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Stem Cells and Cell-Cell Communication in the Understanding of the Role of Diet and Nutrients in Human Diseases

  • Trosko James E.
    • Journal of Food Hygiene and Safety
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    • v.22 no.1
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    • pp.1-14
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    • 2007
  • The term, "food safety", has traditionally been viewed as a practical science aimed at assuring the prevention acute illnesses caused by biological microorganisms, and only to a minor extent, chronic diseases cause by chronic low level exposures to natural and synthetic chemicals or pollutants. "food safety" meant to prevent microbiological agents/toxins in/on foods, due to contamination any where from "farm to Fork", from causing acute health effects, especially to the young, immune-compromised, genetically-predisposed and elderly. However, today a broader view must also include the fact that diet, perse (nutrients, vitamins/minerals, calories), as well as low level toxins and pollutant or supplemented synthetic chemicals, can alter gene expressions of stem/progenitor/terminally-differentiated cells, leading to chronic inflammation and other mal-functions that could lead to diseases such as cancer, diabetes, atherogenesis and possibly reproductive and neurological disorders. Understanding of the mechanisms by which natural or synthetic chemical toxins/toxicants, in/on food, interact with the pathogenesis of acute and chronic diseases, should lead to a "systems" approach to "food safety". Clearly, the interactions of diet/food with the genetic background, gender, and developmental state of the individual, together with (a) interactions of other endogenous/exogenous chemicals/drugs; (b) the specific biology of the cells being affected; (c) the mechanisms by which the presence or absence of toxins/toxicants and nutrients work to cause toxicities; and (d) how those mechanisms affect the pathogenesis of acute and/or chronic diseases, must be integrated into a "system" approach. Mechanisms of how toxins/toxicants cause cellular toxicities, such as mutagenesis; cytotoxicity and altered gene expression, must take into account (a) irreversible or reversal changes caused by these toxins or toxicants; (b)concepts of thresholds or no-thresholds of action; and (c) concepts of differential effects on stem cells, progenitor cells and terminally differentiated cells in different organs. This brief Commentary tries to illustrate this complex interaction between what is on/in foods with one disease, namely cancer. Since the understanding of cancer, while still incomplete, can shed light on the multiple ways that toxins/toxicants, as well as dietary modulation of nutrients/vitamins/metals/ calories, can either enhance or reduce the risk to cancer. In particular, diets that alter the embryo-fetal micro-environment might dramatically alter disease formation later in life. In effect "food safety" can not be assessed without understanding how food could be 'toxic', or how that mechanism of toxicity interacts with the pathogenesis of any disease.

Married Woman's Family Life Management Behavior - Consumer's Purchase Behavior, Dietary Life Behavior, and Satisfaction of Well-Being Oriented Food - (기혼여성의 가정생활관리행동: 웰빙지향 식품 구매행동 및 식생활 행동과 소비만족도)

  • Han, Sung-Hee
    • Journal of Family Resource Management and Policy Review
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    • v.14 no.2
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    • pp.127-152
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    • 2010
  • This study examined the satisfaction of the married women from aged 20s through 50s with well-being oriented foods, considering the importance of each subordinate field and verifying the differences between the groups according to socio-demographic factors, purchase behavior factors, and well-being oriented dietary life factors, followed by an analysis of the relative influence of those relevant factors. A preliminary survey was conducted from January 4th-11th, 2009 to check if there were any problems or misunderstood parts before the main survey. After the preliminary study was conducted, certain problems were adjusted and supplemented, and then the main survey was conducted for twenty-three days, from January 4th to February 5th, 2009. The summaries of this study are as follows: First, in the view of the purchase behavior, the mainly purchased well-being oriented foods were farm products, and the leading purpose of the purchase was for the parents and the children. It was shown that 30% or more of the information sources on well-being oriented foods were families, relatives and neighbors. More than 66% of the purchasing was done at wholesale marts and the topped purchasing frequency was from 5 to 6 per month. More than 71% of payments for well-being oriented foods were \50,000~100,000 per month. More than 51% of the respondents answered that the proper price of well-being oriented foods was 1.2 times to 1.5 times of that of other foods. Second, the satisfaction of the well-being oriented foods was ranked as 3.21 to 3.28 out of 5, and varied with the usages and the methods of weights. Investigating the satisfaction with each subordinate field, the satisfaction with price was shown to be low. The satisfaction with the assortments of foods and the satisfaction with the therapeutic degree by thorough investigation and management of foods were also relatively low. Third, well-being oriented dietary behavior was shown to be characterized by two factors, through factor analysis in this study. One was an eco-friendly oriented behavioral factor and the other was a health oriented selective factor. Fourth, the stepwise multiple regression analysis results investigating the relative influence of the factors effecting satisfaction with well-being oriented foods showed that the top ranked factor affecting total satisfaction was eco-friendly oriented behavioral factor, followed by education level and purchasing sites, especially of consumer groups.

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Profitability Analysis Based on Cropping System of the Land Use Changes in Paddy Field (논 타작물 재배 작부체계별 수익성 분석)

  • Yu, Chan-Ju;Um, Ji-Bum;Ko, Hyeon-Seok;Park, Sang-Youn
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.1
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    • pp.216-222
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    • 2020
  • A comparative analysis of farm incomes was performed from the new composition system of crops, such as feed crops, including soybeans, Italian ryegrass, soybean-potatoes, and soybean-barley planted in rice fields. Through this analysis, the suggested implications were derived, and the technological solutions were determined. The profitability of the composition of soybean-Italian ryegrass showed that the soybeans yield was 325kg/10a, and the sale price was ₩3,962/kg, leading to a gross revenue of ₩1,288,000/10a. The yield of Italian ryegrass was 1,584kg/10a with a sale price of ₩125/kg, showing a gross revenue of ₩198,000/10a. The net income of soybeans was ₩284,000/10a, which means a net income rate of 22.1%, whereas the net income of Italian ryegrass was -₩30,000/10a. The composition of soybeans-potatoes and soybeans-barley showed a gross revenue of ₩930,000/10a and ₩375,000/10a, respectively. The crop composition types have been developed for the Income Type, Production Type of Forage, Improvement Type of Food Self-Sufficiency, and Corresponding Type to Climate Change. On the other hand, regional types have not been developed sufficiently. In addition, various selections of alternative crops and the establishment of crop composition congruent to the specific regions should be developed systematically in terms of the production technology. Therefore, it is necessary to develop the technological establishment of the crop composition through continuous related studies with the mid-to-long term objectives of land utilization and grain self-sufficiency rates.

A Study on the Calculation of Optimal Compensation Capacity of Reactive Power for Grid Connection of Offshore Wind Farms (해상풍력단지 전력계통 연계를 위한 무효전력 최적 보상용량 계산에 관한 연구)

  • Seong-Min Han;Joo-Hyuk Park;Chang-Hyun Hwang;Chae-Joo Moon
    • The Journal of the Korea institute of electronic communication sciences
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    • v.19 no.1
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    • pp.65-76
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    • 2024
  • With the recent activation of the offshore wind power industry, there has been a development of power plants with a scale exceeding 400MW, comparable to traditional thermal power plants. Renewable energy, characterized by intermittency depending on the energy source, is a prominent feature of modern renewable power generation facilities, which are structured based on controllable inverter technology. As the integration of renewable energy sources into the grid expands, the grid codes for power system connection are progressively becoming more defined, leading to active discussions and evaluations in this area. In this paper, we propose a method for selecting optimal reactive power compensation capacity when multiple offshore wind farms are integrated and connected through a shared interconnection facility to comply with grid codes. Based on the requirements of the grid code, we analyze the reactive power compensation and excessive stability of the 400MW wind power generation site under development in the southwest sea of Jeonbuk. This analysis involves constructing a generation site database using PSS/E (Power System Simulation for Engineering), incorporating turbine layouts and cable data. The study calculates reactive power due to charging current in internal and external network cables and determines the reactive power compensation capacity at the interconnection point. Additionally, static and dynamic stability assessments are conducted by integrating with the power system database.

Research on Optimized Operating Systems for Implementing High-Efficiency Small Wind Power Plants (고효율 소형 풍력 발전소 구현을 위한 최적화 운영 체계 연구)

  • Young-Bu Kim;Jun-Mo Park
    • Journal of the Institute of Convergence Signal Processing
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    • v.25 no.2
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    • pp.94-99
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    • 2024
  • Recently, wind power has been gaining attention as a highly efficient renewable energy source, leading to various technological developments worldwide. Typically, wind power is operated in the form of large wind farms with many wind turbines installed in areas rich in wind resources. However, in developing countries or regions isolated from the power grid, off-grid small wind power systems are emerging as an efficient solution. To efficiently operate and expand off-grid small-scale power systems, the development of real-time monitoring systems is required. For the efficient operation of small wind power systems, it is essential to develop real-time monitoring systems that can actively respond to excessive wind speeds and various environmental factors, as well as ensure the stable supply of produced power to small areas or facilities through an Energy Storage System (ESS). The implemented system monitors turbine RPM, power generation, brake operation, and more to create an optimal operating environment. The developed small wind power system can be utilized in remote road lighting, marine leisure facilities, mobile communication base stations, and other applications, contributing to the development of the RE100 industry ecosystem.

Field Survey on Smart Greenhouse (스마트 온실의 현장조사 분석)

  • Lee, Jong Goo;Jeong, Young Kyun;Yun, Sung Wook;Choi, Man Kwon;Kim, Hyeon Tae;Yoon, Yong Cheol
    • Journal of Bio-Environment Control
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    • v.27 no.2
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    • pp.166-172
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    • 2018
  • This study set out to conduct a field survey with smart greenhouse-based farms in seven types to figure out the actual state of smart greenhouses distributed across the nation before selecting a system to implement an optimal greenhouse environment and doing a research on higher productivity based on data related to crop growth, development, and environment. The findings show that the farms were close to an intelligent or advanced smart farm, given the main purposes of leading cases across the smart farm types found in the field. As for the age of farmers, those who were in their forties and sixties accounted for the biggest percentage, but those who were in their fifties or younger ran 21 farms that accounted for approximately 70.0%. The biggest number of farmers had a cultivation career of ten years or less. As for the greenhouse type, the 1-2W type accounted for 50.0%, and the multispan type accounted for 80.0% at 24 farms. As for crops they cultivated, only three farms cultivated flowers with the remaining farms growing only fruit vegetables, of which the tomato and paprika accounted for approximately 63.6%. As for control systems, approximately 77.4% (24 farms) used a domestic control system. As for the control method of a control system, three farms regulated temperature and humidity only with a control panel with the remaining farms adopting a digital control method to combine a panel with a computer. There were total nine environmental factors to measure and control including temperature. While all the surveyed farms measured temperature, the number of farms installing a ventilation or air flow fan or measuring the concentration of carbon dioxide was relatively small. As for a heating system, 46.7% of the farms used an electric boiler. In addition, hot water boilers, heat pumps, and lamp oil boilers were used. As for investment into a control system, there was a difference in the investment scale among the farms from 10 million won to 100 million won. As for difficulties with greenhouse management, the farmers complained about difficulties with using a smart phone and digital control system due to their old age and the utter absence of education and materials about smart greenhouse management. Those difficulties were followed by high fees paid to a consultant and system malfunction in the order.

Comparison of Anticancer Activities of Berberis koreana Extracts Obtained by Different Extraction Processes (추출 공정별 매자나무 추출물의 항암활성 비교)

  • Ha, Ji-Hye;Kwon, Min-Cheol;Seo, Yong-Chang;Choi, Woon-Yong;Chung, Eul-Kwon;Chung, Ae-Ran;Kim, Jin-Chul;Ahn, Ju-Hee;Lee, Hyeon-Yong
    • Korean Journal of Food Science and Technology
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    • v.42 no.2
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    • pp.233-239
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    • 2010
  • This study was conducted to examine the anticancer activities of Berberis koreana extracts according to different extraction processes. The highest extraction yield obtained was 8.26% following extraction by ultrasonification at 60 kHz and $60^{\circ}C$ followed by high pressure at 500MPa. Generally, the extracts from the ultrasonification process showed relatively low cytotoxicities against the human normal cell line, HEK293 showing as low as 15%. This extract inhibited the growth of the digestive related organs cell lines, human stomach adenocarcimoma cell and human epithelial adenocarcinoma cell by up to 80% when administered at 1.0 mg/mL, and showed 2.5-3.5 of selectivity. It was also found that this extract induced the production of nitric oxide levels as high $37.87\;{\mu}M$ from macrophages. For the in vivo experiment using ICR mice, the total serum IgG levels of mice treated with B. koreana extracts from ultrasonification extraction were increased by up to 57 ng/mL. The survival time of this group was longer than that of the other group after the injection of Sarcoma-180 and the increment of their body weights was also greatly suppressed. In addition, the extract showed the highest tumor inhibition activities, leading to a reduction of 78.47%. These results indicate that the highest activities of B. koreana associated with this extraction process can be significantly improved.

Organic Cucumber Productivity Affected by Long-term Application with Homemade Liquid Fertilizers (자가제조액비 장기연용 처리가 유기 오이의 생산성에 미치는 영향)

  • Choi, Hyun-Sug;Jung, Ji-Sik;Jung, Seok-Kyu
    • Korean Journal of Organic Agriculture
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    • v.27 no.1
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    • pp.87-100
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    • 2019
  • The study was initiated to compare crop productivity as affected by a long-term application with homemade liquid fertilizers in leading organic cucumber (Cucumis sativus L.) farms in Suncheon and Kimcheon provinces. A Suncheon farm have applied an EM (effective organism) liquid fertilizer for one year and fifteen years, designating as EM 1-year and EM 15-year plots, respectively, with 4-year and 5-year application of native microbes-liquid fertilizer in Kimcheon farm, designating as Micro 4-year and Micro 5-year plots, respectively. pH in the EM-liquid fertilizer was high to approximately 7.7, and EC in the Micro-liquid fertilizer was 0.1 dS/m higher than those of EM-liquid fertilizer, with similar macro-nutrient concentrations observed in the both liquid fertilizers. Soil EC was the highest to the 10.0 dS/m for the liquid fertilizer with EM 1-year and showed less than 1.5 dS/m for other liquid fertilizer plots. Micro-liquid fertilizer plots had soil OM contents less than 20 g/kg, which was approximately two times less than those of EM plots. Soil microbial properties were not significantly different among the liquid fertilizer plots. SPAD and PS II values were significantly increased by EM 15-year plots with high levels of soil OM and EC. Liquid fertilizer plot with EM 1-year had high concentrations of T-N, Ca, and Na in the cucumber crops but low concentrations of P and Mg, in particular for low K of 1.2% which was two times less than those of desired level for an optimum cucumber growth. The lowest fruit yield was observed for the liquid fertilizer plot with EM 1-year with the highest soil EC accumulated. Liquid fertilizer plot with EM 15-year produced the expanded volume of crop canopy and increased fruit yield. Therefore, long-term of continuous application with an organic liquid fertilizer would have sustainably improved soil stability and the crop productivity.

Development of Smart Digital Agriculture Technology for Food Crop Production in Korea-The Path Forward Based on Expert Feedback (식량작물 생산에 대한 스마트디지털 농업기술의 발전 방향 - 전문가 설문조사 연구)

  • Song, Ki Eun;Jung, Jae Gyeong;Cho, Seungho;Kim, Jae Yoon;Shim, Sangin
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.67 no.1
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    • pp.27-40
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    • 2022
  • Building self-sustainable rural infrastructure and environment through smart digital agriculture technology innovation is one of the major goals of the Korean agricultural administration as a part of the nation's 4th industry revolution. To identify areas for improving and effectively investing in the acceleration of rural development, 207 experts in the areas of crop science and smart digital agriculture technology were interviewed for their opinions and suggestions on 22 questions designed to recognize fundamental agricultural issues to be addressed and solutions to advance technology innovation and rural development. Majority of the participants expected smart digital agriculture technologies to resolve major agricultural issues and help build a better rural environment. To overcome technology gaps and resolve issues more effectively, further investment in training new technology experts and building stronger agricultural technology infrastructure is urgent, and persistent and systematic support from agricultural administration appears to be the key for accelerating the process. While the leading global groups of both public and private sectors have advanced their technologies beyond the field application stage, most of the Korean technologies remain at the early pilot stage. Aging population and lack of labor in rural areas, unknown future climate change, and challenges in sustainable rural development are expected to be resolved by smart digital agriculture technologies. Technological innovations by research institutes should be promptly deployed in the crop production field, and farm training systemically organized by local technology centers can accelerate farming revolution. Standardization of equipment and data systems is another key to the success of digitalization of food crop production and food supply chains nationwide.

A review of the mass-mortalities of sea-cage farm fishes (해상 가두리양식장 양식어류의 대량폐사에 대하여)

  • Han, Jido;Lee, Deok-Chan
    • Journal of fish pathology
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    • v.35 no.1
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    • pp.1-25
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    • 2022
  • The aquaculture industry has developed rapidly over the last three decades and is an important industry that supplies over 15% of humans' animal protein intake; therefore, there is a need to increase production to meet the continuous demand. The fish cage farms on the southern coast (Kyengsangnam-do and Jeollanam-do) of Korea are critical resources in aquaculture because they account for approximately 90% of the national total fish cage farms by water area ratio. However, the current aquaculture environment is being gradually affected by climate change, which is a global issue, and its effects are expected to intensify in the future. Therefore, it is urgently imperative to accurately evaluate the effects of climate change on South Korean aquaculture industries and to develop social and national strategies to minimize damage to the fishing industry. The damage to fish farmed in cage farms on the southern coast is increasing annually and the leading causes are high and low water temperature and red tides, which are directly or indirectly related to climate change. At present, global warming can provide opportunities for aquaculture industrialization of fish or other novel species, with economic implications. However, despite such opportunities, the influx of new species can also cause problems such as ecological disturbances, increase in the reproduction frequency of microalgae such as red tide, increase in disease incidence, and occurrence and periods of high water temperatures in summer. The scale of farmed fish mortality is increasing due to the complex effects of these factors. Increased damages due to fish mortality not only have severe economic impacts on the aquaculture industry, but the social costs of responding to the damage and follow-up measures also increase. various active responses can reduce the mortality damage in fish farms such as improving the management skills in aquaculture, improved species breeding, efficient food management, disease prevention, proactive responses, and system-wide improvements. This review article analyzes the large-scale mortality cases occurring in fish cage farms on the southern coast of Korea and proposes measures to mitigate mortality and enhance responses to such scenarios.