• Genomics & Informatics
• /
• v.11 no.4
• /
• pp.164-173
• /
• 2013

Genomic instability, which occurs through both genetic mechanisms (underlying inheritable phenotypic variations caused by DNA sequence-dependent alterations, such as mutation, deletion, insertion, inversion, translocation, and chromosomal aneuploidy) and epigenomic aberrations (underlying inheritable phenotypic variations caused by DNA sequence-independent alterations caused by a change of chromatin structure, such as DNA methylation and histone modifications), is known to promote tumorigenesis and tumor progression. Mechanisms involve both genomic instability and epigenomic aberrations that lose or gain the function of genes that impinge on tumor suppression/prevention or oncogenesis. Growing evidence points to an epigenome-wide disruption that involves large-scale DNA hypomethylation but specific hyper-methylation of tumor suppressor genes, large blocks of aberrant histone modifications, and abnormal miRNA expression profile. Emerging molecular details regarding the modulation of these epigenetic events in cancer are used to illustrate the alterations of epigenetic molecules, and their consequent malfunctions could contribute to cancer biology. More recently, intriguing evidence supporting that genetic and epigenetic mechanisms are not separate events in cancer has been emerging; they intertwine and take advantage of each other during tumorigenesis. In addition, we discuss the collusion between epigenetics and genetics mediated by heterochromatin protein 1, a major component of heterochromatin, in order to maintain genome integrity.

• The Journal of Asian Finance, Economics and Business
• /
• v.9 no.6
• /
• pp.115-126
• /
• 2022

The study's goal is to determine the amount of climate change's impact on ethnic minority (EM) households' livelihoods, as well as their adaptability to climate change and long-term viability. The research was conducted in Vietnam's Northwestern Sub-region, where ethnic minorities account for more than half of the overall population. The study uses a combination of qualitative and quantitative methods based on a survey of 480 households in 04 provinces severely affected by climate change in the Northwest sub-region of Vietnam. The results show that: climate change (extreme weather events) occurs with increasing frequency, mainly affecting the life expectancy, health, and capital of households; Vulnerable groups (women, ethnic minorities) have a poor adaptive capacity and mainly suffer the consequences of shocks, are afraid to change their livelihoods; Microfinance plays an important role in enhancing the sustainability of livelihoods through increasing capital and financial assets and reducing the vulnerability of ethnic minority households. Finally, research has some solutions for microfinance - special credit specifically for ethnic minority households in the Northwest Sub-region: support for microfinance advice, home credit with transition orientations to adapt to climate change response and relieves its impact on the social lives.

• Journal of the Korean association of regional geographers
• /
• v.8 no.1
• /
• pp.20-39
• /
• 2002

The purpose of this study is to analyze the characteristics of a life cycle of a theme park through looking at Everland in Yongin, Korea. The life cycle of Everland is divided into four stages. In "initial development" stage(1976 - the mid-80's), Everland become inclined the characteristics of an amusement park by constructing the amusement facilities in the Flower Center(botanical garden). In "growth" stage(the mid-80's - the early 90's), Everland had full grown to the amusement park and inclined to a theme park. In "maturity" stage(the early 90's - the mid-90's), many visitors were not motivated to re-visit Everland because the facilities and events did not change often. Therefore, Everland makes plans for multiple theme park. In "rejuvenation" stage(after the mid-90's), Everland has practiced the plans for multiple theme park and has become the family and accommodating-oriented theme resort park. Since 1976 when Everland was opened, it has evolved from an amusement park to a theme park by creating various and continuous innovations in facilities and events.

• Journal of Animal Science and Technology
• /
• v.65 no.4
• /
• pp.792-803
• /
• 2023

This study aimed to assess the impact of weather events on the sorghum-sudangrass hybrid (Sorghum bicolor L.) cultivar production trend in the central inland region of Korea during the monsoon season, using time series analysis. The sorghum-sudangrass production data collected between 1988 and 2013 were compiled along with the production year's weather data. The growing degree days (GDD), accumulated rainfall, and sunshine duration were used to assess their impacts on forage production (kg/ha) trend. Conversely, GDD and accumulated rainfall had positive and negative effects on the trend of forage production, respectively. Meanwhile, weather events such as heavy rainfall and typhoon were also collected based on weather warnings as weather events in the Korean monsoon season. The impact of weather events did not affect forage production, even with the increasing frequency and intensity of heavy rainfall. Therefore, the trend of forage production for the sorghum-sudangrass hybrid was forecasted to slightly increase until 2045. The predicted forage production in 2045 will be 14,926 ± 6,657 kg/ha. It is likely that the damage by heavy rainfall and typhoons can be reduced through more frequent harvest against short-term single damage and a deeper extension of the root system against soil erosion and lodging. Therefore, in an environment that is rapidly changing due to climate change and extreme/abnormal weather, the cultivation of the sorghum-sudangrass hybrid would be advantageous in securing stable and robust forage production. Through this study, we propose the cultivation of sorghum-sudangrass hybrid as one of the alternative summer forage options to achieve stable forage production during the dynamically changing monsoon, in spite of rather lower nutrient value than that of maize (Zea mays L.).

• Health Policy and Management
• /
• v.28 no.3
• /
• pp.222-225
• /
• 2018

Health policy is a historical product in the process of development, including the political and economic factors of the state as well as the social and cultural elements of the country. Bioethics began to debate the ethical questions that arise in the overall process of life's birth and death, and gradually evolved by presenting ethical directions for various social phenomena. Especially, according to the moral awakening of 'scientific medicine' which caused in some human problems in the rapidized scientific society from the late 19th century to the early 20th century, as a result of distress including the concept of various social relations, it is possible to say that it has reached the bioethics. Although health policy and bioethics are different in terms of starting and concept, they can be found in common with social, cultural, and political diversity in the times. In 2004, 'Bioethics Law' was enacted through the issue of research ethics in the life sciences. Therefore, in order to examine ethical aspects of current health policy direction and major issues, it can be divided into before and after enactment of 'Bioethics Law' in 2004. The authors would like to examine how the evolution of the ethical viewpoint on the health policy has changed in line with the enactment of the 'Bioethics Law' and how it is trying to solve it from an ethical point of view. Through the various events that took place in the 1990s and the 2000s, various discussions on bioethics were conducted in Korea. Prior to the enactment of the 'Bioethics Law,' ethical judgments of professions, distribution of healthcare resources, if the discussion focused on the ethical judgment of abortion, and the various events that appeared in the early 2000s became the beginning to inform that the ethical debate about the life, death, and dignity of human beings began in earnest in Korea with the enactment of the 'Bioethics Law.' Since then, 'Hospice and Palliative care Law' which was enacted in 2017, is based on the fact that the health policy of our country focuses on the treatment of the past diseases, health promotion, and delivery of health care services. It was an opportunity to let them know that even the quality problems were included. Therefore, considering the various circumstances, the ethical issue facing Korea's health care system in the future is the change of the demographic structure due to aging and what is to be considered as the beginning and the process of life in the overall process of life. It is the worry about how to die and when it sees as death. This has far exceeded the paradigm of traditional health care policies such as disease prevention and management and health promotion, and calls for innovative policy response at the national level that reflects the new paradigm, which in many cases creates a predictable ethical environment. And health policy should be shifted in the direction of future ethical review considering sustainability in the development process of future health care rather than coercive management.

• Journal of The Korean Society of Agricultural Engineers
• /
• v.62 no.4
• /
• pp.99-110
• /
• 2020

The objective of this study is to analyze the trend of changes in the water circulation rates under climate change by adopting the concept of WCR defined by the Ministry of Environment. With the need for sound water circulation recovery, the MOE proposed the idea of WCR as (1-direct flow/precipitation). The guideline for calculating WCR suggests the SCS method, which is only suitable for short term rainfall events. However, climate change, which affects WCR significantly, is a global phenomenon and happens gradually over a long period. Therefore, long-term trends in WCRs should also be considered when analyzing changes in WCR due to climate change. RCP (Representative Concentration Pathway) 4.5 and 8.5 scenarios were used to simulate future runoff. SWAT (Soil and Water Assessment Tool) was run under the future daily data from GCMs (General Circulation Models) after the calibration. In 2085s, monthly WCR decreased by 4.2-9.9% and 3.3-8.7% in April and October. However, the WCR in the winter increased as the precipitation during the winter decreased compared to the baseline. In the aspect of yearly WCR, the value showed a decrease in most GCMs in the mid-long future. In particular, in the case of the RCP 8.5 scenario, the WCR reduced 2-3 times rapidly than the RCP 4.5 scenario. The WCR of 2055s did not significantly differ from the 2025s, but the value declined by 0.6-2.8% at 2085s.

• Journal of Korea Water Resources Association
• /
• v.49 no.8
• /
• pp.719-729
• /
• 2016

Extreme events of rainfall has increased mainly from climate change, resulting in more severe floods intensified by land use development. Appropriate estimation of design floods gets more attention to ensuring the safety of life and property in flood-prone areas for hydraulic structures such as dams and levees. In the current study, we reestimated the design flood of the Nam River Dam to adopt the influence of climatic change of hydrometeorological variables including recent datasets of extreme rainfall events. The climate change scenarios of extreme rainfall events in hourly scale that has been downscaled was used in analyzing the annual maximum rainfall for the weather stations in the Nam River Dam basin. The estimates of 200-year and 10,000-year return periods were calculated to provide a design flood and a probable maximum flood case for the Nam River Dam. The results present that the new estimate employing the RCP4.5 and RCP8.5 downscaled data is much higher than the original design flood estimated at the dam construction stage using a 200-year return period. We can conclude that the current dam area might be highly vulnerable and need an enhancement of the dam safety regarding the reduction of damage in Sachen bay from the outflow of Nam River Dam.

• Journal of the Korean Society of Costume
• /
• v.50 no.2
• /
• pp.47-58
• /
• 2000

This paper examines how costume, as a means of communication, acts on an individual a society, and a nation by analyzing especially the costume-wearing activities of Gandhi, an Indian national leader, in the nineteenth-century India colonized by Britain. The results are as follows. 1. Change of costume in Gandhi's case corresponds with mental change. 2. Gandhi's costume-wearing activities show his social status. 3. Gandhi's costume acts as a means of communication ; it manipulates and rules social events, transforming social -political identities. Thus, costume has a close relation to man's life. And it is an important means of communication influencing man and man's environments.

• Proceedings of The Korean Society of Agricultural and Forest Meteorology Conference
• /
• 2015.08a
• /
• pp.98-101
• /
• 2015

• Neonatal Medicine
• /
• v.28 no.1
• /
• pp.53-58
• /
• 2021

Intestinal malrotation with midgut volvulus (MV) is a life-threatening surgical emergency. Most events of MV occur in the neonatal period with bilious vomiting, abdominal distension, feeding intolerance, and bloody stools. Neonatal gastric perforation (GP) is a rare and life-threatening condition associated with high mortality. It occurs either in an idiopathic form or in association with gastrointestinal anomalies such as duodenal atresia and MV. The pathogenesis of both MV and GP is related to ischemic change and inflammatory response. MV and GP can lead to morbidities such as sepsis, intestinal ischemia, and organ failure, but not neurologic problems. We herein report the case of a term infant at 5 days after birth, with MV accompanied by GP, who developed periventricular leukomalacia.