• Journal of Acupuncture Research
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• v.24 no.6
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• pp.207-213
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• 2007

Objectives : This study was designed to investigate the effect of SAAM-Acupuncture and GamigungguitangGaNokyong(GMGGTN) on Ankle Fracture. Methods : SAAM-Acupuncture was administered once daily. The following points were selected: $SP_3$(太白), $LU_9$(太淵), $LI_{11}$(曲池). After short leg casting, GMGGTN was taken 3 times per a day from March 28th to April 30th. We evaluated the patient using the Visual Analogue Scale(VAS) and Ankle Range of Motion(ROM). Results : After about 3 weeks of treatment, the patient's short leg cast was removed a week earlier than expected and the patient could walk without crutches and physical therapy. Their VAS changed from 10 to 1. And after added treatment for 2 weeks, there was no pain and limitation of ROM. Conclusions : According to the results, SAAM-Acupuncture and GMGGTN may have rapid effects on ankle fractures. But further studies are required to confirm this effect.

• Journal for History of Mathematics
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• v.20 no.2
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• pp.1-18
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• 2007

In the middle of 19th century, Chosun mathematicians Nam Byung Gil(南秉吉) and Lee Sang Hyuk(李尙爀) studied mathematical structures developed in Song(宋) and Yuan(元) eras on top of their early studies on Jiu zhang suan shu(九章算術) and Shu li jing yun(數理精蘊). Their studies gave rise to a momentum for a prominent development of Chosun mathematics in the century. In this paper, we investigate Nam Byung Gil's JipGoYunDan(輯古演段) and MuIHae(無異解) and then study his theory of equations. Through a collaboration with Lee, Sang Hyuk, he consolidated the eastern and western structure of theory of equations.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.20 no.1
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• pp.53-57
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• 2010

The influence of CaO addition on the crystallization temperature, crystal types, and microstructure of L-A-S ($Li_2O-Al_2O_3-SiO_2$) glass-ceramics system fabricated from a coal bottom ash, produced at thermal power plant, was studied. The glass transition and crystallization temperatures were shifted to the higher temperature position with increasing CaO content in a non-isothermal analysis using a DTA. The major crystalline phases of L-A-S glass-ceramics system produced were identified as ${\beta}$-spodumene ($LiAlSi_2O_6$) and eucryptite ($LiAlSiO_4$). The glass-ceramics showed a bulk and surface crystallization behavior at a time. With increasing CaO content, the ${\beta}$-spodumene peak in XRD increased and some CaO-related phases were formed. The surface crystal grown from the exterior to the center in glass-ceramics showed various shapes by amount of CaO added. Some cracks were generated at the glass-ceramics containing CaO above 9 wt% due to the mismatch of thermal expansion coefficients between a ${\beta}$-spodumene and CaO-related crystal phases.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7867-7869
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• 2015

Objective: To assess the safety and effectiveness of thalidomide (produced by CHANGZHOU PHARMACEUTICAL FACTORY CO.LTD) combined with chemotherapy in treating patients with advanced colorectal cancer. Method: A consecutive cohort of pretreated patients with advanced colorectal cancer were treated with thalidomide combined with chemotherapy. And chemotherapy for patients with advanced colorectal cancer were administered according to the condition of patients. Thalidomide was orally administered at a dosage of 50mg/day to 150mg/day before sleeping for at least 14 days. After at least 14 days of treatment, safety and side effects were evaluated. Results: There were 12 female and 3 male patients with advanced cancer recruited into this study, including 9 patients with colon, 6 patients with rectal cancer. The median age of patients was 57(41-82) years. Partial response was observed in 2 patients (2/15), and stable disease in 3 patients(3/15). Incidences of Grade 1 to 2 myelosuppression was observed in 1/15 patients, and Grade 1 to 2 elevation of hepatic enzyme was recorded in 1/15 patients. Adverse effects on the gastrointestinal tract were documented in 1/15 patients, and were Grade 1. No Grade 3-4 toxicities were diagnosed. No treatment related death was found. Conclusions: Thalidomide combined with chemotherapy was safe and mildly effective in treating patients with advanced colorectal cancer. However, further study should be conducted to clarify the effectiveness of this combination.

• Journal for History of Mathematics
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• v.22 no.4
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• pp.1-14
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• 2009

Since western mathematics and astronomy had been introduced in Chosun dynasty in the 17th century, most of Chosun mathematicians studied Shu li jing yun(數理精蘊) for the western mathematics. In the last two decades of the 19th century, Chosun scholars have studied them which were introduced by Japanese text books and western missionaries. The former dealt mostly with elementary arithmetic and the latter established schools and taught mathematics. Lee Sang Seol(1870~1917) is well known in Korea as a Confucian scholar, government official, educator and foremost Korean independence movement activist in the 20th century. He was very eager to acquire western civilizations and studied them with the minister H. B. Hulbert(1863~1949). He wrote a mathematics book Su Ri(數理, 1898-1899) which has two parts. The first one deals with the linear part(線部) and geometry in Shu li jing yun and the second part with algebra. Using Su Ri, we investigate the process of transmission of western mathematics into Chosun in the century and show that Lee Sang Seol built a firm foundation for the study of algebra in Chosun.

• Proceedings of the KIEE Conference
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• 1996.07c
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• pp.1682-1684
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• 1996

Recently, because diffusion of cordless machine and smart card and so on, and concern of unpolluted materials, one are concerned with Li secondary batteries. Li secondary batteries have high voltage, high energy density and high power density, and heavy metal pollution problems are little. Mn is low price and is distributed much quantity. Therefore, we investigated $MnO_2$. In this study, we worked the electrochemical properties and charge/discharge characteristics of $MnO_2/Li$ cells. In results, the more heating temperature is high, the more ${\gamma}-phase$ varied ${\beta}-phase$, and when $MnO_2$ is heated at $320^{\circ}C$ and super-s-black 20wt% is mixed, characteristics are the best.

• Journal of Ginseng Research
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• v.35 no.1
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• pp.39-44
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• 2011

We studied the acute oral toxicity of black ginseng (BG) produced by heat process in rats. Single acute BG extract doses of 0, 5, 10, and 15 g/kg dissolved in saline were administered by oral gavage and the animals were kept under observation for 14 days. The single administration of BG extract up to 15 g/kg did not produce mortality, behavioral change or abnormal clinical signs in the rats. These results indicated that the oral $LD_{50}$ of the BG extract in the rats is higher than 15 g/kg. Compared to the control group, no treatment-related biologically significant effects of BG extract were noted in the measurements of the body weight or food intake. At the end of the period, the biochemical parameters and hematological parameters were analyzed in the plasma and blood. A histopathological examination of the liver and kidney was also conducted. Only the blood nitrogen urea and potassium levels in the biochemical indices showed significant differences at 10 and 15 g/kg doses of BG extract compared to the control group. These changes were not considered to be due to the toxicity. None of the other clinical chemistry parameters were affected. Therefore, these results indicate that the BG by heat processing is virtually nontoxic.

• Molecules and Cells
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• v.41 no.5
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• pp.401-412
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• 2018

Oxymatrine (OMT) often used in treatment for chronic hepatitis B virus infection in clinic. However, OMT-induced liver injury has been reported. In this study, we aim to investigate the possible mechanism of OMT-induced hepatotoxicity in human normal liver cells (L02). Exposed cells to OMT, the cell viability was decreased and apoptosis rate increased, the intracellular markers of oxidative stress were changed. Simultaneously, OMT altered apoptotic related proteins levels, including Bcl-2, Bax and pro-caspase-8/-9/-3. In addition, OMT enhanced the protein levels of endoplasmic reticulum (ER) stress makers (GRP78/Bip, CHOP, and cleaved-Caspase-4) and phosphorylation of c-Jun N-terminal kinase (p-JNK), as well as the mRNA levels of GRP78/Bip, CHOP, caspase-4, and ER stress sensors (IREI, ATF6, and PERK). Pre-treatment with Z-VAD-fmk, JNK inhibitor SP600125 and N-acetyl-l-cysteine (NAC), a ROS scavenger, partly improved the survival rates and restored OMT-induced cellular damage, and reduced caspase-3 cleavage. SP600125 or NAC reduced OMT-induced p-JNK and NAC significantly lowered caspase-4. Furthermore, 4-PBA, the ER stress inhibitor, weakened inhibitory effect of OMT on cells, on the contrary, TM worsen. 4-PBA also reduced the levels of p-JNK and cleaved-caspase-3 proteins. Therefore, OMT-induced injury in L02 cells was related to ROS mediated p-JNK and ER stress induction. Antioxidant, by inhibition of p-JNK or ER stress, may be a feasible method to alleviate OMT-induced liver injury.

• Journal of Wetlands Research
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• v.7 no.3
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• pp.57-66
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• 2005

This paper is to present the determination of the optimal loss rate parameters and unit hydrographs from the observed single rainfall-runoff event using optimization model. The linear program models has been formulated to derive the optimal unit hydrographs and loss rate parameters for the site of the Su-Jik Bridge in the HwangGuJichen River; one minimizes the summation of the absolute residual between predicted and observed runoff ordinates. In the perturbation stage of parameters the trial and error method has been adopted to determine the loss rate parameters for Kostiakov's, Philip's, Horton's, and Green-Ampt's equation. The unique unit hydrograph ordinates for a given rainfall-runoff event is exclusively obtained with ${\Phi}$ index, but unit hydrograph ordinates depend upon the parameters for each loss rate equations. In this paper the single rainfall-runoff event observed from the sample watershed is considered to test the proposed method. The optimal unit hydrograph obtained by the optimization model has smaller deviations than the ones by the conventional method.

• Bulletin of the Korean Chemical Society
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• v.27 no.9
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• pp.1310-1314
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• 2006

Sulfur-substituted $LiMn_{0.9}Cr_{0.1}O_{2-x}S_x$ $(0\;\leq\;x\;\leq\;0.1)$ layered oxides have been prepared by solid state reaction under inert atmosphere. From powder X-ray diffraction analyses, all the present lithium manganates were found to be crystallized with monoclinic-layered structure. Electrochemical measurements clearly demonstrated that, in comparison with the pristine $LiMn_{0.9}Cr_{0.1}O_2$, the sulfur-substituted derivatives exhibit smaller discharge capacities for the entire cycle range but the recovery of discharge capacity after the initial several cycles becomes faster upon sulfur substitution. The effect of the sulfur substitution on the chemical bonding nature of $LiMn_{0.9}Cr_{0.1}O_{2-x}S_x$has been investigated using X-ray absorption spectroscopic (XAS) analyses at Mn and Cr K-edges. According to Mn K-edge XAS results, the trivalent oxidation state of manganese ion remains unchanged before and after the substitution whereas the local structure around manganese ions becomes more distorted with increasing the substitution rate of sulfur. On the other hand, the replacement of oxygen with sulfur has negligible influence on the local atomic arrangement around chromium ions, which is surely due to the high octahedral stabilization energy of $Cr^{+III} $ ions. Based on the present experimental findings, we have suggested that the decrease of discharge capacity upon sulfur substitution is ascribable to the enhanced structural distortion of $MnO_6$ octahedra and/or to the formation of covalent Li-S bonds, and the accompanying improvement of cyclability would be related to the depression of Mn migration and/or to the pillaring effect of larger sulfur anion.