• Earthquakes and Structures
• /
• v.22 no.5
• /
• pp.487-502
• /
• 2022

China is prone to earthquake disasters, and the higher seismic performance is required by many existing civil buildings. And seismic evaluation and retrofit are effective measures to mitigate seismic hazards. With the development of performance-based seismic design and diverse retrofit technology for buildings, advanced evaluation methods and retrofit strategies are in need. In this paper, we introduced the evolution of seismic performance objectives in China combined with performance-based seismic design. Accordingly, multi-phase evaluation methods and comprehensive seismic capacity assessment are introduced. For buildings with seismic deficiency or higher performance requirements, the retrofit technologies are categorized into three types: component strengthening, system optimization, and passive control. Both engineering property and social property for the retrofit methods are discussed. The traditional seismic retrofit methods usually are costly and disturbing, and for example in Beijing, seismic strengthening costs approx. 1000 RMB/m² (for 160 USD/m²), for hospital building even more expensive as 5000 RMB/m²(for 790 USD/m²). So cost-efficient and little disturbance methods are promising techniques. In the end, some opinions about the retrofit strategy and schemes category are shared and wish to discuss the situation and future of seismic retrofit in China.

• BMB Reports
• /
• v.56 no.7
• /
• pp.374-384
• /
• 2023

Fibrosis is a pathological condition that is characterized by an abnormal buildup of extracellular matrix (ECM) components, such as collagen, in tissues. This condition affects various organs of the body, including the liver and kidney. Early diagnosis and treatment of fibrosis are crucial, as it is a progressive and irreversible process in both organs. While there are certain similarities in the fibrosis process between the liver and kidney, there are also significant differences that must be identified to determine molecular diagnostic markers and potential therapeutic targets. Long non-coding RNAs (lncRNAs), a class of RNA molecules that do not code for proteins, are increasingly recognized as playing significant roles in gene expression regulation. Emerging evidence suggests that specific lncRNAs are involved in fibrosis development and progression by modulating signaling pathways, such as the TGF-β/Smad pathway and the β-catenin pathway. Thus, identifying the precise lncRNAs involved in fibrosis could lead to novel therapeutic approaches for fibrotic diseases. In this review, we summarize lncRNAs related to fibrosis in the liver and kidney, and propose their potential as therapeutic targets based on their functions.

• Nuclear Engineering and Technology
• /
• v.55 no.10
• /
• pp.3591-3598
• /
• 2023

Photoneutron background spectroscopy observations at linac are essential for directing accelerator shielding and subtracting background signals. Therefore, we constructed a Bonner Sphere Spectrometer (BSS) system based on an array of BF₃ gas proportional counter tubes. Initially, the response of the BSS system was simulated using the MCNP5 code. Next, the response of the system was calibrated by using neutrons with energies of 2.86 MeV and 14.84 MeV. Then, the system was employed to measure the spectrum of the ²⁴¹Am-Be neutron source, and the results were unfolded by using the Gravel and EM algorithms. Using the validated system, the undesirable neutron spectrum of the 120 MeV electron linac was finally measured and acquired. In addition, it is demonstrated that the equivalent undesirable neutron dose at a distance of 3.2 m from the linac is 19.7 mSv/h. The results measured by the above methods could provide guidance for linac-related research.

• International Journal of Internet, Broadcasting and Communication
• /
• v.16 no.1
• /
• pp.140-147
• /
• 2024

In Current artificial structures, we must periodically make their safety inspections. In this process, we should consider the safety of workers and the accuracy of safety checks and also consider time and cost savings for safety inspections. Additionally, in the fields of architecture and civil engineering, we are unavoidable the use of foreign commercialized BIM model tools. To address these challenges, we propose mapping crack areas and BIM 3D design drawings based on augmented reality (AR) for the safety inspection of Huge Bridges. For this purpose, we define indexing of 2D/3D drawing models, create the tabulation of all 2D/3D drawings into a database, analyze QR codes, and finally integrate with augmented reality devices. we may expect our method to improve the efficiency of safety inspections on bridge sites. Moreover, we will enable the domestics of our pure technology.

• International Journal of High-Rise Buildings
• /
• v.2 no.3
• /
• pp.257-269
• /
• 2013

This study presents the development of an advanced multiple database-enabled design module for high-rise buildings (DEDM-HR), which seamlessly pools databases of multiple high frequency base balance measurements from geographically dispersed locations and merges them together to expand the number of available building configurations for the preliminary design. This feature offers a new direction for the research and professional communities that can be utilized to efficiently pool multiple databases therefore expanding the capability of an individual database and improving the reliability of design estimates. This is demonstrated, in this study, by the unprecedented fusion of two major established databases, which facilitates interoperability. The DEDM-HR employs a cyberbased on-line framework designed with user-friendly/intuitive web interfaces for the convenient estimation of wind-induced responses in the alongwind, acrosswind and torsional directions with minimal user input. In addition, the DEDM-HR embeds a novel feature that allows the use of wind characteristics defined in a code/standard to be used in conjunction with the database. This supplements the provisions of a specific code/standard as in many cases guidance on the acrosswind and torsional response estimates is lacking. Through an example, results from several international codes and standards and the DEDM-HR with the embedded features are compared. This provision enhances the scope of the DEDM-HR in providing an alternative design tool with nested general provisions of various international codes and standards.

• Structural Engineering and Mechanics
• /
• v.69 no.1
• /
• pp.11-20
• /
• 2019

The biaxial failure mechanism of transversally bedding concrete layers was numerically simulated using a sophisticated two-dimensional discrete element method (DEM) implemented in the particle flow code (PFC2D). This numerical modelling code was first calibrated by uniaxial compression and Brazilian testing results to ensure the conformity of the simulated numerical model's response. Secondly, 21 rectangular models with dimension of $54mm{\times}108mm$ were built. Each model contains two transversely bedding layers. The first bedding layer has low mechanical properties, less than mechanical properties of intact material, and second bedding layer has high mechanical properties, more than mechanical properties of intact material. The angle of first bedding layer, with weak mechanical properties, related to loading direction was $0^{\circ}$, $15^{\circ}$, $30^{\circ}$, $45^{\circ}$, $60^{\circ}$, $75^{\circ}$ and $90^{\circ}$ while the angle of second layer, with high mechanical properties, related to loading direction was $90^{\circ}$, $105^{\circ}$, $120^{\circ}$, $135^{\circ}$, $150^{\circ}$, $160^{\circ}$ and $180^{\circ}$. Is to be note that the angle between bedding layer was $90^{\circ}$ in all bedding configurations. Also, three different pairs of the thickness were chosen in models, i.e., 5 mm/10 mm, 10 mm/10 mm and 20 mm/10 mm. The result shows that in all configurations, shear cracks develop between the weaker bedding layers. Shear cracks angel related to normal load change from $0^{\circ}$ to $90^{\circ}$ with increment of $15^{\circ}$. Numbers of shear cracks are constant by increasing the bedding thickness. It's to be noted that in some configuration, tensile cracks develop through the intact area of material model. There is not any failure in direction of bedding plane interface with higher strength.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.12 no.1
• /
• pp.31-41
• /
• 2010

This paper presents both numerical and physical modeling approaches for the dilation and spalling of rock recognized as typical process of rock around an underground opening at depth. For physical approach, laboratory testing of rectangular beams using a synthetic rock was used to investigate the onset of dilation and spalling. The beams are axially compressed and subjected to 4-point bending to provide non-uniform compressive stresses which are similar to the maximum tangential stress distribution around circular openings. Discrete element numerical analyses using commercial code $PFC^{2D}$ (Particle Flow Code) were performed to evaluate the stress path at various locations in the beams. The findings from these approaches suggest that the onset of dilation in laboratory tests appears to be a good indicator for assessing the stress magnitudes required to initiate spalling.

• Nuclear Engineering and Technology
• /
• v.50 no.3
• /
• pp.356-367
• /
• 2018

A series of tests dedicated to station blackout (SBO) accident scenarios have been recently performed at the $Prim{\ddot{a}}rkreislauf-Versuchsanlage$ (primary coolant loop test facility; PKL) facility in the framework of the OECD/NEA PKL-3 project. These investigations address current safety issues related to beyond design basis accident transients with significant core heat up. This work presents a detailed analysis using the best estimate thermal-hydraulic code TRACE (v5.0 Patch4) of different SBO scenarios conducted at the PKL facility; failures of high- and low-pressure safety injection systems together with steam generator (SG) feedwater supply are considered, thus calling for adequate accident management actions and timely implementation of alternative emergency cooling procedures to prevent core meltdown. The presented analysis evaluates the capability of the applied TRACE model of the PKL facility to correctly capture the sequences of events in the different SBO scenarios, namely the SBO tests H2.1, H2.2 run 1 and H2.2 run 2, including symmetric or asymmetric secondary side depressurization, primary side depressurization, accumulator (ACC) injection in the cold legs and secondary side feeding with mobile pump and/or primary side emergency core coolant injection from the fuel pool cooling pump. This study is focused specifically on the prediction of the core exit temperature, which drives the execution of the most relevant accident management actions. This work presents, in particular, the key improvements made to the TRACE model that helped to improve the code predictions, including the modeling of dynamical heat losses, the nodalization of SGs' heat exchanger tubes and the ACCs. Another relevant aspect of this work is to evaluate how well the model simulations of the three different scenarios qualitatively and quantitatively capture the trends and results exhibited by the actual experiments. For instance, how the number of SGs considered for secondary side depressurization affects the heat transfer from primary side; how the discharge capacity of the pressurizer relief valve affects the dynamics of the transient; how ACC initial pressure and nitrogen release affect the grace time between ACC injection and subsequent core heat up; and how well the alternative feeding modes of the secondary and/or primary side with mobile injection pumps affect core quenching and ensure stable long-term core cooling under controlled boiling conditions.

• Journal of the Korean GEO-environmental Society
• /
• v.12 no.7
• /
• pp.57-65
• /
• 2011

Numerical simulations by three-dimensional Particle Flow Code($PFC^{3D}$, Itasca) considering distinct element method (DEM) were carried out for prediction of triaxial compression test with sand material. The effect of scale conditions for numerical model and distinct material on final prediction results was analyzed by numerical models under various scale conditions, and following observations were made from the numerical experiments. It is very useful to model the initial material condition without any porosity conversion from 2-D to 3-D DEM. Numerical experiments have shown that in all cases considered, 3D distinct element modeling could provide good agreement on stress-strain behavior, volume change and strength properties with laboratory testing results. It was important thing to assess reasonable scale ratio of numerical model and distinct elements for saving calculation time and securing calculation efficiency under condition with accuracy and appropriateness as numerical laboratory. As results of DEM simulations under various scale conditions, most of results show that shear strength properties as cohesion and internal friction angle are similar in condition of $D_{mod}/D_{gmax}$ < 10. It shows that 3-D distinct element method could be used as efficient tool to assess strength properties by numerical laboratory technique.

• Earthquakes and Structures
• /
• v.13 no.6
• /
• pp.519-529
• /
• 2017

The surrounding rocks of underground openings are natural materials and their mechanical behavior under seismic load is different from traditional man-made materials. This paper proposes a framework to comprehensively model the mechanical behavior of surrounding rocks. Firstly, the effects of seismic load on the surrounding rocks are summarized. Three mechanical effects and the mechanism, including the strengthening effect, the degradation effect, and the relaxation effect, are detailed, respectively. Then, the framework for modelling the mechanical behavior of surrounding rocks are outlined. The strain-dependent characteristics of rocks under seismic load is considered to model the strengthening effect. The damage concept under cyclic load is introduced to model the degradation effect. The quantitative relationship between the damage coefficient and the relaxation zone is established to model the relaxation effect. The major effects caused by seismic load, in this way, are all considered in the proposed framework. Afterwards, an independently developed 3D dynamic FEM analysis code is adopted to include the algorithms and models of the framework. Finally, the proposed framework is illustrated with its application to an underground opening subjected to earthquake impact. The calculation results and post-earthquake survey conclusions are seen to agree well, indicating the effectiveness of the proposed framework. Based on the numerical calculation results, post-earthquake reinforcement measures are suggested.