• Journal of Microbiology and Biotechnology
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• v.33 no.5
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• pp.634-643
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• 2023

Chronic obstructive pulmonary disease (COPD), one of the leading causes of death worldwide, is caused by repeated exposure to harmful matter, such as cigarette smoke. Although Lilium longiflorum Thunb (LLT) has anti-inflammatory effects, there is no report on the fermented LLT bulb extract regulating lung inflammation in COPD. Thus, we investigated the protective effect of LLT bulb extract fermented with Lactobacillus acidophilus 803 in COPD mouse models induced by cigarette smoke extract (CSE) and porcine pancreas elastase (PPE). Oral administration of the fermented product (LS803) suppressed the production of inflammatory mediators and the infiltration of immune cells involving neutrophils and macrophages, resulting in protective effects against lung damage. In addition, LS803 inhibited CSE- and LPS-induced IL-6 and IL-8 production in airway epithelial H292 cells as well as suppressed PMA-induced formation of neutrophil extracellular traps in HL-60 cells. In particular, LS803 significantly repressed the elevated IL-6 and MIP-2 production after CSE and LPS stimulation by suppressing the activity of the nuclear factor kappa-light-chain-enhancer of activated B (NFκB) in mouse peritoneal macrophages. Therefore, our results suggest that the fermented product LS803 is effective in preventing and alleviating lung inflammation.

• Journal of the Korean Society of Radiology
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• v.81 no.1
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• pp.219-224
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• 2020

Inflammatory myofibroblastic tumor is a rare benign lesion that accounts for 0.04-1% of all lung tumors and usually appears as a solitary pulmonary nodule or mass. Here, we report the case of an endobronchial inflammatory myofibroblastic tumor in a 21-year-old man with a focus on the imaging findings and a review of previous literature.

• Journal of Korean Dental Hygiene Science
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• v.2 no.2
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• pp.41-51
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• 2019

Introduction: This study intended to identify the current oral health care status and demand of care workers for oral health education. Methods: A survey was distributed to care workers working in 11 nursing homes for older people located in the Chungcheongdo Province. Of those distributed, 217 questionnaires were collected and analyzed. To analyze the collected data, a frequency analysis, t-test, and one-way analysis of variance(ANOVA) were performed using SPSS version 18.0. Results: The demand for an educational course on the 'Management of Oral Health Care for the Aged People' had a score of 4.22 points(full marks were 5.0 points), whereas the score for the necessity for control of oral health was 4.29 points. The control of oral health for the aged people suffering dysphagia scored 4.27 points, whereas the control of oral health for older people who have dementia was 4.27 points. The score for a course on the nutritional control for aged people having difficulties in masticating foods was 4.27. Conclusion: It is clear that the development of educational courses and standardized manuals for care workers on aspects of oral health care is necessary. Therefore, it would be desirable to develop institutional infrastructure for dental hygienists to educate care workers on oral health.

• The Korean Journal of Pesticide Science
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• v.12 no.4
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• pp.323-334
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• 2008

This experiment was carried out to analyze for pesticide residues in 17 different types of the special of geographical indication. We purchased 3 cereal grains, nuts and seeds, 3 fruits, 8 vegetables, mushrooms and other plants (Korean medicines) mainly at the agricultural cooperative's joints markets. Total 209 pesticides including multi-analysed pesticides (204) and single-analysed pesticides (5 ; acephate, methamidophos, monocrotophos, omethoate, vamidothion) were analysed with a GC/MS/MS, an HPLC/UVD (PDA) and a GC/FPD. No. 83 method and single-analysed method (Screening of multi-pesticide residue in the special products of geographical indication) of Korea Food Code was selected for validation in recovery and interferences of matrice. The results were as follows: among the selected 17 the special products, the residual pesticides were detected in 8 types of the special products (40 in 302 samples, detection ratio; 13.2%). All of the samples were not detected over MRLs, but tebuconazole, procymidone and isoprothioran were detected with considerable high frequency. These results could be used as KFDA official methods for the analysis of pesticide residues in foods and reference data will be provided to the related institutions.

• Tuberculosis and Respiratory Diseases
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• v.78 no.4
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• pp.341-348
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• 2015

Background: There have been various results from studies concerning the predictors of recurrence in early-stage nonsmall cell lung cancer (NSCLC). Therefore, an accurate assessment is needed to guide effective adjuvant therapy. We investigated the predictors of a recurrence in patients with resected, early-stage NSCLC and the risk factors associated with locoregional or distant recurrence. Methods: This retrospective study was conducted on patients at the Pusan National University Hospital from January 2006 to December 2011. Patients with pathological stages I or II were included in this study, as based on the seventh edition TNM staging system. Multivariate Cox proportional hazard models were used to identify factors associated with recurrence. Results: Two hundred and forty-nine patients were included. Among them, 180 patients were stage I, and 69 were stage II. Overall, by multivariate analysis, the independent factors associated with a 5-year total recurrence were the presence of visceral pleural invasion (VPI) (p=0.018) and maximal standardized uptake values (SUVs) of tumors on positron emission tomography (PET) >4.5 (p=0.037). The VPI was the only independent risk factor associated with both locoregional and distant recurrence, in the analysis of the patterns of tumor recurrence and their risk factors. In the subgroup analysis of stage I patients, three variables (male, VPI and resection margin positive) were significantly associated with a 5-year recurrence. Conclusion: The independent factors associated with postoperative recurrence in early-stage NSCLC were as follows: PET SUV >4.5 and the presence of VPI. For patients with those factors adjuvant therapy should be recommended as a more efficacious treatment.

• (The)Study of the Eastern Classic
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• no.72
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• pp.157-183
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• 2018

The purpose of this study was to investigate the existence aspects of the Hyangri class in Imsilhyeon, Jeolla Province in the latter half of Joseon based on Woonsuyeonbangseonsaengan, which provides lists of Hyangris in Imsilhyeon from the fourth year(1724) of King Gyeongjong's reign to the early 20th century. It contained the names of total 704 Hyangris, who included 119 Kims, 103 Eoms, 103 Jins, 87 Parks, 86 Muns, 66 Lees, 31 Baeks, 27 Hwangs, and 17 Taes. In addition, there were 12 more family names that produced fewer than ten Hyangris. Based on the share of representative family names among the Hyangris of the area, it is estimated that the dominant family names were Kim, Eom, Jin, Park, Mun, and Lee. Another interesting aspect is that the Jeon and Yang families produced no Hyangris in the 19th century, whereas the Hwang family produced 5% of Hyangris in the century with the Jin family accounting for 10% or more. These findings show that little changes were consistent within the community of Hyangris despite the fact that a couple of families were dominant. The family clans of the family names were checked in Nosogyean, which records that they were the Kim family of Gyeongju, Eom family of Yeongwol, Jin family of Namwon, Park family of Hamyang, Mun family of Nampyeong, and Lee family of Gyeongju. The study then examined the family names of 76 Hojangs that were recorded to hold the Hojang title in Woonsuyeonbangseonsaengan to see whether the family names that produced higher-level Hyangris were the same as the ones above. There was an overall agreement between the family names that produced a lot of Hojangs and those that produced the most Hyangris, but there were differences according to the periods. Six family names produced Hojangs in similar percentage in the 18th century, and only three family names, which were the Jin family of Namwon(13), Mun family of Nampyeong(9), and Eom family of Yeongwol(6), produced more than ten Hojangs in the 19th century. Other noteworthy changes in the 19th century include the rapidly rising frequency of Hojangs serving the term twice or more compared with the 18th century and the concentration of Hojangs on certain family names. These findings indicate that six family names coexisted in the active production of Hyangris in the community of Hyangris in Imsilhyeon in the latter half of Joseon, that there were changes to the family names of higher-level Hyangris internally according to the periods, and that a shift happened toward the leadership of certain family names in the society of Hyangris.

• Tuberculosis and Respiratory Diseases
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• v.79 no.4
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• pp.289-294
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• 2016

Background: The aim of our study was to evaluate the prognostic value of Charlson's weighted index of comorbidities (WIC) in patients with prolonged acute mechanical ventilation (PAMV, ventilator care ${\geq}96$ hours). Methods: We retrospectively enrolled 299 Korean PAMV patients who were admitted in a medical intensive care unit (ICU) of a university-affiliated tertiary care hospital between 2008 and 2013. Survivors were defined as patients who survived for 60 days after ICU admission. Results: The patients' mean age was $65.1{\pm}14.1$ years and 70.6% were male. The mean ICU and hospital length of stay was $21.9{\pm}19.7$ and $39.4{\pm}39.1$ days, respectively. In addition, the 60-day mortality rate after ICU admission was 35.5%. The mean WIC was $2.3{\pm}1.8$, with significant differences between nonsurvivors and survivors ($2.7{\pm}2.1$ vs. $2.1{\pm}1.7$, p<0.05). The area under the curve of receiver-operating-characteristics curve for WIC was 0.593 (95% confidence interval [CI], 0.523-0.661; p<0.05). Based on Kaplan-Meier curves of 60-day survival, WIC ${\geq}5$ had statistically lower survival than WIC <5 (logrank test, p<0.05). In a multivariate Cox proportional hazard model, WIC ${\geq}5$ was associated with poor prognosis (hazard ratio, 1.901; 95% CI, 1.140-3.171; p<0.05). The mortality rate of patients with WIC ${\geq}5$ was 54.2%. Conclusion: Our study showed a WIC score ${\geq}5$ might be helpful in predicting 60-day mortality in PAMV patients.

• Tuberculosis and Respiratory Diseases
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• v.72 no.1
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• pp.15-23
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• 2012

Background: The survival of non-small cell lung cancer (NSCLC) patients with brain metastases is reported to be 3~6 months even with aggressive treatment. Some patients have very short survival after aggressive treatment and reliable prognostic scoring systems for patients with cancer have a strong correlation with outcome, often supporting decision making and treatment recommendations. Methods: A total of one hundred twenty two NSCLC patients with brain metastases who received gamma knife radiosurgery (GKRS) were analyzed. Survival analysis was calculated in all patients for thirteen available prognostic factors and four prognostic scoring systems: score index for radiosurgery (SIR), recursive partitioning analysis (RPA), graded prognostic assessment (GPA), and basic score for brain metastases (BSBM). Results: Age, Karnofsky performance status, largest brain lesion volume, systemic chemotherapy, primary tumor control, and medication of epidermal growth factor receptor tyrosine kinase inhibitor were statistically independent prognostic factors for survival. A multivariate model of SIR and RPA identified significant differences between each group of scores. We found that three-tiered indices such as SIR and RPA are more useful than four-tiered scoring systems (GPA and BSBM). Conclusion: There is little value of RPA class III (most unfavorable group) for the same results of 6-month and 1-year survival rate. Thus, SIR is the most useful index to sort out patients with poorer prognosis. Further prospective trials should be performed to develop a new molecular- and gene-based prognostic index model.

• Korean Journal of Food Science and Technology
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• v.37 no.4
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• pp.537-541
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• 2005

Estimation of concentrations of PAHs [benzo(a)anthracene, chrysene, benzo(b)fluoranthene, benzo(k)fluoranthene, benzo(a)pyrene, dibenzo(a,h)anthracene, benzo(g,h,i)perylene, indeno(1,2,3-c,d)pyrene] in cereals, pulses, potatoes, and their products available in Korean markets gave mean levels of 0.13, 0.08, 0.06, 0.03, 0.08, 0.15, 0.45, and $0.14{\mu}g/kg$, respectively, with recoveries between 82.6-106.6%. Methodology involved saponification and extraction with n-hexane, purification on Sep-Pak Florisil cartridges, and high performance liquid chromatography using a fluorescence detector.

• Journal of Korean Clinical Nursing Research
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• v.22 no.3
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• pp.368-378
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• 2016

Purpose: This research aimed at investigating the relationship among nurses' communication style, nursing service satisfaction, hospital service satisfaction, and intent to revisit the hospital. Methods: A correlational study was conducted including 270 family members of patients who were hospitalized in general wards in a general hospital in J city. Collected data were analyzed using SPSS 21.0 and AMOS 21.0. Results: Affective communication style demonstrated the highest correlation with intent to revisit the hospital, followed by informative communication style, and authoritative communication style. Nursing service satisfaction demonstrated indirect effect through the parameter, hospital service satisfaction to the intent to revisit the hospital. Hospital service satisfaction demonstrated direct effect influencing the intent to revisit the hospital. Conclusion: With respect to nursing service, affective communication style is important to promote intent to revisit the hospital. It is necessary to improve nursing service, since it is an important variable that can improve hospital service satisfaction and hospital revisit intent.