[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2014.35.11.3224

Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer

Yang, Ning-Ning (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS)
Ma, Qing-Yun (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS)
Huang, Sheng-Zhuo (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS)
Dai, Hao-Fu (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS)
Guo, Zhi-Kai (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS)
Yu, Zhi-Fang (College of Food Science and Technology, Nanjing Agriculture University)
Zhao, You-Xing (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS)

Publication Information

Bulletin of the Korean Chemical Society / v.35, no.11, 2014 , pp. 3224-3226 More about this Journal

Abstract

A new androstane derivative, $4{\beta}$ -methyl-15-oxa- $14{\beta}$ -androstane-7-ene- $4{\alpha}$ -carboxylic acid (1) and a known one $4{\beta}$ -methyl-15-oxa- $14{\beta}$ -androstane-7-ene- $4{\alpha}$ -hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.

Keywords

Marasmiellus ramealis (Bull.) Singer; Fermentation; Androstane derivative; AChE inhibitory activity;

Citations & Related Records

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