• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2006년도 6th International Meeting on Information Display
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• pp.660-664
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• 2006

A novel quantified method based on requirement analysis of image quality to improve display image quality was proposed. Nowadays, the image quality was limited by the poor understanding of the image quality requirement, which led to the critical factors of image quality could not be controlled during display development. Our method was set up to resolve this problem by clarifying the relationship between the image quality level and the effect factors in image processing. Moreover, the subjective factors were eliminated extremely by the image quality quantification. The method was applied in the RPTV development life cycle and its efficiency was demonstrated.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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• pp.97-102
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• 2002

Life Science Research Center of SK Chemicals has developed a 3rd-generation anticancer platinum drug for the first time in the nation′s 100-year-old pharmaceutical industry. The Korea Food and Drug Administration (KFDA) approved the sale of "Sunpla" (code name SKI 2053R, general name : Heptaplatin) on July 14, 1999 for the treatment of advance, metastatic gastric cancer. Cisplatin, the 1 st-generation anticancer drug, which was developed by Bristol-Myers of the United States in 1976, is one of the most potent anticancer drugs and is a major component of combination chemotherapy for a variety of human cancers. However its clinical usefulness has frequently been limited not only by undesirable side effects such as severe renal toxicity, nausea, vomiting, ototoxicity, and neurotoxicity but also by the development of resistance. Carboplatin, the 2nd-generation anticancer platinum drug, which was also developed by Bristol-Myers in 1986, has modified the problems of the renal and gastrointestinal toxicities of cisplatin. Carboplatin, however, has no enhanced therapeutic efficacy over cisplatin and does not possess the property to overcome cross-resistance to cisplatin.

• Food Science and Biotechnology
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• 제18권5호
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• pp.1243-1252
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• 2009

User-friendly software was developed to determine the shelf-life of perishable Korean seasoned side dishes in real time based on growth models of spoilage and pathogenic microorganisms. In the program algorithm, the primary spoilage and fastest-growing pathogenic organisms are selected according to the product characteristics, and their growth is simulated based on the previously monitored or recorded temperature history. To predict the growth of spoilage organisms with confidence limits, kinetic models for aerobic bacteria or molds/yeasts from published works are used. Growth models of pathogenic bacteria were obtained from the literature or derived with regression of their growth rate data estimated from established software packages. These models are also used to check whether the risk of pathogenic bacterial growth exceeds that of food spoilage organisms. Many example simulations showed that the shelf-lives of the examined foods are predominantly limited by the growth of spoilage organism rather than by pathogenic bacterial growth.

• International Journal of Reliability and Applications
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• 제15권1호
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• pp.23-50
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• 2014

This paper deals with formulation of optimum multi-objective modified step-stress accelerated life test (ALT) plan for Burr type-XII distribution under type-I censoring. Since it is impractical to estimate only one objective parameter after conducting costly ALT tests; also, it is not desirable to assume instantaneous changes in stress levels because of limited capacity of test equipments and the presence of undesirable failure modes, therefore, an optimum multi-objective modified step-stress ALT plan has been designed. The optimal test plan consists in determining the optimum low stress level and optimal time at which stress starts linearly increasing from low stress by minimizing the weighted sum of the asymptotic variances of the maximum likelihood estimator of quantile lifetimes at design constant stress. The method developed has been illustrated using an example. Sensitivity analysis has been carried out. Comparative study has also been done to highlight the merits of the proposed model.

• Structural Engineering and Mechanics
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• 제9권6호
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• pp.557-568
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• 2000

As time-variant reliability approaches become increasingly used for service life prediction of the aging infrastructure, the demand for computer solution methods continues to increase. Effcient computer techniques have become well established for the reliability analysis of structural systems. Thus far, however, this is largely limited to time-invariant reliability problems. Therefore, the requirements for time-variant reliability prediction of deteriorating structural systems under time-variant loads have remained incomplete. This study presents a computer program for $\underline{REL}$iability of $\underline{T}$ime-Variant $\underline{SYS}$tems, RELTSYS. This program uses a combined technique of adaptive importance sampling, numerical integration, and fault tree analysis to compute time-variant reliabilities of individual components and systems. Time-invariant quantities are generated using Monte Carlo simulation, whereas time-variant quantities are evaluated using numerical integration. Load distribution and post-failure redistribution are considered using fault tree analysis. The strengths and limitations of RELTSYS are presented via a numerical example.

• 대한기관식도과학회지
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• 제19권1호
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• pp.11-14
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• 2013

Gastro-esophageal reflux disease (GERD) is a recurrent, long-term gastrointestinal condition characterised by the abnormal reflux of stomach contents into the esophagus. Heartburn is the most dominant symptom, which can be life long and can considerably reduce quality of life. The main goals of treatment are to alleviate symptoms and prevent relapses, esophageal stricture and adenocarcinoma. This paper presents a review comparing the effectiveness of omeprazole with Nissen fundoplication surgery for the treatment of GERD. Nissen fundoplication is more effective in controlling heartburn symptoms, healing esophagitis and preventing relapses than omeprazole. Quality of life, in terms of productivity and ability to work, is difficult to assess in the omeprazole group and, as a result, a comparison of this aspect is limited. Although fundoplication is expensive in the short term, it is more cost-effective than omeprazole. Nurses need to be aware of the effectiveness of omeprazole and fundoplication to provide patients with accurate information, which assists patients in decision making regarding treatment options.

• 대한안전경영과학회지
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• 제19권3호
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• pp.97-107
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• 2017

This research studies on the demand forecasting for service parts considering parts life cycle, that gets relatively less attentions in the field of forecasting. Our goal is to develop forecasting method robust across many situations, not necessarily optimal for a limited number of specific situations. For this purpose, we first extensively analyze the drawbacks of the existing forecasting methods, then we propose the new demand forecasting method by using these findings and reinforcement leaning technique. Using simulation experiments, we proved that the proposed forecasting method is better than the existing methods under various experimental environments.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2002년도 제9회 학술 발표회 프로그램과 논문초록
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• pp.32-32
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• 2002

To understand the functional roles of the neuron-specific $\beta$-subunit of large-conductance calcium-activated potassium ($BK_{Ca}$) channel, we isolate the full-length complementary DNA of $\beta$4-subunit from rat brain library and investigated its effects on the function of $\alpha$-subunit (Slo). The deduced amino acid sequence of rat $\beta$4 (r$\beta$4), 210 amino acids in length, was closely related to those of $\beta$4 subunits in other mammalian species but showed only a limited sequence homology to the other $\beta$-subunits, $\beta$1 to $\beta$3.(omitted)d)

• 대한전기학회논문지
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• 제41권1호
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• pp.95-106
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• 1992

For commercial application of the MCFC, the life time of the MCFC should exceed 40,000 hours, But the life time of the state-of-the-art MCFC was limited to 15,000 hours. The main reasons of the life time limit can be classified as the deficiency of the electrolyte and cathode dissolution. It has been found that the electrolyte deficiency is caused by the continuous evaporation of the electrolyte. However a recent reaserch shows that an electrolyte pumping phenomenon, which implies, the migration of the electrolyte through the gasket material of the external gas manifold, is also the reason of the electrolyte deficiency. Due to the electrolyte pumping phenomenon, positive end cell of the stack suffers the electrolyte deficiency and negative end cell of stack is flooded with electrolyte. Therefore, the cell performance is degraded. The author invented a new manifoldcasing, which prevents the contact between the wet seal and the gasket of the manifold, and gives a complete elimination of an electrolyte pumping effect.

• 한국철도학회논문집
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• 제8권6호
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• pp.544-549
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• 2005

Nowadays, most of bridge networks are complete or close to completion. The biggest challenge railroad./highway agencies and departments of transportation face is the maintenance of these networks, keeping them safe and serviceable, with limited funds. To maintain the bridges effectively, there is an urgent need to predict their remaining life from a system reliability viewpoint. And, it is necessary to develop the maintenance models based on system reliability concept. In this paper, maintenance models are developed for preventive maintenance and essential maintenance by using system reliability and lifetime distributions. The proposed model is applied to an existing railroad bridge. The optimal maintenance strategy of this bridge is obtained in terms of services life extension and cumulative maintenance cost.