• Macromolecular Research
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• v.9 no.5
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• pp.277-284
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• 2001

Poly(exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride)s [poly(ETA)s] and poly($\alpha$-ethoxy-exo-3,6-epoxy-1,2,3,6-tetrahydrophthaloyl-5-fluorouracil)s [poly(EETFU)s ] with various average molecular weights were prepared by photopolymerizations. The number average molecular weights of the fractionated poly(ETA)s and poly(EETFU)s determined by GPC were in the range of 3,600∼21,000 and 3,600-33,400, respectively. The release rate of 5-FU from poly(EETFU) decreased with increasing average molecular weight. The in vitro cytotoxicity of poly(ETA) against a normal cell line was lower than that of 5-fluorouracil(5-FU), The in vivo antitumor activities of the synthesized samples at dosage of 0.8 mg/kg against mice bearing sarcoma 180 tumor cell line decreased in the following order: poly(EETFU) > poly(ETA) > EETFU > ETA > 5-FU. The antiangiogenic activities of the poly(ETA)s were better than those of 5-FU.

• Knee surgery & related research
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• v.30 no.4
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• pp.311-318
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• 2018

Purpose: The purpose of this study was to evaluate changes in the coronal alignment of the knee and ankle joints after open wedge high tibial osteotomy (OWHTO) to determine factors related to the recurrence (R) of the varus deformity by serial analysis. Materials and Methods: Sixty-four OWHTOs were enrolled in this study. The weight bearing line (WBL) ratio, joint line convergence angle (JLCA), knee joint inclination, mechanical axis-tibial plateau angle, talar inclination (TI), and distal tibia articular angle (DTAA) were serially assessed. Serial correlation analysis between all parameters was performed. Patients were divided into R group and no recurrence (NR) group according to the WBL ratio (55%) at postoperative one year. Results: The preoperative WBL ratio showed significantly negative correlation with serial changes of JLCA, TI, and DTAA (p<0.05). The JLCA, TI, and DTAA as well as WBL ratio showed a significantly larger degree of varus alignment in the R group than in NR group at postoperative 6 weeks and 1 year after OWHTO (p<0.05). Conclusions: Sufficient correction of the WBL and restoration of the JLCA during OWHTO are essential to prevention of the R of varus deformity after the surgery because they are the only modifiable factors during surgery. Level of Evidence: IV, Case series.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2009.11a
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• pp.78-81
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• 2009

A series of hydraulic tests of a fuel pump are performed using water at a room temperature. The pump is under development for 75-ton class liquid rocket engines of the open-loop gas generator type. According to the test results, the fuel pump satisfies its design requirement and its head and efficiency at the design flowrate are higher than the expected value by the computational analysis. Also, it is found that the pressure at the rear bearing outlet is higher than expected because the inlet of bypass pipe line is narrow. Furthermore, the flowrate of the secondary flow is estimated using the pressure difference of the elbow of the bypass pipe line.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.4 no.5
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• pp.951-961
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• 2000

A diagnosis system that provides early warnings regarding machine malfunction is very important for rolling mill so as to avoid great losses resulting from unexpected shutdown of the production line. But it is very difficult to provide early warnings in rolling mill. Because dynamics of rolling mill is non-linear. This Paper proposes a new method for diagnosis of rolling mill using wavelet transform(W) to solve this problem. Proposed method that measures the vibration signals of rolling mill on-line and analyze it using wavelet to acquire pattern data. And we design a fault-diagnosis system that diagnose a rolling mill using this data. Validity of the new method is asserted by real numerical data experiment.

• Journal of Biomedical Engineering Research
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• v.25 no.1
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• pp.49-55
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• 2004

In this paper, we investigated the effects of the photodynamic therapy(PDT) for the tumor mass in mice. In the experimental method, we divided the mice into two control and test group which HepG2 and HeLa cell line induced cancer mass in mice. Photofrin was administered to the tumor-bearing mouse, followed 30 hours later by 630nm and 650nm laser light exposure. After photodynamic therapy we analyzed the two mice group for the tumor mass size, tumor growth, tumor cell necrosis, pathological anatomy change. According to the results, tumor cell necrosis was shown in the tissues which the reduce size of tumor and tumor cell necrotic change according to the irradiation time and light dose amount. The considerable difference, however, between the 630nm and 650nm wavelength was not found for the tumor cell necrotic change and other damage of normal tissue was not found.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7489-7496
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• 2013

This study was conducted to investigate enhancement of anti-tumor effects of the lentogenic Newcastle disease virus Clone30 strain (NDV rClone30) expressing cytosine deaminase (CD) gene against tumor cells and in murine groin tumor-bearing models. Cytotoxic effects of the rClone30-CD/5-FC on the HepG2 cell line were examined by an MTT method. Anti-tumor activity of rClone30-CD/5-FC was examined in H22 tumor-bearing mice. Compared to the rClone30-CD virus treatment alone, NDV rClone30-CD/5-FC at 0.1 and 1 MOIs exerted significant cytotoxic effects (P<0.05) on HepG2 cells. For treatment of H22 tumor-bearing mice, recombinant NDV was injected together with 5-FC given by either intra-tumor injection or tail vein injection. When 5-FC was administered by intra-tumor injection, survival for the rClone30-CD/5-FC-treated mice was 4/6 for 80 days period vs 1/6, 0/6 and 0/6 for the mice treated with rClone30-CD, 5-FC and saline alone, respectively. When 5-FC was given by tail vein injection, survival for the rClone30-CD/5-FC-treated mice was 3/6 vs 2/6, 0/6 and 0/6 for the mice treated with rClone30-CD, 5-FC or saline alone, respectively. In this study, NDV was used for the first time to deliver the suicide gene for cancer therapy. Incorporation of the CD gene in the lentogenic NDV genome together with 5-FC significantly enhances cell death of HepG2 tumor cells in vitro, decreases tumor volume and increases survival of H22 tumor-bearing mice in vivo.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.8
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• pp.1100-1105
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• 2012

Green tea intake is known to have preventive effects against cancer. In this study, we evaluated the tumor suppressive effects of dietary green tea extracts (GTE) as a modulator on cisplatin in an established colon cancer mouse model. The cisplatin-induced cytotoxicity was determined with cell viability of the mouse colon cancer cell line (CT26) in vitro. The influence of GTE on the anti-tumor activity of cisplatin was evaluated by measuring tumor size with digital calipers in mice bearing CT26 colon carcinomas. The CT26 cell viability decreased to 93% at a $20{\mu}g/mL$ concentration of cisplatin. However, cell viability decreased to 15% with a combination of $20{\mu}g/mL$ cisplatin and GTE ($75{\mu}g/mL$). There were no apparent changes in cisplatin-induced cytotoxicity with GTE and epigallocathechin gallate (EGCG) treatments. Tumor size decreased in dietary GTE combining intra-peritoneal cisplatin-injected tumors bearing mice compared with cisplatin or GTE alone administered to tumor-bearing mice. These experiments showed that dietary GTE has a potentiating effect on the cisplatin anti-tumor activity of an established mice colon cancer model. Therefore, the GTE may be a candidate for modulators in anticancer treatments with cisplatin.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2121-2127
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• 2012

Objective: Deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) mutants have been reported to exert suicide gene effects in combined gene/chemotherapy of cancer. Here, we aimed to further evaluate the capacity of the mutanted enzyme and its potential for inhibiting cancer cell growth. Methods: We altered the sequence of the last 10 amino acids of Dm-dNK to perform site-directed mutagenesis and constructed active site mutanted Dm-dNK (Dm-dNKmut), RT-PCR and western bloting studies were used to reveal the expression of lentivirus mediated Dm-dNKmut in a breast cancer cell line (Bcap37), a gastric cancer cell line (SGC7901) and a colorectal cancer cell line (CCL187). [3H]-labeled substrates were used for enzyme activity assays, cell cytotoxicity was assessed by MTT assays, cell proliferation using a hemocytometer and apoptosis induction by thenannexin-V-FITC labeled FACS method. In vivo, an animal study was set out in which BALB/C nude mice bearing tumors were treated with lentivirus mediated expression of Dm-dNKmut with the pyrimidine nucleoside analog brivudine (BVDU, (E)-5-(2-bromovinyl)-(2-deoxyuridine). Results: The Dm-dNKmut could be stably expressed in the cancer cell lines and retained its enzymatic activity. Moreover, the cells expressing Dm-dNKmut exhibited increased sensitivity in combination with BVDU, with induction of apoptosis in vitro and in vivo. Conclusion: These findings underlined the importance of BVDU phosphorylated by Dm-dNKmut in transduced cancer cells and the potential role of Dm-dNKmut as a suicide gene, thus providing the basis for future intensive research for cancer therapy.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.2
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• pp.133-140
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• 2016

In active sonar field, a target detection and localization based on a distributed sensor network has been much studied for the underwater surveillance of the coast. Zhou et al. proposed a target localization method utilizing the positions of target-detected sensors in distributed sensor network which consists of detection-only sensors. In contrast with a conventional method, Zhou's method dose not require to estimate the propagation model parameters of detection signal. Also it needs the lower computational complexity, and to transmit less data between network nodes. However, it has large target localization error. So it has been modified for reducing localization error by Ryu. Modified Zhou's method has better estimation performance than Zhou's method, but still relatively large estimation error. In this paper, a target localization method based on modified Zhou's method is proposed for reducing the localization error. The proposed method utilizes the geometry of the positions of target-detected sensors and a line that represents the bearing of target, a line can be found by modified Zhou's method. This paper shows that the proposed method has better target position estimation performance than Zhou's and modified Zhou's method by computer simulations.

• Journal of Industrial Technology
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• v.14
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• pp.77-87
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• 1994

This research is an experimental work of investigating the behavior of soil nailing system under surcharges whereas most of them were concentrated on evaluating its capacity under selfweight of excavated ground. Model tests in laboratory were performed to investigate the ultimate bearing capacity of soil nailing system under surcharges in forms of strip loading. Tests were carried out to find parameters controlling its capacity such as length of nail, vertical and horizontal spacings between nails, inclination of nail installation, and loading position of surcharges. Failure mechanism of forming failure line due to surcharge to soil nailing system was also observed by using dyed sand and monitoring its behavior. From results of these test, effects of parameters was analyzed qualitatively. Thus, this experimental results could provide meaningful data to analyze and design this system later.