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http://dx.doi.org/10.7314/APJCP.2013.14.4.2307

Enhanced Antitumor Effect of Curcumin Liposomes with Local Hyperthermia in the LL/2 Model  

Tang, Jian-Cai (State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University)
Shi, Hua-Shan (State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University)
Wan, Li-Qiang (State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University)
Wang, Yong-Sheng (Department of Thoracic Oncology, West China Hospital, West China Medical School, Sichuan University)
Wei, Yu-Quan (State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.4, 2013 , pp. 2307-2310 More about this Journal
Abstract
Curcumin previously was proven to inhibit angiogenesis and display potent antitumor activity in vivo and in vitro. In the present study, we investigated whether a combination curcumin with hyperthermia would have a synergistic antitumor effect in the LL/2 model. The results indicated that combination therapy significantly inhibited cell proliferation of MS-1 and LL/2 in vitro. LL/2 experiment model also demonstrated that the combination therapy inhibited tumor growth and prolonged the life span in vivo. Furthermore, combination therapy reduced angiogenesis and increased tumor apoptosis. Our findings suggest that the combination therapy exerted synergistic antitumor effects, providing a new perspective fpr clinical tumor therapy.
Keywords
Curcumin; hyperthermia; anti-angiogenesis; apoptosis; antitumor therapy;
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