• Genomics & Informatics
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• v.14 no.4
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• pp.138-148
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• 2016

The success of genome-wide association studies (GWASs) has enabled us to improve risk assessment and provide novel genetic variants for diagnosis, prevention, and treatment. However, most variants discovered by GWASs have been reported to have very small effect sizes on complex human diseases, which has been a big hurdle in building risk prediction models. Recently, many statistical approaches based on penalized regression have been developed to solve the "large p and small n" problem. In this report, we evaluated the performance of several statistical methods for predicting a binary trait: stepwise logistic regression (SLR), least absolute shrinkage and selection operator (LASSO), and Elastic-Net (EN). We first built a prediction model by combining variable selection and prediction methods for type 2 diabetes using Affymetrix Genome-Wide Human SNP Array 5.0 from the Korean Association Resource project. We assessed the risk prediction performance using area under the receiver operating characteristic curve (AUC) for the internal and external validation datasets. In the internal validation, SLR-LASSO and SLR-EN tended to yield more accurate predictions than other combinations. During the external validation, the SLR-SLR and SLR-EN combinations achieved the highest AUC of 0.726. We propose these combinations as a potentially powerful risk prediction model for type 2 diabetes.

• Computers and Concrete
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• v.33 no.6
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• pp.739-754
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• 2024

This study presents an innovative AI-driven approach to assess the ultimate axial load in Double-Skinned Profiled Steel sheet Composite Walls (DPSCWs). Utilizing a dataset of 80 entries, seven input parameters were employed, and various AI techniques, including Linear Regression, Polynomial Regression, Support Vector Regression, Decision Tree Regression, Decision Tree with AdaBoost Regression, Random Forest Regression, Gradient Boost Regression Tree, Elastic Net Regression, Ridge Regression, and LASSO Regression, were evaluated. Decision Tree Regression and Random Forest Regression emerged as the most accurate models. The top three performing models were integrated into a hybrid approach, excelling in accurately estimating DPSCWs' ultimate axial load. This adaptable hybrid model outperforms traditional methods, reducing errors in complex scenarios. The validated Artificial Neural Network (ANN) model showcases less than 1% error, enhancing reliability. Correlation analysis highlights robust predictions, emphasizing the importance of steel sheet thickness. The study contributes insights for predicting DPSCW strength in civil engineering, suggesting optimization and database expansion. The research advances precise load capacity estimation, empowering engineers to enhance construction safety and explore further machine learning applications in structural engineering.

• Journal of the Korean Data and Information Science Society
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• v.24 no.6
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• pp.1341-1348
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• 2013

To solve the classification problems, various data mining techniques have been applied to database marketing, credit scoring and market forecasting. In this paper, we compare various techniques such as bagging, boosting, LASSO, random forest and support vector machine with the daily lens transaction data. The classical techniques-decision tree, logistic regression-are used too. The experiment shows that the random forest has a little smaller misclassification rate and standard error than those of other methods. The performance of the SVM is good in the sense of misclassfication rate and bad in the sense of standard error. Taking the model interpretation and computing time into consideration, we conclude that the LASSO gives the best result.

• Journal of Sleep Medicine
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• v.15 no.2
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• pp.48-54
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• 2018

Objectives: The aim of this study was to develop a predicting model for the optimal continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA) patient with obesity by using a machine learning. Methods: We retrospectively investigated the medical records of 162 OSA patients who had obesity [body mass index (BMI) ≥ 25] and undertaken successful CPAP titration study. We divided the data to a training set (90%) and a test set (10%), randomly. We made a random forest model and a least absolute shrinkage and selection operator (lasso) regression model to predict the optimal pressure by using the training set, and then applied our models and previous reported equations to the test set. To compare the fitness of each models, we used a correlation coefficient (CC) and a mean absolute error (MAE). Results: The random forest model showed the best performance {CC 0.78 [95% confidence interval (CI) 0.43-0.93], MAE 1.20}. The lasso regression model also showed the improved result [CC 0.78 (95% CI 0.42-0.93), MAE 1.26] compared to the Hoffstein equation [CC 0.68 (95% CI 0.23-0.89), MAE 1.34] and the Choi's equation [CC 0.72 (95% CI 0.30-0.90), MAE 1.40]. Conclusions: Our random forest model and lasso model ($26.213+0.084{\times}BMI+0.004{\times}$apnea-hypopnea index+$0.004{\times}oxygen$ desaturation index-$0.215{\times}mean$ oxygen saturation) showed the improved performance compared to the previous reported equations. The further study for other subgroup or phenotype of OSA is required.

• The Korean Journal of Applied Statistics
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• v.34 no.3
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• pp.411-425
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• 2021

Accelerated failure time (AFT) model represents a linear relationship between the log-survival time and covariates. We are interested in the inference of covariate's effect affecting the variation of survival times in the AFT model. Thus, we need to model the variance as well as the mean of survival times. We call the resulting model mean and variance AFT (MV-AFT) model. In this paper, we propose a variable selection procedure of regression parameters of mean and variance in MV-AFT model using penalized likelihood function. For the variable selection, we study four penalty functions, i.e. least absolute shrinkage and selection operator (LASSO), adaptive lasso (ALASSO), smoothly clipped absolute deviation (SCAD) and hierarchical likelihood (HL). With this procedure we can select important covariates and estimate the regression parameters at the same time. The performance of the proposed method is evaluated using simulation studies. The proposed method is illustrated with a clinical example dataset.

• Journal of the Korean Data and Information Science Society
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• v.27 no.2
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• pp.499-510
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• 2016

It is very important to select relevant variables in regression models for survival analysis. In this paper, we introduce a penalized variable-selection procedure in multi-level frailty models based on the "frailtyHL" R package (Ha et al., 2012). Here, the estimation procedure of models is based on the penalized hierarchical likelihood, and three penalty functions (LASSO, SCAD and HL) are considered. The proposed methods are illustrated with multi-country/multi-center bladder cancer survival data from the EORTC in Belgium. We compare the results of three variable-selection methods and discuss their advantages and disadvantages. In particular, the results of data analysis showed that the SCAD and HL methods select well important variables than in the LASSO method.

• Journal of the Korean Data and Information Science Society
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• v.27 no.1
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• pp.217-223
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• 2016

Outcome misclassification is widespread in classification problems, but methods to account for it are rarely used. In this paper, the problem of inference with misclassified multinomial logit data with a large number of multinomial parameters is addressed. We have had a significant swell of interest in the development of novel methods to infer misclassified data. One simulation study is shown regarding how seriously misclassification issue occurs if the number of categories increase. Then, using the group lasso regression, we will show how the best model should be fitted for that kind of multinomial regression problems comprehensively.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.7
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• pp.3594-3607
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• 2017

The traditional feature extraction methods such as principal component analysis (PCA) cannot obtain the local structure of the samples, and locally linear embedding (LLE) cannot obtain the global structure of the samples. However, a common drawback of existing PCA and LLE algorithm is that they cannot deal well with the sparse problem of the samples. Therefore, by integrating the globality of PCA and the locality of LLE with a sparse constraint, we developed an improved and unsupervised difference algorithm called Sparse Difference Embedding (SDE), for dimensionality reduction of high-dimensional data in small sample size problems. Significantly differing from the existing PCA and LLE algorithms, SDE seeks to find a set of perfect projections that can not only impact the locality of intraclass and maximize the globality of interclass, but can also simultaneously use the Lasso regression to obtain a sparse transformation matrix. This characteristic makes SDE more intuitive and more powerful than PCA and LLE. At last, the proposed algorithm was estimated through experiments using the Yale and AR face image databases and the USPS handwriting digital databases. The experimental results show that SDE outperforms PCA LLE and UDP attributed to its sparse discriminating characteristics, which also indicates that the SDE is an effective method for face recognition.

• Journal of The Korean Society of Agricultural Engineers
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• v.61 no.6
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• pp.9-19
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• 2019

Vegetative Filter Strip (VFS) is the best management practice which has been widely used to mitigate water pollutants from agricultural fields by alleviating runoff and sediment. This study was conducted to improve an equation for estimating sediment trapping efficiency of VFS using several different regularization methods (i.e., ordinary least squares analysis, LASSO, ridge regression analysis and elastic net). The four different regularization methods were employed to develop the sediment trapping efficiency equation of VFS. Each regularization method indicated high accuracy in estimating the sediment trapping efficiency of VFS. Among the four regularization methods, the ridge method showed the most accurate results according to $R^2$, RMSE and MAPE which were 0.94, 7.31% and 14.63%, respectively. The equation developed in this study can be applied in watershed-scale hydrological models in order to estimate the sediment trapping efficiency of VFS in agricultural fields for an effective watershed management in Korea.

• Communications for Statistical Applications and Methods
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• v.28 no.5
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• pp.447-462
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• 2021

In insurance, the surrender rate is an important variable that threatens the sustainability of insurers and determines the profitability of the contract. Unlike other actuarial assumptions that determine the cash flow of an insurance contract, however, it is characterized by endogenous variables such as people's economic, social, and subjective decisions. Therefore, a microscopic approach is required to identify and analyze the factors that determine the lapse rate. Specifically, micro-level characteristics including the individual, demographic, microeconomic, and household characteristics of policyholders are necessary for the analysis. In this study, we select panel survey data of Korean Retirement Income Study (KReIS) with many diverse dimensions to determine which variables have a decisive effect on the lapse and apply the lasso regularized regression model to analyze it empirically. As the data contain many missing values, they are imputed using the random forest method. Among the household variables, we find that the non-existence of old dependents, the existence of young dependents, and employed family members increase the surrender rate. Among the individual variables, divorce, non-urban residential areas, apartment type of housing, non-ownership of homes, and bad relationship with siblings increase the lapse rate. Finally, among the financial variables, low income, low expenditure, the existence of children that incur child care expenditure, not expecting to bequest from spouse, not holding public health insurance, and expecting to benefit from a retirement pension increase the lapse rate. Some of these findings are consistent with those in the literature.