• The Journal of the Acoustical Society of Korea
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• v.40 no.5
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• pp.496-502
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• 2021

Recently, deep speaker embedding approach has been widely used in text-independent speaker verification, which shows better performance than the traditional i-vector approach. In this work, to improve the deep speaker embedding approach, we propose a novel method called group-based speaker embedding which incorporates group information. We cluster all speakers of the training data into a predefined number of groups in an unsupervised manner, so that a fixed-length group embedding represents the corresponding group. A Group Decision Network (GDN) produces a group weight, and an aggregated group embedding is generated from the weighted sum of the group embeddings and the group weights. Finally, we generate a group-based embedding by adding the aggregated group embedding to the deep speaker embedding. In this way, a speaker embedding can reduce the search space of the speaker identity by incorporating group information, and thereby can flexibly represent a significant number of speakers. We conducted experiments using the VoxCeleb1 database to show that our proposed approach can improve the previous approaches.

• Journal of Ginseng Research
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• v.43 no.1
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• pp.20-26
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• 2019

Background: Ginsenosides, which are bioactive components in ginseng, can be converted to smaller compounds for improvement of their pharmacological activities. The conversion methods include heating; acid, alkali, and enzymatic treatment; and microbial conversion. The aim of this study was to determine the bioconversion of ginsenosides in fermented red ginseng extract (FRGE). Methods: Red ginseng extract (RGE) was fermented using Lactobacillus plantarum KCCM 11613P. This study investigated the ginsenosides and their antioxidant capacity in FRGE using diverse methods. Results: Properties of RGE were changed upon fermentation. Fermentation reduced the pH value, but increased the titratable acidity and viable cell counts of lactic acid bacteria. L. plantarum KCCM 11613P converted ginsenosides $Rb_2$ and $Rb_3$ to ginsenoside Rd in RGE. Fermentation also enhanced the antioxidant effects of RGE. FRGE reduced 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and reducing power; however, it improved the inhibition of ${\beta}$-carotene and linoleic acid oxidation and the lipid peroxidation. This suggested that the fermentation of RGE is effective for producing ginsenoside Rd as precursor of ginsenoside compound K and inhibition of lipid oxidation. Conclusion: This study showed that RGE fermented by L. plantarum KCCM 11613P may contribute to the development of functional food materials.

• Journal of Microbiology and Biotechnology
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• v.29 no.8
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• pp.1310-1315
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• 2019

Hyaluronidases enhance therapeutic drug transport by breaking down the hyaluronan barrier to lymphatic and capillary vessels, facilitating their tissue absorption. Commercially available hyaluronidases are bovine in origin; however, they pose risks such as bovine spongiform encephalopathy. The present study aimed to develop a novel, highly active hyaluronidase and assess its function. Therefore, in order to find the most efficient active hyaluronidase, we produced several shortened hyaluronidases with partial removal of the N- or C-terminal regions. Moreover, we created an enzyme that connected six histidines onto the end of the hyaluronidase C-terminus. This simplified subsequent purification using $Ni^{2+}$ affinity chromatography, making it feasible to industrialize this highly active recombinant hyaluronidase which exhibited catalytic activity equal to that of the commercial enzyme. Therefore, this simple and effective isolation method could increase the availability of recombinant hyaluronidase for research and clinical purposes.

• Journal of IKEEE
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• v.23 no.3
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• pp.883-892
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• 2019

This study is the method which is adapted to control ankle joint movement for resolving the problem of gait imbalance in intervals where gait environments are changed and slope walking, as applying terrain-adaptive technique to intelligent above-knee prosthesis. In this development of above-knee prosthesis, to classify the gait modes is essential. For distinguishing the stance phases and the swing phase depending on roads, a machine learning which combines decision tree and random forest from knee angle data and inertial sensor data, is proposed and adapted. By using this method, the ankle movement state of the prosthesis is controlled. This study verifies whether the problem is resolved through butterfly diagram.

• Convergence Security Journal
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• v.21 no.1
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• pp.93-100
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• 2021

Damage caused by intelligent cyber attacks not only disrupts system operations and leaks information, but also entails massive economic damage. Recently, cyber attacks have a distinct goal and use advanced attack tools and techniques to accurately infiltrate the target. In order to minimize the damage caused by such an intelligent cyber attack, it is necessary to block the cyber attack at the beginning or during the attack to prevent it from invading the target's core system. Recently, technologies for predicting cyber attack paths and analyzing risk level of cyber attack using big data or artificial intelligence technologies are being studied. In this paper, a cyber attack path analysis method using attack tree and RFI is proposed as a basic algorithm for the development of an automated cyber attack path prediction system. The attack path is visualized using the attack tree, and the priority of the path that can move to the next step is determined using the RFI technique in each attack step. Based on the proposed mechanism, it can contribute to the development of an automated cyber attack path prediction system using big data and deep learning technology.

• Mycobiology
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• v.48 no.6
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• pp.450-463
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• 2020

The strains 17E-042, 17E-039, and NC13-171 belong to Ascomycota and were isolated from soil collected from Sancheong-gun and Yeongam-gun, Korea. The strain 17E-042 produced white mycelial colonies that developed a sienna color with a round margin on potato dextrose agar (PDA), and the reverse side developed a light sienna color. Morphologically, this strain was similar to the strains of Arthrinium phragmites and A. hydei, but the shorter conidial size of the newly identified strain (17E-042) was distinct. The strain 17E-039 produced macroconidia that were pale yellow to orange-brown, elongated-ellipsoid to oblong, round at both ends, primarily straight but sometimes slightly curved, 0-septate, thin-walled, and filled with numerous droplets, having diameters of 20.4-34.3 × 8.0-12.0 ㎛. And the strain NC13-171 formed hyaline to light brown chlamydospores, solitary or in a chain. Multigene phylogenetic analyses were conducted using sequence data obtained from internal transcribed spacer (ITS) regions, 28S rDNA large subunit (LSU), β-tubulin (TUB2), translation elongation factor 1-alpha (TEF1-α), and RNA polymerase II large subunit (RPB2) genes. The results of molecular phylogeny, the detailed descriptions and illustrations of each species strongly support our proposal that these strains from soil in Korea be designated as Arthrinium minutisporum sp. nov. and two new records of Pezicula neosporulosa and Acrocalymma pterocarpi.

• Tunnel and Underground Space
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• v.31 no.6
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• pp.440-459
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• 2021

Roadheaders have begun to be adopted in Korean tunneling sites. The performance prediction models proposed by the manufacturer are used by Korean construction companies. The models use UCS (uniaxial compressive strength) value to predict the net cutting rate, but the rock specimens conducted for the uniaxial compression test have 1.0 of the diameter to length ratio. It has been reported that the specimen shape generally influences the rock strength. The previous references studying the shape effect were cited, and the UCS data of Korean rocks are also updated to analyze the shape effect on UCS. The cause of effect was discussed by previous theory. The change amount of UCS values of Korean rocks was estimated by the data, and the modified prediction model for NCR was finally suggested.

• Journal of the Korean Wood Science and Technology
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• v.30 no.4
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• pp.66-73
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• 2002

The chemical compositions of the root bark of Ulmus species and mucilage were investigated. The methanol extractives were fractionated with n-hexane, ethyl ether, ethyl acetate and water and antibacterial activities of each fraction were investigated. Although differences of chemical compositions of the Ulmus species were not noticeable, nitrogen and lignin contents of xylem were higher than those of phloem. However, ash and extractive contents showed adverse results. The mucilage of root bark was slowly gushing out by water and similar to pectin substance with high acidic sugar content. In fractionation experiment, the yield of methanol extraction was about 7% and the portion of water-soluble materials in methanol extractives was 78%. These water- soluble materials had the most high antibacterial activity on Staphylococcus aureus and Salmonella typhimurium.

• The Korea Journal of Herbology
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• v.28 no.6
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• pp.155-160
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• 2013

Objectives : Gastric cancer is a leading cause of cancer-related deaths, worldwide. Houttuynia cordata Thunberg (H. cordata) has been used as a medicinal plants and it has an anti-cancer activity in human colorectal cancer and leukemic cancer. However, the potential anti-cancer activity and mechanisms of H. cordata for human gastric cancer cells have not been tested so far. Thus, this study examined the biological effects of H. cordata on the human gastric cancer cell line SNU-1 and AGS. Methods : Inhibition of cell proliferation and cell cycle by H. cordata was carried out by MTT assay and Muse cell cycle analysis and the expressions of protein associated with apoptosis and cell cycle regulation were investigated with Western blot analysis. Results : In MTT assay, the proliferation of SNU-1 and AGS cells was significantly inhibited by H. cordata in a time and dose dependent manner, Inhibition of cell proliferation by H. cordata was in part associated with apoptotic cell death, as shown by changes in the expression ratio of Bax to Bcl-2 by H. cordata. Also, H. cordata regulated the expression of cell cycle regulatory proteins such as pRb, cyclin D1, cyclin E, CDK4, CDK2, p21 and p15. Conclusion : The antiproliferative effect of H. cordata on SNU-1 and AGS gastric cancer cells revealed in this study suggests that H. cordata has intriguing potential as a chemopreventive or chemotherapeutic agent.

• Journal of the Korean Wood Science and Technology
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• v.31 no.1
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• pp.27-31
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• 2003

This paper presents the results of air-drying processes and mositure content (MC) distribution of red pine (P. densiflora) and Japanese larch (L. leptolepis) square timber with 14 cm and 16.5 cm of face size, respectively. The air-drying rates of square timber were comparatively high during the first 8 weeks, after that gradually decreased. The time to air dry square timber from initial MC to specified MC of 18 percent required about 26 weeks for 14.0 cm and 32 weeks for 16.5 cm square of red pine, and 32 weeks for 14.0 cm and 48 weeks for 16.5 cm square of Japanese larch. The longitudinal- and transverse MC distribution of these air-dried squares showed slight moisture gradient. The effect of face size on moisture gradient of Japanese larch square was more pronounced comparing with red pine one.