• 한국콘텐츠학회논문지
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• 제11권3호
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• pp.262-270
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• 2011

본 연구는 swiss ball LSE에 따른 하지 경직도, 균형 및 보행에 관한 효과를 알아보고자 BBS, FRT, 수정된 Ashworth 척도(MAS), TUG 측정 분석 하였다. 대상자는 H병원에서 입원 또는 통원치료를 받고 있는 뇌졸중 환자 중 선정기준에 적합한 34명을 고전적 신경물리치료군 17명, swiss ball LSE 실시군에 17명씩 할당하여 하지의 균형능력은 BBS와 FRT, 경직도는 MAS, 보행능력은 TUG를 사용하여 비교 분석하였다. Swiss ball LSE군에서 BBS와 FRT는 유의하게 증가하였으며, MAS와 TUG는 유의하게 감소하였다. 또한 군간의 비교에서는 FRT와 MAS에서 유의한 차이가 나타났다. 결과적으로 swiss ball LSE는 뇌졸중 환자의 하지 근경직, 균형능력 및 보행능력을 회복시킬 수 있는 것으로 사료된다.

• 한방안이비인후피부과학회지
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• 제22권1호
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• pp.33-45
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• 2009

Objective : Lacca Sinic: Exsiccate (LSE) extracted from Rhus vemicitlus Stokes (RVS) has been used traditionally as a remedy for inflammation in Korea, China, and Japan. However, as yet there is no clear explanation of how LSE affects the production of inflammatory cytokines. This study was to determine the effects of LSE on the mast cell-mediated inflammatory responses. Method : We measured the amount of inflammatory cytokine production induced by the phorbol myristate acetate (PMA) plus calcium ionophore(A231S7) in the human mast cell line (HMC-l) incubated with various concentrations of Laces Sinica Exsiccate (LSE). The $TNF-\alpha$, IL-6 and IL-8 secreted protein levels were measured by the ELISA assay. The $TNF-\alpha$, IL-6 and IL-8 mRNA levels were measured by the RT-PCR analysis. Nuclear and cytoplasmic proteins were examined by Western blot analysis. The NF-${\kappa}B$ promoter activity was examined by a luciferase assay. Result : LSE inhibited the PMA + A231S7-induced $TNF-\alpha$, IL-6, and IL-8 expression and suppressed NF-${\kappa}B$ activation in the stimulated-HMC-1. In addition, LSE inhibited induction of NF-${\kappa}B$ promoter-mediated luciferase activity. Conclusion : In this study, we have found that LSE is an inhibitor of NF-${\kappa}B$ and cytokines on the mast cell-mediated inflammatory responses.

• 대한원격탐사학회지
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• 제29권2호
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• pp.219-233
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• 2013

본 연구에서는 아시아-오세아니아 지역에서의 세 지표면 방출률 자료 (MODIS, CIMSS, KNU)의 시 공간적 분포와 변동 특성을 비교 분석하였다. 세 자료 모두 계절에 관계없이 티베트 고원, 페르시아만 주변의 중동지역 및 호주 사막지역, 저위도 지역에서 매우 유사한 방출률 분포를 보이고 있다. 일부지역을 제외한 대부분 지역에서 $12{\mu}m$ 채널의 방출률이 $11{\mu}m$보다 크며, 특히 티베트 고원과 중동지역, 호주 사막지역 일부에서 그 차이가 크다. 저위도 지역에서의 방출률은 서로 상이하지만 방출률의 계절변동이 크지 않은 공통점을 보이고 있다. 그러나 그 외 대부분 지역에서 세 자료는 방출률의 시 공간 변동성에서 큰 차이를 보이고 있다. KNU 자료는 여름에 높고 겨울에 낮은 방출률을 보여 계절변동이 뚜렷하나, MODIS와 CIMSS 자료는 계절에 따른 방출률 변화가 불규칙하며 뚜렷하지 않았다. KNU와 MODIS(KNU와 CIMSS; MODIS와 CIMSS) 자료간의 공간상관계수의 연평균은 $11{\mu}m$와 $12{\mu}m$ 채널에서 각각 0.423과 0.399 (0.330, 0.101; 0.541, 0.154)로 낮다. 특히 $12{\mu}m$ 채널의 경우 서로 상관성이 매우 낮을 뿐만 아니라 상관계수의 월 변동도 강하게 나타나 세 자료간 일치성이 매우 낮다. 본 연구 결과는 아시아-오세아니아 지역에서의 지표면 방출률 자료 개선이 시급함을 제시한다.

• 한방안이비인후피부과학회지
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• 제19권3호통권31호
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• pp.1-12
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• 2006

Objective : Angiogenesis is an essential process for metastasis of solid tumors and Psoriasis. Lots of Researches for anti-angiogenic effect to angiogenic factors have been carried out in the world. So this experiment was carried out for whether Lacca Sinica Exsiccata(LSE) extracts have an anti-angiogenic effect for angiogenic factors. Methods: To investigate the roles of the LSE extracts, we performed MIS assay, western blots using HaCaT cells and HepG2 cells. And then, HaCaT cells were treated with 10, 50, 100, 250, $500{\mu}g/ml$ LSE extracts. After 4hrs, HaCaT cells were theated with IGF-II protein for 1hr. HepG2 cells were treated with 1, 10, 25, 50, 100, 200 ${\mu}g/ml$ LSE extracts. After 4hrs, HepG2 cells were theated with $CoCl_2$ for 24hrs Results: 1. In $50{\mu}g/ml$ and $100{\mu}g/ml$ density we confirmed the inhibition effect of LSE extracts to $HIF-1{\alpha}$ activation which was induced by IGF-II in HaCaT cells. 2. In $50{\mu}g/ml$ density we confirmed the inhibition effect of LSE extracts to $HIF-1{\alpha}$ activation which was induced by $CoCl_2$ in HepG2 cells. 3. In $25{\mu}g/ml$ density we confirmed the inhibition effect of LSE extracts to VEGF activation which was induced by $CoCl_2$ in HepG2 cells. Conclusion: The above-mentioned results proved that LSE extracts reduced $HIF-1{\alpha}$ protein level in the HaCaT cells and HepG2 cells. These results suggest that inhibition of HaCaT cell and HepG2 cell proliferation by LSE extracts contributes to the anti-angiogenic activities on the keratinocytes and hepatocellular carcinoma.

• 대한통합의학회지
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• 제2권3호
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• pp.39-48
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• 2014

Purpose : The purpose of this study was to identify the effect of lumbar stabilization exercise (LSE) and isometric lumbar strengthening exercise (ILSE) on lumbar strength and lumbar extension range in healthy young adults. Method : Ten healthy young adults (six males and four females) volunteered to carry out the LSE and ILSE program for two weeks. The subjects were randomly allocated to two groups: the LSE group (n=5) and the LSE plus ILSE group (n=5). The LSE consisted of 20 minutes of exercise related to lumbar stabilization, and the ILSE was composed of five minutes of isometric stabilization exercise with a specific device. Each group exercised three times per week for two weeks. Assessment tools were made using the subjects' isometric lumbar strength and lumbar extension range before and after the interventions. Results : Statistical analysis revealed significant differences in isometric lumbar strength and the lumbar extension range between before and after the interventions in each group (p<.05). Also, the lumbar extension range improved significantly in the LSE plus ILSE group compared to the LSE group; however, there was no statistically significant difference in the two groups' isometric lumbar strength (p>.05). Conclusion : The findings suggest that ILSE might be feasible in clinical settings by offering benefits for lumbar function. Future studies will be continued.

• 대한화장품학회지
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• 제39권4호
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• pp.313-322
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• 2013

본 연구에서는 예로부터 민간에서 사용되어진 약초인 토인삼 추출물의 피부보호 효과를 측정하기위해 항산화, 자외선에 의해 유도된 matrix metalloproteinases-1 (MMP-1) 발현저해효과, 자외선에 대한 세포보호효과, 노화세포를 이용한 senescence-associated ${\beta}$-galactosidase (SA-${\beta}$-gal) 활성을 사람 섬유아세포(HDF)를 이용하여 확인하였다. 그 결과, 토인삼 추출물의 free radical과 superoxide radical 소거효과는 처리농도가 증가함에 따라 농도 의존적으로 나타났으며, 토인삼 잎, 줄기 추출물(LSE) 500 ${\mu}g/mL$에서 98.45%와 97.01%의 DPPH와 superoxide radical을 소거하여 우수한 항산화 효과를 나타내었다. 토인삼 잎, 줄기 추출물(LSE)의 MMP-1의 발현 저해효과는 섬유아세포에서 UVA조사 실험에서 우수하게 나타났으며, UVB 조사에 의한 세포보호 효과도 우수하게 나타났다. 또한 노화세포를 이용한 SA-${\beta}$-gal활성은 토인삼 잎, 줄기 추출물(LSE)을 처리하였을 시 염색된 세포의 수가 감소하여 세포내 senescence를 억제하는 것을 확인할 수 있었다. 이상의 결과들을 종합해 보면, 토인삼의 지상부분인 잎, 줄기 추출물(LSE)은 항노화 및 항산화제로서의 우수한 특성으로 피부손상에 의한 산화적 스트레스에 대응하는 새로운 기능성 소재로서의 가능성을 가지는 것으로 평가된다.

• 대한예방한의학회지
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• 제10권1호
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• pp.75-93
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• 2006

Rhus verniciflua Stokes(RVS) has been widely used as a food and traditional herbal medicine in Korea. RVS has been reported that the extract from its wood and fruit has strong antioxidant activity and anticancer effect but there is little information on Lacca Sinica Exsiccata(LSE), the resin of RVS, as a medicinal use. The aim of this study was to evaluate the antidiabetic effect of ethanol-eluted extract of LSE on streptozotocin(STZ) - induced diabetic rats. Diabetes was induced in male Sprague-Dawley rats with STZ injection. Oral administration of LSE extract(50mg or 100mg/kg of body weight/day) was given to diabetic group. During 4 weeks of experiment, diabetic rats showed significant weight loss and decreasing feed efficiency ratios(FER) compared with normal rats, while the diabetic group orally fed with LSE extract showed a trend of decreasing weight loss and a significant increase of FER(p<0.05). In 4 weeks after induction of diabetes, diabetic rats showed an increase in weight of liver, kidney and heart, whereas the diabetic rats administered with LSE extract showed a reduction in the weight of heart. Blood glucose level was decreased in diabetic rats treated with LSE extract, but it was not statistically significant. Glutamic oxaloacetic transaminase, Glutamic pyruvate transaminase and total cholesterol levels were lower in the diabetic group treated with LSE extract than in untreated diabetic group, but not significant. These results present that LSE may partly have antidiabetic effect and may protect against the development of diabetic heart complications resulting from impaired glucose metabolism.

• 동아시아식생활학회지
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• 제14권5호
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• pp.407-417
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• 2004

This study was conducted to investigate the application possibility of leaf and stem extract(LSE) extracted from the mixture of leaf and stem of ginseng radix(Panax ginseng CA. Meyer). This study measured the intake levels and efficiency ratio, growth rate, absorption ratio of carbohydrate, lipid and protein of rat by feeding with LSE during 6 weeks. We analyse the hematological and serum metabolic variables, serum lipid concentrations. Total diet and protein intake levels were low, but efficiency ratios were significantly high in LSE administered groups than the control group. Weight gain, liver and kidney weight of LSE groups were significantly higher than the control group. Blood RBC, Hct, Hb, total protein and albumin concentrations were reasonable levels in LSE administered groups compared to the basal diet group. Also serum total cholesterol, LDL-cholesterol, triglyceride contents of LSE groups were low, but HDL-cholesterol level was higher than the basal diet group. These results imply that leaf and stem of ginseng radix could be used as possible food resources, functional food material and feed stuff.

• 한국콘텐츠학회논문지
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• 제9권7호
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• pp.225-232
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• 2009

연구는 심박수, 수축기 혈압, 이완기 혈압, 말초혈관 산소포화도 알아보고자 바닥과 스위스 볼상에서 요부안정화운동(LSE)에 따른 심혈관기능에 미치는 연구를 하였다. 대상자는 K 산업체 재활센타를 이용한 근골격계 근로자 중 선정기준에 적합한 남성 18명을 실험1군 바닥 적용군에 9명, 실험군 2군 스위스볼 적용군에 9명으로 분류하여 심박수, 수축기 혈압, 이완기 혈압, 말초혈관 산소포화도를 비교하였다. 심박수는 휴대용 심박 측정계(RS400sd, Finland)로, 혈압은 혈압계((FC-110, Japan)로, 말초혈관 산소포화도는 누리텍 체력 측정장치((TF-300-5, Korea)로 측정하고 분석하였다. 두군 모두 운동실시 후에 말초혈관 산소농도가 점차 통계학적으로 유의하게 증가하였으며, 수축기혈압이 통계학적으로 유의하게 감소하였다. 요부안정화운동에 따른 자세변동이 심혈관기능에 영향을 미치지만 지변의 상태에 따른 차이는 크게 영향을 받지 않는다는 결론을 얻었다.

• 동의생리병리학회지
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• 제19권2호
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• pp.459-465
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• 2005

This study was conducted to investigate the application possibility of leaf and stem extract(LSE) extracted from mixture of leaf and stem of ginseng radix (Panax Ginseng C.A. Meyer). We conducted analysis of the ginsenoside content by HPLC. Also we investigate the effects of the LSE on the reduction of serum lipid and improvement of blood parameters in rats fed high fat diet 5 weeks. We examined by analyzing the serum total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride and atherogenic index and hematological datas and serum metabolic variables. Sprague-Dawley rat weigh $150\;g\;{\pm}\;15\;g$, were ramdomly assigned to 4 groups, basal diet only(BDG), high fat diet weithout LSE(FDCG), high fat diet and 10% LSE(FD10G), high fat diet and 20% LSE(FD20G). The result of this study were as follow. Hematological datas of 4 groups were same level, which were not significant. The activities of ALP, GOT and LDH level were significantly different. Total cholesterol, LDL-cholesterol, triglyceride contentrations in serum and atherogenic index were remarkably reduced in LSE supplemented groups as compared high fat control groups. These result imply that LSE could be used as possible for decrease of serum lipid concentration.