• Animal cells and systems
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• v.6 no.3
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• pp.277-282
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• 2002

Topoisomearse II is an essential enzyme in all organisms with several independent roles in DNA metabolism. Recently, it has been demonstrated that the C-terminal region of topoisomerases II is associated with hetero-logous protein-protein interactions in human and yeast. In this study, we identified that RTP1, a rat homologue of EIA binding protein BS69, is another topoisomerae II interacting protein by yeast two-hybrid screening. RTP1 has an E1A-binding domain and a MYND motif, which are known to be required for transcriptional regulation by binding to other proteins and interaction with the leucine zipper motif of topoisomerase II. The physical interaction between RTP1 and topoisomerase ll$\alpha$ was examined by GST pull-down assay in vitro. The expression level of RTP1 peaks in S phase as that of topoisomerase ll$\alpha$. These results suggest that the interaction between topoisomerase ll$\alpha$ and RTP1 might play an important role in regulating the transcription of genes involved in DNA metabolism in higher eukaryotes.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2307-2310
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• 2013

Curcumin previously was proven to inhibit angiogenesis and display potent antitumor activity in vivo and in vitro. In the present study, we investigated whether a combination curcumin with hyperthermia would have a synergistic antitumor effect in the LL/2 model. The results indicated that combination therapy significantly inhibited cell proliferation of MS-1 and LL/2 in vitro. LL/2 experiment model also demonstrated that the combination therapy inhibited tumor growth and prolonged the life span in vivo. Furthermore, combination therapy reduced angiogenesis and increased tumor apoptosis. Our findings suggest that the combination therapy exerted synergistic antitumor effects, providing a new perspective fpr clinical tumor therapy.

• Journal of the Korean Home Economics Association
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• v.33 no.1
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• pp.169-180
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• 1995

To determine the effects of guar suksolgi on blood glucose and lipids in type-ll diabetic subjects, a piece of guar suksolgi(36.3g, 54Kcal) was administered to eight patients for 3 weeks every meal. No significant differences occured indietary intakes and body weight before and after the treatment. Fasting blood glucose levels were decreased from 132.38mg/dI to 114.75mg/dI after the treatment, but not statistically significant. Blood TG levels were increased from 159.13mg/dI to 175.00mg/dI after the treatment, but not statistically significant. Excluding one patient who had extremely high TG level, blood TG levels tended to be decreased from 148.00mg/dI to 121.00mg/dI. TC LDL-c, HDL-c levels were decreased after the treatment, but not statistically significant. HbAIC concentrations were decreased from 8.54mg/kI to 7.80mg/dI after the treatment, but not statistically significant. In the case of three patients who had had normal fasting blood glucose levels, blood glucose levels tended to be decreased at postprandial 30, 60 minutes, and blood insulin levels tended to be decreased at postprandial 30, 60, 90, 120 minutes, although none of the levels were statistically significant. Therefore, if guar suksolgi is adinistered to type-ll diabetic subjects being more hyperglycemic than our patients, their blood glucose and lipids will be decreased significantly.

• Korean journal of food and cookery science
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• v.23 no.4 s.100
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• pp.433-442
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• 2007

This study was conducted to investigate the quality characteristics of Sulgitteok prepared with different ratios of lotus leaf powder, over for 4 days of storage. As the amount of lotus leaf powder increased, the moisture contents of the lotus leaf Sulgitteok decreased; however, this was not consistent for all samples during storage. As the content of the lotus leaf powder increased, the L-values of the lotus leaf Sulgitteok significantly decreased, and the a- and b-values also significantly increased at day 0. The L- and a-values did not show large differences with storage. The total cell count of the lotus leaf Sulgitteok prepared with the 4% lotus leaf powder (LL4) was considerably lower than the other samples at 2 days of storage, indicating that microorganisms were inhibited by increasing amounts of lotus leaf powder. The hardness, gumminess, and chewiness of the lotus leaf Sulgitteok decreased as the amount of lotus leaf powder increased; however, they increased as storage time passed. Increasing amount of lotus leaf powder and the storage time resulted in greater reductions in adhesiveness. Springiness was not significantly different according to the amount of added lotus leaf powder or the storage time. Increasing storage time caused cohesiveness to decreased in all samples except LL2. Also, the results of the sensory evaluation showed that the LL2 lotus leaf Sulgitteok had the highest scores. In conclusion, the lotus leaf Sulgitteok prepared with the 2% lotus leaf powder (LL2) was superior.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.14 no.1
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• pp.154-166
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• 2001

Naesosan(NSS) has been used in Oriental Medicine as a drug that treated carbuncle and cellulitis. So, the purpose of this Study was to investigate effects of NSS on the cytotoxicity of cancer cell lines and lymphocytes in vitro, proliferation of Ll210 cells and lymphocytes in L1210 cells transplanted mice, improvement of blood count in Ll210 cells transplanted mice, tumor weight and body weight in sarcoma-180 cells transplanted mice, survival prolongation in sarcoma-180 cells transplanted mice. We used NSS extract with freeze-dried, 8wks-old male mice(balb/c and ICR mouse $18{\pm}2g$). Ll210 cell lines, and sarcoma-180 cell lines for this Study, The proliferation of cells was tested using a colorimetric tetrazoliun assay(MTT assay). The results of this Study were obtained as follows ; 1. NSS showed significantly cytotoxicitic effects of cancer cell lines, did not show cytotoxicitic effects of lymphocytes. 2, Proliferation of lymphocytes in L1210 cells transplanted mice did not effects by NSS. 3. NSS inhibited significantly the proliferation of L1210 cells in L1210 cells transplanted mice. 4. NSS improved significantly the blood count in Ll210 cells transplanted mice. 5. NSS increased significantly th body weight in sarcoma-180 cells transplanted mice. 6. NSS dereased significantly the tumor weight in sarcoma-180 cells transplanted mice. 7. NSS prolonged significantly the survival time in sarcoma-180 cells transplanted mice.

• Journal of the Korean Society for Precision Engineering
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• v.13 no.7
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• pp.148-157
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• 1996

This paper deals with the applicability of linear elastic fracture mechanics under centrifugal force. Stress intensity factors K are calculated as a function of the inclination crack of length 2a, the position at different angular velocities 1200rpm, 2400rpm and at different values of the inclination crack angle .phi. ( .phi. = 0 .deg. , 15 .deg. , 30 .deg. , 45 .deg. , 60 .deg. , 75 .deg. , 90 .deg. ) and are measured in models of rotation disks using a boundary element method. Especially, stress intensity factors $K_{l}$ and $K_{ll}$ obtained separately from the crack tip of the mixed mode, were used to further investigate the influence of $K_{l}$ and $K_{ll}$ on fracture in rotating disks. With the increase in the speed of rotation, the effect of K/ sub l/became larger where as that of $K_{ll}$ became small. For the increase in the inclination crack angle .phi. , a decrease in $K_{l}$ and an increase in $K_{ll}$ were observed.

• Journal of Society of Preventive Korean Medicine
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• v.5 no.2
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• pp.1-7
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• 2001

Jinhee-Twentyfour method Qigong (陳希夷二十四節氣坐功導引) is a traditional exercise which is known as qi-gong. It was first mentioned in ${\ll}$保生心鑒${\gg}$ published in Myung dynasty. But it is very difficult to know how to master Jinhee-Twentyfour method Qigong (陳希夷二十四節氣坐功導引) So we studied the training methods by analizing several books such as ${\ll}$遵生八${\gg}$ and ${\ll}$內外功圖說輯要${\gg}$ which have pictures of the training methods. It is known that to train Jinhee-Twentyfour method Qigong (陳希夷二十四節氣坐功導引) is not only limited to the exercise of the body but also training of the mind is an important factor. It is very important to know that the system of Hyung(形), Qi(氣), Sin(神) is needed for Jinhee-Twentyfour method Qigong (陳希夷二十四節氣坐功導引)

• The Journal of the Korea Contents Association
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• v.16 no.7
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• pp.633-639
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• 2016

Putting his 'Panic theatre' aesthetics into practice, Fernando Arrabal is a leader of the avant-garde theatre. Creating ${\ll}$Guernica${\gg}$, Arrabal's play, in a dance theatre format, this study tries to analyze the group pathos in fanatical conscious and poetic movement. Logic analysis is based upon the pathos value of the theatre of the Absurd that transcends the unrealistic and the illogic on the authority of dual element of the internal opposition and contradiction of human beings. In ${\ll}$Guernica${\gg}$, the dance of the Absurd found expression in the group pathos phenomenon of fanatical conscious, and was analysed as a new framework of communication structure.

• The Journal of Korean Medicine
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• v.19 no.1
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• pp.358-367
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• 1998

These studies were conducted to investigate the effects of the various aqua-aqupunctures of Hwanggum(Scutellariae Radix) on the proliferation of 3T3-Ll cells. They were tested by means of Sulforhodamin B(SRB) assay. The results were summerized as follows: All tested aqua-aqupunctures inhibited the proliferation of preadipose 3T3-Ll cells. In case of the dilution of Hwanggum aqua-aqupuncture(HG), the results were quite opposite. In 1000 times dilution of HG(${\times}1000$), a low concentration increased the proliferation of preadipose 3T3-Ll cells, but the high($100{\mu}l\;and\;200{\mu}l$) concentration inhibited it. These results suggest that Hwanggum aqua-aqupunctures may be used on the obesity induced by the overgrowth of preadipose 3T3-Ll cells.

• Journal of Acupuncture Research
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• v.17 no.2
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• pp.69-84
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• 2000

We have known that $\ll$Zhen Jiu Da Cheng, 鍼灸大成$\gg$ had been written by Yang Ji Zhou(楊繼洲) in Ming(明) dynasty. And it had been the only textbook of acupuncture & moxibustion for over 300years. This book is composed of 10 chapters dealing almost all the medical theories of that times. This book is so enormous that it is hard to understand essential ideas of the author. But, Yang Ji Zhou revealed his ideas and medical theories in some parts of this book. This part is named that composed of 4 small subjects. These are , , and In this study, I analyze the relation of $\ll$Zhen Jiu Da Cheng, 鍼灸大成$\gg$ and $\ll$Wei Sheng Zhen Jiu Xuan Ji Bi Yao, 衛生鍼灸玄機秘要$\gg$ and then I study further by comparing with other parts of $\ll$Zhen Jiu Da Cheng, 鍼灸大成$\gg$ and other important oriental medical textbooks.