• Proceedings of the Korean Nuclear Society Conference
• /
• 2002.05a
• /
• pp.242-242
• /
• 2002

Two MIMAS MaX fuel rods base-irradiated in a commercial PWR have been reinstrumented and irradiated at a test reactor. The fabrication data for two MOX roda are characterized together with base irradiation information. Both Rods were reinstrumented to be fitted with thermocouple to measure centerline temperature of fuel. One rod was equipped with pressure transducer for rod internal pressure whereas the other with cladding elongation detector. The post irradiation examinations for various items were performed to determine fuel and cladding in-pile behavior after base irradiation. By using well characterized fabrication and re-instrumentation data and power history, the fuel performance code, COSMOS, is verified with measured in-pile and PIE information. The COMaS code shows good agreement for the cladding oxidation and creep, and fission gas release when compared with PIE dad a after base irradiaton. Based on the re-instrumention information and power history measured in-pile, the COSMOS predicts re-instrumented in-pile thermal behaviour during power up-ramp and steady operation with acceptable accuracy. The rod internal pressure is also well simulated by COSMOS code. Therfore, with all the other verification by COSMOS code up to now, it can be concluded that COSMOS fuel performance code is applicable for the design and license for MaX fuel rods up to high burnup.

• YAKHAK HOEJI
• /
• v.55 no.6
• /
• pp.451-455
• /
• 2011

So Cheong Ryong Tang (SCRT) has been used as a traditional herbal medicine for the treatment of the bronchial asthma. In this study, the effect of steaming process on changes in 11 major compounds (homogentisic acid, ephedrine HCl, paeoniflorin, cinnamic acid, cinnam aldehyde, glycyrrhizin, 6-gingerol, schizandrin, methyleugenol, gomisin A and gomisin N) content and neuroprotective activity of SCRT were evaluated. Major compound content was slightly different with steaming produce. The contents of paeoniflorin, cinnamic acid, cinnam aldehyde, 6-gingerol and methyleugenol were decreased and homogentisic acid, ephedrine HCl, glycyrrhizin, schizandrin and gomisin A were increased by steaming process. The neuroprotective activity of steaming SCRT was determined in mouse hippocampal HT22 cells by MTT assay. As a result, neuroprotective activity of a steaming SCRT was higher than that of a non steaming SCRT. This study demonstrated that neuroprotective activity of SCRT can be improved through steaming process.

• Korean Journal of Pharmacognosy
• /
• v.42 no.3
• /
• pp.271-275
• /
• 2011

Sosihotang is a herbal medicine traditionally used to treat chronic liver disease. This study was performed to investigate the effect of steaming Sosihotang at a $121^{\circ}C$ on its major compounds and neuroprotective activity. We evaluated quantitative changes of 6 major compounds in Soshihotang, saikosaponin A, homogentisic acid, baicalin, ginsenoside $Rg_3$, glycyrrhizin and 6-gingerol using HPLC-DAD. After steaming produce, saikosaponin A, homogentisic acid, baicalin, glycyrrhizin and 6-gingerol in Sosihotang were decreased and ginsenoside $Rg_3$ was increased. The neuroprotective activity of steamed Sosihotang was determined by MTT assay, comparing to Sosihotang. The steamed sosihotang showed a higher neuroprotective activity than Sosihotang. In conclusion, steam produce could improve neuroprotective activity of Soshihotang.

• Journal of Sasang Constitutional Medicine
• /
• v.11 no.1
• /
• pp.41-61
• /
• 1999

The purpose of this article is to investigate Lee Je-rna'os viewpoint of Morpho-Image. In the first place, I will define the viewpoint of Morpho-Image as the the structure of recognition and study it through bibliographic study on Lee Je-ma's work. The conclusions summarized as follows; 1. The structure of recognition, represented in "Gyukchigo(格致藁)" "Dongyi Soose Bowon Sasang Chobonkyon(東醫壽世保元四象草本卷)", is based on Taigi(太極), Liangyi(兩儀), Sasang(四象). There are the mind of Taigi(太極), the mind of Liangyi(兩儀) separated from Taigi(太極), the mind of Sasang(四象) separated from Liangyi(兩儀). The mind of Taigi(太極) is the mind of center, the mind of Liangyi(兩儀) is the mind of the mind and body(or the wisdom and action). Two axis, the mind(or wisdom) and the body(or action), cross and make Sasang(四象), affair-mind-body-object which classifies all affairs and objects of humans, society, and the universe as four types. 2. Lee Je-ma summarized everything in view of Sasang(四象), Sasang(四象) in view of Liangyi(兩儀), Liangyi(兩儀) in view of Taigi(太極). 3. The procedure of recognition above is described in , , . Such is transformed in terms of human body and described in .

• Korean Journal of Oriental Medicine
• /
• v.14 no.2
• /
• pp.155-163
• /
• 2008

State Administration of Traditional Chinese Medicine of the People's Republic of China lead Research on Chao medicine's Constitutional Treatment project by which could involve the following principles. First, constitution can be identified, second, constitution correlates to ones susceptibility to diseases, third, constitution can be harmonized, fourth, prescription made according to ones constitution and patterns. These ideas is originated by Lee Je-ma's theory of Four Constitution Type in "DongEuiSooSeBoWon"(Longetivity and Life Preservation in Eastern Medicine). This is much similar to currents trends of personalized medicine in western medical sciences. Therefore further developing Lee's theory would have significant value on various fields of medicine.

• Journal of Sasang Constitutional Medicine
• /
• v.10 no.1
• /
• pp.55-63
• /
• 1998

The symptoms that have same pathologic pattern written in the chapter of Soyangin's general pathology of the book 'Dongyi Soose Bowon' can give us a key to the Dr.Lee Je-Ma's point of view about the constitutional pathophysiology. As the result, Dr. Lee called the person who has yang-hyperactivity/yin-hypoactivity as So-Yang-In. And the Soyangin has two basic pathologic pathway ; excess of Yang-hyperactivity/excess of Yin-hypoactivity. Each pathologic pathway has variatons though, the pathologic pattern results in above two type. Excess Yin-hypoactivity has three variations of pathologic pattern. 1. smaller excess of Yin-hypoactivity with the normal range of Yang-hyperactivity 2. larger excess Yin-hypoactivity with the excitation of Yang-hyperactivity by the extrinsic factor 3. smaller excess Yin-hypoactivity with the loss of Yang-hyperactivity. And excess Yang-hyperactivity also has three variations. In my point of view, CVA, Hematemesis, Vommiting, Abdominal Pain, Gastric Dyscomfort has No.3 type and Asthmatic condition, Dysentery, Edema has No.1 type.

• Journal of Sasang Constitutional Medicine
• /
• v.16 no.3
• /
• pp.118-123
• /
• 2004

1. Objectives Yulkyuk is the interior syndrome of Taeyangin and it's chief symptom is dysphagia. Lee Je-Ma prescribed Mihudeungsikjang-tang for Taeyangin Yulkyuk. In this case we diagnosed a woman's chief complaints as Taeyangin Yulkyuk, prescribed Mihudeungsikjang-tang and experienced the effectiveness and reproduction of Mihudeungsikjang-tang against Yulkyuk. 2. Methods To treatment Taeyangin Yulkyuk we used Mihudeungsikjang-tang 3. Results Mihudeungsikjang-tang is effective against Taeyangin Yulkyuk and curled-up tongue, dry vomiting, dizziness are also the symptoms of Yulkyuk. 4. Conclusions We have many difficulties to diagnose and treatment Taeyangin constitution because there have been few clinical study about Taeyangin yet. Further study on Taeyangin constitution is more needed.

• 한국약용작물학회:학술대회논문집
• /
• 2012.05a
• /
• pp.259-260
• /
• 2012

• 한국약용작물학회:학술대회논문집
• /
• 2012.05a
• /
• pp.257-258
• /
• 2012

• Proceedings of the PSK Conference
• /
• 2003.10b
• /
• pp.195.2-195.2
• /
• 2003

The CH$_2$Cl$_2$ fraction of the bark of Machilus thunbergii Sieb. et Zucc. (Lauraceae) significantly protected primary cultures of rat cortical cells exposed to the excitotoxic amino acid, L-glutamate. Several lignans including (-)-isoguaiacin, meso- dihydroguaiaretic acid, machilin A, (+)-galbelgin, licarin A, (-)-sesamin, and (+)-guaiacin were isolated from the CH$_2$Cl$_2$ fraction using by bioactivity-guided isolation techniques. Among these lignans, (-)-isoguaiacin, meso-dihydroguaiaretic acid, licarin A and (+)-guaiacin had significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells at concentration ranging from 0.1 ${\mu}$M to 10.0 ${\mu}$M. (omitted)