• Animal cells and systems
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• 제8권1호
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• pp.41-47
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• 2004

The kallikrein-kinin system affects regulation of blood pressure, and genes encoding for the components of this system have been considered as good candidates for hypertension. To evaluate the relationship between genetic polymorphisms of candidate genes involved in this system and hypertension, we performed case-control studies using genetic markers in Korean normotensives and hypertensives, respectively. By association study, there was a marginal association with hypertension in AA genotype distribution of A1789G polymorphism in the hKLK1 gene (P=0.0754). Thus, this genetic polymorphism may weakly contribute to the susceptibility to hypertension in Koreans. We also observed that significant linkage disequilibrium exists among three polymorphic sites in the hKLK1 gene studied, suggesting that the three genetic polymorph isms can be useful as genetic markers in clinical association studies. Further studies using larger sample sizes and more genetic markers will be needed to clarify genetic influence of kallikrein-kinin system for hypertension.

• 기술경영경제학회:학술대회논문집
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• 기술경영경제학회 1999년도 제16회 동계학술발표회 논문집
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• pp.255-278
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• 1999

R&D association is a very important institution to promote inter-firm technological cooperation, In Korea, they have begun to be established in 1982, and at now 56 R&D associations are working. The purpose of this study is In analyze the problems of the R&D associations, and to suggest a new direction of their future development Their problems were analyzed from the perspective of cooperative R&D mechanisms, especially with a new concept of R&D community : search community, planning community, community of research itself. This study emphases the importance of the R&D association's role as a planning community, and the institutional linkage between R&D association and National R&D program through the introduction of design-in planning system.

• 한국지역지리학회지
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• 제2권1호
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• pp.1-24
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• 1996

이 논문은 진주지역을 사례로 생산자 서비스와 제조업의 지역적 연계를 연구하고자 하였다. 서비스경제화 과정에 있는 한국경제에서 생산자서비스 부문은 가장 빠르게 성장하는 서비스이다. 진주지역 제조업체들은 일반화된 생산자서비스는 가까운 진주지역에서 구입하고 있으나 고차계층의 서비스일수록 대도시 특히 서울로의 지향이 강하다. 제조업 업종별 생산자서비스의 연계패턴은 유사하며, 진주와 경남지역 출신 제조업체 경영자들이 타 시도 출신자보다 강한 지역연계를 보였다. 진주지역 생산자서비스 공급에서 중요한 역할을 하고 있는 공공적 생산자서비스는 현 단계에서는 지역의 수출기반산업의 역할보다 지역내의 제조업들에게 각종 생산기술관련정보과 서비스를 제공하는 수준이다. 진주지역의 대기업은 고차서비스를 지역외부로부터 조달하며 소규모 기업은 지역내 생산자서비스 이용상태가 저조하다. 지역에서 공급되는 생산자서비스가 지역내 제조업체들이 이용하기에 너무 높거나 아니면 기업활동에 크게 도움되지 못한다는 적실성의 문제로부터 지역경제 발전을 위한 적절한 생산자서비스 육성이라는 지역정책적인 함의를 도출할 수 있다.

• Asian-Australasian Journal of Animal Sciences
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• 제14권11호
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• pp.1505-1510
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• 2001

A method for mapping quantitative trait loci (QTL) was introduced incorporating the information of mixed progeny from complex pedigrees. The method consisted of two steps based on single marker analysis. The first step was to examine the marker-trait association with a mixed model considering common environmental effect and reversed QTL-marker linkage phase. The second step was to estimate QTL effects by a weighted least square analysis. A simulation study indicated that the method incorporating mixed progeny from multiple generations improved the accuracy of QTL detection. The influence of within-genotype variance and recombination rate on QTL analysis was further examined. Detecting a QTL with a large within-genotype variance was more difficult than with a small within-genotype variance. Most of the significant marker-QTL association was detectable when the recombination rate was less than 15%.

• 한국콘텐츠학회논문지
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• 제8권5호
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• pp.29-37
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• 2008

무선채널과 같은 저 대역폭에 비디오 스트림을 전송하기 위해서 H.264와 같은 고압축 코덱이 등장하였다. 저 대역폭으로 고압축 비디오 스트림을 전송할 경우, 패킷 손실로 인하여 화질 열화를 초래한다. 본 논문에서는 H.264 부호화 영상이 전송될 때 손실된 움직임 벡터는 주변에 인접한 움직임 벡터와 높은 상관성을 갖는다는 사실에 착안하여 시-공간적 에러 은닉(temporal-spatial error concealment) 방법을 제안한다. 이때 손실된 블록의 후보 움직임 벡터들은 손실된 블록에 인접한 움직임 벡터들을 평균 연결 알고리즘의 단점을 보완하여 후보 벡터 군을 결정한다. 패킷이 손실되는 환경에서 실험한 결과, 제안한 에러 은닉 방법은 H.264 복호기에서 사용하는 기존 에러 은닉 방법에 비하여 후보 벡터 개수가 평균적으로 1/3정도 감소로 인하여 후보벡터에 대한 왜곡 측정 계산량이 크게 감소하였다. 또한 화질에 대한 객관적 평가 기준인 PSNR은 평균적으로 기존 방법들과 거의 비슷하였다.

• 한국환경성돌연변이발암원학회지
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• 제21권2호
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• pp.106-112
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• 2001

In view of the effect of factor Ⅶ as a risk factor for essential hypertension, we investigated the length (I/D) polymorphism at position 323 promoter region and exon 8-Msp I RFLP of the human factor Ⅶ gene in the Korean patients with essential hypertension and normal controls. There were no significant differences in the allele, genotype and haplotype frequencies of these polymorphisms between normotensive and essential hypertensive subjects. The significant linkage disequilibrium was however, detected between two polymorphic sites. The Msp I RFLP and I/D polymorphism were also significantly associated with plasma triglyceride (TG) levels. Therefore, our results suggest that the significant association between two genetic variations in the human factor Ⅶ gene and plasma TG level may reflect the potential role of human factor Ⅶ gene as one of the genetic components for cardiovascular risk.

• 한국의상디자인학회지
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• 제4권3호
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• pp.27-32
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• 2002

This study attempted to make a comparative analysis of dress and architecture to investigate the spatial effect of transparency expressed in fashion. As a result, the following findings were obtained: First, the openness of the space. It means that the human body or the dress inside it can be seen through or the inside space is opened. The volume, form and color of the undergarment seen through this transparent outer garment brings about any change to design. Also, it can be found that the role of the space is further extended as the inside space is seen through outwardly due to the outer garment. Second, interpenetration of the internal and external space. That the human body and the undergarment are seen through due to transparent dress brings about the linkage between spaces and opens the inside outwardly. Third, the briskness of the space. The trait of transparency that exposes the object behind outwardly as it is causes its form and space to be activated and conveys its spatial briskness.

• 한국주거학회논문집
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• 제17권1호
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• pp.127-134
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• 2006

The purposes of this study are to define 'housing welfare' which constitutes an important theme of discussion today and to present some future policy issues. Recently, the expression 'housing welfare' is widely used in our daily life and written in some laws, but its concept is still ambiguous. Housing welfare can be defined as 'the situation in which citizens gain access to a decent housing and adapt themselves well to the community life. In this context, the goals of housing welfare policy should be as follows: reduction of the number of households living below the minimum standard in housing, promotion of the right to housing, housing provision and management based on housing needs, linkage of housing and other welfare measures, realization of social integration and social justice. But, there are still some controversies on such questions as target group, moral hazard of beneficiaries, social equity, etc. To get all the policy alternatives more effective, efforts should be made to improve the general infrastructure of welfare policies, to prevent NIMBY phenomenon of local actors, and so on.

• 한국과학교육학회지
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• 제16권1호
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• pp.41-50
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• 1996

The purpose of this study is to examine closely the flow process of science education phenomena for the political direction and improvement of science education. Therefore the science education system is analyzed in a view of the legislative system. The results are as follows: 1. The science education system is divided into the plan system, do system and see system by the criteria of plan do see that is the general process of human activity and the area is established as the field of science education administration, school science education, and science education evaluation. 2. The system model that the system characteristics and interrelationship between the systems are conceivable is suggested as the conceptions of boundary, components, variables, parameters, linkage and mishap, gatekeeper etc.

• 대한치매학회지
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• 제17권4호
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• pp.131-136
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• 2018

Alzheimer's disease (AD) related genes have been elucidated by advanced genetic techniques. Familial autosomal dominant AD genes founded by linkage analyses are APP, PSEN1, PSEN2, ABCA7, and SORL1. Genome-wide association studies have found risk genes such as ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-HLA-DRB1, INPP5D, MEF2C, MS4A6A/MS4A4E, NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1. ABCA7, SORL1, TREM2, and APOE are proved to have high odds ratio (>2) in risk of AD using next generation sequencing studies. Thanks to the promising genetic techniques such as CRISPR-CAS9 and single-cell RNA sequencing opened a new era in genetics. CRISPR-CAS9 can directly link genetic knowledge to future treatment. Single-cell RNA sequencing are providing useful information on cell biology and pathogenesis of diverse diseases.