• Biomolecules & Therapeutics
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• v.30 no.1
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• pp.98-116
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• 2022

The small GTPase RhoA has been studied extensively for its role in actin dynamics. In this study, multiple bioinformatics tools were applied cooperatively to the microarray dataset GSE64714 to explore previously unidentified functions of RhoA. Comparative gene expression analysis revealed 545 differentially expressed genes in RhoA-null cells versus controls. Gene set enrichment analysis (GSEA) was conducted with three gene set collections: (1) the hallmark, (2) the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and (3) the Gene Ontology Biological Process. GSEA results showed that RhoA is related strongly to diverse pathways: cell cycle/growth, DNA repair, metabolism, keratinization, response to fungus, and vesicular transport. These functions were verified by heatmap analysis, KEGG pathway diagramming, and direct acyclic graphing. The use of multiple gene set collections restricted the leakage of information extracted. However, gene sets from individual collections are heterogenous in gene element composition, number, and the contextual meaning embraced in names. Indeed, there was a limit to deriving functions with high accuracy and reliability simply from gene set names. The comparison of multiple gene set collections showed that although the gene sets had similar names, the gene elements were extremely heterogeneous. Thus, the type of collection chosen and the analytical context influence the interpretation of GSEA results. Nonetheless, the analyses of multiple collections made it possible to derive robust and consistent function identifications. This study confirmed several well-described roles of RhoA and revealed less explored functions, suggesting future research directions.

• International Journal of Internet, Broadcasting and Communication
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• v.15 no.1
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• pp.13-22
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• 2023

In the age of Web 3.0, the metaverse is emerging as a new innovative element to replace the Internet. Leading major ICT companies, it is striving to become a metaverse platform or infrastructure-oriented company. Along with the expansion of the VR and AR market, governments of each country are investing large budgets in this field. However, security concerns about metaverse are also growing. In addition to potential damage to infrastructure, platform and services, personal information leakage and privacy damage are expected to increase further. In this study, we investigated and closely analyzed cases of infringement on the infrastructure, platform, and service of Metaverse. We have clearly identified the current state of metaverse security and the characteristics of the risks of greatest concern. The research procedure is composed of a method of determining the metaverse security area for case analysis first and deriving the type of threat by area through the type of infringement. In particular, the results were mapped into Domain, Case, and Threat, and the implications of the results were analyzed. Through these results, researchers want to contribute to finding the right direction of research by clearly understanding the latest metaverse security status.

• Membrane and Water Treatment
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• v.14 no.2
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• pp.95-106
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• 2023

In the developing country like India, groundwater is the main sources for household, irrigation and industrial use. Its contamination poses hydro-geological and environmental concern. The hazardous waste sites such as landfills can lead to contamination of ground water. The contaminants existing at such sites can eventually find ingress down through the soil and into the groundwater in case of leakage. It is necessary to understand the process of migration of pollutants through sub-surface porous medium for avoiding health risks. On this backdrop, the present paper investigates the behavior of pollutants' migration through porous media. The laboratory experiments were carried out on a soil-column model that represents porous media. Two different types of soils (standard sand and red soil) were considered as the media. Further, two different solutes, i.e., non-reactive and reactive, were used. The experimental results are simulated through numerical modeling. The percentage variation in the experimental and numerical results is found to be in the range of 0.75- 11.23 % and 0.84 - 1.26% in case of standard sand and red soil, respectively. While a close agreement is observed in most of the breakthrough curves obtained experimentally and numerically, good agreement is seen in either result in one case.

• Proceedings of the KIPE Conference
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• 2020.08a
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• pp.157-159
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• 2020

This paper presents an optimal planar transformer design of a 3-kW Low voltage DC-DC Converter (LDC) with 3.68 kW/L power density for electric vehicle (xEV) application. The transformer is optimized based on the trade-off between footprint and loss using the proposed figure-of-merit (FOM) based optimization. In order to achieve ZVS under entire load range, an external leakage inductance is added and implemented using the proposed magnetic integration technique. A comparison between non-integrated and integrated magnetic core using finite element analysis (FEA) is presented. The result shows that the integrated core can reduce the core loss up to 35 % and core boxed volume up to 15 % compared to the non-integrated core. Experimental results are also provided to validate the proposed magnetic integration technique.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5A
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• pp.817-822
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• 2006

Post-tensioning the full-depth precast slab longitudinally is to eliminate the tensile stresses in the transverse joints and to prevent any leakage through the joints. When the prestressing is applied to full-depth precast slab which does not composite steel girder, stress concentration occurs at the corners of shear pocket, and compressive stress is not uniformly distributed in the section of precast slab. In this paper, full-depth precast slabs using four different shapes of shear pockets are analyzed by commercial finite element program. Round type of shear pockets is superior to reduction in stress concentration.

• Transactions of Materials Processing
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• v.33 no.3
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• pp.169-177
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• 2024

Recently, hydrogen energy has been widely used because of strict regulations on greenhouse gas emissions. For using the hydrogen energy, it is required to supply hydrogen through a tube trailer. However hydrogen tube trailer can have excessive load problems during transportation due to reasons such as road shape and driving method, which may lead a risk of hydrogen leakage. So it is necessary to secure a high level of safety. The purpose of this study is to evaluate structural safety for the conservative design of hydrogen tube trailer. First, finite element(FE) modeling of the designed hydrogen tube trailer was performed. After that, safety evaluation method was established through static structural simulation based on the standard GC207 conditions. In addition, effectiveness of the designed model was confirmed through the results of the structural safety evaluation. Finally, driving simulation was used to derive acceleration graph according to time, which was considered as a dynamic property for the evaluation of conservative tube trailer safety evaluation. And dynamic structural simulation was conducted as a condition for actual transportation of tube trailer by applying dynamic properties. As a results, conservative safety was evaluated through dynamic structural simulation and the safety of hydrogen tube trailer was confirmed through satisfaction of the safety rate.

• Nuclear Engineering and Technology
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• v.56 no.8
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• pp.3397-3404
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• 2024

The shield building of the AP1000 nuclear power plant serves as a crucial protective barrier against radioactive substances. However, past research indicates that structures are susceptible to experiencing aftershocks, which may lead to unforeseeable damage and potential radioactive material leakage. To address this issue, a finite element model of the shield building was established with the damage indexes of the tensile and compressive damage selected for further model analysis. According to the fundamental theory of reliability, the traditional incremental dynamic analysis method was used to analyze the seismic fragility of the shield building by inputting mainshock and aftershock sequences with three strength ratios. The results indicate that the seismic fragility of shield building may be underestimated without considering the influence of aftershocks and the damage state presents an upward tendency as the strength ratio increases. However, the cumulative damage caused by aftershocks is unlikely to exceed the initial damage induced by the corresponding mainshock. Overall, the aggravation of the compressive damage is less pronounced than the increase of the tensile damage as the strength ratio increases.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.843-850
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• 2020

The purpose of this study is to evaluate the structural risk and weakness of a railway tank car through nonlinear collision analysis according to overseas collision safety standards. The goal is to propose a crash safety design guideline for railway tank cars for transporting dangerous goods in Korea. We analyzed the buffer impact test procedure of railway freight cars prescribed in EN 12663-2 and the tank puncture test criteria prescribed in 49CFR179. A nonlinear finite element model according to each standard was modeled using LS-DYNA, a commercial finite element analysis solver. As a result of the buffing impact test simulation, it was predicted that plastic deformation would not occur at a collision speed of 6 km/h or less. However, plastic deformation was detected at the rear of the center sill and at the tank center supporting the structure at a collision speed of 8 km/h or more. As a result of a head-on test simulation of tank puncture, the outer tank shell was destroyed at the corner of the tank head when 4% of the kinetic energy of the impacter was absorbed. The tank shell was destroyed in the area of contact with the impacter in the test mode analysis of tank shell puncture when the kinetic energy of the moving vehicle was reduced by 30%. Therefore, the simulation results of the puncture test show that fracture at the tank shell and leakage of the internal material is expected. Consequently, protection and structural design reinforcement are required on railway tank cars in Korea.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.579-584
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• 2017

The damper oil seal of a high-speed railway vehicle is made from nitrile butadiene rubber (NBR) in order to prevent lubricant from leaking into the damper and to stop harmful contaminants from entering the external environment while in service. Oil leakage through the seal primarily occurs from fatigue failure of the damper. Cumulative damage of the seal occurs due to the contact force between the rod and the rubber during movement due to track irregularities and cants, among other factors. Thus, the design of the oil seal should minimize the maximum principal strain at weak points. In this study, the optimal cross section of the damper oil seal was found using the multi-island genetic algorithm method to improve the durability of the damper. The optimal shape of the oil seal was derived using process automation and design optimization software. Nonlinear material properties for finite element analysis (FEA) of the rubber were determined by Marlow's model. The nonlinear FEA confirmed that the maximum principal strain at the oil leakage point was decreased 24% between the initial design and the optimum design.

• Journal of the Korean Vacuum Society
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• v.17 no.3
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• pp.175-182
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• 2008

This study is concerned with the evaluation of the corrosion resistance of coated semiconductor equipment parts with various processes. To select the appropriate basis for evaluation, replacement parts were observed during the semiconductor manufacturing process. This study also ran a dry corrosion test using $Al_2O_3$, which is mostly used as a coating material. This test quantitatively measured the efficiency of coated parts. Surface morphology, leakage current and breakdown voltage were also evaluated. This study showed that a dry corrosion process led to the drop of electrical properties, for example, the leakage current increase and the dielectric strength decrease. The surface morphology test displayed that surface damage is largely dependent on the exposure time to corrosive environments. By using the values that changed during the corrosion process, it may be possible to contrive a method to evaluate the efficiency of coated parts with various processes.