• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2002년도 춘계공동학술발표회요약집
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• pp.242-242
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• 2002

Two MIMAS MaX fuel rods base-irradiated in a commercial PWR have been reinstrumented and irradiated at a test reactor. The fabrication data for two MOX roda are characterized together with base irradiation information. Both Rods were reinstrumented to be fitted with thermocouple to measure centerline temperature of fuel. One rod was equipped with pressure transducer for rod internal pressure whereas the other with cladding elongation detector. The post irradiation examinations for various items were performed to determine fuel and cladding in-pile behavior after base irradiation. By using well characterized fabrication and re-instrumentation data and power history, the fuel performance code, COSMOS, is verified with measured in-pile and PIE information. The COMaS code shows good agreement for the cladding oxidation and creep, and fission gas release when compared with PIE dad a after base irradiaton. Based on the re-instrumention information and power history measured in-pile, the COSMOS predicts re-instrumented in-pile thermal behaviour during power up-ramp and steady operation with acceptable accuracy. The rod internal pressure is also well simulated by COSMOS code. Therfore, with all the other verification by COSMOS code up to now, it can be concluded that COSMOS fuel performance code is applicable for the design and license for MaX fuel rods up to high burnup.

• 약학회지
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• 제55권6호
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• pp.451-455
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• 2011

So Cheong Ryong Tang (SCRT) has been used as a traditional herbal medicine for the treatment of the bronchial asthma. In this study, the effect of steaming process on changes in 11 major compounds (homogentisic acid, ephedrine HCl, paeoniflorin, cinnamic acid, cinnam aldehyde, glycyrrhizin, 6-gingerol, schizandrin, methyleugenol, gomisin A and gomisin N) content and neuroprotective activity of SCRT were evaluated. Major compound content was slightly different with steaming produce. The contents of paeoniflorin, cinnamic acid, cinnam aldehyde, 6-gingerol and methyleugenol were decreased and homogentisic acid, ephedrine HCl, glycyrrhizin, schizandrin and gomisin A were increased by steaming process. The neuroprotective activity of steaming SCRT was determined in mouse hippocampal HT22 cells by MTT assay. As a result, neuroprotective activity of a steaming SCRT was higher than that of a non steaming SCRT. This study demonstrated that neuroprotective activity of SCRT can be improved through steaming process.

• 생약학회지
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• 제42권3호
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• pp.271-275
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• 2011

Sosihotang is a herbal medicine traditionally used to treat chronic liver disease. This study was performed to investigate the effect of steaming Sosihotang at a $121^{\circ}C$ on its major compounds and neuroprotective activity. We evaluated quantitative changes of 6 major compounds in Soshihotang, saikosaponin A, homogentisic acid, baicalin, ginsenoside $Rg_3$, glycyrrhizin and 6-gingerol using HPLC-DAD. After steaming produce, saikosaponin A, homogentisic acid, baicalin, glycyrrhizin and 6-gingerol in Sosihotang were decreased and ginsenoside $Rg_3$ was increased. The neuroprotective activity of steamed Sosihotang was determined by MTT assay, comparing to Sosihotang. The steamed sosihotang showed a higher neuroprotective activity than Sosihotang. In conclusion, steam produce could improve neuroprotective activity of Soshihotang.

• 사상체질의학회지
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• 제11권1호
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• pp.41-61
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• 1999

연구목적(硏究目的) : 고대철학가(古代哲學家)들은 우주(宇宙)의 본원(本元)을 연구하는 동시에 인류생명의 기원과 본질을 탐구하였는데 기존의 정기학설(精氣學說), 음양학설(陰陽學說), 오행학설(五行學說) 등등은 이러한 시도중의 하나라고 할 수 있다. 이 글에서는 형상관(形象觀)을 사물(事物)을 바로보는 기본적인 인식체계(認識體系), 인식론(認識論), 자연현상(自然現象) 인체현상(人體現象)을 설명하는 이론적(理論的)인 도구 등으로 정의(定意)하고 동무(東武)의 형상관(形象觀)을 고찰하여 보았다. 연구방법(硏究方法) : 동무(東武)는 자신의 형상관(形象觀)을 자신의 저서(著書)인 "격치고(格致藁)", "동의수세보원사상초본권(東醫壽世保元四象草本卷)", "동의수세보원(東醫壽世保元)" 등에서 서술하고 있는데 이러한 동무(東武)의 저서(著書)를 바탕으로 그가 어떤 방법론으로 형상(形象)을 서술하는지에 대해 고찰하고, 이를 인체(人體)에 어떻게 적용하고 있는지에 대해 논(論)하였다. 결론(結論) : 이상의 과정을 통하여 다음과 같은 결론을 얻을 수 있었다. 1. "격치고(格致藁) 태극잠(太極잠)", "격치고(格致藁) 유략(儒略) 사상(事物), "동의수세보원사상초본권(東醫壽世保元四象草本卷)"에 나타나고 있는 인식의 구조는 태극(太極), 양의(兩儀), 사상(四象)을 그 기본으로 하고 있는데 태극지심(太極之心)이 있고, 거기서 이분법적(二分法的)으로 분파된 양의지심(兩儀之心)이 있고, 거기서 분파(分派)된 사상지심(四象之心)이 있다. 태극지심(太極之心)은 중앙지심(中央之心)이고, 양의지심(兩歲之心)은 신심(心身) 또는 지행(知行)으로 표현이 되는데, 심적(心的) 지적(知的) 요소의 축과 신적(身的) 행적(行的) 요소의 축이 교차하여 사심신물(事心身物)의 사상(四象)을 형성한다. 사상(四象)으로부터는 기존의 주역(周易)에서와 같은 이분법적(二分法的)인 분파(分派)에 의해 입괘(八卦)가 형성이 되는 것이 아니라며 사분법적(四分法的)인 분파(分派)에 의해 사사단(四四端)을 형성한다. 이상이 동무의 기본인식체계의 구조라 할 수 있다. 2. 동무(東武)는 사심신물(事心身物)의 사상적(四象的) 시각에서 그 기본을 삼고, 이를 다시 심신양의적(心身兩儀的) 시각에서 요약하여 정리하고 이를 태극적(太極的) 관점에서 전체적으로 요약하여 보는 인식의 요약과정을 갖는다. 3. 이상의 인식과정은 "동의수세보원(東醫壽世保元)" 성명론(性命論) 사단론(四端論) 확충론(擴充論)에도 마찬가지로 정리되어 나타나니, 천품지이정(天稟之已定)의 요소이며, 인(人)의 요소인 사물(事物)의 상하(上下)의 축과 천품지이정지외(天稟之已定之外)의 요소이며 아(我)의 차원인 심신(心身)(지행(知行))의 축을 그 기본구도로 전개하며, 그 양축을 바탕으로 사심신물(事心身物)(천인지행(天人知行))의 사원적(四元的)구도와 그 상호관계를 논(論)하고 있다. 4. 동무(東武)의 태극(太極), 양의(兩儀), 사상(四象) 다시 말해서 심(心), 심신(心身), 사심신물(事心身物)의 인식구조는 인체에서의 용어로 바뀌어져 병증론(病證論)으로의 가교 역할을 하는 장부론(臟腑論)에 표현되고 있다.

• 한국한의학연구원논문집
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• 제14권2호
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• pp.155-163
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• 2008

State Administration of Traditional Chinese Medicine of the People's Republic of China lead Research on Chao medicine's Constitutional Treatment project by which could involve the following principles. First, constitution can be identified, second, constitution correlates to ones susceptibility to diseases, third, constitution can be harmonized, fourth, prescription made according to ones constitution and patterns. These ideas is originated by Lee Je-ma's theory of Four Constitution Type in "DongEuiSooSeBoWon"(Longetivity and Life Preservation in Eastern Medicine). This is much similar to currents trends of personalized medicine in western medical sciences. Therefore further developing Lee's theory would have significant value on various fields of medicine.

• 사상체질의학회지
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• 제10권1호
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• pp.55-63
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• 1998

The symptoms that have same pathologic pattern written in the chapter of Soyangin's general pathology of the book 'Dongyi Soose Bowon' can give us a key to the Dr.Lee Je-Ma's point of view about the constitutional pathophysiology. As the result, Dr. Lee called the person who has yang-hyperactivity/yin-hypoactivity as So-Yang-In. And the Soyangin has two basic pathologic pathway ; excess of Yang-hyperactivity/excess of Yin-hypoactivity. Each pathologic pathway has variatons though, the pathologic pattern results in above two type. Excess Yin-hypoactivity has three variations of pathologic pattern. 1. smaller excess of Yin-hypoactivity with the normal range of Yang-hyperactivity 2. larger excess Yin-hypoactivity with the excitation of Yang-hyperactivity by the extrinsic factor 3. smaller excess Yin-hypoactivity with the loss of Yang-hyperactivity. And excess Yang-hyperactivity also has three variations. In my point of view, CVA, Hematemesis, Vommiting, Abdominal Pain, Gastric Dyscomfort has No.3 type and Asthmatic condition, Dysentery, Edema has No.1 type.

• 사상체질의학회지
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• 제16권3호
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• pp.118-123
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• 2004

1. Objectives Yulkyuk is the interior syndrome of Taeyangin and it's chief symptom is dysphagia. Lee Je-Ma prescribed Mihudeungsikjang-tang for Taeyangin Yulkyuk. In this case we diagnosed a woman's chief complaints as Taeyangin Yulkyuk, prescribed Mihudeungsikjang-tang and experienced the effectiveness and reproduction of Mihudeungsikjang-tang against Yulkyuk. 2. Methods To treatment Taeyangin Yulkyuk we used Mihudeungsikjang-tang 3. Results Mihudeungsikjang-tang is effective against Taeyangin Yulkyuk and curled-up tongue, dry vomiting, dizziness are also the symptoms of Yulkyuk. 4. Conclusions We have many difficulties to diagnose and treatment Taeyangin constitution because there have been few clinical study about Taeyangin yet. Further study on Taeyangin constitution is more needed.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2012년도 심포지엄 및 춘계학술발표회
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• pp.259-260
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• 2012

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2012년도 심포지엄 및 춘계학술발표회
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• pp.257-258
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• 2012

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.195.2-195.2
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• 2003

The CH$_2$Cl$_2$ fraction of the bark of Machilus thunbergii Sieb. et Zucc. (Lauraceae) significantly protected primary cultures of rat cortical cells exposed to the excitotoxic amino acid, L-glutamate. Several lignans including (-)-isoguaiacin, meso- dihydroguaiaretic acid, machilin A, (+)-galbelgin, licarin A, (-)-sesamin, and (+)-guaiacin were isolated from the CH$_2$Cl$_2$ fraction using by bioactivity-guided isolation techniques. Among these lignans, (-)-isoguaiacin, meso-dihydroguaiaretic acid, licarin A and (+)-guaiacin had significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells at concentration ranging from 0.1 ${\mu}$M to 10.0 ${\mu}$M. (omitted)