• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.243-243
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• 1996

백금착물 항암제 후보물질로서 합성된 KBP31705-Cl27, KBP30603-901을 기존 화합물인 cisplatin 및 carboplatin과 pharmacokinetic profile을 비교 검토하였다. 웅성 Sprague-Dawley rat을 sodium pentobarbital 마취하에서 방광 및 대퇴동맥과 정맥에 polyethylene tubing을 사용하여 catheterization시켰다. Urine 배출이 안정화되었을 때 대퇴정맥내로 cisplatin과 KBP31705-Cl27은 2 mg/kg, carboplatin과 KBP 30603-901은 20mg/kg 용량으로 주사한 후 2, 4, 6, 8, 10, 15, 20, 30, 45, 60, 120 분에 대퇴동맥으로부터 혈액을 채취하였으며 urine은 약물투여 후 1시간 간격으로 4시간동안 채취하였다. Plasma와 urine중의 platinum농도는 inductively coupled plasma-mass spectrometer를 사용하여 측정하였고, pharmacokinetic parameters는 non-linear least square computer Program인 PCNONLIN을 이용하여 산출되었다. 혈중 platinum농도와 시간의 관계에서 KBP31705-Cl27은 cisplatin과 비교하여 alpha-phase에서 혈중 농도는 낮지만 비슷한 양상을 나타내었고, beta-phase에서는 비교적 느리게 소실됨을 보였다. Urine으로 4시간동안 배출된 platinum양은 각각 투여량의 52, 56%로서 두 약물에서 비슷하였다. 또한 KBP30603-901은 carboplatin과 비교하여 alpha-phase는 거의 비슷한 패턴을 나타내었으나, beta-phase는 훨씬 느리게 감소하여 반감기가 길다는 것을 보여 주었으며 또한 이것은 urine으로 4시간동안 배출된 platinum양이 KBP30603-901의 경우 투여량의 46%로서 carboplatin의 59%보다 적게 배출된다는 data와도 일관됨을 보여주었다. 이상의 결과로 볼 때 KBP30603-901이 다른 백금착물 항암제보다 체내에 머무르는 시간이 길어 혈중에서 보다 오랜 시간동안 머물러 높은 유효농도를 유지할 수 있을 것으로 사료된다.

• Research in Community and Public Health Nursing
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• v.14 no.4
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• pp.686-698
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• 2003

Purpose: This is a descriptive correlation study purposed to provide basic data for comprehensive nursing care by analyzing the relationship between the burden and the quality of life of family caregivers of cancer patients treated with chemotherapy. Methods: As for the subjects of this study, 66 family caregivers who take care of cancer patients hospitalized and treated with chemotherapy participated in the research. The tool of this study was a structured questionnaire including questions concerning burden(19 items) and the quality of life(33 items). Collected data were analyzed using SPSS PC+ program through descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and stepwise multiple linear regression. Results: 1) The mean score of burden was 2.6383. The mean score of quality of life was 3.3034. These score show that family caregivers perceive a moderate level of burden and the quality of life. 2) Family caregivers' burden was significantly related to symptoms in the cancer patient (r= 0.3501, P=0.0042) and family caregivers(r= 0.5340, P=0.0001). Family caregivers' quality of life was significantly related to symptoms in the cancer patient(r= -0.3528, P=0.0039) and family caregivers(r= -0.5472, P=0.0001). According to the result of examining' the relationship between burden and the quality of life, there was a statistically negative correlation(r= -0.6326, P=0.0001). 3) 'Family income after the onset of the patient' was the most important predictor of the burden of family caregivers($R^2$=0.158). 'Usual relationship with the patient' was the most important predictor of the quality of life of family caregivers($R^2$=0.138). Conclusions: The results presented above indicate that we must consider burden of family caregivers and symptoms experienced by them in order to improve the quality of life of family caregivers of cancer patients treated with chemotherapy.

• Journal of the Korea Convergence Society
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• v.11 no.10
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• pp.125-131
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• 2020

This study sought to reduce the risk of fractures in elite youth taekwondo athletes to find out the relationship between bone mineral density which are used as indicators of early diagnosis of osteoporosis and cardiorespiratory functional capacity which is an indicator of performance and sports injury the harmful to athletes. The Pearson product-moment correlation was performed to investigate the correlation between bone mineral density, cardiorespiratory functional capacity, and sports injury. The bone mineral density and cardiorespiratory functional capacity, sports injury were examined the relationship using the Simple Linear Regression. The bone mineral density were correlated with the ventilation (r=.388), and VO2max (r=.478). Bone mineral density was correlated with sports injury (r=-.292). When the bone mineral density increased by .002 and .006, the ventilation (p=.001) and VO2max (p=.006) increased by about 1. In addition, when the bone mineral density decline by .016, the sports injury increased by about 1. Improving athletes' bone mineral density can prevent sports injury, and it can be used as a sports injury prevention program in the future.

• Journal of the Korean Institute of Gas
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• v.1 no.1
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• pp.21-26
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• 1997

This paper presents the numerical results of six corrugation models which compute the stress behaviours and stress levels of the membrane structure under the hydrostatic pressure of cryogenic liquids and thermal loadings using a non -linear finite element analysis program. A three-dimensional analysis of various corrugation geometries was performed on the maximum mean normal stress distributions along the upper surface of the membrane sheet. Comparisons of the FEM results for various geometry models of the corrugation are presented, which shows that the corrugated configuration of the ring knot model can be effectively performed for the combined forces such as the hydrostatic pressure and thermal loading in comparison with the Technigaz type corrugation which has small comer and apex curvatures. The FEM results show that the ring knot corrugation can be used for the deepest depth, 180m of the LNG storage tank in comparison with other corrugation models.

• Korean Journal of Cognitive Science
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• v.22 no.4
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• pp.347-364
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• 2011

In this paper, we propose a automatic image bases extraction method for visual image reconstruction from brain activity using Non-negative Matrix Factorization (NMF). Image bases are basic elements to construct and present a visual image. Previous method used brain activity that evoked by predefined 361 image bases of four different sizes: $1{\times}1$, $2{\times}1$, $1{\times}2$, $2{\times}2$, and $2{\times}2$. Then the visual stimuli were reconstructed by linear combination of all the results from these image bases. While the previous method used 361 predefined image bases, the proposed method automatically extracts image bases which represent the image data efficiently. From the experiments, we found that the proposed method reconstructs the visual stimuli better than the previous method.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.1
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• pp.155-164
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• 2015

The aim of this study was to identify a variables that can affect Commitment to a Career Choice focusing mainly on the satisfaction with one's major in college and personal agency beliefs. This research carried out a survey on a total of 626 students at 4-year public and private university. The information is processed using the SPSSWIN19.0 program, which carried out frequency analysis, reliability measurement, one-way ANOVA, linear regression analysis, multiple moderating regression analysis, and three-step mediate regression analysis. The results of this study showed that groups showing greater satisfaction with their major had a higher level of commitment to a career choice. Personal beliefs was one thing that can achieve partial mediation or complete mediation when it comes to the relationship between the satisfaction of their major and commitment to a career choice.

• Journal of the Korean Society of Costume
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• v.51 no.2
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• pp.181-192
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• 2001

Men study the nature in two ways. Scientists and mathematicians inquire a branch of those two ways. Mathematical formulations are the tools and the expressions of their nature. Meanwhile, the other branch, the art, alms for different inquiry. Instead of formulating the nature, the artists create their masterpieces from their ultimate source, the Mother Nature. For thousands of years these two branches have grown together, influencing each others work. Some mathematicians find that formulation, are not enough to fully express the beauty of nature. It is believed that such a simple expression, formula, easily omits the careful details of nature. The nature is simply too chaotic to be shaped with a formula. Of those mathematicians, Mandelbrot, one of the first to realize this matter, introduced the world of fractal geometry. Fractals give new possibilities. It allows us not to limit ourselves to linear prospect, rather a whole new view of this chaotic beauty of the nature. A popular practice to understand fractals is in costume design. The artistic characteristic and organization mechanism is appalled to costumes. Meanwhile, another practice, rather aggressive, is using computer to create an image of fractals. This image is then used for motives to generate artistic expressions. Computer and paper ironing technique is used for fashion illustration in this research. The works were synthesized arid transformed from computer programs. To add more traditional painting touch to this work, Paper ironing technique was used. Since the of effect of this technique is so random, irregular, and unordered, it corresponds to fractal consideration. This thesis asserts an another prospect to fractal as a structural way of describing nature ailed fashion illustration, rather than restricting it to only mathematical theory.

• Journal of the Korean Institute of Gas
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• v.10 no.3 s.32
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• pp.34-40
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• 2006

This paper presents the optimized design of O-rings with a rectangular groove and dovetails, which are strongly related on the sealing performance of LPG filling unit. The computed results on the optimal design are analyzed by non-linear MARC finite element program with Taguchi method. O-rings with 4 different groove models are analyzed for 3 different elastomeric materials. The design parameters are given to polymer materials, groove depth, groove width, and diameter of O-rings. The FEM computed results showed that the affection ratios of O-ring diameter and material property are the most influential parameter among the groove width, groove depth, and compression ratio. Thus, this paper recommends model III for a rectangular groove and model IV for a dovetail groove with a given gas supply pressure of 1.764 MPa.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.51 no.2
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• pp.163-168
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• 2006

Improvement of crop yield can be achieved through understanding genetic variation in reproductive characters and its impact on yield components. The present study was performed to evaluate genetic diversity for reproductive growth characters in exotic germplasm resources and to determine the relationships between developmental and growth periods with yield and yield components in soybean cultivar groups. For phenotypic evaluation such as reproductive and agronomic traits, a total of 80 indigenous and exotic soybean cultivars collected from four different geographical regions (China, Japan, Korea, and Vietnam) were grown from May to November of 2003 at the Seoul National University Farm, Suwon, Korea ($127^{\circ}02'E$ longitude, $37^{\circ}26'N$ latitude). Most of all the characters exhibited wide range of phenotypic variation, of which pod number, seed number, and plant yield showed greater range as compared to other characters. Korean cultivar groups showed greater diversity than the other cultivar groups in seven characters. Correlation analysis showed that days to flowering (DTF) and days to maturity (DTM) had close association with agronomic traits as well as yield and yield components. Both DTF and DTM had positive correlation with the other characters except one hundred seed weight. Stepwise multiple linear regression revealed that seed and pod number were identified as being significant for plant yield. The results in this study indicated wide variation in agronomic traits including DTF and DTM, suggesting the valuable genetic resources in a soybean breeding program.

• Journal of the Korean Society of Clothing and Textiles
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• v.19 no.5
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• pp.738-746
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• 1995

The purposes of this study were 1) to find out any significant relationships among genderlogy, gender identity of clothing, and attitudes toward unisex clothing, 2) to investi- gate differences in genderlogy, gender identity of clothing, and attitudes toward unisex clothing between female and male college students, 3) to understand the structual dimension of genderlogy. The theory of this study was Bem's androgyny sex role theory which suggested an individual's masculine and feminine sex role lied on separate lines rather than on a linear line. The research design was an ex post facto survey and the subjects were 222 female college students and 179 male students in Taejeon, Chungnam and Chungbuk province. Using the SPSS program, factor analysis, 1-test, Pearson correlation coefficient, and plot were calculated for statistical analysis. The findings of this study were summarized as follows: 1) The 1.test showed significant differences in genderloy, gender identity of clothing, attitudes toward unisex clothing between female and male college students. 2) There were significant relationship among genderlogy, gender identity of clothing, attitudes toward unisex clothing. 3) The moi or dimensions of genderlogy were found to be traditional sex role and equal sex roles. There were only moderate negative relationship between traditional and equal sex roles and these two dimensions affected differently on the gender identity of clothing, as well as the attitudes toward unisex clothing, therefore traditional sex roles and equal sex roles seemed to lie on separate lines, and the androgyny sex role theory was supported.