• Title/Summary/Keyword: Life analysis

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Expression profiles of microRNAs in skeletal muscle of sheep by deep sequencing

  • Liu, Zhijin;Li, Cunyuan;Li, Xiaoyue;Yao, Yang;Ni, Wei;Zhang, Xiangyu;Cao, Yang;Hazi, Wureli;Wang, Dawei;Quan, Renzhe;Yu, Shuting;Wu, Yuyu;Niu, Songmin;Cui, Yulong;Khan, Yaseen;Hu, Shengwei
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.6
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    • pp.757-766
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    • 2019
  • Objective: MicroRNAs are a class of endogenous small regulatory RNAs that regulate cell proliferation, differentiation and apoptosis. Recent studies on miRNAs are mainly focused on mice, human and pig. However, the studies on miRNAs in skeletal muscle of sheep are not comprehensive. Methods: RNA-seq technology was used to perform genomic analysis of miRNAs in prenatal and postnatal skeletal muscle of sheep. Targeted genes were predicted using miRanda software and miRNA-mRNA interactions were verified by quantitative real-time polymerase chain reaction. To further investigate the function of miRNAs, candidate targeted genes were enriched for analysis using gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment. Results: The results showed total of 1,086 known miRNAs and 40 new candidate miRNAs were detected in prenatal and postnatal skeletal muscle of sheep. In addition, 345 miRNAs (151 up-regulated, 94 down-regulated) were differentially expressed. Moreover, miRanda software was performed to predict targeted genes of miRNAs, resulting in a total of 2,833 predicted targets, especially miR-381 which targeted multiple muscle-related mRNAs. Furthermore, GO and KEGG pathway analysis confirmed that targeted genes of miRNAs were involved in development of skeletal muscles. Conclusion: This study supplements the miRNA database of sheep, which provides valuable information for further study of the biological function of miRNAs in sheep skeletal muscle.

A Study on the Correlation between Optimal Safety of Structures and Minimization of Life Cycle Cost(LCC) (구조물의 최적안전지수와 생애주기비용의 상관관계에 관한 연구)

  • Bang, Myung-Seok
    • Journal of the Korean Society of Safety
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    • v.29 no.6
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    • pp.94-98
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    • 2014
  • This study was intend to develop the optimal design method of suspension bridge by the reliability analysis based on minimization of life cycle cost(LCC). The reliability analysis was performed considering aleatory uncertainties included in the result of numerical analysis. The optimal design was estimated based on life-cycle cost analysis depending on the result of reliability analysis. As the effect of epistemic uncertainty, the safety index (beta), failure probability (pf) and minimum life cycle cost were random variables. The high-level distributions were generated, from which the critical percentile values were obtained for a conservative bridge design through sensitivity assessment.

Characteristics of Shelf-life of Soybean Curd by Electronic Noses - Using PCA and cluster analysis (전자코를 이용한 두부의 저장특성 분석 주성분 분석과 군집분석을 이용하여 -)

  • 김성민;노봉수
    • Journal of Biosystems Engineering
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    • v.27 no.3
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    • pp.241-248
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    • 2002
  • An electronic noses system including six metal oxide sensors was used to predict the characteristics of shelf-life of soybean curd. Soybean curd was stored at two different temperatures defined as low temperature(5$\^{C}$) and high temperature(25$\^{C}$). Resistance changes of the sensors were measured 13 times for 19 days at low temperature and 19 times for 120 hours at high temperature. Three different analytical methods such as graphical analysis(GA), principal component analysis(PCA), and cluster analysis(CA) were used to analyze sensors outputs. The ratio of resistance was decreased according to increasement of shelf-life. Using PCA it was possible to predict freshness and shelf-life time of soybean curds. Also, using CA it was possible to simplify an electronic nose system. Electronic nose system could be an efficient method to predict shelf-life and to evaluate quality in foods.

Quality of Life Using WHOQOL-Bref in Taegu (WHOQOL-Bref를 이용한 대구시민의 삶의 질)

  • 이종렬;박천만
    • Health Policy and Management
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    • v.10 no.3
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    • pp.129-154
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    • 2000
  • This study aims at providing the basic data necessary for developing a model of and the policies for the improved quality of life of the adult population by measuring and analyzing factors affecting the quality of life based on a WHOQOL-Bref survey of 1,200 persons above the age of 20 residing in Taegu Metropolitan City area. 1. The factors affecting their quality of life were measured as follows: The physical conditions got the highest point of 3.31 while the psychological conditions got 3.20 and the environmental conditions got the lowest point of 3.09. The overall quality of life was rated to be at 3.11 2. General conditions affecting the quality of life, such as the economic conditions, health conditions and stress all turned out to be variables having significant differences(p〈0.01) in all the factors affecting the quality of life. 3. Through the analysis, we also found out the positive correlation exists among all the factors determining the quality of life(p〈0.01), while the psychological factor turning out to have the highest correlation value(r=0.640) with the overall quality of life. 4. To find out the factors affecting all the aspects of quality of life, we also conducted a multiple regression analysis employing the general characteristics as an independent variable. The health, economic and stress conditions all turned out to be significant in all aspects(p〈0.01). Summarizing the above analysis, the quality of life has a high correlation with the psychological, physical and environmental conditions. It has also turned out that the health, economic and stress conditions have the greatest influence on the quality of life. Therefore, it is believed to be necessary that a comprehensive program be developed to promote the public health and to formulate a model for improvement of the people's quality of life that can enhance their physical, psychological and social health conditions.

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Living Conditions and Life Satisfaction of Single-person Households by Life Cycle : An Analysis of Single-person Households in Kimpo, South Korea (1인가구의 생애주기별 생활실태 및 생활만족도 : 김포시 1인가구를 중심으로)

  • Kim, Jung Eun;Park, Jeongyun;Seo, Jiwon;Song, Hyerim
    • Journal of Family Resource Management and Policy Review
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    • v.27 no.3
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    • pp.21-37
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    • 2023
  • This study examines the living conditions and life satisfaction of single-person households according to their life cycle. The survey was conducted from August to October 2022, and respondents were single-person households from Kimpo, South Korea. The respondents were categorized to three groups namely, young, middle-aged, and older adults by life cycle, and items regarding their sociodemographic background, personal life, family relations, and life satisfaction were included in the analysis. Descriptive statistics, Chi-square analysis, analysis of variance, and multiple regression analysis were performed. The key findings were as follows. First, significant differences were found according to life cycle in the respondents' diet, clothing, housing, financial and home management, self-care, and leisure life. Second, the variables that significantly affected the level of life satisfaction of single-person households were the life cycle with young adults showing a higher level of satisfaction; having a family member to care; living alone voluntarily, discrimination experience; community awareness; and ties with the local community. Based on the results, it is clear that single-person households have different needs and problems in each stage of life cycle. Thus, to reflect the different experiences and needs of single-person households by life cycle, tailored policy and programs should be provided for young, middle-aged, and older adult single-person households.

A Study on the Consumer's Service Quality Perception Based on the Types of Life-style (소비자의 라이프스타일에 따른 서비스품질 지각 차이에 관한 연구)

  • Park, Yoon-Seo;Lee, Seung-In;Choi, In
    • Journal of Global Scholars of Marketing Science
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    • v.19 no.2
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    • pp.53-67
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    • 2009
  • For the last decades, service quality has been studied as one of the most important tools for a service company to compete with the other companies. Based on these past researches, it has been agreed that the service quality is a basic and powerful tool to create the competitive advantage. Due to similar reason, many service marketing practitioners have been also focused on the service quality to retain the existing consumers and collect the new consumers. However, service quality is subjectively perceived by individual consumers. Consumer evaluation of service quality can be different from each other. Especially consumers with one life-style may evaluate the service quality differently from the consumers with the other life-styles. Therefore we need to know whether there are differences in service quality perception on the categories of life-style. Life-style refers to a distinctive mode of living in its aggregate and broadest sense. It embodies the patterns that were developed and emerged from the dynamics of living in a society. Since the concept of life-style and its relationship to marketing was introduced in 1963 by William Lazer, methods of measuring the life-style and their application have been developed. Life-style has been usually used to segment the marketplace because it offers marketers a unique and important view of the market. When Life-style is combined with clustering methods, life-style segmentation can generate identifiable whole persons rather than isolated fragment. Life-style segmentation begins with people instead of products and classifies them into different life-style types, each characterized by a unique style of living based on a wide range of activities, interests, and opinions(Plummer, 1974). In this study we applies the life-style segmentation based on the AIO(Activities, Interests, and Opinions) to the consumers of the large discount stores. In Korea, the large discount store market has entered into maturity stage so that the market differentiation strategy is becoming a more critical issue to the marketing practitioners. One of the most important tools to differentiate from the competitors in large discount store market is continuously to provide service of better quality than competitors. This study tries to find answers about the following questions: 1) How can we categorize the consumer life-styles in the large discount store? 2) What are the characteristics of the categorized groups? 3) Are there any differences in service quality perception among the consumers with different life-styles 4) Are there any differences in consumer behavior among them in the large discount store? For the purpose, we collected survey data from consumers and analyzed the data with the SPSS package where we had $X^2$-test, factor analysis, ANOVA, MANOVA, and cluster analysis. The survey was made during one month in the April of 2008. Among the collected 306 copies of questionnaires, 281 copies were chosen as the effective samples for empirical analysis except 25 copies with wrong responses. To identify the life-style patterns, we used the measures employed by Kim and Kwon(1999), where 44 items on a seven-point scale were used to measure factors of the life-style patterns. The Principal Component Method was used for factor extraction, and the VARIMAX orthogonal factor rotation was employed. The 7 items showing low factor loading were eliminated. The results of the factor analysis suggested that nine factors of the life-style patterns were identified as follows: 1) the equality-of-sexes and pursuit-of-independence tendency 2) self-management tendency 3) sociable tendency 4) self-display tendency 5) degree of a dilettante life 6) pursuit-of-information tendency 7) bargain hunter tendency 8) TV preference tendency 9) pursuit-of-leisure tendency. Next, after the K-means cluster analysis was performed with nine factors of the life-style patterns, the life-styles of the respondents were classified into four groups which are named as the 'progressive practicality-oriented group', 'positive success-oriented group', 'sociable ostentation-oriented group', 'stable conservation-oriented group'. The analysis results for usage behavior between the market segments showed statistically significant differences in the frequency of usage, duration time in the store, consumer satisfaction, and loyalty. Also, we tried to investigate whether the large discount store consumers differently perceive the quality of service based upon the types of life-style. To measure the service quality of large discount store, we adapted several measurement models measuring the service quality such as SERVPERF, BCP, R-SERVPERF, R-BCP. MANOVA and One-Way ANOVA were performed to confirm the difference in service quality perception based on the market segments. The results have also shown significant differences between life-style types in service quality perception. These findings show that the large discount store marketers should consider consumer life-style as one of the most important market segments for marketing and understand the difference in service quality perception between life-style types. Our findings give important implications to marketers of large discount stores as well as life-style researchers. First, this study showed there were significant differences in consumer's service quality perception and usage behavior between the types of life-style. It provides evidence that the life-style approach can be a important basis in segmenting the large discount store market and will make consumers perceive the service quality high. Second, most previous researches on service quality have been in aggregate level. However, our results imply that the future research on service quality have to focus on segment level.

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Service Life Prediction of Rubber Bushing for Tracked Vehicles

  • Woo, Chang-Su;Kang, In-Sug;Lee, Kang-Suk
    • Elastomers and Composites
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    • v.55 no.2
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    • pp.81-87
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    • 2020
  • Service life prediction and evaluation of rubber components is the foundational technology necessary for securing the safety and reliability of the product and to ensure an optimum design. Even though the domestic industry has recognized the importance thereof, technology for a systematic design and analysis of the same has not yet been established. In order to develop this technology, identifying the fatigue damage parameters that affect service life is imperative. Most anti-vibration rubber components had been damaged by repeated load and aging. Hence, the evaluation of the fatigue characteristics is indispensable. Therefore, in this paper, we propose a method that can predict the service life of rubber components relatively accurately in a short period of time. This method works even in the initial designing stage. We followed the service life prediction procedure of the proposed rubber components. The weak part of the rubber and the maximum strain were analyzed using finite element analysis of the rubber bushing for the tracked vehicles. In order to predict the service life of the rubber components that were in storage for a certain period of time, the fatigue test was performed on the three-dimensional dumbbell specimen, based on the results obtained by the rubber material acceleration test. The service life formula of the rubber bushing for tracked vehicles was derived using both finite element analysis and the fatigue test. The service life of the rubber bushing for tracked vehicles was estimated to be about 1.7 million cycles at room temperature (initial stage) and about 400,000 cycles when kept in storage for 3 years. Through this paper, the service life for various rubber parts is expected be predicted and evaluated. This will contribute to improving the durability and reliability of rubber components.

Development of System and Cost Function Model for Life Cycle Cost Analysis of Bridge (교량의 생애주기비용 분석을 위한 비용함수 모델 및 시스템 개발)

  • Park Mi-Yun;Sun Jong-Wan;Eom In-Soo;Cho Hyo-Nam
    • Proceedings of the Computational Structural Engineering Institute Conference
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    • 2005.04a
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    • pp.704-711
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    • 2005
  • Recently Life Cycle Cost Analysis for civil infrastructures such as pavements, bridges, and dams has been emphasized However, so far, there are few systems available for life cycle cost analysis of bridges at design stage. Therefore, the objective of this paper is to develop a user-friendly life-cycle cost analysis system for LCC-effective optimal design decision making at design stage. The program is based on the proposed LCC model, formulation, analysis modules and systematic procedure that suit Korean construction conditions. It is expected that the developed system can be effectively utilized for more LCC-effective design of bridges. It is applied to an actual bridge design project in order to demonstrate its effectiveness and applicability.

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The Leisure Constraint and Leisure Life Satisfaction of the Institutionalized Elderly in Seoul - Focusing on the Free Institutionalized Elderly - (서울시 시설거주 노인의 여가프로그램제약정도와 여가생활만족도 - 무료양로시설을 중심으로 -)

  • Park Mee Sok
    • Journal of the Korean Home Economics Association
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    • v.43 no.4 s.206
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    • pp.203-223
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    • 2005
  • This study investigated the leisure constraints and leisure life satisfaction of the institutional elderly. The respondents were 302 elderly people residing in 5 free institutionalized elderly homes in Seoul. The data were analyzed by frequency analysis, factor analysis, One-way ANOVA, Duncan's post hoc test and regression analysis using SPSS WIN 12.0 program. Exploratory factor analysis revealed that the 10 items in the proposed scale could be grouped into four factors of constraint on leisure:'physical constraint','psychological constraint','interpersonal constraint', and 'structural constraint 'There were differences in leisure constraints according to sex, age, education degree, interaction with facility colleagues, and interaction with facility staff. There were differences in leisure life satisfaction according to sex, age, having religion or not, interaction with facility colleagues, interaction with facility staff and leisure constraints. Regression analysis results indicated that the main effective factors of leisure life satisfaction were leisure constraints.

Development of a Web-based Analysis Program for Reliability Assessment of Machine Tools (공작 기계의 신뢰성 평가를 위한 웹 기반 해석 프로그램 개발)

  • 강태한;김봉석;이수훈;송준엽;강재훈
    • Proceedings of the Korean Society of Machine Tool Engineers Conference
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    • 2004.10a
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    • pp.369-374
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    • 2004
  • Web-based analysis programs for reliability assessment of machine tools were developed in this study. First, the reliability data analysis program was developed to search for failure rate using failure data and reliability test data of mechanical part. Second, failure mode analysis was developed through performance tests like circular movement test vibration test for machine tools. This analysis program shows correlation between failure mode and performance test result. Third, tool life was predicted by correlation between flank wear and cutting time, using the extended Taylor tool life equation in turning data and the equivalently converted equation in order to apply ball endmill data to Taylor tool life equation in milling data. All the information related to input and result data can be stored in theses programs.

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