• Archives of Pharmacal Research
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• v.27 no.8
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• pp.857-862
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• 2004

Naringenin, dietary flavonoid, is antioxidant constituents of many citrus fruits. In the present study, we investigated the effect of naringenin on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible CYP1 A 1 gene expression in mouse hepatoma Hepa-1c1c7 cells. Naringenin alone did not affect CYP1A1-specific 7-ethoxyresorufin O-deethylase (EROD) activity. In contrast, the TCDD-inducible EROD activities were markedly reduced upon concomitant treatment with TCDD and naringenin in a dose dependent manner. TCDD-induced CYP1A1 mRNA level was also markedly suppressed by naringenin. A transient transfection assay using dioxin-response element (DRE)-linked luciferase and electrophoretic mobility shift assay revealed that naringe-nin reduced transformation of the aryl hydrocarbons receptor(AhR) to a form capable of specif-ically binding to the DRE sequence in the promoter of the CYP1A1 gene. These results suggest the down regulation of the CYP1A1 gene expression by either naringenin in Hepa-1c1c7 cells might be antagonism of the DRE binding potential of nuclear AhR.

• Journal of The Korean Association of Information Education
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• v.2 no.2
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• pp.162-173
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• 1998

Writing a CAI program containing Chinese characters requires a common Chinese character code to share information for educational purposes. A Chinese character code setting needs to allow a mixed use of both vowel and stroke order, to represent Chinese characters in simplified Chinese as well as in Japanese version, and to have a conversion process for data exchange among different sets of Chinese codes. Waste in code area is expected when vowel order is used because heteronyms are recognized as different. However, using stroke order facilitates in data recovery preventing duplicate code generation, though it does not comply with the phonetic rule. We claim that the first and second level Chinese code area needs to be expanded as much as academic and industrial circles have demanded. Also, we assert that Unicode can be a temporary measure for an educational code system due to its interoperability, expandability, and expressivity of character sets.

• Journal of Digital Convergence
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• v.12 no.6
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• pp.341-347
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• 2014

Among methods of the big data process, big data process under the cloud environment is becoming a main topic. As part of solving faced problem and strengthening industrial competitiveness in the medical and health industry, discussion on ways to activate big data is actively being conducted. Because the reason is a paradigm shift, saving pressure for increasing health care costs, and increased consumer interest for the level of service. In this paper, we find out the relationship between the cloud and big data. And we are to research and analysis a cloud-based big data case in the medical field. Finally we propose the efficient utilization and future outlook. For the smooth functioning of cloud-based medical big data, we have to solve the problems like infrastructure extension, analysis/application software development, and professional manpower training. In addition, we have to correct insufficient laws maintenance to the Cloud utilization, and improve the security and the recognition to personal information, and solve authority for data centralization.

• JSTS:Journal of Semiconductor Technology and Science
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• v.17 no.1
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• pp.141-146
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• 2017

In this letter, we propose the use of tunneling field effect transistors (TFET) as a biosensor that detects bio-molecules on the gate oxide. In TFET sensors, the charges of target molecules accumulated at the surface of the gate oxide bend the energy band of p-i-n structure and thus tunneling current varies with the band bending. Sensing parameters of TFET sensors such as threshold voltage ($V_t$) shift and on-current ($I_D$) change are extracted as a function of the charge variation. As a result, it is found that the performances of TFET sensors can surpass those of conventional FET (cFET) based sensors in terms of sensitivity. Furthermore, it is verified that the simultaneous sensing of two different target molecules in a TFET sensor can be performed by using the ambipolar behavior of TFET sensors. Consequently, it is revealed that two different molecules can be sensed simultaneously in a read-out circuit since the multi-sensing is carried out at equivalent current level by the ambipolar behavior.

• Journal of Digital Contents Society
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• v.18 no.1
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• pp.71-77
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• 2017

Virtual advertisement is an advertising technique that using computer graphic in a media production such as a sports image for inserting product image, logo, advertising slogan, etc. Recently, the image insertion of virtual advertisement is actively spreading due to the satisfaction of technical element for the image insertion of virtual advertisement in sports advertisement by increasing of the image processing technology and the computing performance. In addition, image processing technology for automatic insertion has become an important research field in the virtual advertisement field. In this paper, we propose the method of extracting less-informative region by using image processing technique and machine learning to insert a virtual advertisement automatically in sports image. The proposed method analyzes the brightness level of image through the histogram and extracts the less-informative region using the machine learning method.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.37 no.6
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• pp.64-72
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• 2000

This paper deals with the parallel operation of two PWM converters for auxiliary block of high speed train. The parallel operation of AC/DC PWM converter controlled by 3-level PWM switching method to operate switching devices to realize a high power factor and reduce the primary side of the transformer current harmonics is proposed. In this paper, it is presented the phase shift technique between two converters switching phase, solution to eliminate the coupling effects due to the transformer and zero crossing detection method for synchronized with the source and controller. Experimental results for laboratory system with TMS320C31 microprocessor and 10［kVA］PWM converter confirm the validity of the proposed algorithm.

• The Journal of Korean Association of Computer Education
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• v.16 no.1
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• pp.73-80
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• 2013

Government promotes that the strategy of national R&D converts from catch-up R&D type to leading R&D type for the future growth and national competitiveness according to the recent paradigm shift in the research and development. So the many national researches about foundation, source and core technology are actively being made. As a result of these researches, the security has become an important part of success factor in R&D. And so various security diagnosis and evaluation is being conducted about national R&D program. Existing the research security evaluation models are classified domains in terms of security management and created evaluation indicators according to the domains. However the models are inappropriate in case of researchers doing self-diagnosis of research security. This paper set up the domains in aspect of research management and then proposed the evaluation indicator of research security according to the domains. The evaluation indicator model that is suggested can be utilized in self-diagnosis of research security effectively.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.05a
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• pp.907-914
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• 2015

Currently, the previous studies on the concept, configuration, and system regarding spacial information policies show the little progress. However, these studies only propose the basic structure system in terms of a policy theory, seeking and suggesting the basic concept to establish spacial information policies. In the shift of a new paradigm from a PC-based paradigm that began in the mid-2000s to the current smart society based on mobile devises, such as smart phones, this study thus reviewed the strategic direction of the propulsion to establish the desired future strategy for the spatial technology policy with spatial information system that can influence the future national competitiveness of Korea. The results of this study is expected to be used to analyze a variety of issues and technological changes on geospatial intelligence at the global level and to support the establishment of a road-map for policies and research & development on domestic geospatial information.

• Transactions of the Korean hydrogen and new energy society
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• v.18 no.3
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• pp.244-249
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• 2007

The present work considers the concept of enzymatic photoelectrochemical generation of hydrogen through water splitting using a Xe lamp as a source of light. A solar cell was applied to the system in order to shift the level of electrochemical energy of the system, resulting in the rate of hydrogen production at $43\;{\mu}mol/(cm^2{\times}hr)$ in cathodic compartment with an anodized tubular $TiO_2$ electrode(ATTE, $5^{\circ}C$/1hr in 0.5 wt% HF-$650^{\circ}C$/5hr). The trend of the rate of hydrogen production, for the ATTEs with different annealing temperature from $350^{\circ}C$ to $850^{\circ}C$, fairly well coincided with the photoelectrical properties measured by potentiostat. The actual chemical bias through imposition of two electrolytes of different pHs between anode(13.68) and cathode(7.5) was 0.24eV.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1284-1290
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• 2002

Scrophularia buergeriana Miquel (Scrophulariaceae) has been used as an anti-inflammatory drug in the folk medicine recipe and been proved its anti-inflammatory effect in the oriental medicine. Since nitric oxide (NO) and superoxide anion (O/sub 2//sup -/) are ones of the major inflammatory parameters, we studied the effect of aqueous extracts of Scrophularia buergeriana (SB) on NO and O/sub 2//sup -/ production in lipopolysaccharide (LPS)-stimulated mouse peritoneal macrophages. NO, O/sub 2//sup -/production and inducible NO synthase (iNOS) level were significantly reduced in LPS-activated macrophages by SB compared to those without. Electrophoretic mobility shift assay (EMSA) indicated that SB blocked the activation of NF-kB, which was considered to be a potential transcription factor for the iNOS expression. SB also blocked degradation of IkBα. Furthermore, IkB kinase alpha (IKKα), which phosphorylates serine residues of IkB directly, is inhibited by SB. These results suggest that SB could exert its anti-inflammatory actions by suppressing the activation of NF-kB through inhibition of IKK activity.