• Journal of Microbiology and Biotechnology
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• 제33권8호
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• pp.992-997
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• 2023

Ferroptosis is a new kind of programmed cell death of which occurrence in microorganisms is not clearly verified. The elevated level of reactive oxygen species (ROS) influences cellular metabolisms through highly reactive hydroxyl radical formation under the iron-dependent Fenton reaction. Iron contributes to ROS production and acts as a cofactor for lipoxygenase to catalyze poly unsaturated fatty acid (PUFA) oxidation, exerting oxidative damage in cells. While ferroptosis is known to take place only in mammalian cells, recent studies discovered the possible ferroptosis-like death in few specific microorganisms. Capacity of integrating PUFA into intracellular membrane phospholipid has been considered as a key factor in bacterial or fungal ferroptosis-like death. Vibrio species in bacteria and Saccharomyces cerevisiae in fungi exhibited certain characteristics. Therefore, this review focus on introducing the occurrence of ferroptosis-like death in microorganisms and investigating the mode of action underlying the cells based on contribution of lipid peroxidation and iron-dependent reaction.

• 한국간호교육학회지
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• 제16권1호
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• pp.72-82
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• 2010

Purpose: The purpose of this study is to understand the meaning of dignified dying expressed by undergraduate nursing students. Method: Data were collected by in-depth interviews with fifteen nursing students. Conventional qualitative content analysis was used to analyze the data. Result: There were six major themes and eleven sub-categories from the analysis. Six major themes include death with no artificial life support, obedient death as a human nature, death with family members, meaningful death, no self destructive death, and sympathized death receiving from health care providers. Conclusion: The result of this study suggests that the nursing curriculum related to dignified dying can be developed and may affect the teaching and learning settings to improve end-of-life care performance among undergraduate nursing students, as well as, students in human service areas and health care providers.

• Journal of Hospice and Palliative Care
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• 제25권1호
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• pp.42-49
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• 2022

As population aging increases the burden of cancer, the quality of death of patients with cancer is emerging as an important issue alongside their quality of life. To improve the quality of death, it is necessary to prepare for death, allowing patients to die comfortably and with dignity at the end. Considering these issues, I aim to discuss the practical aspects of notifying the patient of the terminal phase of cancer and planning for end-of-life care (i.e., advance care planning). When cancer treatment that can extend the patent's lifespan becomes difficult, the patient enters a treatment transition period. Treatment is shifted from life-prolonging care to life-enhancing care, and end-of-life care must be well planned. Medical providers often worry too much about whether the patient will be disappointed or psychologically traumatized when notified of the terminal phase of their cancer, thus delaying plans for end-of-life care. In fact, patients can accept their condition and prepare for end-of-life care better than we expect. During the treatment transition period, notification of terminal status should be given, and a well-prepared advance care plan should be established early when the patient has decision-making ability. In addition to conveying information, it is always necessary to be sensitive to whether the patient and caregiver understand the information and respond to their emotions.

• BMB Reports
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• 제45권8호
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• pp.482-487
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• 2012

To identify the novel inhibitors of endoplasmic reticulum stress-induced cell death, we performed a high throughput assay with a chemical library containing a total of 3,280 bioactive small molecules. Cyclosporine A and bromocriptine were identified as potent inhibitors of thapsigargiin-induced cell death (cut-off at $4{\sigma}$ standard score). However, U74389G, the potent inhibitor of lipid peroxidation had lower activity in inhibiting cell death. The inhibition effect of cyclosporine A and bromocriptine was specific for only thapsigargin-induced cell death. The mechanism of inhibition by these compounds was identified as modification of the expression of glucose regulated protein-78 (GRP-78/Bip) and inhibition of phosphorylation of p38 mitogen activated protein kinase (MAPK). However, these compounds did not inhibit the same events triggered by tunicamycin, which was in agreement with the cell survival data. We suggest that the induction of protective unfolded protein response by these compounds confers resistance to cell death. In summary, we identified compounds that may provide insights on cell death mechanisms stimulated by ER stress.

• 대한간호학회지
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• 제48권1호
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• pp.59-69
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• 2018

Purpose: The purpose of this study was to investigate variables and construct paths that affect complicated grief. Methods: Participants in this cross-sectional, descriptive study were 164 bereaved spouses of cancer patients at least 12 months before the death. Data were collected from October 2016 to February 2017 using self-report structured questionnaires and were analyzed using IBM SPSS 21.0 and AMOS 20.0. Results: The variables affecting complicated grief of bereaved spouses of cancer patients were the quality of end-of-life care (${\gamma}=.15$, p<.001), preparedness for death (${\beta}=-.06$, p=.005), and coping with bereavement (${\beta}=-.24$, p<.001), whereas the quality of death and dying did not show any effects. Preparedness for death had multiple mediating effects in the relationship between the quality of end-of-life care and complicated grief (z=-2.20, p=.028), and in the relationship between the quality of end-of-life care and coping with bereavement (z=2.11, p=.035). Coping with bereavement had a mediating effect on the relationship between preparedness for death and complicated grief (z=-2.39, p=.017). Conclusion: This study revealed that preparedness for death and coping with bereavement play a prominent role in complicated grief. Therefore, it is important to help in preparing for death and enhancing coping with bereavement of spouses providing end-of-life care to cancer patients. In addition, investigating cultural differences in the relationship between the quality of end-of-life care and complicated grief is recommended.

• 한국콘텐츠학회논문지
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• 제18권7호
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• pp.291-301
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• 2018

본 연구의 목적은 베이비부머의 죽음불안과 삶의 의미의 인과관계에서 이들 간 영성의 매개효과와 조절효과를 검증하는 것이다. 분석을 위한 연구 자료는 A시에 거주하는 1955년부터 1963년까지 출생한 베이비 부머를 대상으로 수집되었으며, 최종 분석에 총 500명의 자료를 사용하였다. 분석방법은 SPSS 21.0을 이용하여 일반적 특성을 알아보기 위한 기술통계분석, 변인 간 상관관계를 알아보기 위한 상관관계분석, 각 변인 간 가설검증을 위한 매개회귀분석, 영성의 조절효과를 알아보기 위해 위계적 회귀분석을 실시하였다. 분석결과는 다음과 같다. 첫째, 죽음불안이 삶의 의미에 유의미한 영향을 미치는 것으로 나타났다. 둘째, 죽음불안과 삶의 의미의 관계에서 영성의 매개효과가 입증되었으며, 조절효과 분석을 통해 죽음불안과 삶의 의미의 관계에서 영성의 조절효과가 유의하게 나타났다. 이러한 결과 베이비부머의 죽음불안 수준에 따라 영성을 강화시킴으로써 삶의 의미를 더욱 높일 수 있음을 나타내는 것으로, 이들의 삶의 의미에 영향을 미치는 죽음불안을 감소 또는 해소하고, 영성을 강화할 수 있는 방안을 모색하였다.

• 지역사회간호학회지
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• 제14권3호
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• pp.445-456
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• 2003

Purpose: This study attempted to propose the basic framework for spiritual nursing intervention by understanding live spiritual experiences of terminal cancer patients. The study duration was from July 2002 to January 2003, and the subjects of this study were patients who were expected to live less than six months. The number of subjects was six and the average time of each interview was about an hour. Method: The data were analyzed using the method of phenomenological study analysis, which Colaizzi (1978) proposed. Result: Through live spiritual experiences. terminal cancer patients showed complex emotion about the Absolute, human, disease, and death: depended on the Absolute through recognizing death and spiritual acknowledgement: recollected the past life: accepted death believing salvation and immortality: recovered relationships with others through forgiving and reconciling with the Absolute and neighbors. Also, they pursued the meaning of pain. death, and life while feeling pain: demanded love and concern to the Absolute and neighbors: had a sense of futility about life and a hope for the future life: transcendental energy towards the world after death. Wishing to have a peaceful end to life. they felt peaceful and comfortable. Conclusion: Terminal cancer patients want to meet a peaceful end to life with a hope for the future and accept the meaning of death with peace and comfort minds(##-minds), which will allow them to carry on peaceful and satisfactory days for the rest of their lives. Thus, it is very important for caregivers to let them have spiritual experiences and care for them.

• 보건의료산업학회지
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• 제6권1호
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• pp.129-140
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• 2012

The purpose of this study was to identify attitude of hospital nurse's on death with dignity. The subjects of the study were 516 nurses. The data was analyzed by SPSS PC 19.0 program. 1) 82.8% participants agree to death with dignity, and they and their family will ask death with dignity in actual situations. 2) The average score of overall attitude on death with dignity was $3.13{\pm}0.52$. 3) With respect to the general characteristics of participants there were statistically significant difference in total score according to age, Marital Status, education level, religion, career, position, and existence of patients with incurable disease around. 4) With respect to the death with dignity related characteristics of participants there were statistically significant difference in total score according to agreement to death with dignity, request to my death with dignity, in case my family member requests death with dignity. Although many nurses had a positive concept of death with dignity, they still have ethical dilemmas in life-sustaining care. Therefore training programs on moral rights are necessary to provide guidelines foe end-of-life care.

• 한국게임학회 논문지
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• 제9권1호
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• pp.105-114
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• 2009

바둑에 있어 사활문제는 컴퓨터 바둑을 구현하기 위해 반드시 극복해야 하는 기본적인 문제이다. 사활문제와 같은 국부적인 바둑 문제를 해결하기 위하여 고려해야 될 중요한 사항은 게임 트리의 엄청난 분기수와 그 깊이를 어떻게 처리하느냐이다. 본 논문에서 수행된 실험의 기본 착상은 둘러싸인 돌들을 죽이기 위해 인식된 첫 수들을 찾아내는 인간의 습성을 모방한 것이다. 바둑에 있어, 유사한 사활문제(패턴)들은 자주 유사한 해들을 갖는다. 유사한 패턴을 분류 하기 위하여 코호넨 신경망(KNN)을 기반으로 한 군집화를 수행하였으며, 실험 결과는 고무적이며 사활문제를 풀기 위해 신경망으로 통제 학습을 사용하는 패턴 일치와 경쟁할 수 있음을 알아냈다.

• 한국콘텐츠학회논문지
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• 제21권4호
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• pp.688-698
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• 2021

본 연구의 목적은 대학병원 간호사의 좋은 죽음에 대한 인식과 사전연명의료의향서 지식이 연명의료 중단에 미치는 영향을 파악하기 위해 시도되었다. 연구대상자는 J도와 G시에 소재하고 있는 3개 대학병원에 근무하는 간호사 207명이었다. 연구결과 연명의료 중단에 대한 태도에 가장 강력한 예측인자는 좋은 죽음에 대한 인식(𝛽=-.32, p<.001)이었고, 좋은 죽음에 대한 교육 경험(𝛽=.15, p=.024), 사전연명의료의향서 지식(𝛽=.14, p=.036)이 영향요인으로 파악되었으며, 모형의 설명력은 14.2%였다. 본 연구결과를 토대로 대학병원 간호사가 연명의료 중단에 대한 긍정적 태도를 가지고 정확한 정보 제공과 상담자로서 제 역할을 할 수 있도록 좋은 죽음에 대한 인식, 사전연명의료의향서 지식을 향상시키기 위한 좋은 죽음과 연명의료에 대한 교육 프로그램의 개발을 제언한다.