• Translational and Clinical Pharmacology
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• v.25 no.3
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• pp.153-156
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• 2017

UI14SDF100CW is a chewable tablet of sildenafil citrate, which was developed to improve compliance through convenience of administration. The purpose of this study was to compare the pharmacokinetic (PK) properties of sildenafil citrate chewable tablets (UI14SDF100CW) and conventional sildenafil citrate film-coated tablets ($Viagra^{(R)}$, Pfizer). A randomized, open-label, single dose, two-treatment, two-period, two-way crossover study was conducted in 60 healthy male volunteers. In each period, the subjects received a single oral dose of UI14SDF100CW or $Viagra^{(R)}$ (both tablets contain 140.45 mg of sildenafil citrate, which is equivalent to 100 mg of sildenafil). Serial blood samples were collected up to 24 h post-dose for PK analysis. The plasma concentration of sildenafil was determined using a validated HPLC-MS/MS assay. PK parameters of sildenafil were calculated using non-compartmental methods. The plasma concentration-time profiles of sildenafil in both formulations were similar. For UI14SDF100CW, the $C_{max}$ and $AUC_{last}$ of sildenafil were $1068.69{\pm}458.25$ (mean${\pm}$standard deviation) mg/L and $3580.59{\pm}1680.29h{\cdot}mg/L$, and the corresponding values for $Viagra^{(R)}$ were $1146.84{\pm}501.70mg/L$ and $3406.35{\pm}1452.31h{\cdot}mg/L$, respectively. The geometric mean ratios (90% confidence intervals) of UI14SDF100CW to $Viagra^{(R)}$ for $C_{max}$ and $AUC_{last}$ were 0.933 (0.853-1.021) and 1.034 (0.969-1.108), respectively, which met the bioequivalence criteria of Korean regulatory agency. In conclusion, UI14SDF100CW and $Viagra^{(R)}$ showed similar PK properties. Therefore, UI14SDF100CW can be an alternative to sildenafil for the treatment of erectile dysfunction, providing better compliance.

• The Southeast Asian review
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• v.21 no.1
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• pp.249-286
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• 2011

This study examines the nature of the world order or the international relations of the 19th century Vietnam. Those who are familiar with the Chinese world order based on the tributary system, have applied the quasi-Chinese world order concept to Vietnam by the terms of 'smaller dragon,' 'little China,' and 'Chinese model.' According to this way of understanding, Vietnamese empire was the imitation or the small sized version of the Chinese empire. Examples are to label Vietnamese emperor as the "Southeast Asian version of the Chinese emperor" or "an absolute photocopy of the Chinese world order." But the author of this article raises questions to this framework of the Chinese Model, and looks for the Vietnamese own world order based on the Southeast Asian tradition. Two issues are discussed in this study. First is the Vietnamese relationships with Southeast Asia. According to author, the first concern of Vietnam in relation to diplomatic relations was to the Mainland Southeast Asian countries. To clarify the contacts with Southeast Asia and Western powers, Vietnamese relationships with the regions of Island Southeast Asian countries were also examined. Second issue is to see the ways how Vietnam maintained its own world order in the course of wars and diplomacy with China. Author argues that the world order of the 19th century Vietnam was closer to the traditional world order of mandala in the Southeast Asia than to the quasi Chinese world order. The relationships among the countries were rather equal than hierarchical. Vietnam regarded the countries of Southeast Asia especially Thailand and Burma as the equal countries. China was one of the equal countries to the eyes of Vietnamese leaders and Vietnam did not have enough room to embody the quasi Chinese world order though the Vietnamese rulers used the titles of emperor, which was the Vietnamese version of Southeast Asian 'king.' In conclusion, the world order of Vietnam is summarized into the two facets of $l{\hat{a}}n$ giao(diplomatic relations with neighbors) and bang giao(diplomatic relations between two countries i.e. Vietnam and China). $l{\hat{a}}n$ giao was to the countries of Southeast Asia while the bang giao was the term and concept for the diplomatic relationship with China. These two relationships composed Vietnamese foreign relationship, ngo?i giao. Author claims that these two relations were based on the spirit of equality that emerged from the beginning of the 19th century.

• Journal of Convergence for Information Technology
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• v.11 no.3
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• pp.20-33
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• 2021

This study is to suggest improvements of personal information protection in South Korea, according to requiring the safety of process and protection of personal information. Accordingly, based on data collection and analysis through literature research, this study derived the issues and suitable standards of personal information for major artificial intelligence services. In addition, this cases studies were reviewed, focusing on the legal compliance and porcessing compliance for personal information proection in major countries. And it suggested the improvement plan applied in South Korea. As the results, in legal compliance, it is required reorganization of related laws, responsibility and compliance to develop and provide AI, and operation of risk management for personal information protection laws in AI services. In terms of processing compliance, first, in pre-processing and refining, it is necessary to standardize data set reference models, control data set quality, and voluntarily label AI applications. Second, in development and utilization of algorithm, it is need to establish and apply a clear regulation of the algorithm. As such, South Korea should apply suitable improvement tasks for personal information protection of safe AI service.

• Tuberculosis and Respiratory Diseases
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• v.84 no.2
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• pp.96-104
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• 2021

Background: Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. This study aimed to assess the efficacy and safety of direct switch from once-daily tiotropium (TIO) 18 ㎍ to indacaterol/glycopyrronium (IND/GLY) 110/50 ㎍ once daily in COPD patients in Korea. Methods: This was a randomized, open-label, parallel group, 12-week trial in mild-to-moderate COPD patients who received TIO 18 ㎍ once daily for ≥12 weeks prior to study initiation. Patients aged ≥40 years, with predicted post-bronchodilator forced expiratory volume in 1 second (FEV₁) ≥50%, post-bronchodilator FEV₁/forced vital capacity <0.7 and smoking history of ≥10 pack-years were included. Eligible patients were randomized in a 1:1 ratio to either IND/GLY or TIO. The primary objective was to demonstrate superiority of IND/GLY over TIO in pre-dose trough FEV₁ at week 12. Secondary endpoints included transition dyspnea index (TDI) focal score, COPD assessment test (CAT) total score, and rescue medication use following the 12-week treatment, and safety assessment. Results: Of the 442 patients screened, 379 were randomized and 347 completed the study. IND/GLY demonstrated superiority in pre-dose trough FEV₁ versus TIO at week 12 (least squares mean treatment difference [Δ], 50 mL; p=0.013). Also, numerical improvements were observed with IND/GLY in the TDI focal score (Δ, 0.31), CAT total score (Δ, -0.81), and rescue medication use (Δ, -0.09 puffs/day). Both treatments were well tolerated by patients. Conclusion: A direct switch from TIO to IND/GLY provided improvements in lung function and other patient-reported outcomes with an acceptable safety profile in patients with mild-to-moderate airflow limitation.

• Journal of Broadcast Engineering
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• v.27 no.2
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• pp.185-197
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• 2022

Recently, deep learning networks with high performance for object recognition are emerging. In the case of object recognition using deep learning, it is important to build a training data set to improve performance. To build a data set, we need to collect and label the images. This process requires a lot of time and manpower. For this reason, open data sets are used. However, there are objects that do not have large open data sets. One of them is data required for license plate detection and recognition. Therefore, in this paper, we propose an artificial license plate generator system that can create large data sets by minimizing images. In addition, the detection rate according to the artificial license plate arrangement structure was analyzed. As a result of the analysis, the best layout structure was FVC_III and B, and the most suitable network was D2Det. Although the artificial data set performance was 2-3% lower than that of the actual data set, the time to build the artificial data was about 11 times faster than the time to build the actual data set, proving that it is a time-efficient data set building system.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.40 no.2
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• pp.91-108
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• 2022

In most cases, optical images have been used as training data of DL (Deep Learning) models for object detection, recognition, identification, classification, semantic segmentation, and instance segmentation. However, properties of 3D objects in the real-world could not be fully explored with 2D images. One of the major sources of the 3D geospatial information is DSM (Digital Surface Model). In this matter, characteristic information derived from DSM would be effective to analyze 3D terrain features. Especially, man-made objects such as buildings having geometrically unique shape could be described by geometric elements that are obtained from 3D geospatial data. The background and motivation of this paper were drawn from concept of the intrinsic image that is involved in high-level visual information processing. This paper aims to extract buildings after classifying terrain features by training DL model with DSM-derived information including slope, aspect, and SRI (Shaded Relief Image). The experiments were carried out using DSM and label dataset provided by ISPRS (International Society for Photogrammetry and Remote Sensing) for CNN-based SegNet model. In particular, experiments focus on combining multi-source information to improve training performance and synergistic effect of the DL model. The results demonstrate that buildings were effectively classified and extracted by the proposed approach.

• Korean Journal of Remote Sensing
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• v.38 no.5_3
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• pp.967-977
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• 2022

The occurrence and intensity of wildfires are increasing with climate change. Emissions from forest fire smoke are recognized as one of the major causes affecting air quality and the greenhouse effect. The use of satellite product and machine learning is essential for detection of forest fire smoke. Until now, research on forest fire smoke detection has had difficulties due to difficulties in cloud identification and vague standards of boundaries. The purpose of this study is to detect forest fire smoke using Level 1 and Level 2 data of Geostationary Environment Monitoring Spectrometer (GEMS), a Korean environmental satellite sensor, and machine learning. In March 2022, the forest fire in Gangwon-do was selected as a case. Smoke pixel classification modeling was performed by producing wildfire smoke label images and inputting GEMS Level 1 and Level 2 data to the random forest model. In the trained model, the importance of input variables is Aerosol Optical Depth (AOD), 380 nm and 340 nm radiance difference, Ultra-Violet Aerosol Index (UVAI), Visible Aerosol Index (VisAI), Single Scattering Albedo (SSA), formaldehyde (HCHO), nitrogen dioxide (NO₂), 380 nm radiance, and 340 nm radiance were shown in that order. In addition, in the estimation of the forest fire smoke probability (0 ≤ p ≤ 1) for 2,704 pixels, Mean Bias Error (MBE) is -0.002, Mean Absolute Error (MAE) is 0.026, Root Mean Square Error (RMSE) is 0.087, and Correlation Coefficient (CC) showed an accuracy of 0.981.

• Journal of Daesoon Thought and the Religions of East Asia
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• v.1 no.2
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• pp.41-59
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• 2022

Caodaism is a new religion from Vietnam which began in late 1925 and spread rapidly across the French colony of Indochina. With a broad syncretic aim, the new faith sought to revivify Vietnamese religious traditions whilst also incorporating religious, literary, and spiritist influences from France. Like Catholicism, Caodaism kept a strong focus on its monotheistic nature and today Caodaists are eager to label their religion a monotheism. It will be argued here, however, that the syncretic nature of this new faith complicates this claim to a significant degree. To make this argument, we will consider here the nature of God in Caodaism through two central texts from two important stages in the life of the religion. The first is the canonized Compilation of Divine Messages which collects a range of spirit messages from God and some other divine voices. These were received in the early years of the faith. The second is a collection of sermons from 1948/9 that takes Caodaist believers on a tour of heaven, and which is entitled The Divine Path to Eternal Life. It will be shown that in the first text, God speaks in the mode of a fully omnipotent and omniscient supreme being. In the second text, however, we are given a view of paradise that is much more akin to the court of a Jade Emperor within an East Asian milieu. In these realms, the personalities of other beings and redemptive mechanisms claim much of our attention, and seem to be a competing center of power to that of God. Furthermore, God's consort, the Divine Mother, takes on a range of sacred creative prerogatives that do something similar. Additionally, cadres of celestial administrators; buddhas, immortals, and saints help with the operation of a cosmos which spins on with guidance from its own laws. These laws form sacred mechanisms, such as cycles of reincarnation and judgement. These operate not in the purview of God, but as part of the very nature of the cosmos itself. In this context, the dualistic, polytheistic, and even automatic nature of Caodaism's cosmos will be considered in terms of the way in which they complicate this religion's monotheistic claims. To conclude, this article seeks to demonstrate the precise relevance of the term 'monotheism' for this religion.

• Herbal Formula Science
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• v.30 no.4
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• pp.241-248
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• 2022

Objective : The purpose of this trial is to observe the preliminary effects of Salvia plebeia (SP) extract on quality of life in patients with solid cancer. Methods : This is a prospective, open-label, single-arm, and single-dose clinical trial. Twenty participants who have been diagnosed with solid cancer between the ages of 20 and 65 will be included. All participants will be administered SP granules for 12 weeks. Data will be collected at 4, 8, and 12 weeks after enrollment. The primary outcome is quality of life, using the Korean version of the Functional Assessment Cancer Therapy-General questionnaire. Secondary outcomes include tumor markers in blood tests for each cancer type, soluble programmed death-ligand 1, the percentage of natural killer cells among lymphocytes, ratio of T-helper and T-suppressor cells, ratio of total T, T-helper, T-suppressor, and B cells in lymphocytes, level of C-reactive protein, and tumor size via radiology examination. Safety will be assessed by clinical laboratory tests and monitoring of adverse events. Discussion : This study aims to observe the effects of an oral administration of SP preparations in patients with solid cancer on changes in quality of life and an improvement in immune function. It is expected to provide objective evidence of the effect and safety of SP for patients with solid cancer. Trial registration: KCT0007315 (Clinical Research Information Service)

• Animal Bioscience
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• v.35 no.2
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• pp.281-289
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• 2022

Objective: The aim of this study was to characterize the exopolysaccharides (EPS)-producing lactic acid bacteria from Taiwanese ropy fermented milk (TRFM) for developing a clean label low-fat fermented milk. Methods: Potential isolates from TRFM were selected based on the Gram staining test and observation of turbid suspension in the culture broth. Random amplified polymorphic DNA-polymerase chain reaction, 16S rRNA gene sequencing, and API CHL 50 test were used for strain identification. After evaluation of EPS concentration, target strains were introduced to low-fat milk fermentation for 24 h. Fermentation characters were checked: pH value, acidity, viable count, syneresis, and viscosity. Sensory evaluation of fermented products was carried out by 30 volunteers, while the storage test was performed for 21 days at 4℃. Results: Two EPS-producing strains (APL15 and APL16) were isolated from TRFM and identified as Lactococcus (Lc.) lactis subsp. cremoris. Their EPS concentrations in glucose and lactose media were higher than other published strains of Lc. lactis subsp. cremoris. Low-fat fermented milk separately prepared with APL15 and APL16 reached pH 4.3 and acidity 0.8% with a viable count of 9 log colony-forming units/mL. The physical properties of both products were superior to the control yogurt, showing significant improvements in syneresis and viscosity (p<0.05). Our low-fat products had appropriate sensory scores in appearance and texture according to sensory evaluation. Although decreasing viable cells of strains during the 21-day storage test, low-fat fermented milk made by APL15 exhibited stable physicochemical properties, including pH value, acidity, syneresis and sufficient viable cells throughout the storage period. Conclusion: This study demonstrated that Lc. lactis subsp. cremoris APL15 isolated from TRFM had good fermentation abilities to produce low-fat fermented milk. These data indicate that EPS-producing lactic acid bacteria have great potential to act as natural food stabilizers for low-fat fermented milk.