• Bulletin of the Korean Chemical Society
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• v.35 no.4
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• pp.1043-1049
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• 2014

Density functional theory (DFT) calculations at the B3LYP/6-31G(d,p) theoretical level were performed for two novel explosives (compounds B and C) based on the guanidine-fused bicyclic skeleton $C_4N_6H_8$ (A). The heats of formation (HOFs) were calculated via isodesmic reaction. The detonation properties were evaluated by using the Kamlet-Jacobs equations. The bond dissociation energies (BDEs) for the thermolysis initiation bond were also analyzed to investigate the thermal stability. The results show that the compounds have high positive HOF values (B, 1064.68 $kJ{\cdot}mol^{-1}$; C, 724.02 $kJ{\cdot}mol^{-1}$), high detonation properties (${\rho}$, D and P values of 2.04 $g{\cdot}cm^{-3}$ and 2.21 $g{\cdot}cm^{-3}$, 9.98 $km{\cdot}s^{-1}$ and 10.99 $km{\cdot}s^{-1}$, 46.44 GPa and 59.91 Gpa, respectively) and meet the basic stability requirement. Additionally, feasible synthetic routes of the these high energy density compounds (HEDCs) were also proposed via retrosynthetic analysis.

• Smart Structures and Systems
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• v.15 no.1
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• pp.119-133
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• 2015

This paper proposed a structural time-varying damage detection method by using synchrosqueezing wavelet transform. The instantaneous frequencies of a structure with time-varying damage are first extracted using the synchrosqueezing wavelet transform. Since the proposed synchrosqueezing wavelet transform is invertible, thus each individual component can be reconstructed and the modal participation factor ratio can be extracted based on the amplitude of the analytical signals of the reconstructed individual components. Then, the new time-varying damage index is defined based on the extracted instantaneous frequencies and modal participation factor ratio. Both free and forced vibrations of a classical Duffing nonlinear system and a simply supported beam structure with abrupt and linear time-varying damage are simulated. The proposed synchrosqueezing wavelet transform method can successfully extract the instantaneous frequencies of the damaged structures under free vibration or vibration due to earthquake excitation. The results also show that the defined time-varying damage index can effectively track structural time-varying damage.

• Structural Engineering and Mechanics
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• v.41 no.6
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• pp.805-822
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• 2012

Offshore pipelines have to withstand combined actions of tension and bending during deepwater installation, which can possibly lead to elliptical buckle and even catastrophic failure of whole pipeline. A 2D theoretical model initially proposed by Kyriakides and his co-workers which carried out buckling response analysis of elastic-plastic tubes under various load combinations, is further applied to investigate buckling behavior of offshore pipelines under combined tension and bending. In association with practical pipe-laying circumstances, two different types of loadings, i.e., bent over a rigid surface in the presence of tension, and bent freely in the presence of tension, are taken into account in present study. In order to verify the accuracy of the theoretical model, numerical simulations are implemented using a 3D finite element model within the framework of ABAQUS. Excellent agreement between the results validates the effectiveness of this theoretical method. Then, this theoretical model is used to study the effects of some important factors such as load type, loading path, geometric parameters and material properties etc. on buckling behavior of the pipes. Based upon parametric studies, a few significant conclusions are drawn, which offer a theoretical reference for design and installation monitoring of deepwater pipelines.

• Smart Structures and Systems
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• v.23 no.3
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• pp.295-306
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• 2019

Shanghai Tower is a 632-meter super high-rise building located in an area with wind and active earthquake. A sophisticated structural health monitoring (SHM) system consisting of more than 400 sensors has been built to carry out a long-term monitoring for its operational safety. In this paper, a reduced-order model including 31 elements was generated from a full model of this super tall building. An iterative regularized matrix method was proposed to tune the system parameters, making the dynamic characteristic of the reduced-order model be consistent with those in the full model. The updating reduced-order model can be regarded as a benchmark model for further analysis. A long-term monitoring for structural dynamic characteristics of Shanghai Tower under different construction stages was also investigated. The identified results, including natural frequency and damping ratio, were discussed. Based on the data collected from the SHM system, the dynamic characteristics of the whole structure was investigated. Compared with the result of the finite element model, a good agreement can be observed. The result provides a valuable reference for examining the evolution of future dynamic characteristics of this super tall building.

• Steel and Composite Structures
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• v.30 no.4
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• pp.337-350
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• 2019

The objective of this paper is to investigate the confinement coefficient of concrete-filled square stainless steel tubular (CFSSST) stub columns under axial loading. A fine finite 3D solid element model was established, which utilized a constitutive model of stainless steel considering the strain-hardening characteristics and a triaxial plastic-damage constitutive model of concrete with features of the parameter certainty under axial compression. The finite element analysis results revealed that the increased ultimate bearing capacity of CFSSST stub columns compared with their carbon steel counterparts was mainly due to that the composite action of CFSSST stub columns is stronger than that of carbon steel counterparts. A further parametric study was carried out based on the verified model, and it was found that the stress contribution of the stainless steel tube is higher than the carbon steel tube. The stress nephogram was simplified reasonably in accordance with the limit state of core concrete and a theoretical formula was proposed to estimate the ultimate bearing capacity of square CFSSST stub columns using superposition method. The predicted results showed satisfactory agreement with both the experimental and FE results. Finally, the comparisons of the experimental and predicted results using the proposed formula and the existing codes were illustrated.

• Journal of Information Processing Systems
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• v.14 no.6
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• pp.1385-1397
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• 2018

There are many factors that affect the wind speed. In addition, the randomness of wind speed also leads to low prediction accuracy for wind speed. According to this situation, this paper constructs the short-time forecasting model based on the least squares support vector machines (LSSVM) to forecast the wind speed. The basis of the model used in this paper is support vector regression (SVR), which is used to calculate the regression relationships between the historical data and forecasting data of wind speed. In order to improve the forecast precision, historical data is clustered by cluster analysis so that the historical data whose changing trend is similar with the forecasting data can be filtered out. The filtered historical data is used as the training samples for SVR and the parameters would be optimized by particle swarm optimization (PSO). The forecasting model is tested by actual data and the forecast precision is more accurate than the industry standards. The results prove the feasibility and reliability of the model.

• Steel and Composite Structures
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• v.42 no.5
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• pp.685-697
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• 2022

In this paper, a vibration-based method using the change ratios of modal data and the experience-based learning algorithm is presented for quantifying the position, size, and interface layer of delamination in laminated composites. Three types of objective functions are examined and compared, including the ones using frequency changes only, mode shape changes only, and their combination. A fine three-dimensional FE model with constraint equations is utilized to extract modal data. A series of numerical experiments is carried out on an eight-layer quasi-isotropic symmetric (0/-45/45/90)s composited beam for investigating the influence of the objective function, the number of modal data, the noise level, and the optimization algorithms. Numerical results confirm that the frequency-and-mode-shape-changes-based technique yields excellent results in all the three delamination variables of the composites and the addition of mode shape information greatly improves the accuracy of interface layer prediction. Moreover, the EBL outperforms the other three state-of-the-art optimization algorithms for vibration-based delamination detection of composites. A laboratory test on six CFRP beams validates the frequency-and-mode-shape-changes-based technique and confirms again its superiority for delamination detection of composites.

• BMB Reports
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• v.39 no.6
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• pp.677-685
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• 2006

Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be targeted for refolding or degradation to maintain the homeostasis of the ER. Derlin-1 was reportedly implicated in the retro-translocation of misfolded proteins from the ER to the cytosol for degradation. In this report, we showed that Derlin-1 was down-regulated in the endothelial cells derived from human hepatic cavernous hemangioma (CHEC) compared with other tested cells. Electron microscopy analysis showed that ER was aberrantly enlarged in CHEC cells, but not in other tested cells. When overexpressed, Derlin-1 induced the dilated ER to return normal size. This ER dynamic was associated with the activation of unfolded protein response (UPR). In CHEC cells where Derlin-1 was down-regulated, increased expression of the immunoglobulin heavy chain-binding protein (Bip) and UPR-specific splicing of X-box DNA-binding protein 1 (XBP1) mRNA were detected, as compared with that in other tested cells, indicating that UPR was activated. After Derlin-1 overexpression, the extent of UPR activation diminished, as evidenced by decreased expression of Bip, reduced amount of the spliced form of XBP1 ($XBP1_S$), and elevated expression of the unspliced form of XBP1 ($XBP1_U$). Taken together, these findings provide another example of a single protein being able to affect ER dynamic in mammalian cells, and an insight into the possible molecular mechanism(s).

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.3981-3986
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• 2014

Ganoderma lucidum polysaccharides (GLP) extracted from Ganoderma lucidum have been shown to induce cell death in some kinds of cancer cells. This study investigated the cytotoxic and apoptotic effect of GLP on HCT-116 human colon cancer cells and the molecular mechanisms involved. Cell proliferation, cell migration, lactate dehydrogenase (LDH) levels and intracellular free calcium levels ($[Ca^{2+}]i$) were determined by MTT, wound-healing, LDH release and fluorescence assays, respectively. Cell apoptosis was observed by scanning and transmission electron microscopy. For the mechanism studies, caspase-8 activation, and Fas and caspase-3 expression were evaluated. Treatment of HCT-116 cells with various concentrations of GLP (0.625-5 mg/mL) resulted in a significant decrease in cell viability (P< 0.01). This study showed that the antitumor activity of GLP was related to cell migration inhibition, cell morphology changes, intracellular $Ca^{2+}$ elevation and LDH release. Also, increase in the levels of caspase-8 activity was involved in GLP-induced apoptosis. Western blotting indicated that Fas and caspase-3 protein expression was up-regulated after exposure to GLP. This investigation demonstrated for the first time that GLP shows prominent anticancer activities against the HCT-116 human colon cancer cell line through triggering intracellular calcium release and the death receptor pathway.

• Structural Engineering and Mechanics
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• v.63 no.6
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• pp.725-734
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• 2017

This paper investigated the effects of rebar corrosion on bond performance between rebar and two different concrete mixes (compressive strengths of 20.7 MPa and 44.4 MPa). The specimen was designed as a rebar centrally embedded in a 200 mm concrete cube, with two stirrups around the rebar to supply confinement. An electrochemical accelerated corrosion technique was applied to corrode the rebar. 120 specimens of two different concrete mixes with various reinforcing steel corrosion levels were manufactured. The corrosion crack opening width and length were recorded in detail during and after the corrosion process. Three different loading schemes: monotonic pull-out load, 10 cycles of constant slip loading followed by pull-out and varied slip loading followed by pull-out, were carried out on the specimens. The effects of rebar corrosion with two different concrete mixes on corrosion crack opening, bond strength and corresponding slip value, initial slope of bond-slip curve, residual bond stress, mechanical interaction stress, and energy dissipation, were discussed in detail. The mean value and coefficient of variation of these parameters were also derived. It was found that the coefficient of variation of the parameters of the corroded specimens was larger than those with intact rebar. There is also obvious difference in the two different concrete mixes for the effects of rebar corrosion on bond-slip parameters.