• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권3호
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• pp.857-872
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• 2014

Recent researches reveal that great benefit can be achieved for data gathering in wireless sensor networks (WSNs) by employing mobile data collectors. In order to balance the energy consumption at sensor nodes and prolong the network lifetime, a multi-track large-scale mobile data collection mechanism (MTDCM) is proposed in this paper. MTDCM is composed of two phases: the Energy-balance Phase and the Data Collection Phase. In this mechanism, the energy-balance trajectories, the sleep-wakeup strategy and the data collection algorithm are determined. Theoretical analysis and performance simulations indicate that MTDCM is an energy efficient mechanism. It has prominent features on balancing the energy consumption and prolonging the network lifetime.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2003년도 The 8th Asian Symposium on Precision Forging ASPF
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• pp.133-137
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• 2003

In this paper presented the net forging technology of planetary gear after much experiment and analysis, technology of two forging processes after billet being one -time heated, and cold net forging was adopted to ensure the gear forming quality. In the process of die producing, electrical rod NC cutting technology was used .the test and application has proved the net forging gear has reached higher quality and met the requirement of design. The net forging gear technology had been put into production.

• Biomolecules & Therapeutics
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• 제30권5호
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• pp.399-408
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• 2022

Diabetic cardiomyopathy (DCM) is described as abnormalities of myocardial structure and function in diabetic patients without other well-established cardiovascular factors. Although multiple pathological mechanisms involving in this unique myocardial disorder, mitochondrial dysfunction may play an important role in its development of DCM. Recently, considerable progresses have suggested that mitochondrial biogenesis is a tightly controlled process initiating mitochondrial generation and maintaining mitochondrial function, appears to be associated with DCM. Nonetheless, an outlook on the mechanisms and clinical relevance of dysfunction in mitochondrial biogenesis among patients with DCM is not completely understood. In this review, hence, we will summarize the role of mitochondrial biogenesis dysfunction in the development of DCM, especially the molecular underlying mechanism concerning the signaling pathways beyond the stimulation and inhibition of mitochondrial biogenesis. Additionally, the evaluations and potential therapeutic strategies regarding mitochondrial biogenesis dysfunction in DCM is also presented.

• Parasites, Hosts and Diseases
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• 제52권5호
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• pp.521-525
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• 2014

Human infections with Lophomonas blattarum are rare. However, the majority of the infections occurred in China, 94.4% (136 cases) of all cases in the world. This infection is difficult to differentiate from other pulmonary infections with similar symptoms. Here we reported a case of L. blattarum infection confirmed by bronchoalveolar lavage fluid smear on the microscopic observations. The patient was a 21-year-old female college student. The previous case which occurred in Chongqing was 20 years ago. We briefly reviewed on this infection reported in the world during the recent 20 years. The epidemiological characteristics, possible diagnostic basis, and treatment of this disease is discussed in order to provide a better understanding of recognition, diagnosis, and treatment of L. blattarum infection.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7245-7249
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• 2014

Glucose regulated protein 78 (GRP78) is usually recognized as a chaperone in the endoplasmic reticulum. However, increasing evidence indicates that GRP78 can be translocated to the cell surface, acting as a signaling receptor for a variety of ligands. Since little is known about the secretion of GRP78 and its role in the progression of colon cancer we here focused on GRP78 from colon cancer cells, and purified GRP78 protein mimicking the secreted GRP78 was able to utilize cell surface GRP78 as its receptor, activating downstream PI3K/Akt and Wnt/${\beta}$-catenin signaling and promote colon cancer cell proliferation. Our study revealed a new mode of action of autocrine GRP78 in cancer progression: secreted GRP78 binds to cell surface GRP78 as its receptor and activates intracellular proliferation signaling.

• Bulletin of the Korean Chemical Society
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• 제24권11호
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• pp.1571-1574
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• 2003

This paper describes an inductively coupled plasma emission spectrometric method for the analysis of Fe in rat plasma. Calibration curves were obtained in the range of 0.125-1.50 ${\mu}g{\cdot}mL^{-1}$. The relative standard deviation ranges from 5.93% to 6.80%, and accuracy was between 87.6 and 102.0%. Dilution with water had no influence on the performance of the method, which could then be used to quantify Fe concentration in plasma up to 0.50 ${\mu}g{\cdot}mL^{-1}$. The limit of quantification was 0.10 ${\mu}g{\cdot}mL^{-1}$. At this level, the average relative standard deviation was 6.8%. The results indicate that the method meets the accuracy and precision requirements for the pharmacokinetic studies. The Fe concentration in rat plasma was measured and the main pharmacokinetic parameters were calculated by Topfit 2.0 (GmbH. Shering AG, Godecke AG, Germany).

• Bulletin of the Korean Chemical Society
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• 제35권11호
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• pp.3224-3226
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• 2014

A new androstane derivative, $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-carboxylic acid (1) and a known one $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5721-5724
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• 2012

We conducted this study to detect associations between XRCC1 Arg399Gln and XPD Lys751Gln genotypes and survival of colorectal cancer patients treated with 5-FU/oxalipatin chemotherapy. We included 289 Chinese patients with advanced colorectal cancer, who had received 5-FU/oxalipatin chemotherapy as first-line treatment from January 2005 to January 2007. All patients were followed up till Nov. 2011. Genotyping for XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms was based upon duplex polymerase-chain-reaction with the PCR-RFLP method. In our study, we found the XRCC1 399 Gln/Gln genotype to confer significantly higher rates of response to chemotherapy when compared to the Arg/Arg genotype [OR (95% CI)= 2.56(1.57-2.55)]. patients with the XPD 751 Gln/Gln genotype had significantly higher rates of response to chemotherapy [OR (95% CI)= 1.54(0.87-2.65)] and those with the XRCC1 399 Gln/Gln genotype had a longer average survival time and significantly lower risk of death than did those with the Arg/Arg genotype [HR (95% CI)= 0.66(0.36-0.95)]. Similarly, those carrying the XPD 751Gln/Gln genotype had 0.51-fold the risk of death of those with XPD 751Lys/Lys [HR (95% CI)= 0.51(0.33 -0.94)]. In conclusion, it is suggested that the XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms should be routinely assessed to determine colorectal patients who are more likely to benefit from 5-FU/oxalipatin chemotherapy.

• Safety and Health at Work
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• 제13권4호
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• pp.394-400
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• 2022

Background: Impacts of exposure are generally monitored and recorded after injuries or illness occur. Yet, absence of conventional after-the-effect impacts (i.e., lagging indicators), tend to focus on physical health and injuries, and fail to inform if workers are not exposed to safety and health hazards. In contrast to lagging indicators, leading indicators are proactive, preventive, and predictive indexes that offer insights how effective safety and health. The present study is to validate an extended Voluntary Protection Programs (VPP) that consists of six leading indicators. Methods: Questionnaires were distributed to 13 organizations (response rate = 93.1%, 1,439 responses) in Taiwan. Cronbach α, multiple linear regression and canonical correlation were used to test the reliability of the extended Voluntary Protection Programs (VPP) which consists of six leading indicators (safe climate, transformational leadership, organizational justice, organizational support, hazard prevention and control, and training). Criteria-related validation strategy was applied to examine relationships of six leading indicators with six criteria (perceived health, burnout, depression, job satisfaction, job performance, and life satisfaction). Results: The results showed that the Cronbach's α of six leading indicators ranged from 0.87 to 0.92. The canonical correlation analysis indicated a positive correlation between the six leading indicators and criteria (1st canonical function: correlation = 0.647, square correlation = 0.419, p < 0.001). Conclusions: The present study validates the extended VPP framework that focuses on promoting safety and physical and mental health. Results further provides applications of the extended VPP framework to promote workers' safety and health.

• 동양고전연구
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• 제66호
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• pp.331-362
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• 2017

음중팔선도는 당나라 시인 두보가 유달리 술을 좋아한 여덟 명의 기이한 행동을 읊은 <음중팔선가>를 도해한 그림이다. 유달리 술을 사랑한 음중팔선은 동아시아의 지식인에게 많은 사랑을 받았고, 이들의 일화는 그림으로 표현되었다. 중국에서는 이공린 <음중팔선도>의 영향으로 두루마리에 백묘법으로 그린 음중팔선도가 유행했다. 우리나라에서도 음중팔선도는 술을 좋아하는 취객의 엉뚱한 행적과 그들이 지닌 남다른 풍류를 그린 시각물로, 혹은 영원한 우정과 무병장수를 기원하는 축수물(祝壽物)로 폭넓게 감상되었다. 기록에 따르면, 김명국의 음중팔선도는 세밀한 담채기법의 8폭 그림이었고, 정조가 어람한 음중팔선도는 8폭으로 된 채색의 대경산수인물화였다. 또한 최근 이한철의 ${\ll}$음중팔선도${\gg}$ 8폭 병풍이 소개되어 김홍도, 김양기로 이어지는 화원들의 고사인물화 제작 양상도 상상해 볼 수 있었다. 특히 음중팔선 중에서 가장 인기가 높았던 이백의 고사는 음중팔선도와 별도로 많이 그려졌고, 심지어 19세기 이후에는 고사도 병풍의 한 폭을 차지하게 되었다. 화보와 초본이 활용되면서 민간에서 비슷한 이백 고사도가 대량 생산된 것이다. 이렇듯 음중팔선도는 세상과 완전히 단절하지 않은 애주가로, 솔직하게 행동하는 풍류인으로, 술로 맺어진 영원한 우정과 무병장수를 염원하는 축수물의 주인공으로 시각화되었다. 이것이 두보의 시의도이자 팔선의 고사도인 음중팔선도가 지닌 다층적 함의라고 할 수 있다.