• Journal of mucopolysaccharidosis and rare diseases
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• 제2권1호
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• pp.23-26
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• 2016

Mucopolysaccharidosis (MPS) I is a rare, progressive and multisystemic disease with insidious initial signs and symptoms, and making an early diagnosis can be a challenge for the first-line general medical practitioner. We report a 6-month-old girl who was brought to our well baby clinic for regular immunization with the manifestations of lumbar gibbus, hirsutism, large Mongolian spots over back and buttock, and mild bilateral legs spasticity noticed by the general pediatrician, and then newly diagnosed with MPS I after referral to the geneticist in time. Her surgical history included inguinal hernia repair at 1 month old, $CO_2$ laser supraglottoplasty for laryngomalacia and tracheostomy due to chronic respiratory failure with ventilator dependence at 2 months old. Understanding and identification of the early signs and symptoms of this disease have the potential to early diagnosis and timely appropriate treatment, which could contribute to a better clinical outcome.

• Computers and Concrete
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• 제23권6호
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• pp.445-457
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• 2019

Cracks are an important distress of concrete bridges, and may reduce the life and safety of bridges. However, the traditional manual crack detection means highly depend on the experience of inspectors. Furthermore, it is time-consuming, expensive, and often unsafe when inaccessible position of bridge is to be assessed, such as viaduct pier. To solve this question, the real-time automatic crack detecting system with unmanned aerial vehicle (UAV) become a choice. This paper designs a new automatic detection system based on real-time comprehensive image processing for bridge crack. It has small size, light weight, low power consumption and can be carried on a small UAV for real-time data acquisition and processing. The real-time comprehensive image processing algorithm used in this detection system combines the advantage of connected domain area, shape extremum, morphology and support vector data description (SVDD). The performance and validity of the proposed algorithm and system are verified. Compared with other detection method, the proposed system can effectively detect cracks with high detection accuracy and high speed. The designed system in this paper is suitable for practical engineering applications.

• Archives of Pharmacal Research
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• 제9권1호
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• pp.21-23
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• 1986

Over twelve alkaloids were delected in the roots of Panax ginseng C. A. Meyor. Among them three alkaloids were isolated and were identified as $N_{9}$-formylharman, ethyl $\beta$-carboline-1-carboxylate and perlolyrine on the basis of spectroscopic studies.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10115-10119
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• 2015

Purpose: The aim of this study was to investigate effects of adipose-derived mesenchymal stem cells (AMSCs) on radioresistance of breast cancer cells. Materials and Methods: MTT assays were used to detect any influence of AMSC supernatants on proliferation of breast cancer cells; cell migration assays were used to determine the effect of breast cancer cells on the recruitment of AMSCs; the cell survival fraction post-irradiation was assessed by clonogenic survival assay; ${\gamma}$-H2AX foci number post-irradiation was determined via fluorescence microscopy; and expression of IGF-1R was detected by Western blotting. Results: AMSC supernatants promoted proliferation and radioresistance of breast cancer cells. Breast cancer cells could recruit AMSCs, especially after irradiation. IGF-1 derived from AMSCs might be responsible for the radioresistance of breast cancer cells. Conclusions: Our results suggest that AMSCs in the tumor microenvironment may affect the outcome of radiotherapy for breast cancer in vitro.

• The Korean Journal of Physiology and Pharmacology
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• 제23권2호
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• pp.95-102
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• 2019

Endoplasmic reticulum (ER) stress is mediated by disturbance of $Ca^{2+}$ homeostasis. The store-operated calcium (SOC) channel is the primary $Ca^{2+}$ channel in non-excitable cells, but its participation in agent-induced ER stress is not clear. In this study, the effects of tunicamycin on $Ca^{2+}$ influx in human umbilical vein endothelial cells (HUVECs) were observed with the fluorescent probe Fluo-4 AM. The effect of tunicamycin on the expression of the unfolded protein response (UPR)-related proteins BiP and CHOP was assayed by western blotting with or without inhibition of Orai1. Tunicamycin induced endothelial dysfunction by activating ER stress. Orai1 expression and the influx of extracellular $Ca^{2+}$ in HUVECs were both upregulated during ER stress. The SOC channel inhibitor SKF96365 reversed tunicamycin-induced endothelial cell dysfunction by inhibiting ER stress. Regulation of tunicamycin-induced ER stress by Orai1 indicates that modification of Orai1 activity may have therapeutic value for conditions with ER stress-induced endothelial dysfunction.

• 한국정보통신학회논문지
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• 제23권1호
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• pp.33-38
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• 2019

본 논문에서는 효과적으로 VPI 환자 음성을 인식하기 위해 DNN-HMM 하이브리드 구조의 음성 인식 시스템을 구축하고 기존의 GMM-HMM 기반의 음성 인식 시스템과의 성능을 비교한다. 정상인의 깨끗한 음성 데이터베이스를 이용하여 초기 모델을 학습하고 정상인의 VPI 모의 음성을 이용하여 VPI 환자 음성에 대한 화자 인식을 위한 기본 모델을 생성한다. VPI 환자의 화자 적응 시에는 DNN의 각 층 별 가중치 행렬을 부분적으로 학습하여 성능을 관찰한 결과 GMM-HMM 인식기보다 높은 성능을 나타냈다. 성능 향상을 위해 DNN 모델 적응을 적용하고 LIN 기반의 DNN 모델 적용 결과 평균 2.35%의 인식률 향상을 나타냈다. 또한 소량의 데이터를 사용했을 때 GMM-HMM 기반 음성인식 기법에 비해 DNN-HMM 기반 음성 인식 기법이 향상된 VPI 음성 인식 성능을 보인다.

• The Korean Journal of Physiology and Pharmacology
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• 제23권1호
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• pp.89-89
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• 2019

• 한국자기공명학회논문지
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• 제23권1호
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• pp.33-39
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• 2019

Studies on the interactions of proteins with partner molecules at the atomic resolution are essential for understanding the biological function of proteins in cells and for developing drug molecules. Solution NMR spectroscopy has shown remarkably useful capability for investigating properties on the weak to strong intermolecular interactions in both diluted and crowded solution such as cell lysates. Of note, the state-of-the-art in-cell NMR method has made it possible to obtain atomistic information on natures of intermolecular interactions between target proteins with partner molecules in living cells. In this mini-review, we comprehensively describe the several technological advances and developments in the in-cell NMR spectroscopy.

• 한국자기공명학회논문지
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• 제23권2호
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• pp.56-60
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• 2019

Study on the structure and dynamics of molecules at the atomic level is of great significance for understanding their function and stability as well as roles for various chemico-physical and biological processes. $^{17}O$ NMR spectroscopy has appeared as an elegant technique for investigating of the physicochemical and structural properties of oxygen-containing compounds such as metal organic frameworks and nanosized oxides. This method has drawn much attention as it provides unique insights into the properties of targets based on atomistic information of local oxygen environments which is otherwise difficult to obtain using other methods. In this mini review, we introduce and discuss the recent study and developments of $^{17}O$ NMR techniques which are tailored for the investigation on the structure and dynamics of water and inorganic materials.

• Journal of Gastric Cancer
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• 제23권1호
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• pp.182-193
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• 2023

Presently, surgery is the only treatment approach for gastric cancer and improving the prognosis of locally advanced gastric cancer is one of the key factors in promoting gastric cancer survival benefit. The MAGIC study was the first to demonstrate the efficacy of neoadjuvant chemotherapy (NAC) in European countries. In recent years, several clinical trials have provided evidence for the use of NAC in Asian patients with locally advanced gastric cancer. However, clinical practice guidelines vary between Asian and non-Asian populations. Optimal NAC regimens, proper target populations, and predictors of NAC outcomes in Asian patients are still under investigation. Herein, we summarized the current progress in the administration of NAC in Asian patients with gastric cancer.