• Journal of Microbiology and Biotechnology
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• 제19권11호
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• pp.1319-1327
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• 2009

Marine red algae of genus Laurencia are becoming the most important resources to produce unique natural metabolites with wide bioactivities. However, reports related to Laurencia undulata, an edible species used as folk herb, are rarely found to date. In this research, 5-hydroxymethyl-2-furfural (5-HMF) was isolated and characterized by nuclear magnetic resonance (NMR) from Laurencia undulata as well as other marine algae. The following characteristics of 5-HMF were systematically evaluated: its antioxidant activities, such as typical free-radicals scavenging in vitro by electron spin resonance spectrometry (ESR) and intracellular reactive oxygen species (ROS) scavenging; membrane protein oxidation; oxidative enzyme myeloperoxidase (MPO) inhibition; as well as expressions of antioxidative enzymes glutathione (GSH) and superoxide dismutase (SOD) on the gene level using the polymerase chain reaction (PCR) method. The results demonstrated that 5-HMF could be developed as a novel marine natural antioxidant or potential precursor for practical applications in the food, cosmetic, and pharmaceutical fields.

• BMB Reports
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• 제46권8호
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• pp.398-403
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• 2013

Inflammatory conditions mediated by activated microglia lead to chronic neuro-degenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases. This study was conducted to determine the effect of floridoside isolated from marine red algae Laurencia undulata on LPS (100 ng/ml) activated inflammatory responses in BV-2 microglia cells. The results show that floridoside has the ability to suppress pro-inflammatory responses in microglia by markedly inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS). Moreover, floridoside down-regulated the protein and gene expression levels of iNOS and COX-2 by significantly blocking the phosphorylation of p38 and ERK in BV-2 cells. Collectively, these results indicate that floridoside has the potential to be developed as an active agent for the treatment of neuro-inflammation.

• 한국수산과학회지
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• 제25권5호
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• pp.392-398
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• 1992

본 연구는 홍조 16종에 대해서 경남 양산군 대송리의 자연개체군을 대상으로 사분포자체 및 과포자체의 출현시기를 파악하였다. 그 결과 G. furcata가 춘$\cdot$하계에 L. intermedia, L. undulata, R. intricata는 하계에, C. dasyphylla, H. charoides는 추계에, C. affinis, P lanceolata, C. ocellatus, A. polyneurum, G. flabelliformis, G. intermedia, C. parvula, C. Paniculatum는 하계와 추계에 사분포자 및 과포자를 형성하여 뚜렷한 계절성을 보였다. 조사대상 16종 중에서 G. flabelliformis, G. intermedia, R. intricate에서는 과포자상(carposporic phase)만 관찰되었고, P. telfairiae, H. charoides, C. parvula, C. Paniculatum에서는 사분포자상(tetrasporic phase)만이 관찰되었다. 이 중 G. flabelliformis는 고수온역인 고리 원자력 발전소취수구에서는 사분포자상만이, 또 C. paniculatum는 과포자상만이 형성되어 자연개체군의 생활사는 불안정하며, 또 수온에 의해 지역적으로 제한됨을 시사하였다. 또한 과포자상 및 사분포자상을 갖는 종 중에서 C. affinis는 과포자상이 우세한 종이며, G. furcata, C. ocellaltus, C. dasyphylla, S. latiuscula는 사분포자상이 우세하였다. 또 C. affinis, C. ocellatus, A. polyneurum, C. dasyphylla, L. intermedia, L. undulata에서는 과포자상의 출현후 1개월 이내에 사분포자상이 출현하는 것으로 나타났다. 생식세포의 형성시기와 생체량의 변동은 생식세포를 형성하는 시점에서 생체량이 극대화되고, 생식세포를 방출하면서 생체량이 점차 감소하는 것으로 나타났다.