• Journal of the Korean Society of Clothing and Textiles
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• v.29 no.2
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• pp.286-297
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• 2005

Recently, due to the gloalization of the industry environment and the consequent multi-national companies led by industrialized countries, fashion companies of newly industrialized countries are pursuing to globalize their businesses. This study conducted to review the global configuration of activities of the added value chain, the strategies to enhance global competitiveness, and global performance of value activities of Korean fashion companies. The data were collected from the survey by questionnaire on Korean fashion companies. The methods of analysis used in this study were regression, and descriptive statistics of the data. the results werw as follows. First, Korean fashion companies were undergoing diverse value activities through their foreign subsidiaries and overseas out-sourced companies in a wide spectrum of business activities ranging from design/planning o products to marketing/logistics. Second, the global competitive strategies that the Korean fashion companies were most focused on were the cost/productivity aspects. The efforts to differentiate the products from competitors, the efforts for innovation, an the efforts of growth were the next strategies. The strategy that was least emphasized was on seeking alliance with other business partners. Third, the result of the globalization efforts showed an overseas market growth of and average of 9%, and an average overseas market profit of 7.8%. The overall satisfaction on the result of the overseas market activities, and the rate of accomplishment of market targets were generally low.

• Restorative Dentistry and Endodontics
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• v.20 no.2
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• pp.577-609
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• 1995

Bacteria have been regarded as one of the most important factors in pulpal and periapical diseases. Streptococci are frequently isolated facultative anaerobes in infected root canals. Recently molecular biological techniques have been rapidly progressed. This study was designed to apply the molecular biological tools to the identification and classification of streptococci in the endodontic microbiology. Streptococci isolated from infected root canals were identified with both Vitek Systems and API 20 STREP. Identification results were somewhat different in several strains of streptococci. Eighteen streptococci and enterococcal was difficult so to digest plasmid DNA using Hind III and EcoRI to differentiate strains by restriction enzyme analysis of plasmid DNA. 16S rDNA of chromosome was amplified by polymerase chain reaction(PCR) and then restricition fragment length polymorphism(RFLP) using several restriction enzymes was observed. The molecular mass of 16S rDNA of chromosomal DNA was approximately 1.4kb. There were three to five RFLP patterns using eight restriction enzymes. RFLP patterns digested with CfoI which recognizes four base sequences were identical in all stains. Hind III which recognizes six base sequences could not digest the 16S rDNA. Restriction enzymes which recognize five base sequences were suitable for RFLP pattern analysis. At least three different restriction enzymes were needed to compare each strains. 16S rDNA PCR-RFLP was simple and rapid to differentiate and classify strains and could be used in the epidemiological study of root canal infections.

• Korean Institute of Interior Design Journal
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• v.25 no.2
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• pp.92-100
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• 2016

Recently, new detached houses on a small plot in low-rise residential urban area have attracted more public interests than ever before. This study aims to categorize basic types of interior plans in small urban detached houses by analyzing the layouts of the public space(LDK) within them which are popular in Japan. The results of this study may be summarized as follows. Unit floor plans were basically classified as 16 types according to the layout of LDK. Among these, the LDK type in a straight line shows the most at 28.9%. Again, these plans were sub-classified into 38 types by plan composition. The new 'LDKL' (a new term the authors propose to be used) type was observed in cases where K was directly connected to L. This type appears at 9 out of 38 types. In the connection of LDK, the LDK type shows the most at 60.8%; secondly the L-DK type at 29.9%; thereafter the LD-K type at 6.2%; and lastly L-D-K type, the least frequently at 1.0%. The cases of inter-level connection between LDK and the surrounding space were observed in various cases such as the open workplace of the upstairs hallway visually connected with LDK through the void space and as the attic space of the pitched roof visually linked to it.

• Biomolecules & Therapeutics
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• v.20 no.3
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• pp.306-312
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• 2012

Resveratrol (trans-3,5,4'-trihydroxystilbene) has received considerable attention recently for the potential neuroprotective effects in neurodegenerative disorders where heme oxygenase-1 (HO-1) and sirtuin 1 (SIRT1) represent promising therapeutic targets. Resveratrol has been known to increase HO-1 expression and SIRT1 activity. In this study, the effects of resveratrol and trans-3,5,4'-trimethoxystilbene (TMS), a resveratrol derivative, on cytotoxicity caused by glutamate-induced oxidative stress, HO-1 expression, and SIRT1 activation have been investigated by using murine hippocampal HT22 cells, which have been widely used as an in vitro model for investigating glutamate-induced neurotoxicity. Resveratrol protected HT22 neuronal cells from glutamate-induced cytotoxicity and increased HO-1 expression as well as SIRT1 activity in a concentration-dependent manner. Cytoprotection afforded by resveratrol was partially reversed by the specific inhibition of HO-1 expression by HO-1 small interfering RNA and the nonspecific blockage of HO-1 activity by tin protoporphyrin IX, but not by SIRT1 inhibitors. Surprisingly, TMS, a resveratrol derivative with methoxyl groups in lieu of the hydroxyl groups, and trans-stilbene, a non-hydroxylated analog, failed to protect HT22 cells from glutamate-induced cytotoxicity and to increase HO-1 expression and SIRT1 activity. Taken together, our findings suggest that the cytoprotective effect of resveratrol was at least in part associated with HO-1 expression but not with SIRT1 activation and, importantly, that the presence of hydroxyl groups on the benzene rings of resveratrol appears to be necessary for cytoprotection against glutamate-induced oxidative stress, HO-1 expression, and SIRT1 activation in HT22 neuronal cells.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.11a
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• pp.731-736
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• 2000

The recently developed BEM-based NAH(nearfield acoustical holography) is a useful technique for identifying the sound source of vibrating objects. The acoustic parameters of a sound source can be reconstructed by using the vibro-acoustic transfer matrix, which is determined by means of BEM, and the sound pressure measured in the nearfield. Theoretically, one can come up with a very nice reconstructed result as the field plane gets near to the source surface. However, when a microphone is placed in the very close nearfield of the source surface, the scattering, reflection, or resonance in the gap between the source and the microphone can distort the acoustic field, and therefore, the measured field pressure would differ from the actual one in the absence of the microphone. In order to analyze this problem, the interference effect of the microphone is numerically calculated by using the nonsingular BEM that yields very small error in the nearfield. From this analysis, it is found that the prediction error of the field pressure decreases firstly and then increases as the microphone approaches the vibrating surface from the farfield to the close nearfield. It is noted that the microphone should be separated from the source surface by at least a diameter of the microphone for an error ratio less than 2% in the low frequency range less than about 2.7kHz. This means that if one wants to put a microphone in the very close nearfield. a microphone with small diameter should be used.

• Journal of Korea Multimedia Society
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• v.10 no.5
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• pp.583-593
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• 2007

We study the page replacement algorithms for demand paging, called CFLRU/C, CFLRU/E and DL-CFLRU/E, that reduce the number of erase operations and improve the wear-leveling degree of flash memory. Under the CFLRU/C and CFLRU/E algorithms, the victim page is the least recently used dean page within the pre-specified window. However, when there is not any dean page within the window, the CFLRU/C evicts the dirty page with the lowest frequency while the CFLRU/E evicts the dirty page with the highest number of erase operations. The DL-CFLRU/E algorithm maintains two page lists called the dean page list and the dirty page list, and first finds the page within the dean page list when it selects a victim. However, when it can not find any dean page within the dean page list, it evicts the dirty page with the highest number of erase operations within the window of the dirty page list. In this thesis, we show through simulation that the proposed schemes reduce the number of erase operations and improve the wear-leveling than the existing schemes like LRU.

• Journal of Radiation Industry
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• v.9 no.4
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• pp.193-198
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• 2015

Most of targeted therapies block the action of certain enzymes, proteins, or other molecules involved in the growth and spread of cancer cells to produce its cytotoxic effect. Either small molecule drugs or monoclonal antibodies are mostly used in targeted therapies. Unfortunately, targeted therapy has a certain degree of unwanted side effect like other cytotoxicity inducing chemotherapies. To overcome and to reduce unwanted side effects during a cancer therapy, recently radiopeptide therapies has got the worlds' attraction for the tumor targeting modalities due to its beneficial effect on less side effect compared to cytotoxic chemotherapies. Among radiopeptide therapies, $^{177}Lu$-DOTATATE is a major modality as an effective one invented so far in treating neuroendocrine tumor (NET) and it has been in clinical trials at least one decade. Although it does have rather effective therapeutic effect on NET, it has less effective in rather large solid tumor. There are many ways to improve or increase therapeutic effect of radiopeptide are a finding the potent small molecules to target the tumor site selectively, or a labeling with radioisotope of emitting high energy, or an improving its biological half-life by introducing different moieties to increase lipophilicity. Present study was focus to increase a biological half-life of radio somatostatin which will target the somatostatin receptor by altering the bifunctional chelator (BFCA) by introducing lipophilic moiety to the somatostatin, which would make the labeled peptide stay longer in the tumor site and thus it can intensify the therapeutic effect on tumor cell itself and around tissues.

• Journal of Information Technology Services
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• v.20 no.4
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• pp.95-111
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• 2021

Recently, many organizations are actively adopting VDI (Virtual Desktop Infrastructure), an IT-based business system, to build a non-face-to-face business environment for smart-work. However, most of the existing research on VDI has focused on the satisfaction of system service quality or the use of IT resources and investment for VDI introduction. However, research on effective management and utilization of factors according to the characteristics of VDI technology is urgently required. This study is an empirical research study on how VDI technology characteristics affect interactions and work performance by identifying differences in utilization factors between general organization members and IT managers, presenting standards for business utilization and management. This study proposed a model and hypothesis that the system technology characteristics for VDI use are mediated by interactions in which users respond to functions appropriate to their work. In order to verify the hypothesis, a questionnaire survey was conducted on 188 people of companies and institutions that have adopted and used VDI through a questionnaire survey. Data analysis was performed with partial least squares (PLS), a structural equation modeling (SEM) technique that uses a component-based approach to estimation. As a result of the empirical analysis, the same environmental function for performing work, N-th security, and remote access function factors for non-face-to-face work have a significant effect on interactivity, and IT managers have an additional significant effect on the management technology characteristics of resource reallocation. Has been shown to affect. The results of this study aim to minimize trial and error due to new introduction by presenting considerations for future VDI introduction through case analysis.

• The Korean journal of internal medicine
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• v.33 no.6
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• pp.1234-1240
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• 2018

Background/Aims: Red blood cell distribution width (RDW) is a value representing the heterogeneity in the size of red blood cell, and it is usually used in distinguishing types of anaemia. Recently, it was reported that it could reflect the burden of inflammation in diverse diseases and their prognosis. Hence, in this study, we investigated whether RDW may contribute to discriminating adult onset Still's disease (AOSD) from sepsis in serious febrile patients within 24 hours after hospitalization. Methods: We reviewed the medical records and enrolled 21 AOSD patients, 27 sepsis patients and 30 matched healthy controls. We collected at least two laboratory results of variables including RDW within 24 hours after hospitalization, and we calculated their mean values. Results: Sepsis patients showed the significantly increased median white blood cell count, compared to AOSD patients ($14,390.0/mm^3$ vs. $12,390.0/mm^3$, p = 0.010). The median RDW in sepsis patients was higher than that in AOSD patients (15.0% vs. 13.3%, p = 0.001), and furthermore, the median RDW in both patient-groups was significantly higher than that in healthy controls. In contrast, the median ferritin level in sepsis patients was lower than that in AOSD patients (544.0 mg/dL vs. 3,756.6 mg/dL, p = 0.001). In multivariate analysis, RDW ${\geq}14.8%$ (odds ratio, 17.549) and ferritin < 2,251.0 mg/dL (odds ratio, 32.414) independently suggested sepsis more than AOSD in patients initially presenting with fever requiring hospitalization. Conclusions: RDW might be a rapid and helpful marker for a differential diagnosis between AOSD from sepsis at an early phase.

• Journal of Ocean Engineering and Technology
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• v.32 no.6
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• pp.419-426
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• 2018

Recently, in an effort to reduce the energy efficiency design index (EEDI), studies on energy saving devices (ESDs) have been conducted. In this study, we designed a post-device suitable for a KRISO container ship (KCS) using computational fluid dynamics (CFD). In order to increase the efficiency of the post-device, a twisted rudder was used, which has a proven performance (showing a 1.34% reduction in DHP compared to the bare hull at 24 knots) in previous research at Pusan National University. In addition, an increase in efficiency was expected by the use of a rudder bulb, including the discontinuous section of the twisted rudder and a divergent propeller cap to prevent the contraction of the wake. The optimization criterion was the case where the delivery power was the least compared with the bare hull. We analyzed the cause of the efficiency increase through an analysis of the self-propulsion factor. The case study for optimization was divided into 4 types (1. clearance of the bulb and cap, 2. shape of the bulb, 3. size of the bulb and cap, and 4. asymmetric bulb). Finally, with a clearance of 50 mm from the ship, a spherical bulb with the cap having an angle of $5^{\circ}$, and an asymmetric rudder bulb with a bulb diameter of 1.2HH/1.4H (horizontal/vertical) showed a 2.05% reduction in DHP compared to the bare hull at 24 knots. We will fabricate a post-device that will be optimized in the future and verify the performance of the post-device through model tests.