• Archives of Pharmacal Research
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• v.28 no.12
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• pp.1350-1357
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• 2005

Nuclear factor kappa B (NF-$\kappa$B) regulates the expression of multiple cytokines, chemokines, and cell adhesion molecules that are involved in the pathogenesis of asthma. We investigated the anti-asthmatic effects and the mechanism of action of DA-9201, an extract of the black rice, in a mouse model of asthma. Mice immunized with ovalbumin (OVA) were administered with DA-9201 (30, 100 or 300 mg/kg) or dexamethasone (DEXA, 3 mg/kg) for 2 weeks and challenged with aerosolized OVA during the last 3 days. Anti-asthmatic effects were assessed by means of enhanced pauses, level of total lgE and Th2 cytokines in plasma or bronchoalveolar lavage fluid (BALF), the percentage of eosinophils in BALF, and histopathological examination. The expression of NF-$\kappa$B in nuclear and cytoplasmic fraction and its DNA-binding activity in lung tissues were analyzed by means of Western blotting and electrophoretic gel mobility shift assay (EMSA), respectively. DA-9201 significantly reduced airway hyperrespon-siveness (AHR), total lgE level in plasma and BALF, IL-4, IL-5, and IL-13 levels in BALF, and the percentage of eosinophils in BALF. Tissue inflammation was significantly improved by DA­9201 treatment. In addition, DA-9201 dramatically suppressed the expression of NF-$\kappa$B and its DNA-binding activity. These results suggest that DA-9201 may be useful for the treatment of asthma and its efficacy is related to suppression of NF-$\kappa$B pathway.

• Korean Journal of Community Nutrition
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• v.28 no.3
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• pp.220-234
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• 2023

Objectives: This study aimed to assess the adherence to dietary guidelines among college students in the post-COVID-19 era and examine the changes in their dietary habits as the learning environment transitioned from remote to in-person classes. Methods: We conducted a survey involving 327 college students in Daejeon from March to April 2023. The survey questionnaires included various factors, including age, gender, type of residence, frequency of use of delivery food, convenience food, and eating out. In addition, we investigated the extent of adherence to the dietary guidelines for Koreans and the degree of dietary changes following the post-COVID-19 shift in class format were investigated. For comparative analysis of the level of adherence to dietary guidelines in relation to dietary habit changes, an ANOVA and a post hoc Scheffe test were employed. We also performed a multiple linear regression analysis to identify dietary factors influencing the level of adherence to dietary guidelines. Results: The study revealed a high rate of convenience food consumption and a low rate of homemade food intake among students. There was a marked increase in the consumption of processed foods, convenience foods, dining out, sweet foods, high-fat fried foods, beverages, and alcohol following the transition from online to in-person classes. When examining adherence to Korean dietary guidelines, the highest scored practice was 'Hydration', and the lowest was 'Breakfast habit'. Increased consumption of convenience foods, late-night snacks, and dining out were negatively correlated with adherence levels to dietary guidelines, specifically correlating with 'Healthy weight', 'Hydration', 'Breakfast habit', and the total score of adherence. The adoption of 'regular meals' was positively associated with increased adherence levels to dietary guidelines. Conclusions: The transition from remote to in-person classes post-COVID-19 led to increased intake of convenience foods, dining out, sweet foods, high-fat fried foods, and alcohol. The rise in convenience food and late-night snack consumption negatively influenced several aspects of the dietary guidelines adherence, thereby suggesting the need for strategies to encourage healthy dietary habits among college students.

• Geomechanics and Engineering
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• v.36 no.4
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• pp.367-380
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• 2024

Investigations has shown that the correct estimation of the effective amplification period is as important as the amplification value itself. It gets more important in 2D basins. This study presents a quantitative coefficient for consideration of the nonlinearity effect in terms of amplification value and the shift in its period which is missing or ineffectively considered in the previous studies. To attain this goal, by the application of a time domain fully nonlinear method, the deviation of the more common equivalent linear results from the basin nonlinear behavior under strong ground motions is investigated quantitatively. Also, despite the increase in the damping ratio, the possibility of the increase in the amplification due to the increase in motion strength is shown. To make the results useful in engineering practice, by introducing nonlinearity ratio, the effect of the nonlinearity is quantitatively estimated for two soft and stiff clayey basins with three different depths under a set of motions scaled to two target spectrum. Results show that at the 100 m depth soft clayey basin, while the nonlinearity ratio shows a 35% deviation at the basin edge part under DD1 motion level, its effect moves to the central part with 20% effect under DD3 motion level. By the increase in depth to 150 m, the results show a decrease in the overall effect of the nonlinear behavior for both clay types. At this depth, the nonlinearity ratio gives a 30% and 17% difference on a limited distance from outcrop at the soft clayey basin under DD1 and DD3 motion levels, respectively. At the 30 m depth basins, the nonlinearity ratio shows up to 25% difference for different cases. The presented ratio would be introduced as nonlinearity coefficients for consideration of the nonlinearity effects in the codes. The presented quantitative margins will help the designer to have a better understanding of the amplification period change because of nonlinearity over 2D basin surface.

• Safety and Health at Work
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• v.15 no.1
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• pp.53-58
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• 2024

Background: As social distancing persists and interest in work-life balance grows, more companies are adopting flexible work policies. While there have been studies on sleep disorders associated with different types of work, such as shift work, research exploring the relationship between flexible work schedules and sleep disorders is still limited, particularly among Korean workers. Methods: We performed a secondary analysis of the 6th Korean Working Conditions Survey, focusing on 31,243 paid workers out of a total of 50,538 participants. We defined flexible workers as those who set their own working hours. Sleep disorders were divided into three categories: 'difficulty falling asleep,' 'frequent waking during sleep,' and 'waking up feeling exhausted and fatigued.' Using scores derived from three specific symptoms, the Minimal Insomnia Symptoms Scale (MISS) was calculated to assess the prevalence of insomnia. We used chi-square tests to analyze demographic and job-related differences. A multivariate logistic regression analysis was employed to identify any relationship between flexible work schedules and sleep disorders. Results: Significant differences were found between flexible and non-flexible workers regarding age, income level, education level, and job type. Flexible workers reported sleep-related symptoms significantly more often. The odds ratio for insomnia was 1.40 (95% CI 1.21-1.61). For males, the odds ratio was 1.68 (1.36-2.08). Conclusion: This study establishes a correlation between flexible work schedules and sleep disorders among Korean salaried workers. Potential causes could include changes in circadian rhythm, increased work demands, and extended working hours. To precisely determine causality and associated diseases, further research is required.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.2
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• pp.185-205
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• 2017

The purpose of this research is to examine the relationship between the adult attachment of married employees, their job motivation and marital relationship. For this purpose, a questionnaire survey was carried out with 370 married employees in the Chungnam area as the target from Sep. 10 to Oct. 14, 2016. The collected data was analyzed using SPSS 23.0 using descriptive statistical analysis, the independent sample T-test, ANOVA analysis, Pearson correlation, and structural equation analysis. First, significant differences were revealed in the level of attachment avoidance, satisfaction with the marriage relationship, and job motivation according to the age group, in the level of attachment avoidance and satisfaction with the marriage relationship according to the education level, in the level of attachment avoidance and satisfaction with the marriage relationship according to the marriage period, in job motivation according to the position, in satisfaction with the marriage relationship according to the average household income, and in satisfaction with the marriage relationship according to the work shift pattern. Second, although a significant negative correlation appeared between attachment anxiety and attachment avoidance, a significant positive correlation was found between attachment avoidance and job motivation. Also, although a significant negative correlation appeared between attachment avoidance and marital relationship, a significant positive correlation was found between job motivation and marital relationship. Third, to examine the mediating effect of satisfaction with the marital relationship on the relationship between adult attachment and job motivation, a structural equation analysis was carried out. As a result, the indirect effect of attachment anxiety on job motivation turned out to be significant and its complete mediating effect was confirmed. This suggests that when developing programs to improve job motivation within the workplace or consultative interventions for the enhancement of marital relationships, the above characteristics of individuals should be taken into consideration.

• Journal of Music and Human Behavior
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• v.14 no.2
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• pp.71-90
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• 2017

The purpose of this study was to compare immediate differences in fatigue and motor performance during instrumental playing in patients with chronic stroke depending on whether singing task was concurrently presented. A total of 12 patients with chronic stroke were recruited from community and daycare centers for older adults in Seoul. Six subjects were randomly assigned to the experimental group and six to the comparison group. The experimental group was asked to sing while playing the electronic drum, and the comparison group only played the drum. The results of this study showed that statistically significant differences in perceived fatigue and exertion were found between the two groups, while no significant group differences were found in level of engagement in playing or force of tapping during drum playing. This study supports the inclusion of a singing task in instrument playing rehabilitation to effectively decrease perceived fatigue and level of intensity of exercises, although this may not lead to immediate changes in motor function or level of target exercises. The results indicate that singing while instrument playing may help stroke patients shift their attention from the executed motor movements to singing and alleviate the attentional and emotional load from intense movements. This study presents implications for how to select and pattern target movements in music therapy intervention for better motor outcomes.

• The Journal of the Korea Contents Association
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• v.16 no.7
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• pp.439-450
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• 2016

Clinical nurses have tendency to change their job while providing care to patient, experiencing extreme stress with shift work, increased demands for technique, and heavy workload. At this point, it is time for investigating resilience in nursing part, and resilience affect to increase organizational commitment and decrease stress and exhaustion at organization. This study is a correlation study to investigate effects resilience on stress, exhaustion, and organizational commitment of clinical nurses. The results are as follows; The participants' resilience level is 3.38(${\pm}.38$), at the maximum of 5, stress level is 3.73(${\pm}.50$) at the maximum of 5, burnout level is 2.74(${\pm}.68$) at the maximum of 6 and organizational commitment level is 4.22(${\pm}.68$) at the maximum of 7. Ftom this study, resilience, stress, and burnout showed negative correlation, and resilience and organizational commitment revealed positive correlation. In order to decrease the clinical nurses' stress, burnout and enhance nurses' organizational commitment, nurse managers have to manage nurses' resilience. For increasing resilience of nurses, nurse manager has to develop resilience program, and training for managing nurses' stress and burnout.

• Journal of Korean Society of Archives and Records Management
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• v.18 no.1
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• pp.129-154
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• 2018

It is time to prepare for the imminent development from the field of records management through decentralization to the records management of the new age in accordance with the flow of decentralization. To overcome a centralized record management system, more archives should be established to realize autonomous and decentralized records management. In accordance with the shift to a full-scale electronic record management environment, the appropriateness and effectiveness of the three-phase system of processing-archival-permanent record management based on physical transfer should be reviewed in terms of transfer cost and work efficiency. The archives should function as institutional archives to carry out the continuous volume record management and the autonomous record management at the institution level. This study examined the possibilities and implications of the archives to expand their functions as archives of institutions for the decentralization of record management and information governance orientation. In addition, the study diversified the types of records management institutions as a way to accomplish this and determined a way to design the functions of archives that integrate the current-end-end-end records management. At each level, institutions should set up archives based on their circumstances and aim at information governance at the level of each archive. Moreover, each archive level should establish a horizontal network to govern record information management.

• Journal of the Korean Applied Science and Technology
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• v.34 no.4
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• pp.717-726
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• 2017

The current allowable cross-contamination level of fatty acid methyl esters (FAME) in aviation turbine fuel (AVTUR) is 50 mg/kg, due to that the presence of FAME in AVTUR can significantly impact the fuel supply system and jet engine. It has been difficult to analyze the level of FAME in AVTUR, since it is consisted of a lot of hydrocarbons. In this study, thus, a new method using multi-dimensional GC-MS (MDGC-MS) was proposed in order to determine the FAME level in AVTUR effectively. Applying to MDGC-MS with Deans switching system enabled us to detect and quantify the FAME with low carbon numbers such as those derived from coconut oil and palm kernel oil. The matrix effect of MDGC-MS method, which could shift the FAME peaks to slightly longer retention times, was reduced by 20 times compared with that of 1-dimensional GC-MS reference method. This developed method could be suitable for qualitative and quantitative analyses to determine the contamination level of trace FAME in AVTUR.

• Korean Journal of Ichthyology
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• v.34 no.3
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• pp.172-178
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• 2022

To investigate the feeding habits and trophic level of the blackthroat seaperch, Doederleinia berycoides in the South Sea of Korea, fish samples were collected by a bottom trawl net from fisheries resources survey vessels of NIFS in February, May, August and November 2021. The total length (TL) of these specimens was from 3.3 to 33.1 cm. D. berycoides fed majorly on Teleostei (especially Engraulis japonicus) based on index of relative importance (%IRI=64.4%). D. berycoides underwent an ontogenetic dietary shift. Smaller individuals (<10.0 cm TL) fed mainly on amphipods. The proportion of amphipods decreased as body size increased, whereas the consumption of Teleostei increased gradually. Examination of the feeding habits according to ontogentic feeding patterns in the diets of D. berycoides revealed that the mean weight of prey (mW/ST) continuously increased, while mean number of prey (mN/ST) decreased and then increased. The estimated average trophic level of the D. berycoides was 3.62±0.64, ranging from 3.31±0.52 to 3.79±0.70.