• Asian Pacific Journal of Cancer Prevention
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• v.15 no.14
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• pp.5697-5699
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• 2014

Objective: To investigate the optimal timing of radiotherapy with alternating/sequential radio-chemotherapy for limited-stage small cell lung cancer (LS-SCLC). Methods: 91 patients with LS-SCLC were retrospectively analyzed and divided into two groups according to the number of chemotherapy cycles before radiotherapy. If the patient received radiotherapy after 3 cycles or fewer cycles of chemotherapy, classification was into the early group, if not, into the late group. All patients received 6 cycles of standard chemotherapy (EP/EC) and conventional radiotherapy (56 gy~ 60 gy/28 f ~30 f). Results: The response rate (RR) of the early and late groups were 85.7% and 81.6%, respectively, with no significant difference (p>0.05). In contrast, the progression-free survival (PFS) in the early group was better than that in the late group (11.8 months vs 9.86 months), and the difference was significant (p<0.05). There was no significant difference between two groups in adverse reactions, which gastrointestinal irritation and bone marrow suppression being the most common (p>0.05). Conclusions: Radiotherapy after 3 cycles or fewer cycles of chemotherapy does not bring significant benefits for RR of patients with LS-SCLC, but it could significantly prolong their PFS without increase in adverse reactions.

• Journal of Information Technology Applications and Management
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• v.20 no.4
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• pp.127-149
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• 2013

Competitiveness of service industry in Korea is relatively lower than OECD countries'. Korean government, therefore, has been trying to improve the competitiveness of service industry by accelerating information technology (IT) adoption. Even though most of factors of IT can be contributed to improve the financial performance, it may be affected differently among various industry types and life cycles of companies. Therefore, it is one of very important research issues to analyze the influential effect of IT considering industry types and organizational life cycles in service industries. The purpose of this study is to find out critical success factors of IT which influence financial performance considering different types and life cycles of service industries. We developed the model and identified key success factors of IT adoption as IT system quality, Information quality, IT maintenance, CEO support, IT education of organization, and IT competence of user. Additional analysis of moderating effect by organizational life-cycle and types of service industry are conducted. For data sampling 856 companies are participated and total 2,000 questionnaires are collected. Structural equation modeling method is conducted for statistical analysis. The results show that the model is valid and most of success factors of it are very useful for improving financial performance of service industries except organizational IT education. Moderating effect of industry types and organizational life cycles is valid but partially accepted. The results might be able to provide useful directions and guide lines of IT acceleration in service industries.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.12 no.4
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• pp.47-54
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• 2013

The main cause of die failure in hot forging is wear. Die wear directly generates the gradual loss of part tolerances, thereby causing deterioration in the dimensional accuracy of a forged part. It is very important to estimate forging cycles, called as die life, at which the die should be repaired or replaced. In this study, in order to estimate the hot forging die life, the finite element simulation of wear on an asymmetric part like a ball joint socket used in vehicle was carried out based on Archard's model. Finite element simulation results were compared with wear amounts of a used die that were measured using a contact stylus profilometer. The simulation results were in relatively good agreement with measurements obtained from the virtual die which was used by 7,000 forging cycles in a forging industry. Consequently, the die life in the hot forging of the ball joint socket was estimated by 10,500 forging cycles on the finisher die.

• Korean Journal of Ecology and Environment
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• v.48 no.4
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• pp.280-286
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• 2015

Life cycles of Sweltsa illiesi and S. lepnevae were determined from a headwater stream in Mt. Jumbong. Identification of nymphs was done by using DNA barcoding. Nymphs begin to have species specific color pattern on their head several months prior to adult emergence and differ in the form of the third antennal segment. Two species appear to have similar semivoltine life cycles in this stream, beginning to hatch from June and finishing adult emergence about 701 days later. The combined annual mean biomass in ash free dry mass (AFDM) was estimated as $96mg\;AFDM\;m^{-2}$. The combined annual secondary production were 373 mg and $297mg\;AFDM\;m^{-2}\;yr^{-1}$, calculated by using size frequency method and increment summation method respectively.

• Structural Engineering and Mechanics
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• v.17 no.1
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• pp.29-50
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• 2004

A total life model was developed to assess the service life of aging aircraft. The primary focus of this paper is the development of crack growth life projection using the response surface method. Crack growth life projection is a necessary component of the total life model. The study showed that the number of load cycles N needed for a crack to propagate to a specified size can be linearly related to the geometric parameter, material, and stress level of the component considered when all the variables are transformed to logarithmic values. By the Central Limit theorem, the ln N was approximated by Gaussian distribution. This Gaussian model compared well with the histograms of the number of load cycles generated from simulated crack growth curves. The outcome of this study will aid engineers in designing their crack growth experiments to develop the stochastic crack growth models for service life assessments.

• Structural Engineering and Mechanics
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• v.35 no.5
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• pp.571-592
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• 2010

An energy-based fatigue life prediction framework was previously developed by the authors for prediction of axial, bending and shear fatigue life at various stress ratios. The framework for the prediction of fatigue life via energy analysis was based on a new constitutive law, which states the following: the amount of energy required to fracture a material is constant. In the first part of this study, energy expressions that construct the constitutive law are equated in the form of total strain energy and the distortion energy dissipated in a fatigue cycle. The resulting equation is further evaluated to acquire the equivalent stress per cycle using energy based methodologies. The equivalent stress expressions are developed both for biaxial and multiaxial fatigue loads and are used to predict the number of cycles to failure based on previously developed prediction criterion. The equivalent stress expressions developed in this study are further used in a new finite element procedure to predict the fatigue life for two and three dimensional structures. In the second part of this study, a new Quadrilateral fatigue finite element is developed through integration of constitutive law into minimum potential energy formulation. This new QUAD-4 element is capable of simulating biaxial fatigue problems. The final output of this finite element analysis both using equivalent stress approach and using the new QUAD-4 fatigue element, is in the form of number of cycles to failure for each element on a scale in ascending or descending order. Therefore, the new finite element framework can provide the number of cycles to failure at each location in gas turbine engine structural components. In order to obtain experimental data for comparison, an Al6061-T6 plate is tested using a previously developed vibration based testing framework. The finite element analysis is performed for Al6061-T6 aluminum and the results are compared with experimental results.

• Journal of the Korean Home Economics Association
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• v.45 no.5
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• pp.121-133
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• 2007

The purpose of this study was to investigate the psychological wellbeing as applied to the bioecological family life welfare model, concerning individual attributes, family backgrounds, and family processes across the family life cycles. Based on Bronfenbrenner's bioecological perspective, the "bioecological family welfare model", which includes person (individual attributes), context (family background), process (mechanism - family process), and time (the family life cycles), was applied as a research paradigm for this study. The sample for the questionnaire study comprised for 900 families, considering the family life cycle in Busan and the Kyungnam area. The families were categorized into 6 family life cycles based on Duvall and Hill's family life cycle. For the final analysis, 628 families were used. According to the path analysis results, the length of commitment before marriage and self-esteem had significant effects on the stress coping ability. Several individual attributes and family backgrounds such as age, length of marriage, family life cycle, self-esteem and stress coping ability had significant effects on marital adjustment. The family life cycle and age were significant variables on family function. The significant variables on psychological wellbeing were monthly income, length of commitment before marriage, stress coping ability and marital adjustment. The regression model showed that the variables of the individual attributes, context and family process accounted for 51% of the psychological wellbeing. The results show that the suggested research model was significant and effective to explain the mechanism of psychological wellbeing. Individual attributes and family context have an impact on stress coping, marital adjustment, and family function, which in turn affect psychological wellbeing.

• Journal of Advanced Marine Engineering and Technology
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• v.28 no.5
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• pp.762-772
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• 2004

Fatigue life of a Piston for large liquid Petroleum liquid injection(LPLi) bus engines is analyzed considering effects of cooling condition parameters : temperature of cooling water, and heat transfer coefficients at oil gallery and bottom surface of piston head. Temperature of the piston is analyzed with varying cooling conditions Stresses of the piston from two load cases of pressure loading. and pressure and thermal loading are analyzed Fatigue life under repeated peak pressure and thermal cycle is analyzed by the strain-life theory. For the two load cases, required loading cycles for engine life are defined, and loading cycles to failure and partial damages are calculated. Based on the resulting accumulated fatigue usage factors, endurance of the piston is evaluated and effects of varying cooling condition Parameters are discussed.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.1
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• pp.145-152
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• 2000

X-ray diffraction method detects change of crystal lattice distance under material surface using diffraction angle 2$\theta$. This technique can be applied to the behavior on slip band and micro crack due to material degradation. The relation between half-value breadth and number of cycle has three stages which constitute rapid decrease in initial number of cycles, slight decrease in middle number of cycles and rapid decrease in final number of cycles. The ratio of half-value breadth takes a constant value on B/B$_{0}$-N diagram with loading condition except early part of fatigue life. The ratio of half-value breadth B/B$_{0}$ with respect to number of cycle to failure N$_{f}$ has linear behavior on B/B$_{0}$-log N$_{f}$ diagram. Therefore, in this paper the estimation of fatigue life by average gradient method has much less estimated mean error than the estimation of fatigue life by log B/B$_{0}$-log N/N$_{f}$ relation.elation.ation.

• Journal of Medicine and Life Science
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• v.16 no.1
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• pp.6-9
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• 2019

Adjuvant fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy for 6 months is the standard treatment of stage III colon cancer to improve patient survival. Recent studies have shown that restricting the treatment to 3 months to reduce toxicity negatively affects the outcome. However, the effect of FOLFOX treatment for a duration of between 3 and 6 months(7~11 cycles) on survival is not known. The effect of a reduced duration of FOLFOX chemotherapy on the prognosis of stage III colon cancer was examined. The 5-year disease-free survival in patients receiving 7~11 cycles of FOLFOX was lower than those receiving 12 cycles(72.9% vs. 87%, respectively). Patients receiving 7~11 cycles who had a bowel obstruction at diagnosis had a significantly higher recurrence rate (66.7% vs. 15.0%) and shorter median disease-free survival (24.7 months vs. not reached) than those receiving 12 cycles. Among patients receiving 12 cycles of FOLFOX, there was no difference in the outcome between those with and those without intestinal obstructions at diagnosis. These results suggest that the completion of 12 cycles FOLFOX chemotherapy is important to improve the patient's prognosis, especially for with intestinal obstructions at diagnosis.