• The korean journal of orthodontics
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• 제43권2호
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• pp.96-100
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• 2013

Objective: To evaluate the effects of contamination by either blood or a hemostatic agent on the shear bond strength (SBS) of orthodontic buttons. Methods: We used 45 freshly extracted, non-carious, impacted third molars that were divided into 3 groups of 15. Each tooth was etched with 37% phosphoric acid gel for 30 s. Human blood or the blood stopper agent was applied to the tooth surface in groups I and II, respectively. Group III teeth were untreated (controls). Orthodontic buttons were bonded to the teeth using light-curing composite resin. After bonding, the SBS of the button was determined using a Universal testing machine. Any adhesive remaining after debonding was assessed and scored according to the modified adhesive remnant index (ARI). ANOVA with post-hoc Tukey's test was used to determine significant differences in SBS and Fisher's exact test, to determine significant differences in ARI scores among groups. Results: ANOVA indicated a significant difference between groups (p < 0.001). The highest SBS values were measured in group III ($10.73{\pm}0.96$ MPa). The SBS values for teeth in groups I and II were significantly lower than that of group III (p < 0.001). The lowest SBS values were observed in group I teeth ($4.17{\pm}1.11$ MPa) (p < 0.001). Conclusions: Contamination of tooth surfaces with either blood or hemostatic agent significantly decreased the SBS of orthodontic buttons. When the contamination risk is high, it is recommended to use the blood stopper agent when bonding orthodontic buttons on impacted teeth.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.487-492
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• 2012

Trace element zinc deficiency or excess is implicated in the development or progression of some cancers. The exact role of zinc in the etiology of colon cancer is unclear. To cast light on this question, an experimental model of colon carcinogenesis was applied here. Six week old rats were given sub cutaneous injections of DMH (30 mg/kg body weight) twice a week for three months and sacrificed after 4 months (precancer model) and 6 months (cancer model). Plasma zinc levels showed a significant decrease (p<0.05) at 4 months and a greater significant decrease at 6 months (p<0.01) as compared with controls. In the large intestine there was a significant decrease in tissue zinc levels (p<0.005) and in CuZnSOD, and alkaline phosphatase activity (p<0.05) in the pre-cancerous model and a greater significant decrease in tissue zinc (p<0.0001), and in CuZnSOD and alkaline phosphatase activity (p<0.001), in the carcinoma model. The tissue zinc levels showed a significant decrease in the small intestine and stomach (p<0.005) and in liver (p<0.05) in the cancer model. 87% of the rats in the precancer group and 92% rats in the cancer group showed histological evidence of precancerous lesions and carcinomas respectively in the colon mucosa. This study suggests that the decrease in plasma zinc, tissue zinc and activity of zinc related enzymes are associated with the development of preneoplastic lesions and these biochemical parameters further decrease with progression to carcinoma in the colon.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• 제29권4호
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• pp.18-29
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• 2015

The purposes of this research and development are as follows: first, to provide pleasant driving environments inside tunnels; second, to improve the current illumination environments lacking in diffusion luminance meters to meet tunnel lighting standards; and, third, to reduce the consumption of tunnel lighting energy accounting for approximately 65% of tunnel maintenance costs because of inadequate visual environments and tunnel operations. Further details are listed below. Firstly, an image luminance meter for tunnels that can implement the L20-method which is a tunnel luminance method that follows the international standards of CIE88, which was developed in order to improve and change the existing illumination-based tunnel lighting operation system to a luminance-based system. (The margin of error of below 5% according to the results of a test by an authorized agency and field test). Secondly, early illumination control is possible since the lighting control system that can be operated based on luminance enables interlocking control of the inside and outside of a tunnel using ethernet communication. Thirdly, guidelines for field application of the system are proposed. In addition, the luminance inducers of tunnels are found and the reflexibility of each facility that may reduce luminance of the boundaries is also proposed. Fourthly, as a result of a test bed, power consumption of luminance-based lighting operations decreased by 15.6% compared to illumination-based operations. Applying the feedback controls and maintenance factors of internal/external luminance meters, it reduced by 36.4%. Therefore, we became able to provide a luminance-based lighting operation system that complies with tunnel lighting design standards and provides a visual environment for drivers.

• The Korean Journal of Pharmacology
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• 제20권1호
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• pp.13-21
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• 1984

The present study was undertaken to investigate an effect of ginseng butanol fraction(total saponin) on the hepatic ethanol metabolism, we used experimental animals for the subject of study. When, in case of ADH and MEOS, ginseng butanol fraction was added, enzyme activity was increased in a small dose, and on the contrary, in a large dose, showed inhibitory effect. in catalase, the activity showed no significant effect by adding ginseng butanol fraction. In the light of kinetic aspect, when, in reaction mixture, ethanol and ginseng butanol fraction were concurrently added and reacted, Km value of ADH and MEOS was decreased. After pretreated with ginseng butanol fraction and inducement of acute toxic state by ethanol, the activities of ADH and MEOS were increased to an extent of about 25% compared to controls. But catalase activity was not significantly affected. In case that ginseng butanol fraction was given to mice fed with 5% ethanol instead of water for 60 days, the activities of ADH and MEOS were increased about 20% to 50% compared to ethanol-treated group. On the contrary, catalase activity was not affected. But blood concentrations of ethanol were decreased due to ginseng butanol fraction treatment. All these observations suggested that reduction of ethanol blood concentration should be dependent upon increased activities of ADH and MEOS. Thereby it suggests the recovery from alcohol intoxication can be prompted by treatment with ginseng.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• 제17권1호
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• pp.123-135
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• 1987

The author observed the effects of retrograde infusion of water soluble contrast media (Tele- brix 30) on the rabbit submandibular glands and compared the effects of different degrees of filling. 26 rabbits were divided into 2 groups of 12 each as experimentals and I group of 2 as normal controls. One experimental group was filled with 0.2㎖ and the other with 0.4㎖. Right submandibular gland of each rabbit was infused with contrast media and left one with physiologic saline as a experimental control, at a constant rate of 0.12㎖/min. using an infusion pump via the main excretory duct. Immediately after the infusion of contrast media, oblique lateral radiographs of the glands were made with occlusal film in order to confirm the glandular filling. The rabbits were sacrificed after varying periods (1, 8, 24 hours and 3, 6, 10 days) and the tissues were prepared for light and electron microscopic examination. The results were as follows: 1. In glands filled with 0.2㎖ contrast media, the initial changes were a few vacuole formation in the acini and slight dilation of the intralobular duct. The moderately severe changes such as vacuole formation in the acini, the abnormal substructure within the secretory granule, dilation of acinar and intercalated duct lumen, scalloping of striated duct lumen and inflammatory cell infiltrate were observed at 3 days. The general appearance was successively recovered, so the tissue had a normal appearance at 10 days. 2. In glands filled with 0.4㎖ contrast media, the most prominent alterations such as severe acinar atrophy, decreased number of secretory granules, proliferation of connective tissue stroma and pronounced inflammatory cell infiltrates appeared at 6 days. Although the general appearance returned to be almost normal at 10 days, acinar cells showed some atrophy and decreased secretory granules. 3. In glands subjected to 0.4㎖ infusion, the alterations were more severe and the recovery was slower than those seen in the glands to 0.2㎖ infusion.

• Journal of fish pathology
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• 제19권3호
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• pp.243-251
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• 2006

The internal defense system of mollusks consists of circulating haemocytes. In order to understand the morphological characterization of haemocytes, light and electron microscopy were carried out in oyster, Crassostera gigas. Four types of haemocytes were recognized: type Ⅰ small hyalinocytes, type Ⅱ large hyalinocytes, type Ⅲ large granulocytes and type Ⅳ small granulocytes. Additionally, the activities of alkaline phosphatase (ALP), acid phosphatase (ACP), peroxidase (POD), α-naphthyl acetate esterase, β-glucuronidase, PAS, sudan black B and oil red O in haemocytes were analysed by immunocytochemical methods. The results indicate that enzymatic activities were abundant and more active in granulocytes than in hyalinocytes. After incubation with haemoctyes and Vibrio FKC, phagocytic index and percentage of phagocytic cell were and shown to be increased from 15 to 120 min. In addition, the enzymatic activities were higher than those of controls: ALP, ACP, α-naphthyl acetate esterase and β-glcuronidase, indicating that these enzymes can be related with phagocytosis in oyster.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제16권3호
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• pp.2135-2140
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• 2015

In this paper, proposed a new lighting control system which can reduce power consumption compared to conventional street lamps and intelligently control the light efficiently depending on whether there is a vehicle on the street. The new lighting control system proposed by this paper detects the presence of cars by collecting and analyzing sounds generated by the movement of cars. Then, the system controls lighting of street lamps based on the above car detection information, and turns on the street lamps sequentially by transmitting the car detection information. Experimental results showed that lightings were controlled based on the presence of cars and that operations of the lamps were made by turning on the lights sequentially by determining the moving direction of cars. This system is considered a technology that can reduce energies by applying to local roads with a few cars moving or national highways where lights are always turned on with low energy efficiency.

• Journal of Astronomy and Space Sciences
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• 제20권2호
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• pp.143-152
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• 2003

We constructed the photometric observation system with a small semi-automatic telescope for the systematic observations of eclipse timings of eclipsing binary stars. The system is consisted of a Paramount GT-1100s mount system, a Celestron 14 optical system, and a SBIG ST-8 camera. We developed the OBSTOOL S/W which controls the telescope and the CCD camera using the COM(Component Object Model) supported by the softwares, The Sky and MaximDL. The system performs photometric observations of a variable, comparison and check stars by moving the telescope to the chosen star separately in a similar way such as the method of photoelectric observation. We wrote pert scripts which enable a data handling pipeline for the obtained data to be classified by each of date, object and filter. And thus the images are easily preprocessed using the IRAF S/W package. Eclipse light curves of some eclipsing binary stars observed with this system are presented.

• The Journal of the Korea institute of electronic communication sciences
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• 제7권3호
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• pp.485-490
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• 2012

In this paper, driver circuit of LED lights for ships is designed and implemented to replace conventional lights with filament which have short life time due to vibration of ships. The driver of LED module is switching circuit without transformer to reduce volume and cost. As switch circuit controls input 220 VAC with PWM, LED module is reliably driven. Power factor is improved by using valley-fill PFC compensation circuit which is handled to pulse current of switching circuit. Serial-parallel LED circuit is applied to reduce change period of lights of long-term navigation ships. Array of serial-parallel can operate even if some of LEDs is damaged. It is suitable for ships that power consumption and power factor of lights including developed drive circuit have 39Watt and 0.925 respectively.

• International Journal of Oral Biology
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• 제45권2호
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• pp.42-50
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• 2020

Lysophosphatidic acid (LPA) is a lipid messenger mediated by G protein-coupled receptors (LPAR1-6). It is involved in the pathogenesis of certain chronic inflammatory and autoimmune diseases. In addition, it controls the self-renewal and differentiation of stem cells. Recent research has demonstrated the close relationship between periodontitis and various diseases in the human body. However, the precise role of LPA in the development of periodontitis has not been studied. We identified that LPAR1 was highly expressed in human periodontal ligament stem cells (PDLSCs). In periodontitis-mimicking conditions with Porphyromonas gingivalis-derived lipopolysaccharide (Pg-LPS) treatment, PDLSCs exhibited a considerable reduction in the cellular viability and osteogenic differentiation potential, in addition to an increase in the inflammatory responses including tumor necrosis factor-α and interleukin-1β expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. Of the various LPAR antagonists, pre-treatment with AM095, an LPAR1 inhibitor, showed a positive effect on the restoration of cellular viability and osteogenic differentiation, accompanied by a decrease in NF-κB signaling, and action against Pg-LPS. These findings suggest that the modulation of LPAR1 activity will assist in checking the progression of periodontitis and in its treatment.