Browse > Article
http://dx.doi.org/10.7314/APJCP.2012.13.11.5721

Association Between Polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln Genes and Prognosis of Colorectal Cancer in a Chinese Population  

Gan, Yi (Department of General Surgery, 3rd Xiang-Ya Hospital of Central South University)
Li, Xiao-Rong (Department of General Surgery, 3rd Xiang-Ya Hospital of Central South University)
Chen, Dao-Jin (Department of General Surgery, 3rd Xiang-Ya Hospital of Central South University)
Wu, Jun-Hui (Department of General Surgery, 3rd Xiang-Ya Hospital of Central South University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.11, 2012 , pp. 5721-5724 More about this Journal
Abstract
We conducted this study to detect associations between XRCC1 Arg399Gln and XPD Lys751Gln genotypes and survival of colorectal cancer patients treated with 5-FU/oxalipatin chemotherapy. We included 289 Chinese patients with advanced colorectal cancer, who had received 5-FU/oxalipatin chemotherapy as first-line treatment from January 2005 to January 2007. All patients were followed up till Nov. 2011. Genotyping for XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms was based upon duplex polymerase-chain-reaction with the PCR-RFLP method. In our study, we found the XRCC1 399 Gln/Gln genotype to confer significantly higher rates of response to chemotherapy when compared to the Arg/Arg genotype [OR (95% CI)= 2.56(1.57-2.55)]. patients with the XPD 751 Gln/Gln genotype had significantly higher rates of response to chemotherapy [OR (95% CI)= 1.54(0.87-2.65)] and those with the XRCC1 399 Gln/Gln genotype had a longer average survival time and significantly lower risk of death than did those with the Arg/Arg genotype [HR (95% CI)= 0.66(0.36-0.95)]. Similarly, those carrying the XPD 751Gln/Gln genotype had 0.51-fold the risk of death of those with XPD 751Lys/Lys [HR (95% CI)= 0.51(0.33 -0.94)]. In conclusion, it is suggested that the XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms should be routinely assessed to determine colorectal patients who are more likely to benefit from 5-FU/oxalipatin chemotherapy.
Keywords
XRCC1 Arg399Gln; XPD Lys751Gln; polymorphisms; colorectal cancer; chemotherapy; response;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Chang-Claude J, Popanda O, Tan XL, et al (2005). Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients. Clin Cancer Res, 11, 4802-9.   DOI
2 Chang PM, Tzeng CH, Chen PM, et al (2009). ERCC1 codon 118 C>T polymorphism associated with ERCC1 expression and clinical outcome to FOLFOX-4 treatment in Asian patients with metastatic colorectal carcinoma. Cancer Sci, 100, 278-83.   DOI
3 Fard-Esfahani P, Fard-Esfahani A, Fayaz S (2011). Association of Arg194Trp, Arg280His and Arg399Gln polymorphisms in X-ray repair cross-complementing group 1 gene and risk of differentiated thyroid carcinoma in Iran. Iran Biomed J, 15, 73-8.
4 Grimminger PP, Brabender J, Warnecke-Eberz U, et al (2010). VallbohmerXRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer. J Surg Res, 164, e61-6.   DOI
5 Handra-Luca A, Hernandez J, Mountzios G, et al (2007). Excision repair cross complementation group1 immunohistochemical expression predicts objective response and cancer-specific survival in patients treated by cisplatin-based induction chemotherapy for locally advanced head and neck squamous cell carcinoma. Clin Cancer Res, 13, 3855-9.   DOI   ScienceOn
6 Hoeijmakers JH, Egly JM, Vermeulen W (1996). TFIIH: a key component in multiple DNA transaction. Curr Opin Gene Dev, 6, 26-33.   DOI
7 International Agency for Research on Cancer (2008). Colorectal Cancer Incidence and Mortality Worldwide in 2008. http://globocan.iarc.fr.
8 Lai JI, Tzeng CH, Chen PM, et al (2009). Very low prevalence of XPD K751Q polymorphism and its association with XPD expression and outcomes of FOLFOX-4 treatment in Asian patients with colorectal carcinoma. Cancer Sci, 100, 1261-6.   DOI
9 Lamas MJ, Duran G, Balboa E, et al (2011). Use of a comprehensive panel of biomarkers to predict response to a fluorouracil-oxaliplatin regimen in patients with metastatic colorectal cancer. Pharmacogenomics, 12, 433-42.   DOI
10 Lamas MJ, Duran G, Gomez A, et al (2012). D.X-ray cross-complementing group 1 and thymidylate synthase polymorphisms might predict response to chemoradiotherapy in rectal cancer patients. Int J Radiat Oncol Biol Phys, 82, 138-44   DOI
11 McWilliams RR, Bamlet WR, Cunningham JM, et al (2008). Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. Cancer Res, 68, 4928-35.   DOI   ScienceOn
12 Lunn RM, Langlois RG, Hsieh LL, et al (1999). XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res, 59, 2557-61.
13 Lv H, Li Q, Qiu W, et al (2012). Genetic Polymorphism of XRCC1 Correlated with Response to Oxaliplatin-Based Chemotherapy in Advanced Colorectal Cancer. Pathol Oncol Res, 18, 1009-14.   DOI
14 Manuguerra M, Saletta F, Karagas MR, et al (2006). XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. Am J Epidemiol, 164, 297-302.   DOI   ScienceOn
15 Mohrenweiser HW, Jones IM (1998). Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation? Mutat Res, 400, 15-24.   DOI
16 Park DJ, Stoehlmacher J, Zhang W, et al (2001). Xeroderma pgmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer. Cancer Res, 61, 8654-9.
17 Parshad R, Tarone RE, Price FM, et al (1993). Cytogenetic evidence for differences in DNA incision activity in xeroderma pigmentosum group A, C and D cells after X-irradiation during G2 phase. Mutat Res, 294, 149-55.   DOI
18 Raabe A, Derda K, Reuther S, et al (2012). Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy. Radiat Oncol, 7, 65.   DOI
19 Raymond E, Faivre S, Woynarowski JM, Chaney SG (1998). Oxaliplatin: mechanism of action and antineoplastic activity. Semin Oncol, 25, 4-12.
20 Rzeszowska-Wolny J, Polanska J, Pietrowska M, et al (2005). Influence of polymorphisms in DNA repair genes XPD, XRCC1 and MGMT on DNA damage induced by gamma radiation and its repair in lymphocytes in vitro. Radiat Res, 164, 132-40.   DOI
21 Saldivar JS, Wu X, Follen M, Gershenson D (2007). Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity. Gynecol Oncol, 107, S56-71.   DOI
22 Schaeffer L, Moncollin V, Roy R, et al (1994). The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor. EMBO J, 13, 2388-92.
23 Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer research, 58, 604-8.
24 Shields PG, Harris CC (2000). Cancer risk and low-penetrance susceptibility genes in gene-environment interactions. J Clin Oncol, 18, 2309-15.   DOI
25 Shore RE, Zeleniuch-Jacquotte A, Currie D, et al (2008). Polymorphisms in XPC and ERCC2 genes, smoking and breast cancer risk. Int J Cancer, 122, 2101-5.   DOI
26 Sung P, Bailly V, Weber C, et al (1993). Human xeroderma pigmentosum group D gene encodes a DNA helicase. Nature, 365, 852-5.   DOI
27 Zhao Y, Deng X, Wang Z, et al (2012). Genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population. Asian Pac J Cancer Prev, 13, 665-9.   DOI   ScienceOn
28 Zhou W, Gurubhagavatula S, Liu G et al (2004). Excision repair crosscomplementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Clin Cancer Res, 10, 4939-43.   DOI