• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2010년도 춘계 종합학술대회 논문집
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• pp.420-422
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• 2010

최근 질병 분석 및 신약을 개발하기 위한 단백질에 대한 연구는 생명 공학의 큰 테마 중 하나이다. 질병 및 단백질 데이터를 분석하기 위한 연구는 대용량의 데이터 처리를 요구하기 때문에 과거 실험을 통해 접근하던 방식에서 벗어나 최근 IT 기술의 결합을 통해 다양한 실험 데이터를 공유하고, 연계함으로써 연구를 가속화하고 있다. 하지만 생명 공학 연구자에게 있어서 IT 지식을 기반을 둔 단백질 분석 도구를 다루는데 많은 어려움이 있다. 이러한 문제를 해결하고자, IT 연구자와 생명 공학 연구자의 협업을 통한 데이터 분석 도구를 개발이 폭넓게 시도되고 있지만, 연구자 간의 협업을 도울 수 있는 통합 인프라는 전무한 실정이다. 본 논문에서는 IT 연구자와 생명 공학 연구자의 협업을 위한 인프라로서 컴포넌트 기반의 질병 및 단백질 데이터 분석 시스템을 설계하고 구현한다.

• 한국약용작물학회지
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• 제13권1호
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• pp.35-40
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• 2005

중국에서 재배되는 목단의 품종 중 화형의 연화정도가 다른 대표적인 6개 품종의 뿌리에 대해 채취시기에 따른 paeonol과 paeoniflorin의 함량을 조사하였다. 6개 품종의 뿌리에서 paeonol의 양은 계절에 관계없이 거의 일정하여 변화가 없었다. 반면 paeoniflorin은 개화기인 5월에 가장 높은 값을 보이다가 6월에 감소, 7월에는 증가, 8월에 다시 감소하다가 9월에는 증가하는 경향을 보였다. 비교한 6개의 품종중 화형의 형태가 단순한 종류가 복잡한 종류에 비해 약리성분을 많이 함유하고 있었다. 단판형화관인 Dan Feng과 만첩형 화관의 Wu Long Feng Sheng의 채취시기에 따른 부위별 약리성분의 분포정도를 비교하였다. Paeonol은 두 품종 모두 뿌리를 제외한 잎과 줄기에 미량으로 존재하며 채취시기가 달라져도 변화가 없었다. Paeoniflorin은 뿌리와 잎 두 부분에 다량으로 존재하여 뿌리에서의 분포양이 계절적으로 증감을 반복하는 반면, 잎은 성장이 가장 왕성한 5월에 가장 높게 분포하고 시기가 지날수록 감소하였다.

• Journal of Computing Science and Engineering
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• 제6권1호
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• pp.1-11
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• 2012

Computed tomography (CT) images are widely used for the analysis of the temporal evaluation or monitoring of the progression of a disease. The follow-up examinations of CT scan images of the same patient require a 3D registration technique. In this paper, an automatic and robust registration is proposed for the rigid registration of 3D CT images. The proposed method involves two steps. Firstly, the two CT volumes are aligned based on their principal axes, and then, the alignment from the previous step is refined by the optimization of the similarity score of the image's voxel. Normalized cross correlation (NCC) is used as a similarity metric and a downhill simplex method is employed to find out the optimal score. The performance of the algorithm is evaluated on phantom images and knee synthetic CT images. By the extraction of the initial transformation parameters with principal axis of the binary volumes, the searching space to find out the parameters is reduced in the optimization step. Thus, the overall registration time is algorithmically decreased without the deterioration of the accuracy. The preliminary experimental results of the study demonstrate that the proposed method can be applied to rigid registration problems of real patient images.

• Toxicological Research
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• 제33권2호
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• pp.141-147
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• 2017

Peripheral ameloblastic odontoma is a rare variant of odontogenic tumor occurring in the extraosseous region. The present report describes a spontaneous tumor in male Sprague-Dawley (SD) rats. The clinically confirmed nodule in the right mandibular region was first observed when the rat was 42 weeks and remained until the terminal sacrifice date when the animal was 48 weeks of age. At necropsy, a well demarcated nodule, approximately $2.5{\times}2.0{\times}2.0cm$, protruded from the ventral area of the right mandible. The nodule was not attached to mandibular bone and was not continuous with the normal teeth. Histopathologically, the tumor was characterized by the simultaneous occurrence of an ameloblastomatous component and composite odontoma-like elements within the same tumor. The epithelial portion formed islands or cords resembling the follicle or plexiform pattern typical of ameloblastoma and was surrounded by mesenchymal tissue. Formation of eosinophilic and basophilic hard tissue matrix (dentin and enamel) resembling odontoma was observed in the center of the tumor. Mitotic figures were rare, and areas of cystic degeneration were present. Immunohistochemically, the epithelial component was positive for cytokeratin AE1/AE3 (CK AE1/AE3), and the mesenchymal component and odontoblast-like cells were positive for vimentin, in the same manner as in normal teeth. On the basis of these findings, the tumor was diagnosed as a peripheral ameloblastic odontoma in an extraosseous mandibular region in a SD rat. In the present study, we report the uncommon spontaneous peripheral ameloblastic odontoma in the SD rat. We also discuss here the morphological characteristics, origin, histochemical, and immunohistochemical features for the diagnosis of this tumor.

• 한국환경복원기술학회지
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• 제20권4호
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• pp.15-28
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• 2017

A protected area means a space designated and protected by law from development pressure and environmental pressure. It is mainly designated to protect specific ecosystems, natural landscapes, and cultural resources from irrational development (or damage), and involves policies of the public sector such as central and local governments. The United Nations Educational, Scientific and Cultural Organization (UNESCO) has conducted conservation and restoration projects for preserving natural ecosystems and genetic resources. In order to conserve the ecosystem in the protected area, national and public organizations purchase private land and use it ecologically; in addition, ecological restoration project is carried out for the purpose of creating waterside ecological belt or preserving ecosystem. Land acquisition refers to the land where highly influenced by the water quality and need to restore, and purchased by negotiating with the landlord. Although the nation and public institution carried out ecosystem restoration project for partial purchase land in order to conserve ecosystem, it is below the expected effect due to lack of comprehensive management system and have some problems in restoration project and unification of management institutions. Land acquisition in Donggang River Basin Ecological Conservation area is initiated in 2005 for creating income of local residents and ecological restoration. However, the lack of overall management and awareness resulted in poor vegetation growth and poor response by local residents due to terrain exposure. As such, there is insufficient research on the current situation and systematic integrated management although the number of land acquisition is increasing year after year. Futhermore, overall recognition and follow-up monitoring of eco-restoration are still inadequate. Therefore, the survey on the awareness of the purchase land ecosystem restoration project is necessary for the efficient restoration project and establishment of the management strategy for land acquisition in the future. Therefore, in this study, we provide fundamental materials on further research projects by carrying out research on the awareness of ecological restoration projects in the Donggang River basin ecological preservation area.

• 한국통신학회논문지
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• 제35권11B호
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• pp.1667-1675
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• 2010

본 논문에서는 무선 휴대 장치의 전력공급을 위해 적용 가능한 고효율 PWM/PFM 모드 DC-DC벅 변환기를 제안한다. 휴대성 확보를 위한 간소화된 보상회로를 사용하고, 휴대장치의 대기 모드 및 저부하에서 높은 효율을 갖도록 설계하였다. 휴대 장치 동작 시간의 대부분을 차지하는 대기모드(저부하: 60mA이하) 및 저부하에서의 고효율 동작을 해서 PFM 동작 모드의 제어를 위해서 상대머신을 설계하였다. 칩 측정 결과 동작모드별로 PWM은 93%, PFM은 92.3%의 최대효율을 확인하였다. 측정된 출력 리플전압은 10mV 이하로 나타났다. 제안된 벅 변환기는 $0.35{\mu}m$ CMOS 공정으로 제작하였으며, 3.3V ~ 2.5V의 입력전압을 받아서 1.8V의 전압을 출력하였다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2001년도 추계정기 학술발표회 초록집
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• pp.25-32
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• 2001

Potatoes have been recognized for a long time as one of the major food crops as well as horticultural crops. Potato production as a table food has been decreased in developed countries, while it has been steadily increased in the third world countries for it importance as food source. It is a new trend to look for the food, not only as a feeding crop but also healthy food. It is also time for the potato producers to look for the potato having high economic value as found in medicinal plants. There are great diversities in potato species, indicating that valuable compounds can be found in different amounts, depending on potato species. We screened the cultivars, breeding clones, and germplasms based on the vitamin C, Vitamin E, antioxidant compounds, diverse sugar types, important amino acids, and other valuable compounds. We could select the breeding clones KC003, 98Wl17, 99j717, and Vally 8 (A group) due to their high levels of antioxidant compounds, and it can be said that most of the red and purple colored potato clones belong to the A group. In the contents of essential amino acids, ‘Taebook Valley’,‘Summer Valley’ and other breeding clones were found to be high in amount. We also made crosses between breeding clones with high biological function and low agronomic traits and low biological function with high quality in agronomic characteristics . The patterns of genetic trends of these offsprings in comparison with their parents will be reported as well. And the potential of using potato as antibody production of anti-cancer will be discussed.

• Macromolecular Research
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• 제17권2호
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• pp.91-98
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• 2009

Conjugated PPV-derived block copolymers containing 2-ethylhexyloxynaphthalene unit were synthesized and characterized in this study. The resulting polymers were soluble in common organic solvents and showed good thermal stabilities, The weight-average molecular weights ($M_w$) of the copolymers ranged from 246,000 to 475,000 with PDIs of $1.3{\sim}2.1$. The optical properties of these polymers, measured both in a chloroform solution and on a film, showed a maximum absorption at $405{\sim}476\;nm$ for Copolymers $I{\sim}VIII$. In the PL spectra, Copolymers $I{\sim}VIII$ showed maximum peaks at $510{\sim}566\;nm$. The HOMOs, LUMOs and band gaps of the PPV derivatives of Copolymers $I{\sim}VIII$ were $5.30{\sim}5.77$, $3.04{\sim}3.24$, and $2.5{\sim}2.2\;eV$, respectively, The multi-layered, light-emitting diodes of ITO/PEDOT/copolymers/LiF/Al exhibited turn-on voltages of $6{\sim}2.5\;V$ Copolymer VIII exhibited the maximum brightness of $3.657\;cd/m^2$. Particularly, Copolymer VII, with an identical composition of MEH-PPV and naphthalene-PPV, showed a maximum luminance efficiency and power efficiency of 2,63 cd/A and 1.06 lm/W, respectively.

• Molecules and Cells
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• 제24권2호
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• pp.185-193
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• 2007

Symbiotic nitrogen fixation with nitrogen-fixing bacteria in the root nodules is a distinctly beneficial metabolic process in legume plants. Legumes control the nodule number and nodulation zone through a systemic negative regulatory system between shoot and root. Mutation in the soybean NTS gene encoding GmNARK, a CLAVATA1-like serine/threonine receptor-like kinase, causes excessive nodule development called hypernodulation. To examine the effect of nts mutation on the gene expression profile in the leaves, suppression subtractive hybridization was performed with the trifoliate leaves of nts mutant 'SS2-2' and the wild-type (WT) parent 'Sinpaldalkong2', and 75 EST clones that were highly expressed in the leaves of the SS2-2 mutant were identified. Interestingly, the expression of jasmonate (JA)-responsive genes such as vspA, vspB, and Lox2 were upregulated, whereas that of a salicylate-responsive gene PR1a was suppressed in the SS2-2 mutant. In addition, the level of JA was about two-fold higher in the leaves of the SS2-2 mutant than in those of the WT under natural growth conditions. Moreover, the JA-responsive gene expression persists in the leaves of SS2-2 mutant without rhizobia infection in the roots. Taken together, our results suggest that the nts mutation increases JA synthesis in mature leaves and consequently leads to constitutive expression of JA-responsive genes which is irrelevant to hypernodulation in the root.

• 정보보호학회논문지
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• 제24권4호
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• pp.607-616
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• 2014

현재 영상감시 시스템에서 얼굴 인식을 통한 사람의 신원 확인은 정면 얼굴이 아닌 관계로 매우 어려운 기술에 속한다. 일반적인 사람들의 얼굴 영상과 입력된 얼굴 영상을 비교하여 유사도를 파악하고 신원을 확인 하는 기술은 각도의 차이에 따라 정확도의 오차가 심해진다. 이런 문제를 해결하기 위해 본 논문에서는 POSIT을 사용하여 얼굴 포즈 측정을 하고, 추정된 각도를 이용하여 3D 얼굴 영상을 제작 후 매칭 하여 일반적인 정면 영상끼리의 매칭이 아닌 rotated face를 이용한 매칭을 해보기로 한다. 얼굴을 매칭 하는 데는 상용화된 얼굴인식 알고리즘을 사용하였다. 얼굴 포즈 추정은 $10^{\circ}$이내의 오차를 보였고, 얼굴인증 성능은 약 95% 정도임을 확인하였다.