• 한국약용작물학회지
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• 제12권2호
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• pp.171-178
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• 2004

The objectives of this study were to establish the genetic transformation system of stilbene synthase in Rehmannia glutinosa. Resveratrol, which is both a phytoalexin with antifungal activity and a phytochemical associated with reduced cancer risk and reduced cardiovascular disease, is synthesized in a limited number of plant species including peanut. Resveratrol synthesis is catalyzed by the enzyme stilbene synthase including resveratrol synthase (RS). Stilbene synthase gene (RS3) obtained from peanut, Arachis hypogaea, Fabaceae has been transferred into chinese foxglove, Rehmannia glutinosa by using Agrobacterium mediated transformation. PCR analysis with RS3 primer confirmed that the targeted gene was introduced into the plant genome, 904 bp in size. Further analyses of identification of transformation using developed other molecular techniques and transgenic plants that RS t-DNA introduced to chinese foxglove (R. glutinosa L) and its reaction product, stilbene such as resveratrol will be isolate and characterize using NMR, MS, and HPLC.

• BMB Reports
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• 제44권2호
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• pp.129-134
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• 2011

Toll-like receptors (TLRs), which recognize structurally conserved components among pathogens, are mainly expressed by antigen-presenting cells such as dendritic cells (DCs), B cells, and macrophages. Recognition through TLRs triggers innate immune responses and influences antigen-specific adaptive immune responses. Although studies on the expression and functions of TLRs in antigen-presenting cells have been extensively reported, studies in lymphoid tissue inducer (LTi) cells have been limited. In this study, we observed that LTi cells expressed TLR2 and TLR4 mRNA as well as TLR2 protein and upregulated OX40L, CD30L, and TRANCE expression after stimulation with the TLR2 ligand zymosan or TLR4 ligand LPS. The expression of tumor necrosis factor superfamily (TNFSF) members was significantly upregulated when cells were cocultured with DCs, suggesting that upregulated TNFSF expression may contribute to antigen-specific adaptive immune responses.

• Asian-Australasian Journal of Animal Sciences
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• 제20권10호
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• pp.1618-1623
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• 2007

The objective of this study was to investigate the effects of dehairing methods and sex on various traits of pork quality, as well as on tissue levels of the boar taint compounds androstenone and skatole. At the early postmortem period, dehided pigs showed higher muscle pH levels (p<0.05), lower temperatures (p<0.05) and lower drip loss (p<0.001) than scalded pigs. Thus, the dehairing method can affect the early postmortem glycolytic rate and water-holding capacity. Moreover, the differences in meat quality traits between the genders were small, and not considered to have practical importance. The scalding method had only a limited effect on the androstenone content. On the other hand, the scalded entire males exhibited a lower content of skatole than the dehided entire males (p<0.01). These results appear to indicate that the heating treatment from the scalding process influenced the reduction of skatole content for the scalded entire males.

• 대한간호학회지
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• 제31권2호
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• pp.279-291
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• 2001

Rapid progress in modern medical technology has made it possible to sustain life and/or delay death using 'heroic' treatments. The availability of life-sustaining treatment brings several issues in end-of-life care such as 'dying with dignity' and an radical increase in health care costs. The use of Advance Directives(AD) have been widely heralded by health care providers, gerontologists, and advocacy groups as means of protecting patients' right to accept or refuse life-sustaining treatment in end-of-life care. The use of AD can not only improve patients' autonomy and quality of life but also bring efficiency in distributing health care resources. The proportion of older persons in Korean population has been increasing. Those 65 years of age or over were about 7 percent of the population. Death and dying is not limited to older persons, but it is more prevalent among them. In conjunction with an aging population and the increasing prevalence of death, the issues of death and dying will become crucial in near future in terms of 'dying with dignity', 'autonomy', and 'self-control'. This paper attempts to explode and establish the concept of advance directives (AD) based on literature review. Data sources are computer searches with the MEDLINE database. Due to the lack of prior study on AD for a Korean cases, studies abroad are reviewed. This paper suggests the need for future study on the possibility of the use of AD in Korea.

• 한국시뮬레이션학회논문지
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• 제21권1호
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• pp.1-8
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• 2012

최근들어, 글로벌 조선소들은 친환경 선박 건조와 환경 친화적 생산 공정에 큰 관심을 보이고 있다. 이러한 추세에 따라 이 연구는 조선소 레이아웃에 전 과정 평가를 적용하는 연구를 수행하였다. 전 과정 평가는 제품과 시스템의 전수명주기와 관련된 환경적 영향을 평가하는 기법으로 특정 산업분야에서 ISO 14040 표준에 따라 적용연구가 수행되고 있다. 전 과정 평가를 조선소 레이아웃에 적용하기 위해 조선소 레이아웃 계획 프레임워크를 분석하고, 조선소 레이아웃에 대한 목록분석을 수행하였으며, 환경적 영향에 대한 이산 사건 시뮬레이션 모델을 구축하였다.

• Computers and Concrete
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• 제4권1호
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• pp.1-18
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• 2007

Over the past decades, an enormous amount of effort has been expended in laboratory and field studies on concrete durability estimation. The results of this research are still either widely scattered in the journal literature or mentioned briefly in the standard textbooks. Moreover, the theoretical approaches of deterioration mechanisms with a predictive character are limited to some complicated mathematical models not widespread in practice. A significant step forward could be the development of appropriate software for computer-based estimation of concrete service life, including reliable mathematical models and adequate experimental data. In the present work, the basis for the development of a computer estimation of the concrete service life is presented. After the definition of concrete mix design and structure characteristics, as well as the consideration regarding the environmental conditions where the structure will be found, the concrete service life can be reliably predicted using fundamental mathematical models that simulate the deterioration mechanisms. The prediction is focused on the basic deterioration phenomena of reinforced concrete, such as carbonation and chloride penetration, that initiate the reinforcing bars corrosion. Aspects on concrete strength and the production cost are also considered. Field observations and data collection from existing structures are compared with predictions of service life using the above model. A first attempt to develop a database of service lives of different types of reinforced concrete structure exposed to varying environments is finally included.

• Parasites, Hosts and Diseases
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• 제49권3호
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• pp.299-302
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• 2011

During experimental Eimeria infections in chickens, facilities are often contaminated by fecal oocysts known to be highly resistant to both chemical and enzymatic treatments. Thus, studies using experimental Eimeria infections have been limited due to the difficulty of complete elimination of residual oocysts from both cages and facilities. To overcome this limitation, simple, inexpensive, and disposable cages were constructed from cardboard boxes and tested during experimental Eimeria maxima infections. The cages were used in animal rooms with only a 1.7% evidence of coccidia contamination between adjacent cages. No significant differences in fecal oocyst output and body weight gain were noted between animals housed in disposable cages and animals housed in wire control cages. This cage design is a useful means for preventing oocyst contamination during experimental conditions, suggesting that this disposable cage design could be used for other avian infectious disease studies.

• KDI Journal of Economic Policy
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• 제39권2호
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• pp.25-51
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• 2017

This paper employs an Overlapping Generations Model to quantify the impacts of Korea's demographic transition toward an older population on the total output growth rate. The model incorporates the projected population through 2060 according by Statistics Korea. The effects of the low fertility and increased life expectancy rates are studied. The model is considered suitable for analyzing the effects of demographic changes on the Korean economy. Under the assumption that the TFP growth rate will not slow considerably in the future, remaining at 1.3% per annum, the gross output growth rate of the Korean economy is projected to slow to 1.1% per annum in the 2050s, from 4.0% in the 2000s. The shrinking workforce due to the decline in fertility plays a significant role in the deceleration of the Korean economy. The increased life expectancy rate is expected to mitigate the negative effect, but the magnitude of its effect is found to be limited.

• Journal of Mechanical Science and Technology
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• 제16권9호
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• pp.1072-1077
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• 2002

A degree of sharpness in wheel grains affects the surface roughness and dimensional accuracy in the grinding process. If a wheel with dull grains is used, the grinding force is increased and the surface roughness is deteriorated. In ovder to produce a precision component economically, the magnitude of the wear amount in the grinding wheel has to be limited. In this study, experimental evaluation of a wheel life varying with the grinding ratio and static grinding force was conducted. The grinding ratio and grinding force were measured to seek the grinding performance of the WA wheel. The relationship between the grinding ratio and static grinding force was presented.

• 아동학회지
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• 제28권4호
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• pp.169-185
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• 2007

Participant observations, in-depth interviews, and analyses of documents were used for collecting data. Children separated from their parents were living with grandparents because their parents were working abroad. Results included socio-cultural and psycho-social factors. (1) The socio-cultural grounded factors or the common characteristics of young children's family life in both living circumstances included early childhood academic achievement orientation, demands of responsibility and obedience, limited opportunity for social development, and societal phenomenadeveloping wide family concept affected by China's Confucianism and Korean-Chinese social culture. (2) Psycho-social grounded factors included the present care-givers' perceptions of the child's agency and their beliefs in the importance of play and friendship. This affected interactions between child and care-giversand child's self-esteem and friendships.