• 한국지역지리학회지
• /
• 제18권3호
• /
• pp.336-350
• /
• 2012

본 연구는 보존가치가 있는 금오도 지역의 지형 지질 경관자원에 관한 전문적인 지식을 기반으로 생태 역사 문화적 요소를 포함하여 금오도의 지역성을 경험할 수 있도록 지오싸이트(geosite)를 발굴하고 해설하는 데 초점을 맞추었다. 지형 지질 경관자원으로서 서부 해안에 위치한 '미역널방' 신선대의 해식애, 직포 사빈, '갈바람통'의 해식애와 해식동, 충산의 육계사주와 육계도, 장지 암설 역빈과 동부 해안에 위치한 여천 대유의 응회암, 연목 '검바위' 우학리의 안산암 분포지를 지오싸이트로 선정하였다. 전반적으로 중생대 퇴적층과 화산암으로 이뤄진 지형들이 발달하였다. 탐방경로는 금오도의 북서쪽 함구미 선착장에서 남동쪽 장지 마을로 이어지는 '비렁길'루트와 동부해안도로를 따라 구성하였으며, 암설지대가 나타나는 장지를 사례로 관광해설표지판을 예시해 보았다.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제42권
• /
• pp.32.1-32.4
• /
• 2020

Background: Le Fort I osteotomy is a highly effective treatment for skeletal jaw deformities and is commonly performed. High Le Fort I osteotomy is a modified surgical procedure performed for improving the depression of the cheeks by setting the osteotomy higher than the conventional Le Fort I osteotomy. Developments in three-dimensional (3D) technology have popularized the use of 3D printers in various institutions, especially in orthognathic surgeries. In this study, we report a safe and inexpensive method of performing a high Le Fort I osteotomy using a novel 3D device and piezosurgery, which prevent tooth root injury without disturbing the operation field for patients with a short midface and long tooth roots. Results: A 17-year-old woman presented with facial asymmetry, mandibular protrusion, a short midface, and long tooth roots. We planned high Le Fort I osteotomy and bilateral sagittal split ramus osteotomy. Prevention of damage to the roots of the teeth and the infraorbital nerve and accurate determination of the posterior osteotomy line were crucial for clinical success. Le Fort I osteotomy using 3D devices has been reported previously but were particularly large in size for this case. Additionally, setting the fixing screw of the device was difficult, because of the risk of damage to the roots of the teeth. Therefore, a different surgical technique, other than the conventional Le Fort I osteotomy and 3D device, was required. The left and right parts of the 3D device were fabricated separately, to prevent any interference in the surgical field. Further, the 3D device was designed to accurately cover the bone surface from the piriform aperture to the infra-zygomatic crest with two fixation points (the anterior nasal spine and the piriform aperture), which ensured stabilization of the 3D device. The device is thin and does not interfere with the surgical field. Safe and accurate surgical performance is possible using this device and piezosurgery. The roots of the teeth and the infraorbital nerve were unharmed during the surgery. Conclusions: This device is considerably smaller than conventional devices and is a simple, low-cost, and efficient method for performing accurate high Le Fort I osteotomy.

• 한국균학회지
• /
• 제50권4호
• /
• pp.263-274
• /
• 2022

표고는 중요한 상업용 버섯이며, 표고에서의 바이러스 감염에 대한 여러 보고가 있었다. 톱밥 재배 품종인 산백향(NIFoS 2778)과 태향고(NIFoS 4317)에 대한 바이러스 검출 결과, 이들이 2개의 mycoviruses (LeV-HKB 및 LeNSRV1)에 감염되어 있음을 확인하였다. 각 품종의 자실체에서 분리된 담자포자에서 유래한 80개의 단핵균사에서 바이러스 감염을 조사한 결과, 대부분의 단 핵균사들이 바이러스에 감염되어 있었으며, LeV-HKB와 LeNSRV1의 수직감염률에 차이가 있었다. LeV-HKB가 LeNSRV1 보다 높은 수직감염률을 나타낸 것이다. 따라서 mycovirus의 수직 감염 기작이 바이러스 종에 따라 다른 것으로 보인다. 다음으로, 담자포자 유래 단핵균사들의 생장속도를 조사하여 바이러스 감염과 생장속도의 상관관계를 조사하였다. 바이러스 감염과 균사 생장속도 사이에 통계적으로 유의한 상관관계가 없었지만, 감염된 바이러스의 종류가 늘어날수록 생장속도가 감소하는 경향을 확인하였다. 본 연구는 mycovirus의 수직 감염 기작을 이해하는 데 기여하고, 바이러스에 감염되지 않은 단핵균사를 이용한 무바이러스 품종 개발을 촉진하는 데 기여할 수 있을 있을 것 기대된다.

• Journal of Plant Biotechnology
• /
• 제47권2호
• /
• pp.118-123
• /
• 2020

The black seed coat of soybeans contain anthocyanins which promote health. However, mature soybean seeds contain anti-nutritional factors like lipoxygenase, lectin and Kunitz Trypsin Inhibitor (KTI) proteins. Furthermore, these seeds can be used only after the genetic elimination of these proteins. Therefore, the objective of this study was to develop novel soybean genotypes with black seed coat and triple recessive alleles (lx1lx1lx2lx2lx3lx3, titilele) for lipoxygenase, lectin, and KTI proteins. From a cross of parent1 (lx1lx2lx3/lx1lx2lx3, ti/ti, Le/Le) and parent2 (lx1lx2lx3/lx1lx2lx3, Ti/Ti, le/le), 132 F₂ seeds were obtained. A 3:1 segregation ratio was observed during F₂ seed generation for the inheritance of lectin and KTI proteins. Between a cross of the Le and Ti genes, the observed independent inheritance ratio in the F₂ seed generation was 9: 3 : 3 : 1 (69 Le_Ti_: 32 leleTi_: 22 Le_titi: 9 leletiti) (χ²=2.87, P=0.5 - 0.1). From nine F₂ seeds with triple recessive alleles (lx1lx1lx2lx2lx3lx3, titilele genotype), one novel strain posessing black seed coat, and free of lipoxygenase, lectin and KTI proteins, was selected. The seed coat color of the new strain was black and the cotyledon color of the mature seed was green. The weight of 100 seeds belonging to the new strain was 35.4 g. This black soybean strain with lx1lx1lx2lx2lx3lx3, titilele genotype is a novel strain free of lipoxygenase, lectin, and KTI proteins.

• 대한치과교정학회지
• /
• 제48권1호
• /
• pp.63-70
• /
• 2018

Objective: The aim of this study is to quantitatively evaluate the stability of the skeletal and dental widths using cone-beam computed tomography (CBCT) after segmental Le Fort I osteotomy in adult patients with skeletal Class III malocclusion requiring maxillary expansion. Methods: In total, 25 and 36 patients with skeletal Class III malocclusion underwent Le Fort I osteotomy (control group) and segmental Le Fort I osteotomy (experimental group), respectively. Coronal CBCT images were used to measure the dental and skeletal widths before (T1) and after (T2) surgery and at the end of treatment (T3). The correlation between the extent of surgery and the amount of relapse in the experimental group was also determined. Results: In the control group, the dental width exhibited a significant decrease of $0.70{\pm}1.28mm$ between T3 and T2. In the experimental group, dental and skeletal expansion of $1.83{\pm}1.66$ and $2.55{\pm}1.94mm$, respectively, was observed between T2 and T1. The mean changes in the dental and skeletal widths between T3 and T2 were $-1.41{\pm}1.98$ and $-0.67{\pm}0.72mm$, respectively. There was a weak correlation between the amount of skeletal expansion during segmental Le Fort I osteotomy and the amount of postoperative skeletal relapse in the experimental group. Conclusions: Maxillary expansion via segmental Le Fort I osteotomy showed good stability, with a skeletal relapse rate of 26.3% over approximately 12 months. Our results suggest that a greater amount of expansion requires greater efforts for the prevention of relapse.

• 건축역사연구
• /
• 제11권4호
• /
• pp.99-115
• /
• 2002

Centered on Durand and Le Corbusier, this study analyses the changing status of the grid and axis in modern architecture. In the Renaissance, the taxis grid operated as a contour grid, defining the elements and space of the building as part of closed harmonized world. In his Pre'cis des lec., ons d'architecture, Durand provides the most explicit demonstration of a new modem grid in which its lines function as spatial and structural axes. In principle these axes are coordinates for the placements of a priori elements but in Beaux-Arts practice, as Durand himself acknowledged, they involve a simultaneous process in which the spatial axis sets up the basic parti and the structural axis is developed into the building's poche'. As a coordinate, Durand's grid provides a place for the 'subject' to enter the architectural process. At the same time, it is the object of the subject's gaze, the dense site of the subject's transformative actions. Though Le Corbusier is noted for his frequent attacks on the academic system, his architecture should be seen within the continuity of the classical tradition. He redefines the Beaux-Arts axis as a moving and seeing observer, and continues the discipline of the plan, the essential discipline of the Beaux-Arts system. In his dialectics, an intellectual scheme which extends to his commentators, the intention and will of the subject must come in tune with the objective material form of the building. Like Durand, Le Corbusier's axis provides the medium for the subject to enter. Unlike the Beaux-Arts system, however, Le Corbusier's mobile subject no longer has a holistic view of the building previously provided by the central axis. If there is a parti for Le Corbusier, it consists of the domino grid as a potential, but nonetheless, tangible form. In comparison with the Beaux-Arts structural grid, his gaze no longer lingers on their lines because they no longer constitute a formal process tied to the development of a thick articulated structure. Le Corbusier's grid constitutes a 'loose' form, one that breaks down the hierarchical nature of the Beaux-Arts system.

• BMB Reports
• /
• 제41권4호
• /
• pp.328-333
• /
• 2008

A variety of anti-inflammatory agents have been shown to exert chemopreventive activity via targeting of transcription factors such as NF-${\kappa}B$ and AP-1. Lithospermum erythrorhizon (LE) has long been used in traditional oriental medicine. In this study, we demonstrated the inhibitory effects of LE extracts on lipopolysaccharide (LPS)-stimulated production of inflammatory cytokines. As an underlying mechanism of inhibition, LE extracts reduced LPS-induced transactivation of AP-1 as well as NF-${\kappa}B$ in mouse macrophage cells. Electrophoretic mobility shift assays indicated that LE extracts inhibited the DNA binding activities of AP-1 and NF-${\kappa}B$. In addition, phosphorylation of $I{\kappa}B-{\alpha}$ protein was suppressed by LE extracts. Moreover, LE extracts inhibited c-Jun N-terminal kinase and extracellular signal-regulated signaling pathways. Our results suggest that the anti-inflammatory activity of LE extracts may be mediated by the inhibition of signal transduction pathways that normally lead to the activation of AP-1and NF-${\kappa}B$. These inhibitory effects may be useful for chemoprevention of cancer or other chronic inflammatory diseases.

• The Plant Pathology Journal
• /
• 제29권3호
• /
• pp.350-355
• /
• 2013

Plants protect themselves from diverse potential pathogens by induction of the immune systems such as systemic acquired resistance (SAR). Most bacterial plant pathogens thrive in the intercellular space (apoplast) of plant tissues and cause symptoms. The apoplastic leaf exudate (LE) is believed to contain nutrients to provide food resource for phytopathogenic bacteria to survive and to bring harmful phytocompounds to protect plants against bacterial pathogens. In this study, we employed the pepper-Xanthomonas axonopodis system to assess whether apoplastic fluid from LE in pepper affects the fitness of X. axonopodis during the induction of SAR. The LE was extracted from pepper leaves 7 days after soil drench-application of a chemical trigger, benzothiadiazole (BTH). Elicitation of plant immunity was confirmed by significant up-regulation of four genes, CaPR1, CaPR4, CaPR9, and CaCHI2, by BTH treatment. Bacterial fitness was evaluated by measuring growth rate during cultivation with LE from BTH- or water-treated leaves. LE from BTH-treatment significantly inhibited bacterial growth when compared to that from the water-treated control. The antibacterial activity of LE from BTH-treated samples was not affected by heating at $100^{\circ}C$ for 30 min. Although the antibacterial molecules were not precisely identified, the data suggest that small (less than 5 kDa), heat-stable compound(s) that are present in BTH-induced LE directly attenuate bacterial growth during the elicitation of plant immunity.

• 동의생리병리학회지
• /
• 제24권6호
• /
• pp.970-975
• /
• 2010

Because Lonicerae Flos has effects of antiinflammatory and antioxidant, we studied an effect of Lonicerae Flos on reflux esophagitis (RE) through those effects. Rats were treated with three different dosages of LF (500, 250 and 125 mg/kg) orally for 14 days before pylorus and forestomach ligation. Six hrs after pylorus and forestomach ligation, we dissected a stomach and examined a stomach volume, gastric acid output, pepsin release in the stomach, total hexose, sialic acid in stomach tissue and histamine contents of sera. The results were compared with an ${\alpha}$-tocopherol (once orally, 1hr before operation, 30 mg/kg) treated group in which the effects on RE were already confirmed. Lonicerae Flos extract (LE) reduced gastric volumes compared to RE control. This indicate that LE protect a stomach mucosa by depressing of gastric acid release and corresponse with a reducing histamine content of serum. And LE decreasd a volume of pepsin in stomach compraed to RE control, LE increased contents of total hexose and sialic acid based on esophageal and gastric mucus. This indicated that an increased mucus by LE protected inflammation of esophagus mucosa and gastric mucosa induced by gastric acid. So, LE suppressed a gasric acid by decreasing a pepsin release in stomach, suppressed an injury of esophagus inducted by gastric acid with increasing esophageal mucus and a minimum dose of LE to RE was 250 mg/kg. The results suggest that antioxidant effects of LF could attenuate the severity of reflux esophagitis and prevent the esophageal mucosal damage, and validate its therapeutic use in esophageal reflux disease.

• 대한인간공학회지
• /
• 제30권6호
• /
• pp.689-694
• /
• 2011

Objective: The aim of this study is to evaluate the fluctuation of signal amplitude during repetitive dynamic contraction based on surface electromyography(EMG). Background: The most previous studies were considered isometric muscle contraction and they were difference to smoothing window length by moving average filter. In practical, the human movement is dynamic state. Dynamic EMG signal which indicated as the nonstationary pattern should be analyzed differently compared with the static EMG signal. Method: Ten male subjects participated in this experiment, and EMG signal was recorded by biceps brachii, anterior/posterior deltoid, and upper/lower trapezius muscles. The subject was performed to repetitive right horizontal lifting task during ten cycles. This study was considered three independent variables(muscle, amplitude processing technique, and smoothing window length) as the within-subject experimental design. This study was estimated muscular activation by means of the linear envelope technique(LE). The dependent variable was set coefficient of variation(CV) of LE for each cycle. Results: The ANOVA results showed that the main and interaction effects between the amplitude processing technique and smoothing window length were significant difference. The CV value of peak LE was higher than mean LE. According to increase the smoothing window length, this study shows that the CV trend of peak LE was decreased. However, the CV of mean LE was analyzed constant fluctuation trend regardless of the smoothing window length. Conclusion: Based on these results, we expected that using the mean LE and 300ms window length increased reproducibility and signal noise ratio during repetitive dynamic muscle contraction. Application: These results can be used to provide fundamental information for repetitive dynamic EMG signal processing.