Nandrolone, 19-nortestosterone, is a synthetic androgenic-anabolic steroid promoting muscle growth. Nandrolone is also present in pig meat and sera at non-negligible levels. A number of scientific reports have suggested a positive relationship between incidence of infertility and increased meat consumption in humans. The present study was designed to determine out the effect of feeding nandrolone on the testis of the male reproductive tract. Mixtures of food and nandrolone at different concentrations (0.005 ppm and 0.5 ppm) were supplied to pubertal male rats for 6 weeks. Body weight was recorded every week during the entire experimental period. At the end of the treatment, the testis, epididymis, and epididymal fat were collected and weighted. Sperm numbers in the caudal epididymis were counted. Differential gene or protein expression of steroidogenic enzymes in the testes among experimental groups was determined by semi-quantitative real-time PCR or western blotting analysis, respectively. Histological changes of the testis induced by nandrolone treatment were examined by hematoxylin and eosin staining. Immunohistochemical analysis was employed to detect changes in the localization of steroidogenic enzymes in the testes among experimental animals. There were no significant changes on body, testis, epididymis, and epididymal fat weights among experimental groups. A significant increase of caudal sperm number was found in the 0.5 ppm nandrolone-treated group. Histological examination of the testes noted a high frequency of germ cell sloughing in seminiferous tubules of 0.5 ppm nandrolone-treated rats. Even though transcript levels of $3{\beta}$-hydroxysteroid dehydrogenase (HSD) I, $17{\beta}$-HSD4, and $17{\alpha}$-hydroxylase were influenced by nandrolone treatments, protein levels of all molecules examined in the present study were not significantly affected. Immunohistochemical analysis showed no visible changes in the localization of steroidogenic enzymes in the testes among experimental groups. The current study showed that oral intake of nandrolone in male rats for 6 weeks did not cause significant damage to the testis. It is considered that a feeding effect of nandrolone on male fertility would not be remarkable.
KSCE Journal of Civil and Environmental Engineering Research
/
v.36
no.3
/
pp.341-348
/
2016
Harbor facilities require long-term durability and safety, and also maintain the performance requirement until the durability life. However, existing harbor facilities are becoming superannuated with durable years and durability is declined by erosion of the sea and damage from sea. In addition, harbor facilities will be in demand for the expansion of harbor and offshore structures with rising economic power by enhancement of domestic industry and increase of import and export. Therefore, in this study, two kinds of nondestructive test (NDT) techniques (schmidt rebound hammer and ultrasonic sensor) are verified for the effective maintenance of underwater concrete structures including harbor facilities. Sea field applicability of Schmidt hammer and ultrasonic sensor was verified by comparing field test result with sea field test result and also deduced the compressive strength estimation equation by depth of the water. On the basis of the sea field test result, compressive strength estimation equation which was deduced by multiple regression analysis indicated highest accuracy compared to other equations, especially it will be more likely to be used in underwater because of the depth of water correction. In the future, if schmidt hammer and ultrasonic sensor which were invented as waterproofing are used with ROV (Remotely Operated Vehicle), it will be possible to make a diagnosis of high reliability for underwater concrete structures and set up a ubiquitous concept of NDT system.
Journal of Advanced Marine Engineering and Technology
/
v.38
no.3
/
pp.342-348
/
2014
Onshore great fires can normally be extinguished by firefighters using special firefighting equipment and its suitable method. However, offshore fires on the ships are to be extinguished by the crew without any supports from the onshore. Also, crews working on board are exposed to high risk of emergency evacuation due to the complicated structure arrangement of the ships and different accident types such as fire and ship collisions. As most of damage and loss of life in fire are associated with suffocation, shortening of evacuation time is an important factor to improve a survival rate. In this study, visibility in the accommodation area is analyzed by using the temperature and smoke flow which are obtained by the Fire Dynamic Simulator(FDS) as a Three-Dimensional Fire Analysis program to understand the survival rate of the crew upon the fire. The fire doors for most of ships are designed to close automatically when the fire alarm is activated. These automatic closing of the fire doors is a very effective system to delay the spread of flame and smoke flow for the unmanned spaces of the fire protected area. However, if the crew cannot escape within the estimated time, the crew inside the fire protected area will be damaged a lot. In this paper, the comparative analysis between the evacuations by using the fire door from the fire protected area and the suggested fire shielding structure in this study is carried out by the smoke flow rate and the temperature rise rate.
Cha, Eun-Jeong;Hwang, Ho-Seong;Yang, Kyung-Jo;Won, Seong-Hee;Ko, Seong-Won;Kim, Dong-Ho;Kwon, H. Joe
Atmosphere
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v.19
no.2
/
pp.183-198
/
2009
The purpose of this study is to summarize the tropical cyclone (TC) activity of 2008 over the western North Pacific including the verification of the official track and intensity forecast errors of these TCs. The TC activity - frequency, Normalized Typhoon Activity (NTA), and life span - was lower than 58-year (1951-2008) average. 22 tropical cyclones of tropical storm (TS) intensity or higher formed in the western North Pacific and the South China Sea in 2008. The total number is less than 58-year average frequency of 26.4. Out of 22 tropical cyclones, 11 TCs reached typhoon (TY) intensity, while the rest 11 TCs only reached severe tropical storm (STS) and tropical storm (TS) intensity - six STS and five TS storms. One typhoon KALMAEGI (0807) among them affected the Korea peninsula. However, no significant impact - casualty or property damage - was reported. On average of 22 TCs in 2008, the Korea Meteorological Administration (KMA) official track forecast error for 48 hours was 229 km. There was a big challenge for individual cyclones such as 0806 FENGSHEN and 0817 HIGOS presenting significant forecast error, with both intricate tracks and irregular moving speed. The tropical cyclone season in 2008 began in April with the formation of NEOGURI (0801). In May, four TCs formed in the western North Pacific in response to enhanced convective activity. On the other hand, the TC activity was very weak from June to August. It is found that the unusual anti-cyclonic circulation in the lower level and weak convection near the Philippines are dominant during summertime. The convection and atmospheric circulation in the western North Pacific contributed unfavorable condition for TC activity in the 2008 summertime. The 2008 TC activity has continued the below normal state since mid 1990s which is apparent the decadal variability in TC activity.
To study the regeneration process of tree species after clear cutting, we investigated the density of seedling occurred after 1 year in the coniferous forest of Sikotuko Hokkaido, northern Japan that was clearcut after windthrow damage due to typhoon. As the results, 25 species of tree seedlings were growing and the density of seedlings and sprouts was $9.8trees/m^2$ ($1.25tres/m^2{\sim}54.44trees/m^2$) in the area of clear cutting. The 87% ($8.6/m^2$) of all seedlings was current seedlings and non-animal dispersal seedlings (average density $7.2tree/m^2$) were about 5 times more than animal-dispersal seedlings ($1.4tree/m^2$). The seedling density was beyond $6tree/m^2$ within 10m and $2{\sim}9tree/m^2$ in 150~250m from a natural forest. Number of non-animal dispersal seedlings were decreased along the distance from a natural forest but there was not such a tendency in animal dispersal seedlings. The variation in seedling density was higher in non-animal dispersal seedling than in animal dispersal seedling. In natural regeneration of tree species after clear-cutting, the possibility that pioneer species like Betula spp. etc. will be composed of the major species is high. Therefore, in order to maintain the species diversity, the nurture work for reducing competition among the individuals is necessary.
The Transactions of the Korea Information Processing Society
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v.6
no.8
/
pp.2233-2244
/
1999
It is essential to guarantee high reliability of embedded real-time systems since the failure of such systems may result in large financial damage or threaten human life. Though many researches have devoted to fault tolerant mechanisms, most of them are object-level fault tolerant mechanisms that can detect errors occurred in a single object and treat the errors in object-level. As embedded real-time systems become more complex and larger, there exist faults that cannot be detected by or tolerated with object-level fault tolerance. Hence, system-level fault tolerance is needed. System-level fault tolerance examines the status of a system whether the system is normal or not by analyzing the status of objects. When an error is detected it should be capable of locating the fault and performing an appropriate recovery and reconfiguration action. In this paper, we propose RobustRTO(Robust Real-Time Object) that provides object-level fault tolerance capability and RMO(Region Monitor real-time Object) that offers system-level fault tolerance capability. Then we show how highly dependable fault tolerant systems can be modeled by RobustRTO and RMO. The model is presented based on real-time objects.
Park, Jung-Han;Choi, Gyu-Hyun;Kim, Young-Soo;Jung, Seong-Hoon;Lee, Sang-Houck;Lee, Pyeong-Koo;Lee, Woan-Kyu
Economic and Environmental Geology
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v.41
no.3
/
pp.359-372
/
2008
A number of researches on disaster risk reduction using the most advanced equipments and scientific technologies have been performed to minimize the damage of property and to protect human life. Although the Korean government is trying to enlarge the research area for disaster risk reduction, the investment size and the applicable results in this area have stayed in the lower level comparing to other scientific fields in Korea and the same field in advanced countries. However, the National Emergency Management Agency (NEMA), a government Agency which is responsible for disaster management coordination, was established in June 2004 establishing an efficient and well-organized system to cope with various disasters. In this study, investment size by the government was evaluated and associated areas were also identified. We also analyzed the roles on research and development for disaster risk reduction among different government Ministries were analyzed and role assignment to each Ministry was proposed. The role assignment has been concreted by conducting the process of approval in the government.
This study supplies basic data to develop a greenhouse model for reducing the damage to single-span greenhouses caused by strong winds and heavy snow. Single-span plastic greenhouses are predominantly used for growing crops in Korea. Thus, the safety wind speeds for single-span greenhouses were calculated and compared with the actual wind speeds and snow depths over a period of 8 years in different regions to analyze the structural safety of single-span greenhouses. The unit wind load and unit snow load were applied to different designs of single-span greenhouse according to the cultivated crop to achieve a structural analysis. As a result, the maximum section force for the wind and snow load was greatest for leaf and root vegetables, where the safety wind speeds for single-span greenhouses according to the cultivated crop were 17.7 m/s(leaf vegetables), 20.2 m/s (fruit vegetables), and 22.3 m/s (root vegetables). Thus, the single-span greenhouses were not found to be safe for the wind load in most regions, except for Hongcheon, Icheon and Sungju. Plus, the safety snow depths for single-span greenhouses according to the crop were 8.8 cm (leaf vegetables), 9.4 cm (fruit vegetables), and 11.8cm (root vegetables). Thus, when comparing the safety snow depths with the actual snow depths, the single-span greenhouses were not found to be safe. Therefore, to improve the safety of single-span greenhouses, the structures need reinforcement by reducing the interval between rafters or increasing the size of the pipes. However, additional research is needed.
Kim, Sung-Su;Sim, Yun-Beom;Park, Soo-Hyun;Lee, Jae-Ryeong;Sharma, Naveen;Suh, Hong-Won
The Korean Journal of Physiology and Pharmacology
/
v.20
no.1
/
pp.83-89
/
2016
Sepsis is the life-threatening response to infection which can lead to tissue damage, organ failure, and death. In the current study, the effect of orally administered D-glucose on the mortality and the blood glucose level induced by D-Galactosamine (GaLN)/lipopolysaccharide (LPS)-induced sepsis was examined in ICR mice. After various amounts of D-glucose (from 1 to 8 g/kg) were orally fed, sepsis was induced by injecting intraperitoneally (i.p.) the mixture of GaLN /LPS. Oral pre-treatment with D-glucose dose-dependently increased the blood glucose level and caused a reduction of sepsis-induced mortality. The oral post-treatment with D-glucose (8 g/kg) up to 3 h caused an elevation of the blood glucose level and protected the mortality observed in sepsis model. However, D-glucose post-treated at 6, 9, or 12 h after sepsis induction did not affect the mortality and the blood glucose level induced by sepsis. Furthermore, the intrathecal (i.t.) pretreatment once with pertussis toxin (PTX; $0.1{\mu}g/5ml$) for 6 days caused a reduction of D-glucose-induced protection of mortality and hyperglycemia. Furthermore, once the hypoglycemic state is continued up to 6 h after sepsis initiated, sepsis-induced mortality could not be reversed by D-glucose fed orally. Based on these findings, it is assumed that the hypoglycemic duration between 3 and 6 h after the sepsis induction may be a critical time of period for the survival. D-glucose-induced protective effect against sepsis-induced mortality appears to be mediated via activating PTX-sensitive G-proteins in the spinal cord. Finally, the production of hyperglycemic state may be critical for the survival against the sepsis-induced mortality.
Mosquitos serve as vectors for diseases, causing inconvenience as well as a threat to human life and health. Concern about mosquitos introducing and spreading new diseases has been intensifying. We observed a variety of mosquito habitats based on land cover classification from Korea's Ministry of Environment, and the mosquito species that could appear were classified according to the each habitat type. Finally, we suggested the best control methods for each type of habitat considering habitat characteristics and the ecological traits of mosquitos. Urban areas harbor various habitats for pests, contributing significantly to mosquito habitats. Control must be performed regarding larva and adults because various sources for habitats exist. Public mosquito control programs such as educational training, as well as information brochures can be effective in managing mosquito populations and public health. Agricultural areas show high densities of mosquito larva to lentic zones such as reservoirs, wetlands, paddy fields. So, biological control using natural predators may be effective in controlling mosquito populations. Forests are major habitats for Aedes albopctus, so physical controls should be deployed for residents living nearby, and excessive deforestation should be minimized. Other areas including aquatic ecosystems should be adopted regarding biological control using Bti (Bacillus thuringiensis var. israelensis) and chemical control for eradicating mosquitos. We classified habitats into four types of land cover patterns considering ecological traits and habitat preference, and suggest adequate control methods for each habitat type. Our suggestion can be used to positively contribute toward effective managing mosquito's density and reducing the damage to public health.
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