• Journal of Microbiology and Biotechnology
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• v.28 no.1
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• pp.136-144
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• 2018

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Bacillus Calmette-$Gu\acute{e}rin$ (BCG) vaccine is the only TB vaccine currently available, but it is not sufficiently effective in preventing active pulmonary TB or adult infection. With the purpose of developing an improved vaccine against TB that can overcome the limitations of the current BCG vaccine, we investigated whether adjuvant formulations containing de-O-acylated lipooligosaccharide (dLOS) are capable of enhancing the immunogenicity and protective efficacy of TB subunit vaccines. The results revealed that the dLOS/dimethyl dioctadecyl ammonium bromide (DDA) adjuvant formulation significantly increased both humoral and Th1-type cellular responses to TB subunit vaccine that are composed of three antigens, Ag85A, ESAT-6, and HspX. The adjuvanted TB vaccine also effectively induced the Th1-type response in a BCG-primed mouse model, suggesting a potential as a booster vaccine. Finally, the dLOS/DDA-adjuvanted TB vaccine showed protective efficacy against M. tuberculosis infection in vitro and in vivo. These data indicate that the dLOS/DDA adjuvant enhances the Th1-type immunity and protective efficacy of the TB subunit vaccine, suggesting that it would be a promising adjuvant candidate for the development of a booster vaccine.

• Imaging Science in Dentistry
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• v.45 no.2
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• pp.95-101
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• 2015

Purpose: This study used cone-beam computed tomography (CBCT) to characterize mandibular molar root and canal morphology and its variability in Belgian and Chilean population samples. Materials and Methods: We analyzed the CBCT images of 515 mandibular molars (257 from Belgium and 258 from Chile). Molars meeting the inclusion criteria were analyzed to determine (1) the number of roots; (2) the root canal configuration; (3) the presence of a curved canal in the cross-sectional image of the distal root in the mandibular first molar and (4) the presence of a C-shaped canal in the second mandibular molar. A descriptive analysis was performed. The association between national origin and the presence of a curved or C-shaped canal was evaluated using the chi-squared test. Results: The most common configurations in the mesial root of both molars were type V and type III. In the distal root, type I canal configuration was the most common. Curvature in the cross-sectional image was found in 25% of the distal canals of the mandibular first molars in the Belgian population, compared to 11% in the Chilean population. The prevalence of C-shaped canals was 10% or less in both populations. Conclusion: In cases of unclear or complex root and canal morphology in the mandibular molars, CBCT imaging might assist endodontic specialists in making an accurate diagnosis and in treatment planning.

• Journal of Korean Physical Therapy Science
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• v.8 no.2
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• pp.1081-1090
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• 2001

This study was conducted to find out effect of dynamic balance performance in normal adult when obscuring vision in half of the both eye and to prepare the basic data treatment of brain damage patient with visual field deficit. The subject for this study included 40 healthy right-handed and 20 left-handed were dynamic balance performance when obscuring vision in half of the both eye. who age from 20 to 30 years in normal adult without neurosurgical orthopedic, performance balance disability or other medical disorders. Of these individuals 20 right-handed and 20 left-handed were executed dynamic balance performance when obscuring vision in half of the both eye. individuals of right, left-handed were executed dynamic performance when obscuring vision in half of the both eye measure with a Balance Performance Monitor (BPM) Data print Software Version 5.3. In other to determine the statitsical significance of the result, instrumentation was used to t-test, chisquare of the SAS(Strategic Application Software) The result of the study were that: 1) Significant differences in LOS were found right-handed and left-handed subject when dynamic performance without obscuring vision and obscuring vision(p<0.05). 2) Significant differences in LOS were founded left-handed when dynamic performance were executed obscuring vision and without obscuring vision(p<0.05). 3) Significant differences in LOS were founded right-handed when dynamic performance were executed obscuring vision and without obscuring vision(p<0.05).

• Journal of Korean Neurosurgical Society
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• v.40 no.4
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• pp.217-226
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• 2006

Malignant gliomas are the most common type of primary brain tumor and are in great need of novel therapeutic approaches. Advances in treatment have been very modest, significant improvement in survival has been lacking for many decades, and prognosis remains dismal. Despite "gross total" surgical resections and currently available radio-chemotherapy, malignant gliomas inevitably recur due to reservoirs of notoriously invasive tumor cells that infiltrate adjacent and non-adjacent areas of normal brain parenchyma. In principle, the immune system is uniquely qualified to recognize and target these infiltrative pockets of tumors cells, which have generally eluded conventional treatment approaches, In the span of the last 10 years, our understanding of the cancer-immune system relationship has increased exponentially; and yet we are only beginning to tease apart the intricacies of the central nervous system and immune cell interactions. This article reviews the complex associations of the immune system with brain tumors. We provide an overview of currently available treatment options for malignant gliomas, existing gaps in our knowledge of brain tumor immunology, and strategies that might be exploited for improved design of "custom immunotherapeutics." We will also examine major new immunotherapy approaches that are being actively investigated to treat patients with malignant glioma, and identify some current and future research priorities in this area.

• Asian-Australasian Journal of Animal Sciences
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• v.10 no.4
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• pp.435-438
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• 1997

Twelve newborn goat kids born of philippine does (3.5 and 5 years old) were used in this study. Four mother (candidate) doe goats were randomly allocated to each group. The mother does were infected orally with three levels (0, 15,000 and 30,000 larvae) of infective Haemonchus contortus larvae. Before infection all animals were housed in individual pens with concrete floors. They were provided with a uniform management. Estrus of does were synchronized using PGF2 alpha. All the animals were bred naturally by the same buck. Baby goat born of infected mother goats were divided into three groups. $T_1$, $T_2$ and $T_3$), respectively, from mother treatment groups. Birth weight and growth of goat kids born from H. contortus infected mother goats were determined. Birth weights of kids of $T_1$, $T_2$ and $T_3$ were 1.9, 1.5 and 1.2 kg, respectively. No significant (p > 0.05) differences in birth weight of kids for the 3 treatment groups were found. However, significant (p < 0.05) effects of stomach worm infection and duration of infection on liveweight gain of kids were observed. After second and third week of birth, respectively, the kids of groups 3 and 2 registered lover liveweight gains than the kids in control group. However, no significant (p > 0.05) difference in liveweight gain was found between the kids of infected mother does. Fecal egg counts of the infected mother does showed patent infections which also indicated by postmortem worm counts. However, no worm egg was found in the feces of the test kids.

• Journal of Satellite, Information and Communications
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• v.2 no.2
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• pp.1-9
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• 2007

In this paper, we describe the performance degradation of satellite Wibro system and compensation method in the high-speed railroad channel environment. High-speed railroad channel environment is divided into LOS channel and tunnel. In the LOS channel, signal blocking caused by railroad power feeder structures can be a critical problem which is can be solved with antenna diversity. On the other hand, multi path interference phenomenon, representable by propagation model of Optic Fiber, occurred in the tunnel may be another obstacle. These satellite Wibro system performance degradations in railroad channel environment are addressed and adequate compensation methods are proposed and verified through computer simulation. In addition, the ICI caused by Doppler shift in OFDM system is analyzed with its compensation method.

• Investigative Magnetic Resonance Imaging
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• v.21 no.4
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• pp.210-222
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• 2017

Purpose: To develop a novel combination of controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) with integrated SSFP (CAIPI-iSSFP) for accelerated SSFP imaging without banding artifacts at 3T. Materials and Methods: CAIPI-iSSFP was developed by adding a dephasing gradient to the balanced SSFP (bSSFP) pulse sequence with a gradient area that results in $2{\pi}$ dephasing across a single pixel. Extended phase graph (EPG) simulations were performed to show the signal behaviors of iSSFP, bSSFP, and RF-spoiled gradient echo (SPGR) sequences. In vivo experiments were performed for brain and abdominal imaging at 3T with simultaneous multi-slice (SMS) acceleration factors of 2, 3 and 4 with CAIPI-iSSFP and CAIPI-bSSFP. The image quality was evaluated by measuring the relative contrast-to-noise ratio (CNR) and by qualitatively assessing banding artifact removal in the brain. Results: Banding artifacts were removed using CAIPI-iSSFP compared to CAIPI-bSSFP up to an SMS factor of 4 and 3 on brain and liver imaging, respectively. The relative CNRs between gray and white matter were on average 18% lower in CAIPI-iSSFP compared to that of CAIPI-bSSFP. Conclusion: This study demonstrated that CAIPI-iSSFP provides up to a factor of four acceleration, while minimizing the banding artifacts with up to a 20% decrease in the relative CNR.

• Journal of Preventive Medicine and Public Health
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• v.23 no.4 s.32
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• pp.451-464
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• 1990

The variation in resource utilization for hospitalized patients who had a group of similar diseases -- a Korean Diagnosis Related Group (KDRG) -- among the same type of hospitals was studied to assess the utillization variation due to the practice pattern of hospitals. Information about inpatients who were beneficiaries of the medical insurance for teachers and government officials discharged from 20 large university teaching hospitals in Seoul during 1986 and information about the hospitals were analyzed to achieve the study objective. A total of 20,223 non-outlier patients in 100 most frequent KDRGs were included in the analysis. Case charges after the review and length of stay (LOS) were used as measures of resource utilization during a hospitalization. A substantial variation among hospitals was found in most KDRGs : o the ratio of the maximum and the minimum among the mean case charges of hospitals was greater than 2 in 83 KDRGs ; o the difference between the maximum and the minimum among the mean case charges of hospitals was greater than 100,000 Won in 94 KDRGs : o the ratio of the maximum and the minimum among the mom LOS of hospitals was greater than 2 in 82 KDRGs ; o the difference between the maximum and the minimum among the mean LOS of hospitals was greater than 3 days in 94 KDRGs. The practice pattern of hospitals explained more than 20% of charge variation in 49 KDRGs and more than 20% of LOS variation in 43 KDRGs. The study results indicated need for a new health policy initiative for cost containment and quality assurance.

• Asia-Pacific Journal of Business
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• v.8 no.1
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• pp.45-65
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• 2017

This study which focused on factors and challenges affecting the decision-making of indigenous corn farmers ascertained the determinants that make farmers decide to engage in and continue corn farming activities in Paracelis, Mountain Province, in Northern Philippines. Determinants of decision and motivational factors of corn farmers were examined based on survey responses of 120 indigenous corn farmers by applying chi-square test analysis. Results showed that there were some decision and motivational factors that were significantly related to specific characteristics of corn farmers and there were also similarities of factors that affected the decision making of farmers in terms of engaging in and sustaining corn farming activities. Among the identified driving forces, financing capability and availability of land area were highly related with farm size and with a farmer's educational attainment. Knowledge or experience and interest in corn farming were also related with educational attainment. All the identified driving forces were found to be unrelated to farmers' age. The motivational factor identified as "personally satisfying" was found to be related with age, educational attainment and years in the farming business. Factors which affected a farmer's decision to sustain corn farming activities ("sustaining" factors) such as availability of different networks is highly related to educational attainment, years in the farming business and farm size while high market price of corn was the only "sustaining" factor linked to educational attainment. Based on these factors and cited problems in corn farming, recommendations were offered to address the issues raised by farmers.

• Physical Therapy Korea
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• v.6 no.3
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• pp.11-21
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• 1999

Human balance is maintained through a complex process involving sensory detection of body motions, integration of sensorimotor information within the central nervous system, and execution of appropriate musculoskeletal responses. The basic task of balance is to position the body center of gravity (COG) over some portion of the support base. When the COG extends beyond the base of support, the person has exceeded the limits of stability (LOS). At this point, a step or stumble is required to prevent a fall. Automatic postural responses operate to keep the COG over the base of support. They are a set of functionally organized, long-loop responses that act to keep the body in a state of equilibrium. There are four commonly identified automatic postural responses, or strategies. These are ankle strategy, hip strategy, suspensory (knee) strategy, and stepping strategy. Thus, the purpose of this study was to evaluate the LOS using various knee strategies. Forty subjects participated in this study. The subjects were comprised of 20 males and 20 females who were without neurologic, orthopaedic or balance performance impairments. The LOS was measured with a Balance Performance Monitor (BPM) Dataprint Software Version 5.3. The results of this study were as follows: 1) Knee joint angle which is to increase stability of standing balance with using knee strategy was at mid-range. 2) There were statistically significant differences in anteroposterior LOSs according to the knee strategy. 3) There were no statistically significant differences in mediolateral LOSs according to the knee strategy. 4) There were statistically significant differences of anteroposterior LOSs with using knee strategy according to gender. 5) There were no statistically significant differences in mediolateral LOSs with using knee strategy according to gender.