• Journal of Pharmaceutical Investigation
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• v.36 no.4
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• pp.223-229
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• 2006

[ $PGE_1$ ]-ethyl ester intraurethral solutions were prepared in ethanol/propylene glycol mixture with penetration enhancer and viscosity-enhancing agent. The stability of $PGE_1$-ethyl ester in intraurethral solution was investigated at various temperature. Simultaneous determination of $PGE_1$-ethyl ester and $PGE_1$ was performed using a validated HPLC technique. In pentobarbital anesthetized cats, increase in intracavernous pressure(ICP), increase in penile length and duration of erectile response were determined after intraurethral application of $PGE_1$-ethyl ester solutions. $PGE_1$-ethyl ester solutions, when instilled into the eyes of rabbits, produces no noticeable irritation, or slight transient conjunctival irritation. From these results, ocular irritation of this solutions was judged as practically non-irritating. The stability study indicates that the therapeutically effective content in solution is well maintained for 46 weeks or longer when they are stored at $4^{\circ}C$. After intraurethral application of $PGE_1$-ethyl ester, ICP was increased and penile erection was induced. $PGE_1$-ethyl ester intraurethral solutions for erectile dysfunction could be developed and evaluated by employing feline erection model.

• The Korean Journal of Zoology
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• v.31 no.1
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• pp.21-28
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• 1988

The present study was carried out to examine the fertilizability of the mouse oocytes pre-ex-posed to dbcAMP which is a well-known inhibitor of the oocyte maturation. The oocytes once cultured in the dbcMP-containing medium for a certain length of, time were cultivated in the dbcMp-free medium to induced the maturation, then mixed with sperms, and observed following culture for 24 hours. The fertilization rate of cocytes was judged by the index of the number of 2-cell embryo developed 24hr following insemination. The fertilization rate of the oocyte previously incubated with dbcAMP (100 g/ml) for 2, 4, 8 16 hours was 32.3, 14.5, 4.7 and 8.8%, respectively, while that of the control was 53.3% indicating that the fertilizability was decreased as a function of time exposed to dbcAMP. The pretreatment of dbcMP, however, didn't affect the process of sperm penetration to egg. In addition, there is no prominent changes in the morphological architecture of fertielized eggs which has been exposed to dbcAMP as revealed by electron microscopic observation. Consequendy, it can be concluded that the mouse cocytes once inhibited their maturation by dbcMP may retain, in some extent, the fertilizability, although most of the fertilized egg may not proceed to further development because of the failure of pronucleus formation.

• Journal of ILASS-Korea
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• v.23 no.4
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• pp.192-204
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• 2018

In this study, a 3D CFD analysis method for the combustion process was established for a low calorific value syngas-diesel dual-fuel engine operating under very lean fuel-air mixture condition. Also, the accuracy of computational analysis was evaluated by comparing the experimental results with the computed ones. To simulate the combustion for the dual-fuel engine, a new dual-fuel chemical kinetics set was used that was constituted by merging two verified chemical kinetic sets: n-heptane (173 species) for diesel and Gri-mech 3.0 (53 species) for syngas. For dual-fuel mode operations, the early stage of combustion was dominated by the fuel burning inside or near the spray plume. After which, the flame propagated into the syngas in the piston bowl and then proceeded toward the syngas in the squish zone. With the baseline injection system and piston shape, a significant amount of unburned syngas was discharged. To solve this problem, effects of the injection parameters and piston shape on combustion characteristics were analyzed by calculation. The change in injection variables toward increasing the spray plume volume or the penetration length were effective to cause fast burning in the vicinity of TDC by widening the spatial distribution of diesel acting as a seed of auto-ignition. As a result, the unburned syngas fraction was reduced. Changing the piston shape with the shallow depth of the piston bowl and 20% squish area ratio had a significant effect on the combustion pattern and lessened the unburned syngas fraction by half.

• Journal of Pharmaceutical Investigation
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• v.36 no.3
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• pp.169-174
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• 2006

The aim of this work was to prepare tenoxicam-ethanolamine salt with improved physicochemical properties for transdermal application. Tenoxicam-ethanolamine salt was prepared in methylene chloride and its physicochemical properties were investigated by DSC and FT-lR. The broad peak of tenoxicam around 3600-3200 $cm^-1$ was shifted to lower wavenumber and more broadened. The characteristic endothermic melting peak of tenoxicam appeared at $223^{\circ}C$. The melting peak of tenoxicam-ethanolamine salt was shifted to $159^{\circ}C$. In contrast to relatively small difference in the partition coefficients of tenoxicam and the tenoxicam-ethanolamine salt, large difference in aqueous solubility was observed. $Crovol^{\circledR}$ PK4O (PEG-12 palm kernel glycerides) provided the highest skin flux for both compounds. The order of the enhancing effect of the various vehicles tested was similar for tenoxicam and tenoxicam-ethanolamine salt, which indicated that their enhancing mechanism for tenoxicam and tenoxicam-ethanolamine salt is similar. Tenoxicam-ethanolamine salt had a higher skin flux than tenoxicam by 1.2- to 31.7-fold, depending on the vehicles used. It is suggested that the vehicles with medium HLB value, 1 double bond, and lower ethylene oxide chain length have a better ability to modify the permeability of the stratum corneum and to promote the effective penetration of tenoxicam and tenoxicam-ethanolamine salt.

• Asian Journal of Turfgrass Science
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• v.17 no.2_3
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• pp.87-97
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• 2003

The growth characteristics of creeping bentgrass seeded in the seaside landfill golf course are as follows. 1. As a result of analysis on the chemical characteristics of soil mixture used for turfgrass ground in this experiment, soil pH was 7.9, which is somewhat higher than the creeping bentgrass reference value of pH 5.5∼6.5; T-N(%) was 0.02, which is proper for the reference value, and trace element too lacked. 2. The cultivar with the fastest water infiltration was Seaside II recorded as 226.2cm/sec, while that with the slowest water infiltration was Pennlinks recorded as 141.1 cm/hr which was too faster than the USGA water infiltration reference value of 15∼30cm/hr. For the surface hardness of turfgrass ground with different cultivars, no statistically significant variation was found between the Penncross grass and the Pennlinks recorded as 18.6mm and 19.1 mm, respectively. The soil penetration was the highest in Pennlinks recorded as 7.6kg/$\textrm{cm}^2$ and lowest in Penn A-1 as 6.1kg/$\textrm{cm}^2$. 3. As a result of evaluation on visual quality at the early stage of growth, Penncross showed the most excellent visual quality compared to the others. However, Penn A-1 showed the most excellent visual quality at a late stage of growth around Sep. 17, 2003, and it was also excellent in the evaluation of visual color. Seaside II showed higher density around the root and the longest root length and was highly resistant to salt compared to others, but the initial sprouting rate was not satisfied, and the visual quality in the summer season was inferior to others. 4. As a result of measurement of the traffic injury, Penncross showed the most tolerant to the traffic stress and Pennlinks showed the most susceptible.

• International Journal of Highway Engineering
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• v.19 no.5
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• pp.69-75
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• 2017

PURPOSES : The purpose of this study is to evaluate different types of Ground Penetrating Radar (GPR) testing for characterizing the road cavity detection. The impulse and step-frequency-type GPR tests were conducted on a full-scale testbed with an artificial void installation. After analyzing the response signals of GPR tests for detecting the road cavity, the characteristics of each GPR response was evaluated for a suitable selection of GPR tests. METHODS : Two different types of GPR tests were performed to estimate the limitation and accuracy for detecting the cavities underneath the asphalt pavement. The GPR signal responses were obtained from the testbed with different cavity sizes and depths. The detection limitation was identified by a signal penetration depth at a given cavity for impulse and step-frequency-type GPR testing. The unique signal characteristics was also observed at cavity sections. RESULTS : The impulse-type GPR detected the 500-mm length of cavity at a depth of 1.0 m, and the step-frequency-type GPR detected the cavity up to 1.5 m. This indicates that the detection capacity of the step-frequency type is better than the impulse type. The step-frequency GPR testing also can reflect the howling phenomena that can more accurately determine the cavity. CONCLUSIONS :It is found from this study that the step-frequency GPR testing is more suitable for the road cavity detection of asphalt pavement. The use of step-frequency GPR testing shows a distinct image at the cavity occurrences.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.41 no.6
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• pp.415-421
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• 2017

As stricter environmental regulation have led to an increase in the water treatment cost, it is necessary to quantitatively study the input power of the aeration process to improve the energy efficiency of the water treatment processes. The objective of this study is to propose the empirical correlations for the mass transfer coefficient with the gas hold-up and input power in order to investigate the mass transfer characteristics of the aeration process. It was found that as the input power increases, the mass transfer coefficient increases because of the decrease of gas hold-up and increase of Reynolds number, the penetration length, and dispersion of mixed flow. The correlations for the volumetric mass transfer coefficients with gas hold-up and input power were consistent with the experimental data, with the maximum deviation less than approximately ${\pm}10.0%$.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.21 no.9
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• pp.1149-1164
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• 1997

In this study, the applicability of the RNG k-.epsilon. model to the analysis of the complex flows is studied. The governing equations based on a non-orthogonal coordinate formulation with Cartesian velocity components are used and discretized by the finite volume method with non-staggered variable arrangements. The predicted results using the RNG k-.epsilon. model of three complex flows, i.e., the flow over a backward-facing step and a blunt flat plate, the flow around a 2D model car are compared to these from the standard k-.epsilon. model and experimental data. That of the unsteady axisymmetric turbulent flow within a cylinder of reciprocating model engine including port/valve assembly and the spray characteristics within a chamber of direct injection model engine are compared to these from the standard k-.epsilon. model and experimental data. The results of reattachment length, separated eddy size, average surface pressure distribution using the RNG k-.epsilon. model show more reasonable trends comparing with the experimental data than those using the modified k-.epsilon. model. Although the predicted rms velocity using the modified k-.epsilon. model is lower considerably than the experimental data in incylinder flow with poppet valve, predicted axial and radial velocity distributions at the valve exit and in-cylinder region show good agreements with the experimental data. The spray tip penetration predicted using the RNG k-.epsilon. model is more close to the experimental data than that using the modified k-.epsilon. model. The application of the RNG k-.epsilon. model seems to have some potential for the simulations of the unsteady turbulent flow within a port/valve-cylinder assembly and the spray characteristics over the modified k-.epsilon. model.

• Journal of the Korea Organic Resources Recycling Association
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• v.27 no.3
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• pp.75-80
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• 2019

The article is devoted to the interpretation of ammonia, one of the fine dust precursors, absorption behavior in water turbulent flow. The water flow was considered as a turbulent flow with Reynolds number more than $10^4$, because ammonia gas penetration depth was deeper at turbulent flow compared to laminar flow. For the interpretation, the dimensionless mass transfer governing-equation and the constant physical-properties at room temperature were used. The diffusivity of ammonia in water and the kinematic viscosity of water were $2{\times}10^{-9}m^2/s$ and $1{\times}10^{-6}m^2/s$, respectively. The concentration distribution of ammonia in water was estimated with respect to the position from the point where the water started to be exposed to ammonia. The quantitative distribution as a function of the mixing length was also acquired. The quantitative interpretation may provide the insight how much the turbulent flow was more efficient to remove ammonia rather than the laminar flow.

• Journal of ILASS-Korea
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• v.15 no.2
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• pp.74-82
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• 2010

In order to understand the behavior of transient gaseous injection used in an LPG (Liquefied Petroleum Gas) engine, turbulent incompressible transient jets with butane and propane were measured and analyzed at pressures of 1.5 bar and 2.0 bar with injector diameters of 3 mm and 5 mm. Mie-scattering method with a tracer was used, and images were processed to investigate the behavior of butane and propane jets. Distances from the nozzle to transition region were measured as $L_e/d_{inj}$=4.35~19.4, where $L_e$ and $d_{inj}$ indicate respectively a distance from nozzle to transition point and nozzle diameter. Slits and tubes around jet at near-field were introduced to measure the effect of entrainment and the diameter of jet, which revealed that the entrainment of surrounding air is significant for developing jet diameter. When the entrainment is restricted, the behavior of jet became deviating from the baseline. It was found that the virtual origin located outside of a nozzle towards jet tip within the conditions of this work, and its location was estimated as $x_o/d_{inj}$=0.56~7.25, where $x_o$ is a distance from nozzle to virtual origin.