mycology
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• v.45 no.1
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• pp.68-73
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• 2017

In 2015, the leaves of broadleaf liriope, Liriope muscari, showing anthracnose symptoms were found in a field of Korea. The fungus was isolated and identified as Colletotrichum liriopes based on the morphological characteristics and nucleotide sequence data of the glyceraldehyde-3-phosphate dehydrogenase, internal transcribed spacer and actin genes. To the best of our knowledge, this is the first report of C. liriopes isolated from L. muscari in Korea.

• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.469-474
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• 2016

Liriopogons (Liriope and Opiopogon) species are used as a main medicinal ingredient in several Asian countries. The Liriopes Radix (tuber, root of Liriope platyphylla) has to be a promising candidate due to their source of phytochemicals. Steroidal saponins and their glycosides, phenolic compounds, secondary metabolites are considered of active constituents in Liriopes Radix. Spicatoside A, a steroidal saponin, could be more efficacious drug candidate in future. In this review, we summarized the available knowledge on phytochemical and pharmacological activities for spicatoside A. It significantly suppressed the level of NF-${\kappa}B$, NO, iNOS, Cox-2, IL-$1{\beta}$, IL-6 and MAPKs in LPS-stimulated inflammation. The production of MUC5AC mucin was increased. MMP-13 expression was down-regulated in IL-$1{\beta}$-treated cells and reduced glycosaminoglycan release from IL-$1{\alpha}$-treated cells. The neurite outgrowth activity, PI3K, Akt, ERK1/2, TrkA and CREB phosphorylation and neurotropic factors such as NGF and BDNF were upregulated with increased latency time. It also showed cell growth inhibitory activity on various carcinoma cells. From this, spicatoside A exerts anti-inflammation, anti-asthma, anti-osteoclastogenesis, neurite outgrowth, memory consolidation and anticancer activities. Further studies are needed on spicatoside A in order to understand mechanisms of action to treat various human diseases.

• Korean Journal of Pharmacognosy
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• v.10 no.3
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• pp.108-111
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• 1979

In vivo antioxidant activities were screened over 30 kinds of crude drugs which are most frequently prescribed in oriental medicine. Of these, only Ginseng Radix, Cimicifugae Rhizoma, Zingiberis Rhizoma(steam dried), Alismatis Rhizoma, and Liriopes Tuber were shown to be positive in the activity.

• YAKHAK HOEJI
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• v.8 no.2
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• pp.54-58
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• 1964

Effects on the bacteria gwoth of 96 kinds of crude drugs described in "Pen-Tsao-Kang-Mu" was investigated. Galla Rhois, Moutan Cortex Radicis, Aconiti Tuber, Euphorbiae Radix and PAeoniae Radix showed the antibacterial activity but Cnidii Rhizoma, Coicis Semen, Angelicae gigantis Radix, Asparagi Radix and Liriopes Tuber show the gwoth promoting action of all bacteria used in this experience. It can be seen that 10 kinds of crude drugs classified as poisonous plants inhibited the growth or had no effect by never promoted. 32 kinds of crude drugs as drugs acting on the gastrointestinal system showed antibacterial activity on E. coli $O_{55}$ and E. coli $O_{111}$. 18 kinds on inflammation showed antibacterial activity on Staphylococcus aureus and Sarcina lutea.

• Journal of Pharmacopuncture
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• v.24 no.3
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• pp.138-141
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• 2021

Objectives: This study aims to describe the utilization of herbal formulas from Wenrejingwei by using network analysis and understand the treatment of acute exogenous febrile diseases. Methods: We constructed a matrix of high-frequency herbal combinations (HCs) from Wenrejingwei and Shang Han Lun and cluster networks based on cohesive analysis. Network analysis was performed to compare the results. Results: The results of the high-frequency HC network in Wenrejingwei showed cohesive patterns in three categories corresponding to dampness-heat and warm-fever treatment. Compared to the Shang Han Lun network, the Wenrejingwei network indicated a careful approach in the use of pungent and warm herbs such as Guizhitang. Moreover, the combination of Scutellaria baicalensis and Coptis chinensis along with the use of herbs strengthening yin, such as Ginseng Radix and Liriopes Radix, provide evidence of a holistic approach in the treatment of exogenous febrile diseases by considering the balance of the human body damaged by heat. Conclusion: The results of this study could help select appropriate herbal formulas and treatment methods for treating Onbyeong and modern acute febrile infectious diseases.