• Biomolecules & Therapeutics
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• v.28 no.2
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• pp.184-194
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• 2020

Histone deacetylase (HDAC) inhibitors represent a novel class of anticancer agents, which can be used to inhibit cell proliferation and induce apoptosis in several types of cancer cells. In this study, we investigated the anticancer activity of MHY4381, a newly synthesized HDAC inhibitor, against human prostate cancer cell lines and compared its efficacy with that of suberoylanilide hydroxamic acid (SAHA), a well-known HDAC inhibitor. We assessed cell viability, apoptosis, cell cycle regulation, and other biological effects in the prostate cancer cells. We also evaluated a possible mechanism of MHY4381 on the apoptotic cell death pathway. The IC₅₀ value of MHY4381 was lower in DU145 cells (IC₅₀=0.31 µM) than in LNCaP (IC₅₀=0.85 µM) and PC-3 cells (IC₅₀=5.23 µM). In addition, the IC₅₀ values of MHY4381 measured in this assay were significantly lower than those of SAHA against prostate cancer cell lines. MHY4381 increased the levels of acetylated histones H3 and H4 and reduced the expression of HDAC proteins in the prostate cancer cell lines. MHY4381 increased G2/M phase arrest in DU145 cells, and G1 arrest in LNCaP cells. It also activated reactive oxygen species (ROS) generation, which induced apoptosis in the DU145 and LNCaP cells by increasing the ratio of Bax/Bcl-2 and releasing cytochrome c into the cytoplasm. Our results indicated that MHY4381 preferentially results in antitumor effects in DU145 and LNCaP cells via mitochondria-mediated apoptosis and ROS-facilitated cell death pathway, and therefore can be used as a promising prostate cancer therapeutic.

• Journal of Advanced Navigation Technology
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• v.15 no.5
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• pp.687-695
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• 2011

The defect caused by the software industry that is the source of knowledge-centric, information-centric and technology-centric affects an engine which operate a major role for operation of aircraft. Therefore, we should minimize the danger from the defect by strengthening the stability of aviation through the stability analysis of software. In this paper, we examine the laws and systems about the aircraft defects and software safety and propose the enhancement and the enactment of the law or measures to strengthen aviation safety. We should the existing law or system as items, such as the revision related to the safety analysis, standards of quality assurance including safety, application of quality assurance that you must attach the safety analysis report, assessment of detailed instructions of certification authorities. In addition, we should enact the new law and system as items such as the mandatory software evaluation and certification, continuous assessment based on the software life cycle, mandatory introduction of a standardized development methodology, strengthening of advanced workforce system. We can expect the improvement of software quality and an enhanced aviation safety by improving existing laws or systems and enacting new laws or systems.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.8
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• pp.3602-3610
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• 2013

The risk of failure in the development of modern weapon systems has been increasing as the demand on the capability and the resulting complexity of the weapons on the war fields are increasing drastically. The analysis of failure has indicated that the main causes can be the following: one is attributed to the unsatisfaction of the system operation concept; and the other is the use of premature technology. As such, DAPA in Korea is urging that the weapons systems development should meet the required operational capability (ROC) as a critical performance requirement. On the other hand, an approach to risk management is to use the technology readiness level (TRL) assessed for each individual technology alone. However, the method of TRL cannot assess the effect of integration between technologies and cannot be performed at system level, which is crucial to systems development. In order to improve the shortfalls, a concept of system readiness level (SRL) has been studied by introducing the technologies integration and also some forms of analysis of advanced degree of difficulty studied separately, but no model considering both of two reported yet. In this paper, under the framework of meeting the ROC, an improved SRL assessment model is presented, which is also considering the advanced degree of difficulty simultaneously. The application of the improved assessment method is discussed in connection with the life cycle of the weapon systems development in conformance with the ROC of DAPA.

• Journal of Navigation and Port Research
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• v.30 no.6 s.112
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• pp.447-455
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• 2006

Together with the trend of enhancement in domestic industrial development and economic progress due to import and export, the demand for construction of the roads, bridges, especially port facilities, and several coastal protection and ocean structures is increasing rapidly. MOMAF of Korean Government is driving construction cf 9 new ports and renovation cf the existing fishery ports. Among these structures most of bridge base, wharves, dolphins, quays, and jetties are being newly built cf steel or concrete pile. As the base, supporting bulkheads, and piles are underwater after construction, it is difficult to figure out the status of structures and not enough to get maintenance and strengthen the structures. Every year, moreover, these works suck the government budget due to higher incomplete maintenance expense for protection from corrosions cf structures and increased underwater construction period. For the purpose cf cutting down the expense cf government budget, it is necessary to extend the life cycle of the existing structures. Therefore, we developed a new method for maintenance of submerged structures near the waterline by allowing dry work environment with the floating caisson. The method shows easy to move around the working area and handle. It also showed not only a significant reduction of maintenance expenses and time for anti-corrosion work but also better protection This will be a milestone to reduce the maintenance and construction expenses for the shore and water structures.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.26-33
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• 2016

The cost of preparing munitions in weapon system operation and management has been rapidly increasing and current weapon systems have become complicated and diverse due to new warfare pattern changes and the rapid growth of advanced scientific technology. Moreover, as a part of the execution plans of creative economics, the Korean government is actively reviewing how to minimize the costs of preparing munitions. Accordingly, this study derived the issues of munitions management for decreasing munitions preparing costs. First, the issues of munitions management were introduced through review and analysis with respect to the munitions classification criteria, regulations and systems, and equipment maintenance information systems. Second, we proposed the application and necessity for the real-name system which is responsible for munitions management and the fragmentation of the maintenance instructions status classification criteria.. Also, we were analyzed that the effects depending on the application. Finally, we proposed that the linkage system which is currently military active with equipment maintenance information systems as well as the total life-cycle management system (TLCSM) improvements to the itemized data and records management system by utilizing IT technology CMB that must be done in order to improve the issues.

• International Journal of Highway Engineering
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• v.13 no.1
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• pp.139-148
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• 2011

Asphalt concrete overlay method is used by general maintenance and rehabilitation of construction for aged concrete pavement in Korea. However, in case of the AC overlay method to extend service life of the existing concrete pavements, various distresses of reflection crack, pothole and rutting are the typical problems of the asphalt overlay on existing concrete pavement since it has different physical characteristics between asphalt overlay and existing concrete pavement. To achieve this, application of concrete overlay method is required instead of AC overlay method. Concrete overlay method has advantages that can reduce maintenance cycle and costs since it has excellent bearing value for heavy vehicles and no rutting. However, technical problems of detour road construction, traffic control and other disadvantages happened by long curing time. Thus, in this study and experimental research were launched to evaluate the workability, durability and resistance against environmental loading of Very Rapid Hardening Acrylic Polymer Modified Concrete(VRH-APMC) for application of bonded concrete overlay method. Test results showed that the compressive and bond strength were exceed 21MPa and 1.4MPa of target strength after four hours for rapid traffic opening properties. And tests of resistance against environmental loading results showed that VRH-APMC secured excellent durability. Thus, it was known that VRH-APMC was suitable material for large scale bonded concrete overlay method, and it was possible to use maintenance and rehabilitation method which needs enough workability and rapid traffic opening.

• Journal of the Korean Society for Nondestructive Testing
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• v.35 no.2
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• pp.141-149
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• 2015

In the fabrication of electronic circuits used in electronic products, molybdenum thin films are deposited on semiconductors to prevent oxidation. During the deposition, the presence of a particle or dust at the interface between the thin film and substrate causes the decrease of adhesion, performance, and life cycle. In this study, a damage measurement targeting two kinds of glass substrate, with and without particles, was performed in order to measure the change in the molybdenum thin film deposition area in the presence of a particle. Clean and dirty molybdenum thin film specimens were fabricated and directly deposited on a substrate using the sputtering method, and a reflection-type digital holographic interferometer was configured for measuring the damage. Reflection-type digital holography has several advantages; e.g., the configuration of the interferometer is simple, the measurement range can be varied depending on the magnification of a microscopic lens, and the measuring time is short. The results confirm that reflection-type digital holography is useful for the measurement of the damage and defects of thin films.

• The Journal of the Korea Contents Association
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• v.13 no.11
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• pp.957-967
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• 2013

While a vast number of cad drawings are produced in the life cycle of construction projects from the planning, design, and construction phases to the maintenance and control phases, the creation and distribution of non-standard drawings make it difficult for the construction parties to communicate with one another and to recycle, maintain, and control drawings by project phase. The Korea standard of CAD drawing in construction CALS/EC, which stipulates the standard for construction CAD drawings, is based on roads, rivers, and railways in line- and unit-based structures, allowing the creation of standardized CAD drawings. Such standard, however, cannot be easily applied to construction projects with multiple facilities like harbors, housing sites, or lands consisting of surface forms. In particular, port field consist of complex docks and amenities located in a certain coastal area based on multiple objectives. They also contain the concept of housing sites, like background land, and are composed of various civil engineering facilities, construction facilities, and port field, so that the existing CAD drawing standard cannot be easily implemented. Therefore, the purpose of this study is to maximize the efficiency of the information related to drawing information and to ultimately support smooth information exchanges in construction design by conducting a development research on the expansion of the CAD drawing standard that meets the needs of port field.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.10
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• pp.48-54
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• 2020

DMSMS (Diminishing Manufacturing Sources and Material Shortage) is increased by developing the scientific technique and downsizing the military part market. DMSMS affects the increase in total life cycle costs and serviceability. Therefore, advance control for parts is important to reduce the cost, and a database is needed to share information on the DMSMS. A task needs to be performed continuously by setting the major control item to management more efficiently. The purpose of this study was to deduce the major control item for the DMSMS management system. Thus, the pre-control item basis of the DAPA (Defense Acquisition Program Administration) Manual and the SD-22 Manual were first selected, and the results of the survey were analyzed by AHP (Analytic Hierarchy Process) method. Fifteen of the detailed items were stratified into three criteria (Impact, Probability, and cost of the DMSMS), and each weight for the items was calculated using a nine-point scale survey. The AHP survey was executed with 25 specialists in the DMSMS management field, and the score of consistency ratio over 0.1 was excluded. The model explained the results and suggested future directions for development.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.744-754
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• 2017

In this study, an analytic hierarchy process (AHP) was conducted with the aim of developing a post-disaster refugee housing performance index system (PPS) to improve the post-disaster refugee housing (PRH) performance criteria for the foundation of quality-based development. The PRH was defined as a mid-term temporary housing facility that is used for a certain period before the permanent housing is established. The safety, rapidity, reusability, habitability, and economy were derived from major performance factors through prior research. A hierarchical PPS was organized by linking the major performance factors with the whole life cycle process of PRH. The priority of each performance index of PPS was determined quantitatively using the analytic hierarchy process through an expert survey. Based on AHP analysis, the performance criterion of the total weight 1-10 ranking and the performance criterion of the first rank in each category were classified into the essential performance criterion (must be achieved) and the others were classified into the recommended performance criterion (optional achieved) and the performance index was constructed considering all stages of PRH development. With the completion of the PRH performance index, it is expected that victims will be able to secure stable residence and return to their daily lives quickly.