• Title/Summary/Keyword: LIFE FROM

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Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress (암 환자의 말초신경병증 관련 일상활동장애와 삶의 질: 심리적 디스트레스의 매개효과)

  • Kim, Kyung Yeon;Lee, Seung Hee;Kim, Jeong Hye;Oh, Pok Ja
    • Journal of Korean Academy of Nursing
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    • v.45 no.5
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    • pp.661-670
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    • 2015
  • Purpose: The purpose of this study was to examine the mediation of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life in order to provide a basis for planning nursing interventions to improve the quality of life in cancer patients. Methods: A purposive sample of 130 patients treated with chemotherapy were recruited in the cross-sectional survey design. Data were collected using self-report questionnaires. The instruments were the Chemotherapy Induced Peripheral Neuropathy Assessment Tool (CIPNAT), Hospital Anxiety Depression Scale (HADS), and Functional Assessment of Cancer Therapy-General (FACT-G). Results: The mean score for disturbance in ADL from chemotherapy induced peripheral neuropathy was 3.30. Overall quality of life was 2.48. The mean score was 1.04 for psychological distress. The prevalence was 35.4% for anxiety and 47.7% for depression. There were significant correlations among the three variables, disturbance in ADL from chemotherapy induced peripheral neuropathy, psychosocial distress, and quality of life. Psychosocial distress had a complete mediating effect (${\beta}$= -.74, p <.001) in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life (Sobel test: Z= -6.11, p <.001). Conclusion: Based on the findings of this study, nursing intervention programs focusing on disturbance of ADL management, and decrease of psychological distress are highly recommended to improve quality of life in cancer patients.

Antioxidant and Neuronal Cell Protective Effects of Columbia Arabica Coffee with Different Roasting Conditions

  • Jeong, Ji Hee;Jeong, Hee Rok;Jo, Yu Na;Kim, Hyun Ju;Lee, Uk;Heo, Ho Jin
    • Preventive Nutrition and Food Science
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    • v.18 no.1
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    • pp.30-37
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    • 2013
  • In vitro antioxidant activities and neuronal cell protective effects of ethanol extract from roasted coffee beans were investigated. Colombia arabica coffee (Coffea arabica) green beans were roasted to give medium ($230^{\circ}C$, 10 min), city ($230^{\circ}C$, 12 min) and french ($230^{\circ}C$, 15 min) coffee beans. Total phenolics in raw green beans, medium, city and french-roasted beans were $8.81{\pm}0.05$, $9.77{\pm}0.03$, $9.92{\pm}0.04$ and $7.76{\pm}0.01$ mg of GAE/g, respectively. The content of 5-O-caffeoylquinic acid, the predominant phenolic, was detected higher in medium-roasted beans than others. In addition, we found that extracts from medium-roasted beans particularly showed the highest in vitro antioxidant activity on ABTS radical scavenging activity and FRAP assays. To determine cell viability using the MTT assay, extracts from medium- roasted beans showed higher protection against $H_2O_2$-induced neurotoxicity than others. Lactate dehydrogenase (LDH) leakage was also inhibited by the extracts due to prevention of lipid peroxidation using the malondialdehyde (MDA) assay from mouse whole brain homogenates. These data suggest that the medium-roasting condition to making tasty coffee from Columbia arabica green beans may be more helpful to human health by providing the most physiological phenolics, including 5-O-caffeoylquinic acids.

Development of Biologically Active Compounds from Edible Plant Sources-I. -Isolation of Major Components from the Tuber of Ipomoea batatas Lam.- (식용 식물자원으로부터 활성물질의 탐색-I. -고구마(Ipomoea batatas Lam.) 괴근 주요성분의 분리-)

  • Ahn, Eun-Mi;Bang, Myun-Ho;Kim, Hae-Yeong;Baek, Nam-In
    • Applied Biological Chemistry
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    • v.40 no.6
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    • pp.583-587
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    • 1997
  • The MeOH extracts obtained from the tuber of Ipomoea batatas Lam. were solvent-fractionated with EtOAc, n-BuOH, and $H_2O$, respectively. From EtOAc fraction four different compounds were isolated through the repeated silica gel column chromatographies. From not only the results of NMR and MS data but also the adaptation of hydrolysis, methylation, and acetylation, the chemical structures of compounds were elucidated as resin glycoside, simonin I, ${\beta}-sitosterol$, and two kinds of unsaturated fatty acids.

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Antioxidant and Antihypertensive Activities of Solvent Extract from Styela clava Tunic, Fishery Waste (수산폐기물인 미더덕껍질 용매 추출물의 항산화 및 항고혈압 활성)

  • Lee, Sang-Mee;Lee, Ye-Ram;Cho, Kwang-Sik;Park, Soo-Yun;Jang, Eun-Young;Hwang, Dae-Youn;Jung, Young-Jin;Son, Hong-Joo
    • Journal of Environmental Science International
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    • v.24 no.7
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    • pp.917-925
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    • 2015
  • Styela clava tunic is generated in large amounts as a waste from S. clava processing plants and leads to environmental problems. It destroys the beach scenery and causes a bad smell and pollution by trashing on the seashore. Therefore, purpose of this study was to investigate antioxidant and antihypertensive activities of different solvent extracts from S. clava tunic for recycling of fishery waste. Antioxidant and antihypertensive activities of all extracts were concentration-dependent. Of extracts, hot water extract showed the highest DPPH radical scavenging activity with the lowest effective concentration ($EC_{50}$) value (0.733 mg/ml). Chloroform extract exhibited the highest metal chelation activity with the lowest $EC_{50}$ value (2.696 mg/ml). Autoclaved water extract showed the highest NO radical scavenging activity with the lowest $EC_{50}$ value (0.491 mg/ml) and n-hexane extract showed the highest reducing power ($A_{700}=1.897$ at 100 mg/ml). And n-butanol extract showed the highest SOD-like activity with the lowest $EC_{50}$ value (19.116 mg/ml) and ACE inhibition activity with the lowest inhibitory concentration($IC_{50}$) value (0.149 mg/ml). These results indicate that extracts obtained from S. clava tunic may potential candidate to reduce diseases caused by various oxidative stresses and hypertension.

Isolation and Molecular Characterization of a New CRT Binding Factor Gene from Capsella bursa-pastoris

  • Wang, Xinglong;Liu, Li;Liu, Sixiu;Sun, Xiaoqing;Deng, Zhongxiang;Pi, Yan;Sun, Xiaofen;Tang, Kexuan
    • BMB Reports
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    • v.37 no.5
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    • pp.538-545
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    • 2004
  • A new CRT binding factor (CBF) gene designated Cbcbf25 was cloned from Capsella bursa-pastoris, a wild grass, by the rapid amplification of cDNA ends (RACE). The full-length cDNA of Cbcbf25 was 898 bp with a 669 bp open reading frame (ORF) encoding a putative DRE/CRT (LTRE)-binding protein of 223 amino acids. The predicted CbCBF25 protein contained a potential nuclear localization signal (NLS) in its N-terminal region followed by an AP2 DNA-binding motif and a possible acidic activation domain in the C-terminal region. Bioinformatic analysis revealed that Cbcbf25 has a high level of similarity with other CBF genes like cbf1, cbf2, and cbf3 from Arabidopsis thaliana, and Bncbf5, Bncbf7, Bncbf16, and Bncbf17 from Brassica napus. A cold acclimation assay showed that Cbcbf25 was expressed immediately after cold triggering, but this expression was transient, suggesting that it concerns cold acclimation. Our study implies that Cbcbf25 is an analogue of other CBF genes and may participate in cold-response, by for example, controlling the expression of cold-regulated genes or increasing the freezing tolerance of plants.

Residual Characteristics of Bifenthrin and Imidacloprid in Squash (Bifenthrin과 Imidacloprid의 호박 중 관류특성)

  • Lee, Eun-Young;Noh, Hyun-Ho;Park, Young-Soon;Kang, Kyung-Won;Lee, Kwang-Hun;Lee, Jae-Yun;Park, Hyo-Kyung;Yun, Sang-Soon;Jin, Chung-Woo;Han, Sang-Kuk;Kyung, Kee-Sung
    • The Korean Journal of Pesticide Science
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    • v.13 no.2
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    • pp.79-86
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    • 2009
  • In order to elucidate the residual characteristics of the insecticides, bifenthrin and imidacloprid, the pesticides were sprayed onto the squash and their residues were analyzed with GC-ECD and HPLC. Detection limits of the pesticides were $0.005\;mg;kg^{-1}$ and recoveries of bifenthrin and imidacloprid in squash were from 100.87 to 104.31 and from 79.71 to 92.54%, respectively. Half-lives of bifenthrin and imidacloprid in squash were from 1.8 to 2.9 and from 1.5 to 2.5 days, respectively. Initial concentration of bifenthrin and imidacloprid sprayed at the recommended rate and double rate of recommendation were less than their MRLs. And also, residueal concentrations of the pesticides were rapidly decreased in squash with time. At harvest, estimated daily intakes (EDIs) of the pesticides were less than 0.6% of their acceptable daily intakes (ADIs).

A Study on the Buddha's Life Relief in the Gupta Period at Sarnath, India (인도 굽타시대 사르나트 불전도에 대한 일고찰)

  • KOH, Jeong Eun
    • SUVANNABHUMI
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    • v.1 no.2
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    • pp.21-41
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    • 2009
  • The Art of the Buddha's Life which depicts the life and before-life of Buddha flourished in Sanci and Bharhut in the ancient India and in Gandhara during the Kushan period. More than one hundred scenes from Buddha's life were represented in the form of relief sculpture or wall painting. They are found in Gandhara and Mathura during the Kushan period, Amaravati and Nagarjunakonda during the Satavahana period, in Mathura and Sarnath during the Gupta period, and during the Pala Period. They unfolded in various forms and styles according to the text(Buddhist scripture), layout, and expressive technique. In Mathura, where the Evolution of the Buddha image was made about the same time as in Gandhara during the Kushan period, the Buddha's life was presented in a number of scenes related to the sacred sites; in four or eight scenes. In the case of the Eight Great Events of the Buddha's Life, the four scenes out of eight were different from those that were represented in Sarnath during the Gupta period, manifesting a transitional period. The Gupta period is widely known as the time when the classic artistic style was established. The art of Buddha's Life was produced only in Sarnath during this period, and it was the time when the Eight Great Events of the Buddha's Life was established as iconography, providing a model for those of the Pala period. Also, it was the time when the single image of Buddha was produced such as the 'Buddha delivering his first sermon,' 'Buddha's Enlightenment,' and 'Buddha's Death,' thus showing the emergence of the single Buddha image from the narrative Buddha's life image. In this paper, a general introduction of the relief sculpture of the Buddha's life from Sarnath during the Gupta period was given. The art of Buddha's life gave great influences on that of China, Korea, Japan and Southeast Asia, and can be emphasized as an important subject in understanding the development of the Buddhist art in East Asia. A further study will be made on the art of Buddha's Life of Southeast Asia in the future, which will enhance the understanding of the art of Buddha's Life in East Asia as a whole.

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A Study on the Prediction of Fatigue Life in Die (금형의 피로수명 예측에 관한 연구)

  • 여은구
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.8 no.4
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    • pp.87-92
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    • 1999
  • Generally the life of die is limited by fatigue fracture or dimensional inaccuracy originated from wear. In this paper to predict the fatigue life of die the stress and strain histories of die can be predicted by the analysis of elastic-plastic finite element method and the elastic analysis of die during the process analysis of workpiece. Also the stress-life curve of die material can be obtained through experiment. With the above to재 facts we propose the analysis method of prediction fatigue life in die,. In the proposed model the analysis of elastic-plastic finite element method for material is carried out by using ABAQUS. Surface force resulted from the contacting border of the die and workpiece is transformed into the nodal force of die to implement elastic analysis. besides the proposed analysis model of die is applied to extrusion die and forging. die.

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