• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.4
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• pp.516-523
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• 2015

This study investigated the antimutagenic and anticancer effects of Platycodon grandiflorum extract (PGE) and its fractions against carcinogenic N-nitrosodimethylamine (NDMA) and genotoxicity. The Ames Salmonella mutagenicity test employing histidine mutants of Salmonella Typhimurium TA98 and TA100 was used to examine the mutagenicity of PGE and its fractions. Bacterial reversion assay with S. Typhimurium TA98 and TA100 did not show a significantly increased number of revertant colonies. The same test was used to examine the ability of PGE and its fractions to prevent acquisition of N-methyl-N'-nitro-N-nitrosoguanidine- and 4-introquino-line-1-oxide-induced mutations. PGE and its fractions inhibited mutagenesis in a dose-dependent manner. Among the fractions, ethyl acetate fraction from PGE (PGEA) exhibited a higher antimutagenic effect than other fractions. PGE and its fractions suppressed the growth of cancer cell lines, including human cervical adenocarcinoma, human hepatocellular carcinoma, human breast adenocarcinoma, human lung carcinoma, and transformed primary human embryonic kidney cells. In addition, we evaluated the antitumor activity of PGEA and its fractions in sacorma-180 solid tumor-bearing mice. In vivo anticancer activity results showed that PGE and its fractions could more effectively suppress tumor growth than the control. PGEA showed higher in vitro and in vivo anticancer effects than PGE and other fractions, and PGEA inhibited NDMA formation. Thus, we showed that PGEA has antimutagenic and anticancer activities, making it a candidate anticancer material under these experimental conditions.

• Journal of the Korean Geosynthetics Society
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• v.14 no.3
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• pp.31-42
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• 2015

The Reinforced subgrade for railroad (RSR) was constructed for one way railway line with the dimension of 5 m high, 6 m wide and 20 m long to evaluate its performance under train design load. The RSR has characteristics of short length (0.3-0.4 H) of reinforcement and rigid wall, 30 and 40 cm vertical spacing of reinforcement installation. To enhance economics and constructability, three kinds of connections (welding, hinge & bolt, bold wire) were also designed to realize the integration between rigid wall and reinforced subgrade. Two times of static loading tests were done on the full size railroad subgrade. The maximum applied pressure was 0.98 MPa (the maximum test load 5.88 MN), which corresponds to 19.6 times of the design load for railroad subgrade, 50 kPa. The performance on the RSR was evaluated with the safety on the failure, subgrade bearing capacity and settlement, horizontal displacement of wall, and reinforcement strain. Based on the full scale test, we confirmed that the RSR with the conditions of 0.35 H (35% of height) short reinforcement length, hinge & bolt type connection for integration between rigid wall and reinforced subgrade, and 40cm vertical spacing of reinforcement installment shows good performance under train design load.

• Geotechnical Engineering
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• v.10 no.2
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• pp.25-40
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• 1994

In order to investigate behavior of lateral flow by plasticity of soils and construction control due to it, in the case of unsymmetrical surcharge load on the soft soils, we examine the existing theoretical background, and compared and analysed the experimental results by model test. After model test fabricated by model test apparatus, which made full remolding samples of soft soils, we observed the state of behavior for deformation with increasing load step to constant time interval. The critical surcharge and ultimate capacity showed tendency to approach to the proposed value of Jaky and Meyerhof, and the lateral flow pressure of which the maximum value was acted on the depth calculated by z/H=0.26+1.71cu and one third value of the maximum lateral flow pressure acted on the ground surface, approach the trapezoid distribution And maximum lateral flow pressure will be calculated by proposed equation of Hong or simple equation which($\alpha=0.4$) the flow pressure coefficient . of proposed equation by Tschebotarioff exchanged to($\alpha=K_0$) . Basides, the failure surcharge by [(q/$y_m$)-q] and [$S_y-(y_m/S_y)$] showed the smaller than ultimate bearing capacity, especially failure criteria line of control diagram of [$S_y(y_m/S_y)$] will be calculated by following equation. $S_y.=3.15exp[-0.58(y_m/S_y)$

• Journal of the Korean Geotechnical Society
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• v.35 no.7
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• pp.15-27
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• 2019

The purpose of this study is to investigate the mechanism about damages occurring at quay wall and backfill in Youngilman Port during Pohang earthquake (M5.4) on November 15, 2017. In the field investigation, the horizontal displacement of the caisson occurred between 5 cm and 15 cm, and the settlement at backfill occurred higher than 10 cm. 2D-effective Stress Analysis was performed to clarify the mechanism for the damage. The input earthquake motion used acceleration ($3.25m/s^2$) measured at bedrock of Pohang habor. Based on a numerical analysis, it was found that the effective stress decreased due to the increase of excess pore pressure in the backfill ground and the horizontal displacement of the caisson occurred by about 14 cm, and the settlement occurred by about 3 cm. In backfill, the settlements occurred between 6 cm and 9 cm. This is similar to field investigation results. Also, it was found that the backfill soil was close to the Mohr-Coulomb failure line due to the cyclic loading from the effective stress path and the stress-strain behavior. It may be related to decreasing of bearing capacity induced by the reduction of effective stress caused by the increase of the excess pore water pressure.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.47 no.7
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• pp.489-498
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• 2019

The airloads and structural loads of Light Civil Helicopter (LCH) rotor are investigated using a loose CFD/CSD coupling. The structural dynamics model for LCH 5-bladed rotor cwith elastomeric bearing and inter-bladed damper is constructed using CAMRAD-II. Either isolated rotor or rotor-fuselage model is used to identify the effect of the fuselage on the aeromechanics behavior at a cruise speed of 0.28. The fuselage effect is shown to be marginal on the aeromechanics predictions of LCH rotor, though the effect can be non-negligible for the tail structure due to the prevailing root vortices strengthened by the fuselage upwash. A lifting-line based comprehensive analysis is also conducted to verify the CFD/CSD coupled analysis. The comparison study shows that the comprehensive analysis predictions are generally in good agreements with CFD/CSD coupled results. However, the predicted comprehensive analysis results underestimate peak-to-peak values of blade section airloads and elastic motions due to the limitation of unsteady aerodynamic predictions. Particularly, significant discrepancies appear in the structural loads with apparent phase differences.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.42.1-42.1
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• 2019

We observed 80 dense cores ($N(H_2)$ > $10^{22}cm^{-2}$) in the Orion molecular cloud complex which contains the Orion A (39 cores), B (26 cores), and ${\lambda}$ Orionis (15 cores) clouds. We investigate the behavior of the different molecular tracers and look for chemical variations of cores in the three clouds in order to systematically investigate the effects of stellar feedback. The most commonly detected molecular lines (with the detection rates higher than 50%) are $N_2H^+$, $HCO^+$, $H^{13}CO^+$, $C_2H$, HCN, and $H_2CO$. The detection rates of dense gas tracers, $N_2H^+$, $HCO^+$, $H^{13}CO^+$, and $C_2H$ show the lowest values in the ${\lambda}$ Orionis cloud. We find differences in the D/H ratio of $H_2CO$ and the $N_2H^+/HCO^+$ abundance ratios among the three clouds. Eight starless cores in the Orion A and B clouds exhibit high deuterium fractionations, larger than 0.10, while in the ${\lambda}$ Orionis cloud, no cores reveal the high ratio. These chemical properties could support that cores in the ${\lambda}$ Orionis cloud are affected by the photo-dissociation and external heating from the nearby H II region. An unexpected trend was found in the $[N_2H^+]/[HCO^+]$ ratio with a higher median value in the ${\lambda}$ Orionis cloud than in the Orion A/B clouds than; typically, the $[N_2H^+]/[HCO^+]$ ratio is lower in higher temperatures and lower column densities. This could be explained by a longer timescale in the prestellar stage in the ${\lambda}$ Orionis cloud, resulting in more abundant nitrogen-bearing molecules. In addition to these chemical differences, the kinematical difference was also found among the three clouds; the blue excess, which is an infall signature found in optically thick line profiles, is 0 in the ${\lambda}$ Orionis cloud while it is 0.11 and 0.16 in the Orion A and B clouds, respectively. This result could be another evidence of the negative feedback of active current star formation to the next generation of star formation.

• Journal of the Korean Geotechnical Society
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• v.35 no.11
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• pp.25-36
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• 2019

The safety barrier is installed on road embankment to prevent vehicles from falling into road side slope. Among the safety barrier, flexible guardrails are usually installed. The flexible guardrail generally consists of a protection cross-beam and supporting in-line piles. These guardrail piles are installed nearby slope edge of road embankment because the side area of the road is much narrow. The protection cross-beam absorbs impact energy caused by vehicle collision. The pile-soil interaction also absorbs the rest of the impact energy and then, finally, the flexible guardrail system resists the impact load. This paper aims to investigate the pile-soil interaction subjected to impact load using centrifuge model tests. In this study, a single pile was installed in compacted residual soil and loaded under lateral impact load. An impact loading system was designed and developed available on centrifuge tests. Using this loading system, a parametric study was performed and the parameters include types of loading and ground. Finally, the ultimate bearing capacity of supporting pile under impact load was analyzed using load-displacement curve and soil reaction pressure distributions at ultimate were evaluated and compared with previous studies.

• Microbiology and Biotechnology Letters
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• v.35 no.2
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• pp.118-127
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• 2007

Germanium-fortified yeast (GY) is a organic germanium-fortified yeast with potent immune modulating activities including anti-inflammatory effect. Through cell line studies, we observed that GY can modulate the diverse immune activity but little evidence was provided on the mechanism of GY in modulating immune activities in other higher animals. In this study, we investigated the effect of GY on modulation of immune function in mice. GY was administered in normal mice or tumor-bearing mice and then effect of GY on modulation of host immune system was analyzed by using ex vivo isolated macrophages, B cells, NK cells. Admistration of GY in mice induced macrophage activation thereby increased effector function of macrophage such as increased phagocytosis, chemotaxis, adherence, $O_2-release$, NO, $TNF-{\alpha}$ production. In addition, GY administration Increased B lymphocyte activation and plaque forming cells. Furthermore, GY administration increased NK-cell mediated cytotoxicity. Furthermore, GY administration suppressed progression of tumor in mice by increasing $TNF-{\alpha}$ production and effector function of NK cells. Our results showed that GY has a potent immunostimulatory function in vivo mice model. Proper modulation and administration of GY in human could be helpful to maintaining immunological homeostasis by modulating host immune system.

• Journal of Navigation and Port Research
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• v.42 no.6
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• pp.546-554
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• 2018

The Bulk market, unlike the line market, is characterized by stiff competition where certain ship or freight owners have no influence on freight rates. However, freights are subject to macroeconomic variables and economic external shock which should be considered in determining management or chartering decisions. According to the results analyzed by use of ARIMA Inventiom model, the impact of the financial crisis was found to have a very strong bearing on the BDI index. First, according to the results of the VEC model, the libor rate affects the BDI index negatively (-) while exchange rate affects the BDI index by positively (+). Secondly, according to the results of the VEC model's J ohanson test, the order ship volume affects the BDI index by negatively (-) while China's economic growth rate affects the BDI index by positively (+). This shows that the shipping company has moved away from the simple carrier and responded appropriately to changes in macroeconomic variables (economic fluctuations, interest rates and exchange rates). It is believed that the shipping companies should be more aggressive in its "trading" management strategy in order to prevent any unfortunate situation such as the Hanjin Shipping incident.

• Economic and Environmental Geology
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• v.39 no.2 s.177
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• pp.163-171
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• 2006

This study is the case of groundwater development based on the geometrical fracture model of target area established only through geological fracture mapping technique. A fracture mapping of $9km^2$, eastern Munsan, has been conducted to determine geological and hydrological factors for new water well placement in the Gyeonggi gneiss complex. Geophysical exploration was not applicable because of small restricted area and dense underground utilities at the site. Form line mapping on the basis of foliation orientation and rock type revealed a synform of NS fold axis bearing to the south. An EW geological cross-section passed through the site area shows a F2 synform as a double-wall ice cream spoon shape. Three regional faults of $N20^{\circ}E,\;N30^{\circ}W$, and NS have been dragged into the site to help understand extensional fault paths. The $N20^{\circ}E$ fault with dextral sense is geometrically interpreted as a western fault of two flexural conjugate type-P shear faults in the F2 synformal fold. The NE cross-section reveals that a possible groundwater belt in the western limb of super-posed fold area is formed as a trigonal prism within 100 m depth of the intersectional space between the $N20^{\circ}E$ fault plane and the weakly sheared plane of transposed foliation. Another possible fault for water resource strikes $N40^{\circ}E$. Recommended sites for new water well placement are along the $N20^{\circ}E\;and\;N40^{\circ}E$ faults. As a result of fracture mapping, 145 ton/day of water can be produced at one well along the $N20^{\circ}E$ fault line. Exploration of groundwater in the area is succeeded only using with geological fracture mapping and interpretation of geological cross-section, without any geophysical survey. Intersection of fault generated with the F2 synformal fold and foliation supply space of groundwater reserver.