• Biomolecules & Therapeutics
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• 제6권4호
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• pp.417-422
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• 1998

Loxoprofen sodium (sodium 2-[4-(2-oxocyclopentylmethyl)phenyl] propionate dehydrate) is a nonsteroidal antiinflammatory drug of $\alpha$-phenyl propionic acid derivative. To test the bioequivalence of loxoprofen, the pharmacokinetic parameters of new preparation of loxoprofen, LENOX was compared with LOXONIN as a reference drug. Fourteen healthy volunteers were entered to the stydy (Yonsei University College of Medicine, Severance Hospital IRB approval No. 9608). They were administered 60 mg of loxoprofen in 2$\times$2 cross-over design. There was one week of drug-free interval between doses. The blood sample was taken on schedule up to 8 hours, and the plasma concentration loxoprofen was measured by reverse phase high-performance liquid chromatography (HPLC) with UV-detector. There were no significant difference between two preparations when AUC, Cmax, and Tmax were compared by ANOVA. The mean differences of AUC, Cmax, and Tmax were within 20% of the reference drug: the values were 2.22,5.61, and 12.50%, respectively. The confidence limits of AUC and Cmax but not Tmax satisfied the bioequivalence criteria. These results suggest that the tested LENOX is bioequivalent to the reference drug.

• 한국안전학회지
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• 제11권2호
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• pp.79-88
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• 1996

A hypothetical accident in the containment vessel of liquid metal reactor could cause a pressure, temperature rise, and a strong aerosol release. The computer codes relating to the modelization of these accident make it necessary to use various input parameter, among which is the dynamic shape factor of aerosols produced. Combustion experiments of sodium spray fire carried out in a closed vessel, which was vertical cylinder made of 1.2m in diameter and 1.8m hight with a volume of 1.7$m^3$. The results of theoretical analysis presented here was compared to data obtained from experiments. The experimental results were summarized as follows. 1) The aerodynamic diameter and geometric diameter of aerosols are decreasing with increasing of injection pressure and injection temperature of sodium 2) The dynamic shape factor of aerosol is proportional to the aerodynamic diameter for a given particle. 3) The correspondence between the aerodynamic diameter and geometric diameter can be as $D_{ae}=0.70 D_{ge}$. 4) Peak pressure rose with increase in pressure and temperature of injection sodium, being more sensitive to the injection pressure than the injection temperature.

• 청정기술
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• 제7권4호
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• pp.291-297
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• 2001

본 연구는 중금속 추출 공정에 쓰이는 사차 암모늄 염인 Aliquat 336을 포함하는 콜로이드 액상 에이프런 (colloidal liquid aphrons, CLAs)을 지용성 계면활성제와 수용성 계면활성제를 사용하여 제조하였고 연속상에서 농축된 CLAs의 안정성을 표면으로 떠오르는 유기 용매의 양을 시간에 따라 측정하여 평가하였다. 다양한 조건에서 CLAs의 안정성을 비교하기 위해서 반감기가 도입되었다. 전해질의 첨가나 pH의 변화와 같은 연속상의 상태 변화는 CLAs의 파괴(break-up) 속도에 상당히 영향을 미치는데 이 파괴 속도가 급격히 변화하는 임계 응집 농도가 존재한다. pH의 변화에 따른 임계 응집 농도를 측정하였고 이온의 세기, 수용성 계면활성제 Sodium Dodecyl Sulfonate (SDBS)의 농도에 대한 CLAs의 안정성에 대한 영향을 고찰하였다.

• International Journal of Safety
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• 제4권2호
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• pp.24-29
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• 2005

An experimental study was presented for extinguishing characteristics of liquid fuel fire by water mist($Dv_{0.99}{\leq}200{\mu}m$) containing potassium acetate and sodium acetate trihydrate. To evaluate the extinguishing performance of water mist containing additives, the evaporation characteristics of a water droplet on a heated surface was examined. The evaporation process was recorded by a charge-coupled-device camera. Also, small-scale extinguishing tests were conducted for n-heptane pool fire in ventilated space. During the experiments, flame temperatures were measured, and concentrations of oxygen and carbon monoxide were analyzed by a combustion gas analyzer. The average evaporation rate of water droplet containing additives was lower than that of pure water at a given surface temperature and decreased with the concentration increase due to the precipitation of salt in the liquid-film and change of surface tension. In case of using additives, the fire extinguishing times was shorter than that of pure water at a given discharge pressure and it was because the momentum of a water droplet containing additives was increased. And also dissociated metal atoms, potassium or sodium, were reacted as a scavenger of the major radical species OH, H which were generated for combustion process. Moreover, at a high pressure of 4 MPa, the fire was extinguished through blowing effect as well as primary extinguishing mechanisms.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 추계학술대회 논문집 전문대학교육위원 P
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• pp.1-3
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• 1999

EM (ElectroMagnetic) pump is used for the purpose of transporting liquid sodium coolant with electrical conductivity in the LMR(Liquid Metal Reactor). (In the present study, pilot EM pump has been designed by using of equivalent circuit method which is commonly employed to analyze linear induction machines for the test of removal of residual heat. The length and diameter of the pump have fixed values of 840 mm and 101.6 mm each by taking account of geometrical size of circulation loop for the installation of EM pump. Flowrate versus developing pressure is related from Laithwaite's standard design formula and the characteristic analyses of developing force and efficiency are carried out according to change of input frequency. From the characteristic curve, input frequency of 13 Hz is determined as the design frequency. On the other hand, The annular air gap size of 6.05 mm is selected not to bring about too much hydraulic loss. Resultantly design analysis makes pump have the electrical input of 604 VA and the hydrodynamical capacity of 1.3 bars and 40 l/min.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2003년도 가을 학술논문집
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• pp.220-225
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• 2003

원자력발전소에서 발생하는 방사성 폐액은 일반적으로 액체폐기물처리계통 폐액증발기 및 농축 폐액건조설비에서 증발 및 건조 공정을 통해 수분을 함유하지 않은 분말형태로 변한다. 이 분말형태의 폐기물은, 취급 시와 처분 후 안전성을 확보할 수 있도록, 파라핀과 균일하게 혼합되어 고화된 후 철제드럼에 포장된다. 농축폐액건조설비를 이용하여 농축폐액을 건조시킨 후 분말 형태의 폐기물을 파라핀과 혼합하는 공정을 수행할 때, 방사성 폐액 중 붕소와 나트륨의 몰비가 0.2를 초과하는 경우, 분말형태의 폐기물이 파라핀과 균일하게 혼합되지 않고 층을 이루어 분리되어 드럼에 안정고화가 잘 안되는 경우가 발생하였고 또한 일부는 드럼화 전에 설비 내에 고착되는 현상이 발생하는 것을 경험하였다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1999년도 춘계학술대회 논문집
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• pp.434-437
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• 1999

An EM pump is used for the purpose of transporting the electrically conducting liquid sodium of the high temperature that is used as a coolant in the liquid metal reactor. In the present study, the pilot pump has been designed and manufactured for the high temperature of $600^{\circ}C$ by the equivalent circuit materials and the consideration of the materials and functions. The length and diameter of the pump are given as 84 cm and 10 cm each due to the fixed geometry of the circulation system to be installed. The characteristic of the developing pressure and efficiency is found out by using Laithewaite\`s standard design formula. It is shown that the developing pressure and efficiency are maximized at the frequency of 15 Hz from the curve. The annular channel gap of 3.95 mm is selected in the range of the reasonable hydraulic frictional loss. The components of the pump consist of the material for the high temperature. And then, the pump is manufactured to have the nominal flowrate of 40 1/min and developing Pressure of 1.3 bar.

• Bulletin of the Korean Chemical Society
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• 제17권10호
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• pp.949-951
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• 1996

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2017년도 춘계학술논문요약집
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• pp.333-333
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• 2017

• Journal of Pharmaceutical Investigation
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• 제14권4호
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• pp.161-169
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• 1984

The tests of dissolution and bioavailability of six formulas of lorazepam tablet under various binders were performed. Lorazepam can be seperated in pharmaceutical preparation and biological plasma by high performance liquid chromatograph. Dissolution process of lorazepam tablet was largely influenced by binder and the dissolution rate was increased by sodium starch glycolate and microcrystalline cellulose, the slower dissolution rate in starch. Bioavailability of lorazepam tablet got relationship with dissolution rate, because tablets containing sodium starch glycolate and microcrystalline cellulose as binder maintained higher plasma level than other binders.