• Natural Product Sciences
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• v.21 no.1
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• pp.34-41
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• 2015

The objective of this study is to characterize a toxicity of Epimedii Herba (EH) in F344 rats and to find a dose levels for the 13 weeks toxicity study. EH is well known as medicinal herb in many Asian countries for traditional medicines of antibacterial and antiviral effects, estrogenic and antiestrogenic effects, and for treatment of osteoporosis, hypotensives, fatigue, kidney disorders, and related complications. However, the indispensable and basic information of toxicological evaluation of EH extract is insufficient to support its safe use. Therefore, we conducted toxicological evaluation of this drug in compliance with OECD and MFDS guideline in this study. The extract of EH was administered orally to F344 rats at dose levels of 0, 500, 1000, 2000, 3500, and 5000 mg/kg/day for 2 weeks. Each group was composed of 5 male and female rats. In this study, there were no treatment of EH-related adverse changes in clinical observations, mortality, body weights, food consumption, urinalysis, gross finding at necropsy, and organ weight examination. Total red blood cell count, hematocrit, mean corpuscular hemoglobin concentration, total cholesterol, and phospholipid were decreased in males and females at 5000 mg/kg/day compared to the control animals. Mean corpuscular volume and reticulocyte counts were increased in males and females at 5000 mg/kg/day compared to control animals. Therefore, we recommend that dose level of 5000 mg/kg/day is a highest treatment group in 13-week EH extract exposure study for further toxicity assessment.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6819-6822
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• 2014

Background: The aim of this study was to evaluate the accuracy of a new scoring system in Korean patients with hematuria at high risk of bladder cancer. Materials and Methods: A total of 319 consecutive patients presenting with painless hematuria without a history of bladder cancer were analyzed, from the period of August 2012 to February 2014. All patients underwent clinical examination, and 22 patients with incomplete data were excluded from the final validation data set. The scoring system included four clinical parameters: age (${\geq}50$ = 2 vs. <50 =1), gender (male = 2 vs. female = 1), history of smoking (smoker/ex-smoker = 4 vs. non-smoker = 2) and nature of the hematuria (gross = 6 vs. microscopic = 2). Results: The area under the receiver-operating characteristic curve (95% confidence interval) of the scoring system was 0.718 (0.655-0.777). The calibration plot demonstrated a slight underestimation of bladder cancer probability, but the model had reasonable calibration. Decision curve analysis revealed that the use of model was associated with net benefit gains over the treat-all strategy. The scoring system performed well across a wide range of threshold probabilities (15%-45%). Conclusions: The scoring system developed is a highly accurate predictive tool for patients with hematuria. Although further improvements are needed, utilization of this system may assist primary care physicians and other healthcare practitioners in determining a patient's risk of bladder cancer.

• Korean Journal of Veterinary Research
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• v.43 no.1
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• pp.165-169
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• 2003

The aim of the present study was to analyse grunts of the sows and to extract parameters from the time and frequency signals in nursing behavior. Five crossbred $Landrace{\times}Yorkshire$ sows were used on day 5 or 6 postpartum. The grunts and the behaviors of the five sows were recorded with five digital camcorders. Three parameter groups [Group I: Formant vector alone, Group II: Formant vector+parameters from time signal, Group III: Formant vector+parameters from time signal-parameters eliminated by stepwise discriminant analysis backward (SDAB)] with parameter vectors extracted from single grunts in the maximum grunting rate period were used for individuality of the sows. The parameter groups were compared by a discriminant function analysis. The classification system adopted in the Group II represented the higher discriniation rate than those in other groups (Group I: 63.3%, Group II: 83.0%, Group III: 80.0%). This study demonstrated that formant, intensity, and pitch were available sound parameters for individuality of the sows during nursing behavior.

• The Korean Journal of Ecology
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• v.24 no.1
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• pp.27-34
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• 2001

We described the vegetation of a disturbed lagoon wetland in relation to water and soil environments in Kungae lagoon reclaimed 30 years ago. Water depth and soil organic matter showed a great spatial heterogeneity in Kungae wetland which was changed into a freshwater marsh by the dike construction. Detrended canonical correspondence analysis suggested that differences in vegetation structure were primarily the result of variation in water depth or microtopography and soil organic matter Various emergent vegetations were developed in the wetland: species such as Phragmites australis, Calamagrostis epigeios, Carex dispalata and Lythrum anceps in a wide area, hydrophyes such as Typha angustifolia and Scirpus tabernaemontani at the low elevation with deep water, ruderals such as Bidens frondosa and Persicaria perfoliata near upland with much soil organic matter and sand-dune vegetation such as Carex kobomugi, Diodia tens, Pinus thunbergii and Potentilla egedei var. groenlandica at the high elevation. These results suggest that development of a prototype for wetland restoration from vegetation analysis of other natural lagoons and restoration of natural water tables and hydrologic connections between the diked wetland and the sea are important in the disturbed Kungae wetland.

• Korean Journal of Pharmacognosy
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• v.39 no.3
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• pp.233-236
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• 2008

In order to find the antioxidative components, fractionation of Cyperus amuricus (Cyperaceae) methanol extract was performed by measuring the DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging effect. Three compounds, 3,4-dimethoxy benzoic acid (1), 4-hydroxybenzoic acid (2), and piceatannol (3) were isolated from the active ethylacetate soluble fraction of C. amuricus through repeated silica gel and Sephadex LH-20 column chromatography. Among them, compound 3 showed the significant antioxidative effect on DPPH free radical scavenging test. These compounds are reported for the first time from this plant.

• The Plant Pathology Journal
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• v.25 no.2
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• pp.165-171
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• 2009

Biological control activity of Acremonium strictum BCP, a mycoparasite on Botrytis cinerea, was examined against six plant diseases such as rice blast, rice sheath blight, cucumber gray mold, tomato late blight, wheat leaf rust, and barley powdery mildew in growth chambers. The spore suspension of strain BCP showed strong control activities against five plant diseases except against wheat leaf rust. On the other hand, the culture filtrate of A. strictum BCP was effective in controlling only cucumber gray mold and barley powdery mildew. Further in vivo biocontrol activities of A. strictum BCP against tomato gray mold were investigated under greenhouse conditions. Control efficacy of the fungus on tomato gray mold increased in a concentration-dependent manner. Treatment of more than $1{\times}10^6$ spores/ml significantly controlled the disease both in tomato seedlings and in adult plants. The high disease control activity was obtained from protective application of the strain BCP, whereas the curative application did not control the disease. Foliar infections of B. cinerea were controlled with $1{\times}10^8$ spores/ml of A. strictum BCP applied up to 7 days before inoculation. In a commercial greenhouse, application of A. strictum BCP exhibited the similar control efficacy with fungicide procymidone (recommended rate, $500{\mu}g/ml$) against strawberry gray mold. These results indicate that A. strictum BCP could be developed as a biofungicide for Botrytis diseases under greenhouse conditions.

• Journal of the Korean Applied Science and Technology
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• v.37 no.5
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• pp.1151-1158
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• 2020

The purpose of this study was to examine the mediating effects of perceived nursing professionalism and career preparation behavior on the effects of major satisfaction of nursing students. For this purpose, 231 nursing students from 4 university in 4 city were sampled for convenience. The result of this study were as follows:First, nursing professionalism of nursing students directly affected career preparation behavior and major satisfaction, which was statistically significant. Second, nursing professionalism showed mediating effects in relationship between career preparation behavior. Third, the major satisfaction of nursing students directly affected nursing professionalism and career preparation behavior. Based on the results of the research, it is necessary to develop an intervention program that strengthen major satisfaction of nursing students.

• Journal of Korean Academy of Nursing Administration
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• v.13 no.3
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• pp.352-361
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• 2007

Purpose: The purpose of this study was to develop roles and organizational policy of advanced practice nurses (APNs) in an acute hospital setting. Method: The design of the study was to descriptive-exploratory. Sample consisted of 43 participants who included 13 nurses, 18 nurse managers and 12 physicians. Survey, interview and focus group interview were performed to obtain the data. Results: The expected roles of APNs were education and counseling, direct management patient care with advanced skills, research, and collaboration and coordination among several departments. The expected outcomes were patient satisfaction, improved access to care, decreased the rate of complications, and speedy provision of services. Based on research, a proposal of APNs roles and organizational policy in a hospital setting was developed, which included definition of APNs, qualification, roles and specific roles, specialty areas, accountability, recruitment and affiliation, privileges, and expected outcomes. Conclusion: This study gives a guideline on how to introduce and use APNs in acute care tertiary settings.

• Journal of Korean Academy of Nursing
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• v.42 no.2
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• pp.181-189
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• 2012

Purpose: This study was done to compare breast feeding rates and factors influencing feeding practice between late preterm ($34{\leq}GA<37$) and preterm infants (GA<34). Methods: A survey was done of 207 late preterm and 117 preterm infants in neonatal intensive care units (NICU) of 4 university hospitals in D city. Data were collected from July 2009 to June 2010 from 324 medical records in the NICU. Breast-feeding at home was checked either by telephone survey or questioning during hospital visits. Results: Rate of breast feeding for late preterm infants was significantly lower than for preterm infants. There was no significant difference in breast-feeding at home. We found differences in factors influencing breast feeding between the two groups. Factors influencing feeding for late preterm infants were type of delivery, mothers' occupation, feeding type during hospitalization, time elapse from hospital discharge, total admission days, infant's body weight at first feeding and length of NPO (nothing by mouth). Factors influencing feeding for preterm infants were birth order, maternal disease and obstetric complications, and one-minute Apgar score. Conclusion: Results of the study show low rates of breast-feeding for late preterm infants indicating a need for breast-feeding education for mothers of these infants.

• Imaging Science in Dentistry
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• v.44 no.1
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• pp.15-20
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• 2014

Purpose: This study aimed to assess the three-dimensional (3D) facial changes after orthognathic surgery by evaluating the spherical coordinates of facial lines using 3D computed tomography (CT). Materials and Methods: A 19-year-old girl was diagnosed with class III malocclusion and facial asymmetry. Orthognathic surgery was performed after orthodontic treatment. Facial CT scans were taken before and after orthognathic surgery. The patient had a menton deviation of 12.72 mm before surgery and 0.83 mm after surgery. The spherical coordinates of four bilateral facial lines (ramal height, ramal lateral, ramal posterior and mandibular body) were estimated from CT scans before and after surgery on the deviated and opposite side. Results: The spherical coordinates of all facial lines changed after orthognathic surgery. Moreover, the bilateral differences of all facial lines changed after surgery, and no bilateral differences were zero. Conclusion: The spherical coordinate system was useful to compare differences between the presurgical and postsurgical changes to facial lines.