• PNF and Movement
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• 제14권2호
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• pp.121-130
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• 2016

Purpose: The purpose of this study was to investigate the effects of visual and auditory stimulation on the ability to perform exercise. Methods: One hundred twenty subjects were randomly divided into four groups (Green light and Fast tempo music, GF; Green light and Slow tempo music, GS; Red light and Fast tempo music, RF; and Red light and Slow tempo music, RS). One of either two visual stimuli or one of two auditory stimuli were applied to each group. The experiment was conducted randomly twice in two environments: one had visual and auditory stimuli and one had no stimulation. Muscle strength, grip, endurance, quickness, agility, concentration, and balance were measured to determine the ability to perform exercise. Results: Significant differences were found in the muscle strength of the participants who were exposed to the auditory factor and the interaction of visual and auditory factors. In endurance, significant differences were found in all of the factors: visual, auditory, and the interaction of visual and auditory. In quickness, agility, and balance ability there were significant differences in the visual factor. In concentration, there was a significant difference in the auditory factor. Conclusion: Visual stimuli, auditory stimuli, and their interaction influenced the ability to perform exercise. These facts imply that providing the proper environmental stimulation is important to increase the ability to perform during exercise.

• Journal of Microbiology
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• 제41권2호
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• pp.161-164
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• 2003

Recombinant light chain of Clostridium botulinum neurotoxin type B stimulated transglutaminase activity in a dose dependent manner, Compared to native toxin, recombinant light chain showed av greater stimulatory effect on transglutaminase activity. Zn-chelating agents, inhibiting the proteolytic activity of the clostridial toxins, did not interfere with this stimulation. These results suggest that the light chain plays a major stimulatory role, which is not due to its metallopeptidase activity, but is possibly due to specific interaction with transglutaminase. More importantly, this report provides a new insight into the intracellular action of C. botulinum neurotoxins.

• 터널과지하공간
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• 제23권6호
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• pp.572-580
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• 2013

이 사례연구에서는 스위스 바젤에서 진행되었던 인공지열발전(EGS) 프로젝트인 Deep Heat Mining Basel(DHMB)의 미소진동 관리시스템을 살펴보았다. 인공지열발전 프로젝트에 꼭 필요한 인공지열저류층 생성을 위한 수리자극으로 인해 발생하는 유도진동은 안전관리시스템을 수립하여 수리자극의 압력과 유량을 관리하여야 한다. DHMB프로젝트에서는 수리자극 기간 동안 지속적인 관측활동을 통해 미소진동 발생 진도에 따라 단계별로 대응하는 경보시스템과 커뮤니케이션 대응 절차가 사전에 수립되어 관리되었다. 그러나 수리자극을 위한 주입 완료 후에도 지열저류층에서 발생한 주입이후 진동현상으로 인해 예상보다 큰 지진이 발생하자 프로젝트가 중단되었다. 사후분석 결과 실시간 경보시스템은 주입이후 진동 현상을 감안한 새로운 미소진동 안전관리시스템을 수립하는 것이 필요하다고 확인되었다.

• 대한전기학회논문지:시스템및제어부문D
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• 제55권10호
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• pp.458-463
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• 2006

The purpose of this work is to investigate the fundamental properties of the gradual muscle force potentiation. We investigated the dependence of force potentiation on both the pulse-amplitude and the pulse-duration with different ramp-up time. The experimental results showed that the force increment ratio (FIR) during constant electrical stimulation decreased with pulse-amplitude and also with pulse-duration. The FIR was greater with short ramp-up time in both the pulse-amplitude and pulse-width modulation. The feasible mechanism might be that the myosin light chain phosphorylation induces the force potentiation and it occurs only in the fast type muscle fibers which are recruited first. These observations indicate that muscle potentiation must be understood well for the accurate control of muscle force.

• 생명과학회지
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• 제25권5호
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• pp.585-593
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• 2015

Stress fiber (SF) 변화는 세포외부의 결합인자와 세포 수용체와 결합후 리모델링을 위해 액틴골격에 신호를 전달하며 일어난다. 이 연관은 결합장소에서 기계적 활동과 신호전달활동을 조절하는 다양한 스케폴드들과 신호 전달자에 의해 매게된다. Heterotrimeric transmembrane lymphotoxin α1β2 (LTα1β2)는 용해성 homotrimeric LT α를 포함하는 tumor necrosis factor (TNF) 계로 림프조직을 구성하는데 중요한 역할을 한다. LTα1β2와 LTβR의 결합은 fibroblastic reticular cell (FRC)에서 신호전달을 촉발한다. Agonistic anti-LTβR antibody 단독 혹은 LTα 그리고 TNFα의 조합으로 LTβR 자극은 세포의 액틴과 형태적 변화를 보았다. Agonistic anti-LTβR antibody의 FRC에서 작용을 통한 세포골격 재배열이 myosin과의 관련성을 확인하기위해 myosin light chain kinase (MLCK)의 저해제인 ML-7과 myosin light chains (MLC)와 myosin phosphatase target subunit 1 (MYPT1)의 인산화에 대한 효과를 확인하였다. MLCK 저해는 액틴 세포골격 재배열과 세포형태 변화를 유도하였다. 또한, MLC와 MYPT1인산화가 LTβR 자극에 의해 줄어드는 것을 확인하였다. DNA chip 분석은 myosin and actin 구성선분이 전사체 수준에서도 줄어드는 것을 보였다. 결론적으로 LTβR 자극은 FRC에서 SF변화는 myosin과 관련되어 있다는 것을 제시한다.

• 대한통합의학회지
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• 제8권1호
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• pp.87-99
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• 2020

Purpose : This study aims to investigate the effect of somatosensory stimulation on the upper limb sensory and function and self-esteem of stroke patients. Methods : This study period was march 4 to april 4 (5 weeks). The subject were 20 stroke patients with somatosensory impairment in B hospital, seongnam, gyeonggi province. They were devided into two group-experimental and control-with 10 members each. The members of the experimental group underwent somatosensory stimulation, whereas the members of the control group underwent an occupation-based intervention for 5 weeks. Thirty-minute therapy was provided 3 times per week for 5 weeks. Before and after the intervention, both groups were evaluated via light touch, static two-point discrimination, stereognosis, Fugl-Meyer assessment (FMA), and self-esteem scale Results : In this study, light touch was not significant in both groups. Static two-point discrimination was significant among the experimental group member's index fingers. Among the control group members, it was significant in the ring finger. The comparison between the two groups was significant in the index finger. The stereognosis results were significant in the experimental group but not in the control group. The comparison between the groups after the intervention was not significant. FMA was significant in the shoulder/ elbow/ forearm (SEF), hand and coordination among the experimental group. Among the control group, it was significant in the SEF and hand. The comparison between the groups was significant in the SEF, hand and coordination. The self-esteem scale results were significant among both groups, and the comparison between the group's score was likewise significant. Conclusion : In conclusion, somatosensory stimulation therapy increases the static two-point discrimination, stereognosis, upper extremity function, and self-esteem of patients with stroke. Therefore, while somatosensory stimulation therapy is not the best therapy, it is one of the best occupational therapies for stroke patients.

• Medical Lasers
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• 제10권1호
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• pp.15-21
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• 2021

As technology advances at a rapid rate, innovations in regenerative medicine will eventually include the use of energy-based therapeutics, such as low intensity-pulsed ultrasound stimulation (LIPUs), pulsed electromagnetic field stimulation (PMFs), and low-level laser/light therapy (LLLt) or photobiomodulation therapy (PBMt). Among these treatments, LLLt/PBMt attracted significant attention by the turn of the century, as evidenced by the numerous publications compared to LIPUs and PMFs, particularly for augmented bone regeneration (ABR). This is a testament of how the maturation of technology and scientific knowledge leads to latent compounded applications, even when the value of a technique is reliant on empirical data. This article reviews some of the notable investigations using LLLt/PBMt for bone regeneration published in the past decade, focusing on how this type of therapy has been utilized together with the existing regenerative medicine landscape.

• The Journal of Korean Physical Therapy
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• 제2권1호
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• pp.47-63
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• 1990

The purpose of this study was to determined the effect of low-frequency electrical stimulation on the denervated gastrocnemius muscles of the albino rats, Sprague-Dawley. Fifteen Sprague-Dawley adult male albino rats were divided into non-treated (normal) group, denervated (control) group, denervated and electrical stimulated (experiments). The gastrocnemius muscles of the right leg were submaximally stimulated with 30 Hz electrical stimulation. After 4-week period, the animals were sacrificed, and muscle were removed, fixed by immersion, and processed for light and electron microscopy. The numbers of Ag-NOR increased significantly (p<0.001), but significant reductions of girth(p<0.01), wet muscle weight (p<0.001), high glycogen content fiber (p<0.01), and mitochondrial number (p<0.05) were found in denervated control group. In comparison with control group, significant increase of right leg girth (p<0.05), wet muscle weight (p<0.001), high glycogen content fiber (p<0.05), numbers of Ag-NOR(p<0.001), number of mitochondria (p<0.01), mitochondrial volume found in electrical stimulated experimental group. The results suggest that the electrical stimulation of the muscle partially prevented the denervated atrophy in the rat gastrocnemius muscles.

• Korean Journal of Acupuncture
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• 제28권3호
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• pp.13-23
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• 2011

Objectives : The aim of this study was to develop the combined medical stimulus system consisted of the PEMFs (Pulsed electromagnetic fields) and LED which are able to stimulate local point such as acupoints and trigger points. Methods : To evaluate the therapeutic effect on the musculoskeletal disorders and the possibility of alternative method on manual acupuncture, we compared the fatigue recovery of two groups by analyzing the EMG and peak torque (non-stimulation and, stimulation group) after strenuous knee exercise. We chose the LR9 as a stimulation point. Results : The median frequency (MF) and fatigue index (F.I) of the stimulation group were recovered faster than those of the non-stimulation group. Also the peak torques of both groups were not restored until after 20 minutes. However, the peak torque of the stimulation group was regained higher than that of the non-stimulation group. Conclusions : We confirmed that the proposed combined stimulus system had useful effects as treatment instrument of musculoskeletal disorder using non-invasive method of PEMFs and LED.

• Journal of Plant Biology
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• 제33권3호
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• pp.203-210
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• 1990

Effects of blue and red light on photorespiration in the leaf disks of pea were studied. The rate of total 14CO2 fixation was more or less higher under red light than blue light irradiation of the same quantum (94.8 $\mu$Em-2.S-1/mV). The release of 14CO2 by photorespiration was more stimulated under blue than red light. Among the photorespiratory intermediates, 14C was more incorporated ito serine under blue light than red light. However, 14C was more incorporated into glycine under red light than blue light. The incorporation of 14C into glycolate was very low under both light qualities, but higher under red light than blue light. Among the enzymes related to photorespiration, only glycolate oxidase was activated and/or synthesized by blue light irradiation. Moreover, more 14C2 was released from glycoate-1-14C under blue light than red light irradiation, but 14C2 release from glyoxylate-1-14C and glycine-1-14C showed no difference by the either light qualities. These results suggest that blue light is more effective in the photorespiratory CO2 evolution than red light. The reason is considered that glycolate is easily metabolized under blue light due to the stimulation of the glycolate oxidase activity.