• Journal of Platform Technology
• /
• 제6권1호
• /
• pp.24-30
• /
• 2018

LMT 는 10 가지 풍경요소 그림을 이용하여 내담자의 심리 상태를 분석하는 그림 검사기법이다. 본 논문에서는 LMT 그림 분석에 필요한 지식 베이스를 구축한다. 이를 기반으로 그림 검사 후 내담자에게 제공되는 평가 보고서를 생성하는 LMT 그림 진단지원 시스템을 제안하고, 구현한다. 이 시스템은 각종 문헌 및 연구 결과를 기반으로 진단 결과를 생성하기 때문에 진단 결과의 객관성을 제고한다. 또한, 향후 LMT 그림분석에 대한 지식을 지식 베이스에 축적할 수 있어 지속적으로 확장이 가능하다. 본 시스템은 웹 기반으로 서비스할 수 있도록 구현되었으며, 실제 사례를 이용하여 지원 시스템의 효과성을 보였다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제33권4호
• /
• pp.670-677
• /
• 2020

Objective: Interleukin-6 (IL-6) is a T cell-derived B cell stimulating factor which plays an important role in inflammatory diseases. In this study, the pharmacokinetic properties of LMT-28 including physicochemical property, in vitro liver microsomal stability and an in vivo pharmacokinetic study using BALB/c mice were characterized. Methods: LMT-28 has been synthesized and is being developed as a novel therapeutic IL-6 inhibitor. The physicochemical properties and in vitro pharmacokinetic profiles such as liver microsomal stability and Madin-Darby canine kidney (MDCK) cell permeability assay were examined. For in vivo pharmacokinetic studies, pharmacokinetic parameters using BALB/c mice were calculated. Results: The logarithm of the partition coefficient value (LogP; 3.65) and the apparent permeability coefficient values (P_app; 9.7×10^-6 cm/s) showed that LMT-28 possesses a moderate-high cell permeability property across MDCK cell monolayers. The plasma protein binding rate of LMT-28 was 92.4% and mostly bound to serum albumin. The metabolic half-life (t_1/2) values of LMT-28 were 15.3 min for rat and 21.9 min for human at the concentration 1 μM. The area under the plasma drug concentration-time curve and C_max after oral administration (5 mg/kg) of LMT-28 were 302±209 h·ng/mL and 137±100 ng/mL, respectively. Conclusion: These data suggest that LMT-28 may have good physicochemical and pharmacokinetic properties and may be a novel oral drug candidate as the first synthetic IL-6 inhibitor to ameliorate mammalian inflammation.

• 한국레이저가공학회:학술대회논문집
• /
• 한국레이저가공학회 2002년도 추계학술발표대회 논문개요집
• /
• pp.87-89
• /
• 2002

• International Journal of Advanced Culture Technology
• /
• 제9권2호
• /
• pp.64-71
• /
• 2021

The purpose of this study is to analyze the impact of participatory design workshops conducted to design forest play spaces that reflect young children's needs and demands on the development of spatial concepts in young children. As a research method for this purpose, we used the participatory design workshop (6 times) and Landscape Montage Techniques (LMT). We conducted this study at the "Songsan-mulbit Forest Experience Center for children (FECC)" located in Gwangsan-gu, Gwangju Metropolitan City, from the second week of May to third week of June 2018 for preschoolers in K-kindergarten (six and seven-year-old integrated classes; 41 preschoolers in total). We conducted the LMT evaluation on the same preschoolers before and after the workshop, and the drawings of 39 preschoolers drawn for LMT evaluation before and after the workshop were subject to the final evaluation. As a result of the study, the cognitive levels for the spatial concept after the workshop are higher than those for the spatial concept before the workshop, especially showed the result of comparing the LMT values of 6 age and 7 age, there were significant differences on pre and post workshop in p<0.01.

• Asian-Australasian Journal of Animal Sciences
• /
• 제11권1호
• /
• pp.1-7
• /
• 1998

A total of 120 pigs $(L\;{\times}\;LW\;{\times}\;D)$ averaged 14.16 kg of body weight were reared under six dietary treatments to evaluate the effects of amino acid supplementation on their performances. Treatments were 1) 18% CP diet (control); 2) 15% CP+0.28% Lys (B, 15L); 3) B+0.06% Met (15LM); 4) B+0.13% Thr (15LT) ; 5) B+0.06% Met+0.13% Thr (15LMT); 6) B+0.06% Met+0.13% Thr+0.05% Trp (15LMTT). Each treatment had 4 replicates with 5 pigs per replicate. The daily weight gains were statistically similar in 15LMT, 15LMTT and control groups. Threonine and methionine supplementation resulted in improved growth performance and nutrient digestibilities, while tryptophan supplementation had little beneficial effect. However, the best feed conversion was found in the control group. Dry. matter and CP digestibilities were improved in the 15LMT and 15LMTT groups. Gross energy, crude fat and phosphorus digestibilities were not affected by the treatment. Among the 15% CP groups, nitrogen digestibility showed the tendency to be increased as the more synthetic amino acids were added. Dry matter and nitrogen excretions were significantly reduced by feeding low protein, amino acid fortified diets, while phosphorus excretion was not influenced. Essential amino acids digestibility was higher in 15LT, 15LMT and 15LMTT groups and lower in the control. The 15LT group showed the best lysine digestibility, and methionine digestibilities were higher in all treated groups than control one. Threonine digestibilities higher in 15LT 15LMT, and 15LMTT than the control. The result shows that threonine and methionine should be added to the diet containing 15% CP diet, fortified with lysine to get same performance of 18% CP diet.

• Computers and Concrete
• /
• 제7권4호
• /
• pp.285-301
• /
• 2010

In this work we first review the statistical data on large fires in urban areas, presenting a detailed list of causes of fires, the type of damage to concrete and reinforced concrete structures. We also present the modern experimental approach for studying the fire-resistance of different structural components, along with the role of numerical modeling to provide more detailed information on quantifying the temperature and heat flux fields. In the last part of this work we provide the refined models for assessment of fire-induced damage in structures built of concrete and/or reinforced-concrete. We show that the refined models of this kind are needed to provide a more thorough explanation of damage and to complete the damage assessment and post-fire evaluations.

• Computers and Concrete
• /
• 제5권4호
• /
• pp.417-434
• /
• 2008

This paper deals with damage induced anisotropy modeling for concrete-like materials. A thermodynamics based constitutive relationship is presented coupling anisotropic damage and elasticity, the main idea of the model being that damage anisotropy is responsible for the dissymmetry tension/compression. A strain written damage criterion is considered (Mazars criterion extended to anisotropy in the initial model). The biaxial behavior of a family of anisotropic damage model is analyzed through the effects of yield surface modifications by the introduction of new equivalent strains.

• Advances in aircraft and spacecraft science
• /
• 제3권3호
• /
• pp.317-330
• /
• 2016

Nowadays, the interest of aerospace and automotive industries on virtual testing of medium-frequency vibrational behavior of shallow shell structures is growing. The development of software capable of predicting the vibrational response in such frequency range is still an open question because classical methods (i.e., FEM, SEA) are not fully suitable for the medium-frequency bandwidth. In this context the Variational Theory of Complex Rays (VTCR) is taking place as an ad-hoc technique to address medium-frequency problems. It is a Trefftz method based on a weak variational formulation. It allows great flexibility because any shape function that satisfies the governing equations can be used. This work further develops such theory. In particular, orthotropic materials are introduced in the VTCR formulation for shallow shell structures. A significant numerical example is proposed to show the strategy.

• 영재교육연구
• /
• 제24권2호
• /
• pp.313-333
• /
• 2014

본 연구는 과학영재 고등학생 집단과 일반계 고등학생 집단의 자아존중감과 풍경구성법의 반응특성을 살펴보았다. 이를 위해 과학영재 고등학교와 일반계 고등학교 2학년 학생 113명을 연구대상으로 선정하여, 자아존중감 척도검사와 풍경구성법을 실시한 후 SPSS.PASW18을 사용하여 분석하였다. 첫째, 과학영재 고등학생 집단과 일반계 고등학생 집단의 자아존중감 척도를 실시하였다. 연구 결과 일반계 고등학생 집단보다 과학영재 고등학생 집단의 자아존중감이 전체적으로 높았다. 둘째, 풍경구성법에 나타난 과학영재 고등학생 집단과 일반계 고등학생 집단 간의 반응특성을 살펴보았다. 풍경구성의 통합성, 원근과 공간감 표현, 추가 항목 수, 문과 창문의 유무 4개 항목에서 통계적으로 유의미한 차이를 보였다. 본 연구 결과 과학영재 고등학생 집단과 일반계 고등학생 집단 간의 자아존중감과 풍경구성법 반응특성에서 통계적으로 유의미한 차이가 있는 것으로 나타났다.

• Advances in aircraft and spacecraft science
• /
• 제3권2호
• /
• pp.171-195
• /
• 2016

The present paper is a review of the main activities carried out within the context of the COMPTINN' program, a joint research project founded by a FUI program (Fonds $Unifi{\acute{e}}s$ $Interminist{\acute{e}}riels$) in which four research teams focused on the thermo-oxidation behaviour of HTS-TACTIX carbon-epoxy composite at 'high' temperatures ($120^{\circ}C-180^{\circ}C$). The scientific aim of the COMPTINN' program was to better identify, with a multi-scale approach, the link between the physico-chemical mechanisms involved in thermo-oxidation phenomena, and to provide theoretical and numerical tools for predicting the mechanical behaviour of aged composite materials including damage onset and development.