• Title/Summary/Keyword: Linear hypothesis

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Agrobacterium sp.-derived β-1,3-glucan enhances natural killer cell activity in healthy adults: a randomized, double-blind, placebo-controlled, parallel-group study

  • Lee, Yeon Joo;Paik, Doo-Jin;Kwon, Dae Young;Yang, Hye Jeong;Park, Yongsoon
    • Nutrition Research and Practice
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    • v.11 no.1
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    • pp.43-50
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    • 2017
  • BACKGROUND/OBJECTIVES: The present study investigated the hypothesis that a highly pure linear ${\beta}$-1,3-glucan produced by Agrobacterium sp. R259 enhances human natural killer (NK) cell activity and suppresses pro-inflammatory cytokines. SUBJECTS/METHODS: In an eight-week, double-blind, randomized, placebo-controlled clinical trial, 83 healthy adults with white blood cell counts of $4,000-8,000cells/{\mu}L$ were participated and randomly assigned to take two capsules per day containing either 350 mg ${\beta}$-1,3-glucan or placebo. Six participants withdrew their study consent or were excluded due to NK cell activity levels outside the normal range. NK cell activity and serum levels of immunoglobulin G (IgG) and cytokines, such as interferon (IFN)-${\gamma}$, interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12 and tumor necrosis factor (TNF)-${\alpha}$ were measured. RESULTS: NK cell activity and the serum levels of IL-10 were significantly higher from baseline to week 8 in the ${\beta}$-glucan group compared with the placebo group (P = 0.048, P = 0.029). Consumption of ${\beta}$-1,3-glucan also significantly increased NK cell activity compared with placebo after adjusting for smoking and stress status (P = 0.009). In particular, the effect of ${\beta}$-1,3-glucan on NK cell activity was greater in participants with severe stress than in those experiencing mild stress. However, the administration ${\beta}$-1,3-glucan did not significantly modulate the levels of IFN-${\gamma}$, IL-2, IL-4, IL-6, IL-12, TNF-${\alpha}$ and IgG compared with the placebo. CONCLUSION: The results showed that supplementation with bacterial ${\beta}$-1,3-glucan significantly increased NK cell activity without causing any adverse effects. Additionally, the beneficial effect of ${\beta}$-1,3-glucan on NK cell activity was greater in participants experiencing severe stress.

A Study for Influence VMD Components on Commitment and Post-purchase Satisfaction within SPA Stores (SPA 매장의 VMD 구성요소가 몰입과 구매 후 만족에 미치는 영향)

  • Shin, Mi-Hyang
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.6
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    • pp.2540-2550
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    • 2012
  • The purpose of this study to analysis influence commitment and post-purchase satisfaction on VMD components within SPA stores. VMD Components are consist of product directing and space directing as independent variables, we are empirical study on affective commitment and post product purchasing satisfaction. To validate the hypothesis by path analysis conducted between variables using SPSS 12.0 and LISREL8.7, the results are as follows : First, product directing and space directing have significant effect on commitment and post-purchase satisfaction. Second, commitment have significant effect on post-purchase satisfaction. Third, we found commitment have mediate effects from analysis direct affect and indirect affect of path coefficients. Contribution of this study to found VMD components consist of product directing and space directing are both important factors SPA stores, among them space directing is more important role commitment and after purchasing satisfaction. And that is based on emotion-cognitive theory by revalidation, these results are used on developing VMD strategy that is required at the time of practical and theoretical guidance of SPA stores.

An Empirical Study on the relevance of Web Traffic for Valuation of Internet Companies (인터넷 기업의 웹 트래픽 정보와 기업가치의 상관관계에 관한 실증연구)

  • Yi, Sung-Wook;Hwang, Seung-June
    • Journal of Intelligence and Information Systems
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    • v.15 no.4
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    • pp.79-98
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    • 2009
  • Web traffic is becoming an important indicator to make inferences about internet companies' future prospects so that traditional firm valuation methods need to be modified to integrate the ideas of web traffic information as a major asset of internet companies. It is because web traffic is a measure of attracting visitors to firm's web site and is the basis for internet companies' marketing expenditure and customer acquisition and retention. Also the web traffic represents the internet companies' technological advances and marketability. The major purpose of this study is to show the relevance of web traffic for valuation of internet companies. For this, we test hypothesis with the firm's web traffic and financial data using the analysis model of Hand(2000a) derived from the log-linear model introduced by Ye and Finn(1999). Test results show that the web traffic, more specifically the number of unique visitors, visits, and page views are all positively related to the firm's value. This implies that the web traffic information should be considered as one of the important non-financial indicator for the internet firm valuation.

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Controlling Ownership and R &D Investment in Chinese Firms (지배주주 지분율과 연구개발 투자: 중국 상장기업을 대상으로)

  • Cho, Young-Gon;Li, Chun-Hong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.12
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    • pp.162-169
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    • 2016
  • Using 1795 observations from the 5 year-359 firm panel data collected during the period from 2009 to 2013 in Chinese stock exchanges, this study examines the impact of the controlling shareholders' ownership on R & D expenditure. This empirical study finds that when firms are state-owned, the controlling shareholders' ownership has a U shaped relation with the level of R & D expenses. A non-linear relation is also found when piece-wise regression models are applied. This empirical study also finds that when firms are private-owned, the controlling shareholders' ownership is negatively related to the level of R & D expenses, and no structural changes in the relation are found when piece-wise regression models are applied. These results support the hypothesis that the effects of the controlling shareholders' ownership on R & D expenses may differ depending on the ownership type of the controlling shareholders. This finding suggests that the differences in the controlling shareholders' incentives due to their ownership type should be considered when exploring the relation between the controlling shareholders' ownership and corporate strategic decisions.

Construction of a artificial levee line in river zones using LiDAR Data (라이다 자료를 이용한 하천지역 인공 제방선 추출)

  • Choung, Yun-Jae;Park, Hyeon-Cheol;Jo, Myung-Hee
    • Proceedings of the Korea Water Resources Association Conference
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    • 2011.05a
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    • pp.185-185
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    • 2011
  • Mapping of artificial levee lines, one of major tasks in river zone mapping, is critical to prevention of river flood, protection of environments and eco systems in river zones. Thus, mapping of artificial levee lines is essential for management and development of river zones. Coastal mapping including river zone mapping has been historically carried out using surveying technologies. Photogrammetry, one of the surveying technologies, is recently used technology for national river zone mapping in Korea. Airborne laser scanning has been used in most advanced countries for coastal mapping due to its ability to penetrate shallow water and its high vertical accuracy. Due to these advantages, use of LiDAR data in coastal mapping is efficient for monitoring and predicting significant topographic change in river zones. This paper introduces a method for construction of a 3D artificial levee line using a set of LiDAR points that uses normal vectors. Multiple steps are involved in this method. First, a 2.5-dimensional Delaunay triangle mesh is generated based on three nearest-neighbor points in the LiDAR data. Second, a median filtering is applied to minimize noise. Third, edge selection algorithms are applied to extract break edges from a Delaunay triangle mesh using two normal vectors. In this research, two methods for edge selection algorithms using hypothesis testing are used to extract break edges. Fourth, intersection edges which are extracted using both methods at the same range are selected as the intersection edge group. Fifth, among intersection edge group, some linear feature edges which are not suitable to compose a levee line are removed as much as possible considering vertical distance, slope and connectivity of an edge. Sixth, with all line segments which are suitable to constitute a levee line, one river levee line segment is connected to another river levee line segment with the end points of both river levee line segments located nearest horizontally and vertically to each other. After linkage of all the river levee line segments, the initial river levee line is generated. Since the initial river levee line consists of the LiDAR points, the pattern of the initial river levee line is being zigzag along the river levee. Thus, for the last step, a algorithm for smoothing the initial river levee line is applied to fit the initial river levee line into the reference line, and the final 3D river levee line is constructed. After the algorithm is completed, the proposed algorithm is applied to construct the 3D river levee line in Zng-San levee nearby Ham-Ahn Bo in Nak-Dong river. Statistical results show that the constructed river levee line generated using a proposed method has high accuracy in comparison to the ground truth. This paper shows that use of LiDAR data for construction of the 3D river levee line for river zone mapping is useful and efficient; and, as a result, it can be replaced with ground surveying method for construction of the 3D river levee line.

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The Effects of Visitor's Service Quality Affecting Visitor's Satisfaction in National Parks (국립공원(國立公園)의 탐방(探訪)서비스 질(質)이 탐방만족도(探訪滿足度)에 미치는 영향(影響))

  • Lee, Ju-Hee;Bae, Min-Ki
    • Journal of Korean Society of Forest Science
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    • v.95 no.1
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    • pp.113-123
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    • 2006
  • The purpose of this paper was to identify the effects of visitor's service quality affecting visitor's satisfaction in national parks(NPs). After reviewing the literature, this research selected and developed the indicators of visitor's service (VS) and have formulated the hypothesis of this research. This research had obtained data through a questionnaire, which surveyed 4,423 visitors at 8 NPs in 2005. We have analyzed the data using descriptive statistical methods, factor analysis, Pearson's correlation analysis, and multiple linear regression method. We found that 1) the results of factor analysis, the five factors of visitor's service (FVSs) i.e., assurance, reliability, empathy, tangibles, responsiveness have extracted. 2) in bivariate analysis, the positive relationships between user's satisfaction and FVSs are fairly low but statistically significant. The higher the value of the five factors of VS the higher the degree of user's satisfaction, 3) in multiple regression analysis, FVSs have been statistically significant at one percent level, and 4) the relative contribution of the assurance of VS on user's satisfaction have been determined to have respectively 2.85 times more important than that of the empathy of VS. The research results suggest that the management of natural resources, cultural resources, and park facilities in national park was the most important factor to increase visitor's satisfaction.

A Controlled Study on Serum Insulin-Like Growth Factor 1 (Somatomedin C) Levels in Fibromyalgia (섬유근통 증후군 환자에서 Somatomedin C (Insulin-Like Growth Factor 1)의 농도와 임상증상과의 관계)

  • Yoo, Byung-Hoon;Kang, Jeong-Kweon;Oh, Wan-Soo;Yon, Jun-Heum;Kim, Jeong-Won;Hong, Ki-Hyuk;Song, Chan-Woo
    • The Korean Journal of Pain
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    • v.12 no.1
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    • pp.27-35
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    • 1999
  • Background: Fibromyalgia is a common syndrome of musculoskeletal pain and fatigue. Lacking distinctive histological or laboratory abnormality in diagnosis, it has often been considered a form of "psychogenic rheumatism". Fibromyalgia causes much distress to the affected patients and often frustrates physicians, who are unable to start rational therapy on any logical disease pathology. Methods: Growth hormone is essential for muscular homeostasis. In the present study, the notion that the stage-4 sleep anomaly typically seen in the fibromyalgia syndrome may disrupt growth hormone secretion was tested. Because growth hormone has a very short half-life, serum levels of somatomedin C were measured; somatomedin C is the major mediator of growth hormone's anabolic actions and is a prerequisite for normal muscle homeostasis. Serum levels of somatomedin C using acid-extraction procedure and two-site immunoradiome-tric assay (IRMA) and number of tender points were measured in 27 female patients with fibromyalgia from 40 to 60 years old and 27 healthy controls. Results: There were no differences in the concentration of somatomedin C between fibromyalgia patients and controls ($mean{\pm}SD$: $178.3{\pm}75.5$ ng/ml versus $166.3{\pm}76.6$ ng/ml; p=0.55). And there were no correlations between number of tender point and serum somatomedin C level by linear regression analysis. Conclusions: These findings did not support that there is a distinctive disruption of the growth hormone-somatomedin C neuroendocrine axis in a fibromyalgia syndrome. But we can not discard the hypothesis that disturbed sleep predispose to muscle pain.

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A study on the Effect of Mentoring Skills and Mentoring Functions on Initial Start-up Performance and Satisfaction (멘토의 역량과 멘토링 기능이 창업의 초기성과만족도에 미치는 영향에 관한 연구)

  • Bang, Hye-Min;Jeon, In-Oh
    • The Journal of the Korea Contents Association
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    • v.15 no.5
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    • pp.444-454
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    • 2015
  • This study reports on initial founder performance and satisfaction that is affected by mentoring skills and mentoring functions. Through the empirical analysis, seen the initial founder performance and satisfaction as a respective dependent variable, this study intends to provide efficient direction of the responsibility mentor and present a method that enhances the survival of the initial start-up founder. The frequency analysis was conducted to determine the general characteristics of the sample, by leveraging the statistical package SPSS 20.0 for Windows program, details of the items measuring tools present a statistical analysis of sample data, 120 people have gathered in the survey data for this factor analysis was performed with a correlation to classify each region was calculated to Cronbach's ${\alpha}$ factor to determine the reliability of the measurement tool, and tested the hypothesis using linear regression analysis for verification. Was found to play an important role to draw the founder and mentor mentoring skills and capabilities in early stage start-ups, and conclusions drawn from this process. In particular, modeling of the mentor with a sound mind and behavior brought the better performance and satisfaction of the initial start-up founder. If a mentor provides mentoring with more interests in career development and psychosocial functions of the mentoring functions, it is seen to be more efficient way to improve survival rate of initial start-up as well as increasing a founder's performance and satisfaction.

Curve Number for a Small Forested Mountainous Catchment (산지 소유역 유출곡선지수)

  • Oh, Kyoung-Doo;Jun, Byong-Ho;Han, Hyung-Geun;Jung, Sung-Won;Cho, Young-Ho;Park, Soo-Yun
    • Journal of Korea Water Resources Association
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    • v.38 no.8 s.157
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    • pp.605-616
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    • 2005
  • In this paper, runoff curve numbers (CN's) for a small forested mountainous catchment are estimated using rainfall-runoff data measured at Sulma experimental catchment every 10 minutes and a new guideline for applying the antecedent rainfall conditions (ARC's) for small mountainous watersheds in Korea is proposed. Sulma experimental catchment is a typical natural mountainous basin with $97\%$ of forested land cover and CN's are estimated to be in the range between 51 and 89 with median value of 72. The test hypothesis stating as 1-day ARC is better than 5-day ARC in determining CN's for a small mountainous watershed is shown to be acceptable. Also, linear regression equations for the estimation of CN's for small mountainous catchments are proposed. As there is no significant investigations available on CN's for small mountainous catchments, the newly proposed relationships between CN's and ARC may be used as a preliminary guideline to assign CN's for the estimation of floods from rainfall data on mountainous regions.

The Effects of the Performance-Oriented Culture of Community Welfare Centers on the Job Performance of Social Workers (사회복지관의 성과지향적 문화가 사회복지사의 직무수행에 미치는 영향)

  • Moon, Young-joo
    • Korean Journal of Social Welfare Studies
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    • v.45 no.3
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    • pp.179-207
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    • 2014
  • The purpose of this study was to investigate the effects of the performance-oriented culture of a community welfare center on the job performance of its social workers. For that purpose, the study conducted a survey by mail with 1,162 social workers working for community welfare centers around Busan and Gyeongnam Province from January 4 to 31, 2013. Of the collected questionnaires, a total of 755 from 81 community welfare centers were used in the final analysis. This study used the SPSS 21.0, AMOS 21.0, and HLM 6.02 statistical software packages to perform data analysis for each hypothesis. The analysis results of the unconditional model of the hierarchical linear model, the unconditional random coefficient model, and the conditional model show that the job satisfaction and organizational commitment of social workers had positive (+) effects on their job performance. Secondly, customer orientation, one of the sub-elements of performance-oriented culture, had positive (+) effects on the job performance of social workers, whereas the result orientation had negative (-) effects on it. In addition, innovation orientation had no impacts on their job performance. Based on those findings, the study proposed management plans for organizational culture to enhance the job performance of social workers.