• Journal of Chest Surgery
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• 제40권11호
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• pp.782-785
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• 2007

Lemierre 증후군은 구인두 감염증에 의해 유발되며 이차적으로 내경정맥의 패혈성 혈전정맥염이 발생하고 원격전이성 감염증이 흔하다. Fusobacterium necrophorum이 가장 흔한 원인 균주이고, 항균제의 출현 이전에는 사망률이 매우 높은 흔한 질환이었다. 항균제의 출현과 구인두 감염증에 대한 광범위한 항균제의 사용으로 발병이 매우 드물어, 이제는 잊혀져 가는 질환이 되었으나, 여전히 높은 사망률을 보이고 있다. 합병증과 사망률을 줄이기 위해서 빠른 진단과 적절한 항생제 치료가 필수적이다. 패혈성 폐색전증을 동반한 Lemierre 증후군 1예를 보고한다.

• Pediatric Infection and Vaccine
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• 제23권2호
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• pp.143-148
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• 2016

Lemierre 증후군은 급성 입인두 감염의 합병증으로 생기는 질환으로, 이차적인 혈전 정맥염과 여러 장기를 침범하는 전이성 색전이 특징이다. 1940년대 이후 항생제가 도입되면서 "잊혀진" 질환이었지만, 영상의학 검사가 발달하면서 Lemierre 증후군의 보고가 많아지고 있다. 건강한 16세 남자 환자가 입인두 감염 후에 5일간 지속된 발열과 경부 강직으로 응급실에 내원하였다. 입원 초기에는 뇌수막염에 준하여 치료를 시작하였으나 추후 경부 전산화 단층촬영에서 오른쪽 속목정맥 안의 혈전이 발견되어 Lemierre 증후군으로 진단하였다. 환자는 입원 2일째 갑자기 복시를 호소하였으나 곧 증상이 호전되었으며, 그 외 전이성 색전에 의한 증상은 발견되지 않았다. 총 3주간의 항생제 치료 후 정맥 내 혈전이 소실된 것을 경부 초음파로 확인하고 치료를 종료하였다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제39권2호
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• pp.85-89
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• 2013

Lemierre syndrome is caused by an infection in the oropharyngeal region with subsequent thrombophlebitis in the internal jugular vein. The thrombus from the thrombophlebitis can invade other vital organs, such as liver, lungs, or joints, resulting in secondary infection, which further exacerbates the fatal prognosis of this syndrome. Lemierre syndrome, also called postanginal sepsis or necrobacillosis, was first reported by Dr. Lemierre in 1936. In his report, Lemierre mentioned that out of 20 patients who suffered from this syndrome, only two survived. He also stated that all of the 20 patients complained of infections in the palatine tonsils and developed sepsis and thrombophlebitis in the internal jugular vein. Once called a "forgotten disease," this syndrome showed a very high mortality rate until usage of antibiotics became prevalent. In this case report, the authors present a 71-year-old female patient who suffered from Lemierre syndrome with thrombosis extended to the right sigmoid sinus.

• 대한두경부종양학회지
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• 제35권2호
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• pp.31-34
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• 2019

Lemierre's syndrome is rare disease characterized by anaerobic sepsis, internal jugular vein thrombosis, septic emboli that resulted from head and neck infection. Lemierre's syndrome has significant morbidity, so immediate, accurate diagnosis and treatment is needed. It is necessary to perform contrast-enhanced computed tomography (CT) for diagnosis. Systemic antibiotics is recommended, and surgical interventions, anticoagulation may beis considered for treatment. We report misdiagnosed case as a simple deep neck infection on initial ultrasonography with simultaneous abscess aspiration but finally diagnosed and treated internal jugular vein thrombophlebitis (Lemierre's syndrome) on CT scan. We report a case of a 45-year-old patient, who was diagnosed with a simple deep neck infection and treated with simultaneous abscess aspiration, but finally diagnosed and treated internal jugular vein thrombophlebitis (Lemierre's syndrome) on CT scan.

• Tuberculosis and Respiratory Diseases
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• 제58권1호
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• pp.73-77
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• 2005

Lemierre 증후군은 인두염 후에 이차적인 내경정맥의 혈전정맥염, 다음 단계로 폐나 관절에 전이감염을 특징으로 한다. 항생제 사용 이전에는 비교적 흔한 질환이었으나 항생제 보급 이후로 드물게 보고 되고 있어서 진단이 지연되고 적절한 치료가 이루어지지 않으면 치명적인 경과를 취할 수 있다. 최근 전형적인 Lemierre 증후군의 임상양상을 보였던 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제34권8호
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• pp.644-647
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• 2001

Lemierre 증후군은 원발성 구인두 감염증으로 인하여 내경정맥의 패혈성 혈전정맥염과 원격전이성 감염증이 발생하는 드물고도 진행이 빠른 임상적 상태로 특징지워진다. 심한 흉부 외상으로 기관 절개하에서 기계호흡 치료 중이던 40세 남자 환자가 우측 경부의 현저한 종창과 폐렴증상이 나타나면서 전신적인 패혈증상이 동반되었다. 경부 전산화 단층촬영과 자기공명 혈관조영술에서 우측 내경정맥이 큰 중심 괴사성 혈전에 의해 완전히 폐쇄되어 있었으며, 주위로의 염증파급이 매우 심한 혈전정맥염의 소견을 보였다. Clindamycin과 haparin의 투여에도 불구하고 염증소견은 더욱 악화되었다. 즉각적인 내경정맥 혈전제거술 및 절제술을 시행하였으며, 이후 환자의 전신적인 패혈증상과 폐렴 그리고 국소적인 염증소견이 소실되었다.

• 대한기관식도과학회지
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• 제16권2호
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• pp.149-153
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• 2010

Lemierre syndrome, also known as postanginal sepsis, is a severe complication of an acute oropharyngeal infection that result in septic thrombophlebitis of the internal jugular vein with subsequent septicemia. This disease is relatively rare, but it has significant morbidity and is potentially fatal. Early diagnosis based on computed tomography with contrast enhancement is mandatory and immediate treatment including intravenous antibiotics, anticoagulants, or surgical approach should be considered. We report a case of Lemierre syndrome after deep neck infection which was successfully treated using antibiotics and anticoagulants.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권3호
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• pp.214-217
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• 2018

Inflammatory bowel disease (IBD) is a well-recognized risk factor for thrombotic events in adults but data on children are scarce. In the great majority of adult patients, thrombotic events are usually deep vein thrombosis and pulmonary embolism. Other sites such as jugular veins are extremely rare. We present a case of Lemierre syndrome in an adolescent girl with active ulcerative colitis and discuss possible risk factors. This is the first reported case of severe Lemierre syndrome with thrombus extension to cranial veins in a patient with ulcerative colitis. Early recognition of Lemierre syndrome in patients who present with rapidly worsening symptoms of neck pain, fever and signs of pharyngitis is imperative because it increases a chance of favorable prognosis. It is important for pediatricians treating IBD patients not to underestimate possible thrombotic events in children with IBD. Recognition of additional risk factors is crucial for prompt diagnosis and adequate treatment.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권3호
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• pp.256-259
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• 2007

Abscesses are common in the oral and maxillofacial area. However, secondary thrombosis of the internal jugular vein accompanying the primary abscess is rare. In 1936, Andre Lemeierre studied 20 patients who showed an initial oropharyngeal infection, septicemia, internal jugular vein thrombosis, and secondary spread of the infection, and after then this condition Lemierre syndrome. Clinically, these patients present with tonsilitis lasting several days, continuous fever, and cervical pain. In the past, ligation and excision of the internal jugular vein was often performed. Current therapeutic modality for this condition is appropriate antibiotic prescription and surgical drainage of abscess. This case report presents a patient who showed symptoms of Lemierre syndrome, initiated as an oropharyngeal infection then developed thrombosis of the internal jugular vein. This patient was admitted into Seoul National University Dental Hospital. In addition to routine antibiotic therapy, surgical incision and drainage of the infection site was performed. Without ligation or excision, the thrombosed IJV disappeared eventually. As the Lemierre syndrome is not a common disease, this case report and review of the literature would be useful regarding a treatment of patients with Lemierre syndrome.

• Journal of Chest Surgery
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• 제44권6호
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• pp.437-439
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• 2011

Lemierre syndrome is caused by acute oropharyngeal infections with secondary septic thrombophlebitis of the internal jugular vein and is characterized by frequent metastatic infections. A 56-year-old man presented with severe reddish inflammatory swelling of the right cervical soft tissue. Thrombophlebitis in the right internal jugular vein and multiple pulmonary embolisms were identified on neck and chest computed tomography (CT). He was treated with antibiotics and heparin for 4 weeks and then discharged without other complications.