• Title/Summary/Keyword: Lack of Penetration

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Bayesian methods in clinical trials with applications to medical devices

  • Campbell, Gregory
    • Communications for Statistical Applications and Methods
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    • v.24 no.6
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    • pp.561-581
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    • 2017
  • Bayesian statistics can play a key role in the design and analysis of clinical trials and this has been demonstrated for medical device trials. By 1995 Bayesian statistics had been well developed and the revolution in computing powers and Markov chain Monte Carlo development made calculation of posterior distributions within computational reach. The Food and Drug Administration (FDA) initiative of Bayesian statistics in medical device clinical trials, which began almost 20 years ago, is reviewed in detail along with some of the key decisions that were made along the way. Both Bayesian hierarchical modeling using data from previous studies and Bayesian adaptive designs, usually with a non-informative prior, are discussed. The leveraging of prior study data has been accomplished through Bayesian hierarchical modeling. An enormous advantage of Bayesian adaptive designs is achieved when it is accompanied by modeling of the primary endpoint to produce the predictive posterior distribution. Simulations are crucial to providing the operating characteristics of the Bayesian design, especially for a complex adaptive design. The 2010 FDA Bayesian guidance for medical device trials addressed both approaches as well as exchangeability, Type I error, and sample size. Treatment response adaptive randomization using the famous extracorporeal membrane oxygenation example is discussed. An interesting real example of a Bayesian analysis using a failed trial with an interesting subgroup as prior information is presented. The implications of the likelihood principle are considered. A recent exciting area using Bayesian hierarchical modeling has been the pediatric extrapolation using adult data in clinical trials. Historical control information from previous trials is an underused area that lends itself easily to Bayesian methods. The future including recent trends, decision theoretic trials, Bayesian benefit-risk, virtual patients, and the appalling lack of penetration of Bayesian clinical trials in the medical literature are discussed.

The Paradox of China's Cultural Rise (중국 문화굴기의 역설)

  • Kim, SeungSoo
    • Korean journal of communication and information
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    • v.76
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    • pp.31-60
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    • 2016
  • The task of this essay deals with the China's Cultural Rise in analizing the power of media and 'Go Global' policy. The phenomena of Chinese cultural hegemony over Asia beg study. I review the Chinese cultural industry going global. The notion of cultural hegemony is introduced in this study, in order to explain the rise of China accelerating a penetration and influence of Chinese cultural capital and its power. A peaceful rise of China links to its cultural hegemony over Asian countries. Currently, China has not sufficiently enjoyed the soft power due to its lack of globally accepted ideological dynamics in China's culture and media. But in the near future, market-driven Chinese cultural capital and contents will replace Korean ones.

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Simple Interpretation of VLF Data (VLF 전자탐사 자료의 해석)

  • Kim Hee Joon;Nam Myung Jin;Song Yoonho;Suh Jung Hee
    • Geophysics and Geophysical Exploration
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    • v.8 no.2
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    • pp.184-190
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    • 2005
  • We have attempted to give some physical into the factors that control the response of subsurface target to plane wave excitation at VLF (very low frequency) frequencies. Although the VLF technique has some serious disadvantages, such as a lack of penetration depth and limited frequencies, its advantages are also extremely important to have made it by far the most popular electromagnetic technique in current use. In the magnetic-field measurement mode these lightweight, relatively low-priced tools allow us to survey large areas rapidly and inexpensively, to locate and roughly define subsurface electrical conductors. When used in the electric-field mode the technique is, in simple environments, capable of quantitative interpretation and once again the speed and relative cheapness of these devices makes them a natural 'first electromagnetic tool ' to use in reconnaissance mapping.

Fraud Detection System in Mobile Payment Service Using Data Mining (모바일 결제 환경에서의 데이터마이닝을 이용한 이상거래 탐지 시스템)

  • Han, Hee Chan;Kim, Hana;Kim, Huy Kang
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.26 no.6
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    • pp.1527-1537
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    • 2016
  • As increasing of smartphone penetration over the world, various mobile payment services have been emerged and fraud transactions have drastically increased. Although many financial companies have deployed security solutions to detect fraud transactions in on/off-line environment, mobile payment services still lack fraud detection solutions and researches. The mobile payment is mainly comprised of micro-payments and payment environment is different from other payments, so mobile-specialized fraud detection is needed. In this paper, we propose a FDS (Fraud Detection System) based on data mining for mobile payment services. The method of this paper is applied to the real data provided by a PG (Payment Gateway) company in Korea. The proposed FDS consists of two phases; (1) the first phase is focused on classifying transactions at high speed (2) the second is designed to detect abnormal transactions with high accuracy. We could detect 13 transactions per second with 93% accuracy rate.

Study on an Evaluation of Remote Control Torch Performance to reduce CO2 Welding Defects (CO2 용접결함 감소를 위한 원격 제어 토치 성능 평가 연구)

  • Kim, Jeong-Hyeok;Oh, Seck-Hyeog;Lee, Hae-Gil
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.10
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    • pp.6282-6288
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    • 2014
  • $CO_2$ welding is used widely in the field. On the other hand, welding defects occur when welders cannot adjust the current and voltage needed for welding and have to stop working to adjust the current and voltage, causing sudden cooling down of the welding structure inside a vehicle or tank where the control panel is invisible or when work site is far. This study used three types of existing $CO_2$ welders. This also applied SS400 rolled steel for welding structural purposes for remote control torch welding, perform a welding test through v-groove butt welding with a remote control torch and existing $CO_2$ welding torch, conducted visual inspection on the appearance of a welded top bead. In addition, the appearance quality of the welding part was monitored mainly through penetrant testing and a bending test to evaluate the welding defect reduction and the effect on the performance and compatibility by replacing the existing welder.

Modeling and Analysis of Propagation Characteristics for Mountain Region at 2.3 GHz (2.3 GHz 대역 산악 지형 전파 특성 분석 및 모델링)

  • Han, Il-Tak;Choi, Moon-Young;Kim, Chang-Gu;Bae, Moon-Kwan;Choi, Jong-Chan;Yoon, Young-Ki;Pack, Jung-Ki
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.19 no.2
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    • pp.200-206
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    • 2008
  • To implement a mobile radio system, wave-propagation models are necessary to determine propagation characteristics accurately, Currently, the empirical/theoretical prediction models for urban environments are fairly well-developed. But there is a lack of a suitable prediction model for mountain region. So in this paper, to develop the prediction model for mountain region, propagation environments are classified based on three basic mechanisms: reflection, diffraction, penetration(absorbtion and scattering), and measurements have been performed for the classified mountain regions including open area, forest and ridge. Using the measurement data, empirical modeling of propagation characteristics are performed, and then a prediction model for mountain region is proposed.

Technology Commercialization from Research Institutes to ICT-based Spin-offs (ICT기반 연구소기업의 기술사업화)

  • Park, Jae-Sue
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.23 no.6
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    • pp.690-696
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    • 2019
  • New companies expecting market penetration by adopting technology commercialization process could face high uncertainty and constraints. In particular, ICT-based firms that enter competitive markets must deal with more complex situations. Although in-depth research has been done to solve the problem, there is still a lack of understanding of how startups' technology commercialization process is successful. To discuss the issue, this paper presents the technology commercialization model and determinants.(policy, finance, work team, organizational culture, overcoming the difficulties etc.) the suitability of the framework. From this analysis it emerged that the sustainability of organizational capabilities is as important as the adherence to the technology commercialization process for companies. As the organizational capacity has decreased, the driving force for technology commercialization has weakened. Therefore, the technology commercialization process does not guarantee the success of the market entry but is understood as a means of market access. If the organizational capacity is not strengthened, there is no successful technology commercialization process.

A study of Polarization Modulator to Single-cell type in Polarized Glasses 3D Display System Using Binocular Parallax

  • Kong, Kyung-Bae;Kwon, Jung-Jang
    • Journal of the Korea Society of Computer and Information
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    • v.24 no.11
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    • pp.71-78
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    • 2019
  • Most 3D displays that are currently in the market adopt the binocular disparity method creating a different image for the left and right eye for a 3 dimensional effect. However, commercialized 3D image output devices lack in performance making it uncomfortable for the viewer and restrict the viewer to certain positions. In this paper, we propose a single-cell polarized lens type stereoscopic system which has a smaller viewing angle and reduced crosstalk, with improved light penetration compared to existing double-cell structures; and analyzed the single-cell polarized lens type stereoscopic system properties, and conducted an effect analysis of performance improvement compared to the dual-cell type. Results showed that the single-cell type had a 25% improved performance, and the 3D crosstalk index which is an important index for quality characteristics of stereoscopic systems, increased over about 37%, compared to the dual-cell type.

Study on tension-tension fatigue strength properties of underwater welded joints of SM41A-2 Plate-to-Plate (수중용접한 국산 SM41A-2강판의 편진반복 인장하중하의 피로강도특성에 관한 연구)

  • 오세규;박주성;한상덕
    • Journal of Advanced Marine Engineering and Technology
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    • v.11 no.2
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    • pp.71-81
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    • 1987
  • Nowadays, the high development of industrial technique demands the optimal design of marine structures to be welded under the water, because the underwater welding of the ship hull and marine structures can decrease manpower and cost of production. However there is not available at present any report on fatigue behavior about underwater welded joints. In this paper under tention- tension repeated fatigue stress with frequency of 10 cycles per second by local controlled system, the fatigue strength properties of underwater welded joints of SM41A-2 Plate-to-Plate of 10 mm thickness were experimentally examined. The results obtained were as follows : 1) The fatigue strength of underwater welded joints of SM41A-2 was peaked at the heat input of about 1, 400 joule/mm(180 A, 36 V), while, at the heat input of more than about 1, 100 joule/mm (160 A, 33 V) that of the underwater welds at the higher than cycle of life rather than the lower cycle was higher than that of the base metal but lower than that of the atmosphere welds on account of both cooling and notch effects. 2) The fatigue limit of underwater welds increased with an increase of heat input resulting in a peak of that at the heat input of about 1, 400 joule/mm and then decreased gradually. 3) The fatigue strength at N cycles was peaked between the heat input of about 1, 400 and 1, 700 joule/mm where the strain was rapidly increased. 4) It was confirmed that the optimal zone of heat input condition for obtaining the underwater welds fatigue strength higher than that of the base metal exists, and if out of this zone, the fatigue strength of the underwater welds was lower than that of the base metal because of lack weld penetration, inclusion of slag, voids, etc. 5) By the fatigue test, the underwater welds fractured brittly without visual deformation, so the strain was remarkably less than of the atmosphere welds. 6) The fatigue life factor was peaked at the heat input of about 1, 600 joule/mm (200 A, 36 V) at which the mean strain is a little higher than that of the base metal but quite lower than those of the atmosphere welds, resulting in good underwater welds because both fatigue strength and ductility of the underwater welds are higher than those of the base metal at such heat input.

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Study on Characteristics of Dose Distribution in Tissue of High Energy Electron Beam for Radiation Therapy (방사선 치료용 고에너지 전자선의 조직 내 선량분포 특성에 관한 연구)

  • Na, Soo-Kyung
    • The Journal of Korean Society for Radiation Therapy
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    • v.14 no.1
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    • pp.175-186
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    • 2002
  • The purpose of this study is directly measure and evaluate about absorbed dose change according to nominal energy and electron cone or medical accelerator on isodose curve, percentage depth dose, contaminated X-ray, inhomogeneous tissue, oblique surface and irradiation on intracavitary that electron beam with high energy distributed in tissue, and it settled standard data of hish energy electron beam treatment, and offer to exactly data for new dote distribution modeling study based on experimental resuls and theory. Electron beam with hish energy of $6{\sim}20$ MeV is used that generated from medical linear accelerator (Clinac 2100C/D, Varian) for the experiment, andwater phantom and Farmer chamber md Markus chamber und for absorbe d dose measurement of electron beam, and standard absorbed dose is calculated by standard measurements of International Atomic Energy Agency(IAEA) TRS 277. Dose analyzer (700i dose distribution analyzer, Wellhofer), film (X-OmatV, Kodak), external cone, intracavitary cone, cork, animal compact bone and air were used for don distribution measurement. As the results of absorbed dose ratio increased while irradiation field was increased, it appeared maximum at some irradiation field size and decreased though irradiation field size was more increased, and it decreased greatly while energy of electron beam was increased, and scattered dose on wall of electron cone was the cause. In percentage depth dose curve of electron beam, Effective depth dose(R80) for nominal energy of 6, 9, 12, 16 and 20 MeV are 1.85, 2.93, 4.07, 5.37 and 6.53 cm respectively, which seems to be one third of electron beam energy (MeV). Contaminated X-ray was generated from interaction between electron beam with high energy and material, and it was about $0.3{\sim}2.3\%$ of maximum dose and increased with increasing energy. Change of depth dose ratio of electron beam was compared with theory by Monte Carlo simulation, and calculation and measured value by Pencil beam model reciprocally, and percentage depth dose and measured value by Pencil beam were agreed almost, however, there were a little lack on build up area and error increased in pendulum and multi treatment since there was no contaminated X-ray part. Percentage depth dose calculated by Monte Carlo simulation appeared to be less from all part except maximum dose area from the curve. The change of percentage depth dose by inhomogeneous tissue, maximum range after penetration the 1 cm bone was moved 1 cm toward to surface then polystyrene phantom. In case of 1 cm and 2 cm cork, it was moved 0.5 cm and 1 cm toward to depth, respectively. In case of air, practical range was extended toward depth without energy loss. Irradiation on intracavitary is using straight and beveled type cones of 2.5, 3.0, 3.5 $cm{\phi}$, and maximum and effective $80\%$ dose depth increases while electron beam energy and size of electron cone increase. In case of contaminated X-ray, as the energy increase, straight type cones were more highly appeared then beveled type. The output factor of intracavitary small field electron cone was $15{\sim}86\%$ of standard external electron cone($15{\times}15cm^2$) and straight type was slightly higher then beveled type.

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