• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7045-7047
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• 2015

Background: Mean platelet volume (MPV) is a marker which has been investigated in many cancers but data for head and neck lesions are limited. We aimed to study the MPV levels in head and neck cancers as a diagnostic marker. Materials and Methods: A total of 96 head and neck cancer patients and 31 control patients who did not meet exclusion criteria were enrolled in the study. The cancer locations, the platelet and MPV levels at the first diagnosis time were collected. Results: The head and neck cancer location distribution between these patients was 2 (2.1%) buccal, 9 (9.4%) tongue, 6 (6.3) lip, 1 (1%) gingiva, 1 (1%) hypopharynx, 1 (1%) ear, 58 (60.4%) larynx, 2 (2.1%) maxilla, 2 (2.1%) nasal, 1 (1%) nasopharynx, 2 (2.1%) palatal, 3 (3.1%) primary unknown, 1 (1%) retromolar, 1 (1%) thyroid, 2 (2.1%) tonsil, and 4 (4.2%) salivary gland. MPV levels were significantly different between cancer and control group (p=0.002). The cut-off point for MPV predicting head and neck cancer is >10 fL (sensitivity=55.21, specificity=87.10). Conclusions: MPV level increase, a readily assessable parameter which does not bring extra costs can warn us regarding head and neck cancer risk.

• Journal of Welding and Joining
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• 제16권1호
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• pp.77-87
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• 1998

This paper deals with the effect of laser welding parameters on the weld formation. Thin steels for automotive application were prepared so as to be welded with high power carbon dioxide laser system. Major process parameters were position of focus and travel speed. The effect of shielding gas was also discussed by employing the high speed photometry. Test results showed that the optimal position of focus varied in accordance with the joint configuration; bead-on-plate, butt or lap welding. It was recommended that the position of focus for the lap welding be located at slightly inner part of the material to be welded. In this case, however, it was noticeable that the weld penetration ratio, d/t$_{0}$ dropped drastically at the critical region. Results also demonstrated that both the bead width and penetration reduced as the travel speed increased. The penetration ratio showed two distinct regions; stabilized zone at the lower range of the travel spped and sudden drop zone at the higher range of travel speed. Lower limit of the penetration for acceptable weld was proved to be about 90% of the parent metal thickness based on the physical properties of the weld. Mixed gas application for both the shielding of molten metal and laser induced plasma control was recommended as far as the penetration was concerned.d.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.622-627
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• 2008

Experiment of active noise control on supersonic jet noise was conducted by use of microjet injection. The microjets were injected to the shear layer of the main jet through 22 small holes at the lip of a rectangular nozzle. Based on the measurement of farfield sound pressure, it was found that the jet noise was effectively reduced by several dB(in some cases up to 10 dB). The power levels of all measurement points were also reduced by use of microjet injection. The microjet affected not only the broadband noise but also the screech tone noise. The sound pressure level, the frequency of the screech tone, and the structure of the jet could be changed by the microjet. Flow visualization with schlieren technique was also made to observe the effect of microjet on the flow field.

• Journal of Trauma and Injury
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• 제32권3호
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• pp.168-171
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• 2019

The treatment outcome remains poor of severe facial injuries because of the high risk of compromised airway or massive bleeding. We experienced two successful treatment cases of severe facial injury by the chainsaw. A 52-year-male had his face injured by the chainsaw during his work. He was transferred to the Level I trauma center using the Doctor-Helicopter. During his flight, bleeding control was tried and the information was given to the trauma surgeons before his arrival. His consciousness was alert and the vital signs were stable. The crushing wound, mandible open fracture, deep laceration of tongue, lip, neck and arterial bleeding were noted around his mandible. Nasotracheal intubation was performed under the bronchoscope-guided. Emergency operation (open reduction & internal fixation, primary repair with neurorrhaphy) was performed. At 30 hospital days, he was discharged with facial palsy on left mandibular area. A 30-year-male had his face injured by the chainsaw. He was transferred to our Level I trauma center from the local hospital. The deep-mutiple lacerations on right upper eyelid and forehead with the bony exposure were noted. The vital signs were stable and emergency operation was performed. He was discharged at 20 hospital days. Bone loss or tissue loss were not devastating than we expected even though the injury was occurred by the chainsaw. Aggressive treatment including airway manipulation or bleeding control and maximal opportunity of therapy are absolutely needed.

• Applied Biological Chemistry
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• 제41권2호
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• pp.166-174
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• 1998

저장성이 좋지 않은 숙면(熟麵)을 식초, 젖산, 구연산, 사과산과 같은 유기산에 침지하여 총균수와 기계적 물성을 측정하고 관능검사를 하여 유기산의 효과를 알아보았다. 면가닥을 각각의 유기산 수용액에서 30초간 침유(沈遺)시켜 $pH\;4.7{\pm}0.25$로 맞추어 포장 후 $15^{\circ}C$에서 4일간 저장하는 동안 총균수와 혼탁도를 비교 측정했다. 총균수에서는 식초, 젖산, 구연산, 사과산, 대조구 순으로 총균수 억제 효과를 나타내었고 혼탁도에서는 대조구, 젖산, 사과산, 구연산, 식초 순으로 높았다. 또한 $35^{\circ}C$에서 30일간 저장하면서 Rheometer를 이용하여 물성을 측정한 결과 견고성과 부착성은 대조구보다 유기산처리구가 높게 나타났고, 응집성과 탄성은 다소 감소 추세였으나 큰 변화가 없었다. 껌성은 대조구보다 사과산과 구연산 처리구가 다소 높았다. 관능검사에 의한 종합적인 선호도 순서는 사과산>구연산, 젖산>대조구, 식초순으로 1% 수준의 유의적 차이의 결과를 얻었다.

• 혜화의학회지
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• 제13권2호
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• pp.337-345
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• 2004

Using aged Wistar rat living body change by aging CheongSimYeonJaTang was each orally administrated and achieved research about aging control. In Wistar rat 10, 30, 50 week and 40 week CheongSimYeonJaTang between 10 weeks form condition change of weight, change of intestine weight, hematology, blood chemistry, research result about serum content following conclusion get. 1. Observed gain in weight than control group form of CheongSimYeonJaTang to aged Wistar rat. 2. Is thought to promote activation of living body action gaining intestine weight along with gain in weight. 3. Displayed decrease of MDA's content of serum than control group form of CheongSimYeonJaTang to aged Wistar rat. 4. Change that is Wistar rat's hematological value by aging according to 10, 30, 50 week WBC, RBC, Hgb, monocytes, eosinophil etc. increase, and HCT, PLT etc. showed tendency that decrease according to old-week, and observed improvement that is hematological value than control group form of CheongSimYeonJaTang. 5. Change that is Wistar rat's biochemical value by aging was measured highest in 50 week because ALT, AST, BUN, CRN, T-bili., T-chol, TG, TP, ALB, A/G, P etc. increase according to 10, 30, 50 week, and observed improvement that is biochemical value than control group form of CheongSimYeonJaTang. Is considered by being effect that CheongSimYeonJaTang living body function decline by aging by this result.

• 대한소아치과학회지
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• 제35권2호
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• pp.351-356
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• 2008

뇌성마비(cerebral palsy)는 비진행성의 정신, 운동 장애를 총칭하는 용어로, 소아 장애의 흔한 원인이 된다. 자해 행위란(self-injurious behavior) 자살 의도없이 자신의 신체 일부를 고의적으로 손상시키는 것으로, 종종 반복적인 행동으로 나타난다. 소아에서의 이러한 자해 습관은 정상적인 어린이에서는 드물며, 증후군, 유전질환, 정신지체 어린이 등에서 그 발생률이 높게 보고된다. 구강 내 자해 행위의 가장 흔한 유형은 혀나 입술 혹은 구강 점막을 물어뜯는 것이다. 이러한 자해 행위를 조절하기 위하여 행동 수정법, 약물 치료, 신체 속박술, 치과적 장치의 적용, 외과적 수술 또는 치아 발치술 등의 다양한 방법들이 제시되었다. 이 중 마우스가드 등의 치과적 장치를 이용한 방법은 구강 내 자해 행위의 감소와 조직의 보호를 위해 가장 보존적이며 적합한 방법이라고 사료된다. 본 증례에서는 자해 습관에 의해 하순과 협점막에 궤양성 병소를 가진 뇌성마비 환아에 있어서, 변형된 마우스가드를 이용하여 자해에 의한 손상을 방지하고 만족할 만한 치유 양상을 보였기에 이를 보고하는 바이다.

• 대한전자공학회논문지
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• 제17권5호
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• pp.15-21
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• 1980

기존의 기계적인 점화장치를 전자식 점화장치로 대치한 엔진 제어시스템에 대하여 연구하였다. 점화차단기(Breaker)의 기계적인 접점을 없애고, 무접점 magnetic pick up sensor를 사용하여 속도신호 및 크랭크축의 기준점을 얻은 후, 연소 효률을 높이기 위하여 점화코일의 2차측 spark 전압을 종래의 10000∼15000볼트로 부터 30000∼40000볼트로 높이고 에너지 점화장치(High Energy Ignition System)을 설계 개발하여 실장시험(field test)을 행하였고, 점화시간의 조정을 위하여 종래의 기계적인 진각장치 대신에 microprocessor를 사용하여 엔진속도 및 흡입기관의 진공도(intake manifold vacuum)에 의한 점화시기 데이타가 결정되도록 하는 방법을 연구하였다.

• 대한치과교정학회지
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• 제33권3호
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• pp.185-197
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• 2003

비증후군성 구순구개열을 발생시키는 주요유전자로 추측이 되는 OFC1 유전자(위치 염색체 6p24.3)의 한국인에서 나타나는 특성을 연구하였다. 3대에 걸쳐서 처음으로 비증후군성 구순구개열이 나타난 40 명의 환자(남자 20명, 여자 20명, 평균 나이 : 14.2세)와 3대에 걸쳐서 비증후군성 구순구개열을 포함한 어떤 선천성 기형도 나타나지 않았던 정상 성인 40명 (남자 20명, 여자 20명, 평균 나이 : 25.6세)을 연구 대상으로 하였다. 중합효소 연쇄 반응법을 이용하여 OFC1 유전자를 분리 증폭한 후, 염기 서열 분석을 통해서 대립유전자형을 밝히고, BLAST 와 Pedant-Pro 데이터베이스를 이용하여 단백질의 상동성 검색을 수행하였으며, 그 결과는 다음과 같다. 1. OFC1 유전자는 'CA' 연쇄반복서열을 가진 극소위성 표지자로 밝혀졌다. 2. 환자군과 대조군의 OFC1 유전자의 특별한 차이는 발견되지 않았다. 3. 한국인에서 나타난 'CA' 연쇄반복서열의 형태는 'ABI linkage map 2'의 TA(CA)11TA(CA)10과는 달리, TA(CA)n의 형태를 띄었으며, 연쇄반복의 수는 17회에서 26회로 다양하게 나타났다. 4. 'CA' 연쇄반복서열의 횟수에 따라서, 9가지의 대립유전자형이 발견되었으며, 나타나는 빈도는 환자군과 대조군에서 유사하였다. 5. 'ABI linkage map 2'의 'CA' 연쇄반복서열 사이의 염기서열 T가 한국인에서는 C로 치환되어 있었지만, ORF예측을 하였을 때 예상되는 아미노산의 배열 차이는 관찰되지 않았다. 6. 한국인 OFC1 유전자의 염기서열로 예측되는 단백질을 알아보기 위하여 BLAST 검색을 한 결과, Telomerase reverse transcriptase(TERT, locus 5p15.33, NCBI Genome Annotation ; NT023089)와 Nucleotide binding protein 2(NBP2, locus 17q22, NCBI Genome Annotation; NT010783)가 유사한 구조를 가지는 단백질로 밝혀졌다. 7. Pedant-Pro 데이터베이스로 단백질 구조의 상동성 검색을 한 결과, OFC1 유전자는 적어도 하나의 transmembrane region과 non-gloular region을 가지는 구조로 밝혀졌다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9241-9247
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• 2014

Background: Rs31489 in the cleft lip and palate transmembrane1-like gene (CLPTM1L) has been identified to be associated with lung cancer through genome-wide association studies (GWAS). However, some recent replication studies yielded inconclusive results. Thus, we undertook this study to investigate the precise effect of rs31489 on lung cancer susceptibility. Materials and Methods: A hospital-based case-control study in 1,673 Chinese subjects (611 individuals with lung cancer and 1,062 controls) and a meta-analysis among 32,199 subjects (16,364 cases and 15,835 controls) were performed in this study. Results: In our case-control study, rs31489 was inversely associated with lung cancer (AC versus CC: OR=0.68, 95%CI=0.52-0.88; additive model: OR=0.68, 95%CI=0.54-0.85; dominant model: OR=0.65, 95%CI =0.51-0.84). Stratification analysis by smoking status showed a significant association and strong genetic effect in non-smokers but not in smokers. Our meta-analysis further confirmed the association, although with significant heterogeneity contributed by study design and source of controls, as shown by stratified analysis. Sensitive and cumulative analyses both indicated robust stability of our results. In addition, there was no observable publication bias in our meta-analysis. Conclusions: Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.