• Korean Journal of Microbiology
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• v.23 no.1
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• pp.20-24
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• 1985

The effects of various nitrogen soruces on the expression of nif gene were investigated using nif-lac fusants of Klebsiella pneumoniae. K. pneumoniae UK 2979 was infected with Mudl lysate prepared by heat induction of K. pneumoniae UK 4482. About 80 nif-lac fusants were isolated and designated as LX series. In the prescence of $NH_4^+,\;{\beta}-galactosidase$ activities on nif-lac fusants were greatly repressed. Amino acids, such as serine, glutamine and asparagine, were found to support the growth of K. pneumoniae M5al quite well, and showed a repressive effect on ${\beta}-galactosidase$ activities of nif-lac fusants LX-9 and LX-22 in NFHM. Glutamic acid, histidine and arginine rendered poor growth but high activities of ${\beta}-galactosidase$. Good cell growth and high enzyme activity were observed when complex nitrogen sources, such as casitone, proteose pepone, were employed. ${\beta}-galactosidase$ activities of LX-9 and LX-22 in nitrogen free minimal medium increased sharply within first 4 hours.

• Science of Emotion and Sensibility
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• v.16 no.3
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• pp.305-310
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• 2013

This user-centered research aims to empirically evaluate color temperature (K) and illuminance (lx) of residential bathroom lightings to determine the most optimal lighting conditions for productive task performance as well as for satisfying users' emotional needs. Using 3 LED lighting fixtures, 4 types of lighting contexts were investigated; main lighting, task lighting, shower lighting, and bath lighting. Two lightings were installed parallel to the vertical edges of the main bathroom mirror to be used as main and task lighting, while another fixture was installed above the bathtub to be used for shower and bathing. For each lighting context, subjects (N＝54) were instructed to perform a few tasks during which time the users were exposed to different lighting conditions with color temperature ranging from 2700 K ~ 6500 K and illuminance ranging from 100 lx ~ 700 lx. Upon completing the given tasks, subjects were asked to evaluate the lighting conditions and their applicability for performing the given tasks. Based on the user evaluations, the most optimal lighting conditions for the different lighting scenarios are as follow: 1) 3500 K ~ 4300 K and 150 lx for main lighting, 2) 3500 K ~ 4300 K and 500 lx ~ 700 lx for task lighting, and 3) 2700 K ~ 3500 K and 100 lx ~ 150 lx for shower/bath lighting. These results can be used to adjust the lighting standards suggested by KS, as well as be utilized by both engineers and designers in designing new types of user-centered bathroom lightings.

• Journal of KIISE:Computing Practices and Letters
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• v.10 no.2
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• pp.146-155
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• 2004

Currently most of commercial operating systems contain a high-level audit feature to increase their own security level. Linux does not fall behind the other commercial operating systems in performance and stability, but Linux does not have a good audit feature. Linux is required to support a higher security feature than C2 level of the TCSEC in order to be used as a server operating system, which requires the kernel-level audit feature that provides the system call auditing feature and audit event. In this paper, we present LxBSM, which is a kernel module to provide the kernel-level audit features. The audit record format of LxBSM is compatible with that of Sunshield BSM. The LxBSM is implemented as a loadable kernel module, so it has the enhanced usability. It provides the rich audit records including the user-level audit events such as login/logout. It supports both the pipe and file interface for increasing the connectivity between LxBSM and intrusion detection systems (IDS). The performance of LxBSM is compared and evaluated with that of Linux kernel without the audit features. The response time was increased when the system calls were called to create the audit data, such as fork, execve, open, and close. However any other performance degradation was not observed.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2002.05a
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• pp.305-309
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• 2002

본 연구에서는 조도조건에 따른 VDT작업자의 각성도를 평가하기 위하여 10 lx와 1500 lx 2종류의 조도 조건으로 하여 모니터 상에서 1자리 숫자 3개를 더하는 단조연산작업을 수행하였다. 그 결과 155 lx보다 비교적 졸음이 쉽게 유발되며 주의집중정도가 낮은 조도 10 lx에서의 정답률이 더 낮게 나왔다. 또한, 두 조도조건 하에서 호흡간격은 작업수행시 큰 차이가 안 나타난 반면 RR간격은 10 lx에서는 작업수행 횟수가 증가함에 따라 점차 증가하지만 1500 lx에서는 거의 변화가 없었다.

• Biomolecules & Therapeutics
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• v.31 no.4
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• pp.425-433
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• 2023

During liver injury, hepatic stellate cells can differentiate into myofibroblast-like structures, which are more susceptible to proliferation, migration, and extracellular matrix generation, leading to liver fibrosis. Anaerobic glycolysis is associated with activated stellate cells and glyceraldehyde (GA) is an inhibitor of glucose metabolism. Therefore, this study aimed to investigate the anti-fibrotic effects of GA in human stellate LX-2 cells. In this study, we used cell viability, morphological analysis, fluorescence-activated cell sorting (FACS), western blotting, and qRT-PCR techniques to elucidate the molecular mechanism underlying the anti-fibrotic effects of GA in LX-2 cells. The results showed that GA significantly reduced cell density and inhibited cell proliferation and lactate levels in LX-2 cells but not in Hep-G2 cells. We found that GA prominently increased the activation of caspase-3/9 for apoptosis induction, and a pan-caspase inhibitor, Z-VAD-fmk, attenuated the cell death and apoptosis effects of GA, suggesting caspase-dependent cell death. Moreover, GA strongly elevated reactive oxygen species (ROS) production and notably increased the phosphorylation of ERK and JNK. Interestingly, it dramatically reduced α-SMA and collagen type I protein and mRNA expression levels in LX-2 cells. Thus, inhibition of ERK and JNK activation significantly rescued GA-induced cell growth suppression and apoptosis in LX-2 cells. Collectively, the current study provides important information demonstrating the anti-fibrotic effects of GA, a glycolytic metabolite, and demonstrates the therapeutic potency of metabolic factors in liver fibrosis.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2002.11a
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• pp.749-753
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• 2002

Wireless technology is glowing rapidly in the new millennium period. By this technical progress, new idea which separate CDMA 2000-1x service and existing mobile service by the account appears in interconnection market. Especially fixed operator and mobile operator insist contrary opinions. Account Separation of CDMA 2000-lx service is not studied despite it's importance. This paper deal with this subject and analyse logic of operators opinion. By the result of this paper, CDMA 2000-lx is more a 3rd generation service than a 2.5rd generation service and the current account separation criteria based on using frequency bandwidth is not desirable.

• Korean Journal of Applied Biomechanics
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• v.24 no.2
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• pp.167-172
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• 2014

The purpose of this study was to investigate walking standard time and joint powers of the lower extremities on the changes of illuminations in the elderly women. Ten older women ($70.90{\pm}3.28$ years, $154.70{\pm}3.47$ cm, $53.80{\pm}5.39$ kg) with normal vision and no gait disabilities participated in this study. All the experiments were performed on a level walkway from low to high lighting (six conditions). A 3-dimensional motion capturing system, force-plate, and EMG were used to acquire and analyze walking motion, force, and muscle activity data; the sampling frequency was 100 Hz, 1000 Hz and 1000 Hz respectively. To test the differences on walking standard time and joint powers of the lower extremities between the six lighting conditions, one-way repeated ANOVAs were evaluated. The following results were drawn: First, mean standard time was about 1.3 sec/stride, and velocities were smaller with lighting increasing except 100 Lx. Second, the joint power patterns of ankle and knee were not consistent, but only hip joint power was a greatest in 6 Lx and a smallest in 400 Lx. Third, standard times(100 Lx<300 Lx, 400 Lx) were statistically significant, and hip joint max powers (100 Lx>others) were also statistically significant. But ankle and knee joint max power were not statistically significant. These results showed that standard times from low to high lighting were not consistent, and hip joint of 100 Lx has a greatest rotational torque. We suggested that gait strategies of them as to changing illuminations were not consistent and findings may represent a lack of adaptability in the elderly women.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.14 no.2
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• pp.104-109
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• 2003

The purpose of this study is to analyze the EGG measures from Lx Speech Studio program (Laryngograph Ltd, UK) in patient with vocal nodule. Thirty female adults (15 patient with vocal nodule, 15 normal speaker) produced sustained vowel and read the passage. They were grouped into three groups based on Grade (GRBAS) : normal-G0, nodule-Gl, nodule-G2. Estimates of Fx (Hz), Qx(%), Jitter, Shimmer, and HNR were made from a 500msec midportion of vowel. In addition, DFx(Hz), DQx(%), CFx(%) and CAx(%) were obtained from reading the passage. These data were compared among groups. The results were as follow Jitter, Shimmer, HNR were significantly higher in nodule-G2 group than in normal-G0 & patient-Gl group. In nodule-G2 group, CFx and CAx from reading passage were significantly higher. For patients with nodule, asymmetry or irregularity were observed in graphs of QxFx ＆ CFx provided by Quantitative Analysis.

• Journal of Astronomy and Space Sciences
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• v.17 no.1
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• pp.45-52
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• 2000

We examined and corrected the periodic error of the LX200-16 Telescope driving system of Chungbuk National University Campus Observatory. Before correcting, the standard deviation of the periodic error in the direction of East-West was $\sigma$=7."2. After correcting, we found that the periodic error was reduced to $\sigma$=1."2.

• Advances in Traditional Medicine
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• v.10 no.4
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• pp.254-262
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• 2010

Artemisia capillaris (A. capillaries) is known to play roles in many cellular events, such as cell proliferation, differentiation, and apoptosis. We investigated the antifibrogenic efficacy of A. capillaris in the immortalized human hepatic stellate cell line LX2. Cell proliferation was determined by the MTT assay. Cell cycle was analyzed by the flow cytometry. Apoptotic cells were measured using a cell death detection ELISA. Caspase activity was detected by a colorimetric assay. The mRNA level of Bcl-2 and Bax mRNA were measured by real-time PCR. MEK and ERK protein were detected by Western blot analysis. We provide evidence that A. capillaris induces cell cycle arrest, apoptosis, and potently inhibits the mitogen-activated protein kinase pathway. A. capillaris inhibited cell proliferation of LX2 cells in a dose- and time-dependent manner, increased the apoptosis fraction at cell cycle analysis with an accompanying DNA fragmentation, and resulted in a significant decrease in Bcl-2 mRNA levels and an increase in Bax expression. Exposure of LX2 cells to A. capillaris induced caspase-3 activation, but co-treatment of A. capillaris with the pan-caspase inhibitor Z-VAD-FMK, and the caspase-3 inhibitor Z-DEVE-FMK, blocked apoptosis. A. capillaris down-regulated Mcl-1 protein levels and inhibited phosphorylation of MEK/ERK, suggesting that it mediates cell death in LX2 cells through the down-regulation of Mcl-1 protein via a MEK/ERK-independent pathway.